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THE SILVER SCOOTER

空中英语教室（初级版．大家说英语） 2015年第9期 26-27,52页

作者： peter smith Simon Stopps

Intravital imaging of adriamycin-induced renal pathology using two-photon microscopy and optical coherence tomography

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Journal of Innovative Optical Health Sciences 2018年第5期11卷 59-68页

作者： Hengchang Guo Hsing-Wen Wang Qinggong Tang Erik Anderson Reuben Falola Tikina smith Yi Liu Moshe Levi peter M.Andrews Yu Chen Fischell Department of Bioengineering University of Maryland College Park MD 20742USA Department of Biochemistry and Molecular&Cellular Biology Georgetown University Medical Center Washington DC 20007 USA Central Animal Resources Facility University of Maryland College ParkMD 20742USA

Adriamycin(doxorubicin),a common cancer chemotherapeutic drug,can be used to induce a model of chronic progressive glomerular disease in *** our studies,we evahuated renal changes in a rat model after Adriamydin injection using two photon microscopy(TPM),optical coherence tomography(OCT)and Doppler OCT(DOCT).Taking advantage of deep penetra-tion and fast scanning speed for three dimensional(3D)label-free imaging,OCT/DOCT system was able to reveal glomerular and tubular pathology noninvasively and in real *** imaging renal pathology following the infusion of fAuorophore-labeled dextrans of different molecular weights,TPM can provide direct views of glomerular and tubular flow dynamics with the onset and progression of renal ***,glomerular permeability and filtration,proximal and distal tubular flow dynamics can be revealed.6-8 weeks after injection of Adriamycin,TPM and OCT/DOCT imaging revealed glomerular sclerosis,compromised flow across the glomerular wall,tubular atrophy,tubular dilation,and variable intra-tubular flow *** results indicate that TPM and OCT/DOCT provide real-time imaging of renal pathology in vivo that has not been previously available using conventional microscopic procedures.

关键词： Chronic kidney disease(CKD) glomeruloscerosis Optical Coherence Tomography(OCT) Tubular Atrophy Two-photon Microscopy(TPM)

Science to support conservation action in a large river system:The Willamette River,Oregon,USA

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Water Biology and Security

Water Biology and Security 2023年第4期2卷 20-35页

作者： Rebecca Flitcroft Luke Whitman James White Rose Wallick Laurel Stratton Garvin Cassandra smith Robert Plotnikoff Michael Mulvey Tobias Kock Krista Jones peter Gruendike Carolyn Gombert Guillermo Giannico Andrew Dutterer Daniel Brown Hannah Barrett Brian Bangs Robert M.Hughes U.S.D.A.Forest Service Pacific Northwest Research Station3200 SW Jefferson WayCorvallisOR97331USA Oregon Department of Fish and Wildlife 28655 OR-34CorvallisOR9733USA U.S.Geological Survey Oregon Water Science Center601 SW 2nd AveSuite 1950PortlandOR97204USA Snohomish County Department of Conservation and Natural Resources 3000 Rockefeller AvenueEverettWA98201USA Oregon Department of Environmental Quality Laboratory and Environmental Assessment Division 7202 NE Evergreen ParkwaySuite 150HillsboroOR97124USA U.S.Geological Survey Western Fisheries Research Center5501A Cook-Underwood RoadCookWashington WA 98605USA River Design Group 311 SW Jefferson AvenueCorvallisOR97333USA Bureau of Reclamation Sedimentation and River Hydraulics GroupDenver Federal CenterDenverCO80225USA Oregon State University Department of FisheriesWildlifeand Conservation SciencesNash 104CorvallisOR97331USA Oregon Watershed Enhancement Board 775 Summer Street NESalemOR97301USA U.S.Fish and Wildlife Service 911 NE 11th AvenuePortlandOR97204USA Amnisopes Institute 2895 SE GlennCorvallisOR97333USA

Management and conservation efforts that support the recovery and protection of large rivers are daunting,reflecting the complexity of the challenge and extent of effort(in terms of policy,economic investment,and spatial extent)needed to afford measurable *** large systems have generally experienced intensive development and regulation,compromising their capacity to respond to disturbances such as climate change ***,large river and basin management require insights gained from social,ecological,geophysical,and hydrological *** multidisciplinary perspective can unveil the integrated relationship between a river network's biotic community and seasonally variableenvironmental conditions that are *** rivers andtheir basins are constantly changing due to anthropogenic influences and as climate modifies patterns of temperature and *** of these factors,the state of knowledge must advance to address changing *** Willamette River,in western Oregon,USA,is a prime example of a basin that has experienced significant degradation and investment in rehabilitation in recent *** science has facilitated development of fine-scale,spatially extensive datasets and models that can generate targeted conservation and rehabilitation actions that are prioritized across the entire river *** prioritization allows investment decisions to be driven by site-specific conditions while simultaneously considering potentials for ecological ***,we review hydrologic,geomorphic,ecologic,and social conditions in the Willamette River basin through time—including pre-settlement,river development,andcontemporary periods—andoffer a futurevisionfor ***,detailed informationaboutfish populations and habitat,hydrologic conditions,geomorphology,water quality,and land use can be leveraged to make informed decisions about protection,rehabilitation,and develop

关键词： Rehabilitation Flood mitigation Hydropower Fish Multidisciplinary

Impact of endoscopic sinus surgery on otologic symptoms associated with chronic rhinosinusitis

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2017年第1期3卷 -页

作者： Neville W.Teo Jess C.Mace Timothy L.smith peter H.Hwang Department of Otolaryngology Singapore General HospitalSingaporeDepartment of Otolaryngology-Head and Neck SurgeryStanford University School of MedicineStanfordCAUSA Department of Otolaryngology-Head and Neck Surgery Oregon Health & Science UniversityPortlandORUSA Department of Otolaryngology-Head and Neck Surgery Stanford University School of MedicineStanfordCAUSA

OBJECTIVE:To evaluate improvements in otologic symptoms after endoscopic sinus surgery (ESS) in patients with chronic rhinosinusitis (CRS), and identify differences in symptoms, if any, between CRS patients with (CRSwNP) and without (CRSsNP) nasal polyposis.;METHODS:Prospective multi-center observational cohort study.;METHODS:Academic tertiary medical centers.;METHODS:Adults with medically recalcitrant CRS who elected ESS were enrolled in a prospective, multi-center, observational cohort study between March, 2011 and October, 2014. Preoperative evaluation of subjects included assessment of clinical characteristics, measures of disease severity, and quality of life evaluation using the 22-item SinoNasal Outcome Test (SNOT-22). Postoperative improvement in otologic symptoms (ear fullness, dizziness, ear pain) scores were evaluated and compared between CRSwNP and CRSsNP subgroups.;RESULTS:395 study patients completed both preoperative and postoperative evaluations, with an average follow-up of 13.9 months after ESS. The prevalence of patients reporting at least one otologic symptom preoperatively (87%) significantly decreased after ESS (63%; p<0.001). Significant postoperative improvement across all otologic scores was also reported (p<0.001). Relative mean improvement in otologic symptom severity was similar for both CRSwNP and CRSsNP, except patients with CRSwNP reported significantly greater postoperative improvement in ear fullness compared to CRSsNP (54% vs. 41%; p=0.039). A total of 61%, 44%, and 43% of patients reported experiencing improvement in "ear fullness", "dizziness" and "ear pain", respectively.;CONCLUSIONS:Sinus surgery significantly improves otologic symptoms associated with CRS. CRSwNP patients reported slightly greater relief of ear fullness than CRSsNP patients following ESS.

关键词： Ear symptoms chronic rhinosinusitis endoscopic sinus surgery