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Introducing 3d-potting:a novel production process for artificial membrane lungs with superior blood flow design

Bio-design and Manufacturing 2022年第1期5卷 141-152页

作者： Fellx Hesselmann Jannls M.Focke peter C.Schlansteln NIklas B.Steuer Andreas Kaesler Sebastlan d.Relnartz Thomas Schmltz-Rode Ulrlch SteInselfer Sebastlan V.Jansen Jutta Arens department of Cardiovascular Engineering Instituteof Applied Medical EngineeringHelmholtz.InstituteRWTH Aachen UniversityPauwelsstrasse 2052074 AachenGermany department of diagnostic and Interventional Radiology Uniklinik RWTH AachenPauwelsstrasse 3052074 AachenGermany department of Biomechanical Engineering Faculty of EngineeringTechnology University of TwenteDrienerlolaan 57522 NB EnschedeThe Netherlands

Currently,artificial-membrane lungs consist of thousands of hollow fiber membranes where blood flows around the fibers and gas flows inside the fibers,achieving diffusive gas *** both ends of the fibers,the interspaces between the hollow fiber membranes and the plastic housing are filled with glue to separate the gas from the blood *** a uniaxial centrifugation process,the glue forms the“potting.”The shape of the cured potting is then determined by the centrifugation process,limiting design possibilities and leading to unfavorable stagnation zones associated with blood *** this study,a new multiaxial centrifugation process was developed,expanding the possible shapes of the potting and allowing for completely new module designs with potentially superior blood flow guidance within the potting ***-phase simulations of the process in conceptual artificial lungs were performed to explore the possibilities of a biaxial centrifugation process and determine suitable parameter sets.A corresponding biaxial centrifugation setup was built to prove feasibility and experimentally validate four conceptual designs,resulting in good agreement with the *** summary,this study shows the feasibility of a multiaxial centrifugation process allowing greater variety in potting shapes,eliminating inefficient stagnation zones and more favorable blood flow conditions in artificial lungs.

关键词： Potting process Flow design Membrane lung Artificial lung Hollow fiber membrane module Manufacturing

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Novel ecosystems created by coal mines in central Queensland’s Bowen Basin

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Ecological Processes 2013年第1期2卷 368-379页

作者： peter d Erskine Andrew T Fletcher Centre for Mined Land Rehabilitation The University of QueenslandBrisbane QLD 4072Australia

Introduction:Open-cut coal mining began in central Queensland’s Bowen Basin approximately 50 years *** this period of time,mine rehabilitators have used a variety of tree,shrub,and groundcover species to create‘novel ecosystems’to stabilise soils and provide vegetative cover for pre-supposed final end-land *** examine post-mining rehabilitation from multiple soil and vegetation monitoring activities in the Bowen Basin to assess the similarity of landforms,plant composition,and trends in plant diversity compared to unmined reference ***:Rehabilitated spoil dumps and reference sites were assessed using soil and vegetation data contained in compliance monitoring reports from Goonyella Riverside,Moura,Oaky Creek,Rolleston,and Blackwater ***,soil chemistry,and plant species mixes of rehabilitation aged from 2 to 22 years were compared to selected reference ***:Mines in this region have generally proposed one of two post-rehabilitation end-land uses:either pasture for cattle grazing or reconstructed native communities which potentially provide native fauna *** data from a selection of these mine sites suggest that when their rehabilitation was compared to nearby reference sites median slope values were between 2.5 and 7 times steeper and soil pH,electrical conductivity,and phosphorus levels were significantly *** steeply sloped landforms,poor soil characteristics,depauperate native species pool,and uniform presence of exotic pasture grasses in the rehabilitation indicate that most of these newly created ecosystems should not be used for cattle grazing and also have few natural ***:Legislative and community expectations have changed progressively over time and,although much of the rehabilitation is currently dominated by an assemblage of exotic buffel grass(Cenchrus ciliaris)and Acacia spp.,recent environmental authorities suggest these‘novel ecosystems’will be judged against native refere

关键词： Coal mining Completion criteria Environmental conditions Novel ecosystems

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Computational History:Challenges and Opportunities of Formal Approaches

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Journal of Social Computing 2023年第3期4卷 232-242页

作者： Jürgen Jost Roberto Lalli Manfred d.Laubichler Eckehard Olbrich Jürgen Renn Guillermo Restrepo peter F.Stadler dirk Wintergrün the Max Planck Institute for Mathematics in the Sciences Leipzig 04103Germany the Santa Fe Institute Santa FeNM 87501USA the Max Planck Institute for the History of Science Berlin 14195Germany the School of Complex Adaptive Systems and the Global Biosocial Complexity Initiative Arizona State UniversityTempeAZ 85287USA the department of Computer Science and Interdisciplinary Center for Bioinformatics Leipzig UniversityLeipzig 04109Germany

We propose a program for a computational analysis,based on large scale datasets,of deep conceptual and formal structures,representing the mechanisms of historical transformations in different domains ranging from biological to social,cultural,and knowledge *** conceptualize such systems as consisting of complex multi-layer *** properties of such networks may explain the spreading of *** relations between the dynamics of interacting networks may help to identify *** systems may show path and context *** illustrate our approach by case studies from all those types of systems.

关键词： computational history history of science network analysis big data

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How does male-male competition generate negative frequency-dependent selection and disruptive selection during speciation？

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Current Zoology 2018年第1期64卷 89-99页

作者： peter d. dIJKSTRA Shana E. BORdER department of Biology Central Michigan University Mount Pleasant MI 48859 USA

Natural selection has been shown to drive population differentiation and speciation. The role of sexual selection in this process is controversial; however, most of the work has centered on mate choice while the role of male-male competition in speciation is relatively understudied. Here, we outline how male-male competition can be a source of diversifying selection on male competitive phenotypes, and how this can contribute to the evolution of reproductive isolation. We highlight how negative frequency-dependent selection (advantage of rare phenotype arising from stronger male-male competition between similar male phenotypes compared with dissimilar male phenotypes) and disruptive selection (advantage of extreme phenotypes) drives the evolution of diversity in competitive traits such as weapon size, nuptial coloration, or aggressiveness. We underscore that male-male competition interacts with other life-history functions and that variable male competitive phenotypes may represent alternative adaptive options. In addition to competition for mates, aggressive interference competition for ecological resources can exert selection on competitor signals. We call for a better integration of male-male competition with ecological interference competition since both can influence the process of speciation via comparable but distinct mechanisms. Altogether, we present a more comprehensive framework for studying the role of male-male competition in speciation, and emphasize the need for better integration of insights gained from other fields studying the evolutionary, behavioral, and physiological consequences of agonistic interactions.

关键词：男性竞争分裂频率否定形成期配偶选择自然选择

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The genetics and biology of KRAS in lung cancer

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Chinese Journal of Cancer 2013年第2期32卷 63-70页

作者： peter M.K.Westcott Minh d.To Pharmaceutical Sciences and Pharmacogenomics Program University of California SanFrancisco Helen diller Comprehensive Cancer Center University of California SanFrancisco Thoracic Oncology Program Department of SurgeryUniversity of California SanFrancisco

Mutational activation of KRAS is a common oncogenic event in lung cancer and other epithelial cancer *** to develop therapies that counteract the oncogenic effects of mutant KRAS have been largely unsuccessful,and cancers driven by mutant KRAS remain among the most refractory to available *** undertaken over the past decades have produced a wealth of information regarding the clinical relevance of KRAS mutations in lung *** Kras-driven mouse models of cancer,together with cellular and molecular studies,have provided a deeper appreciation for the complex functions of KRAS in ***,a much more thorough understanding of these complexities is needed before clinically effective therapies targeting mutant KRAS-driven cancers can be achieved.

关键词： RAS基因肺癌生物学遗传学基因突变致癌作用临床意义小鼠模型

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The modifying influence of HLA classⅡdQB1^(*)06:02 on the Streptococcus and clinical phenotype correlation among anti-Ro+mothers of children with neonatal lupus

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Genes & diseases 2023年第4期10卷 1169-1171页

作者： Robert M.Clancy Carla J.Guthridge Miranda C.Marion Joel Guthridge Timothy d.Howard peter M.Izmirly Mala Masson Jill P.Buyon Judith A.James Carl d.Langefeld department of Medicine Division of RheumatologyNYU Grossman School of MedicineNew YorkNY 10016USA Arthritis and Clinical Immunology Oklahoma Medical Research FoundationOklahoma CityOK 73104USA department of Biostatistics and data Science Wake Forest School of MedicineWinstone SalemNC 27101USA Center for Precision Medicine Wake Forest School of MedicineWinstoneSalemNC 27101USA department of Biochemistry Wake Forest School of MedicineWinstoneSalemNC 27101USA

The genus Streptococcus,a gram-positive bacterium,con-tains species associated with immune activation at morbid outcomes,including scarlet fever,endocarditis,meningitis,and rheumatic *** both stool and saliva,there is a pos-itive correlation between Streptococcus abundance and Sjogren’s syndrome(SS)and systemic lupus erythematosus(SLE).

关键词： lupus mother fever Streptococcus

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diversifying Resistance Mechanisms in Cereal Crops Using Microphenomics

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Plant Phenomics 2023年第1期5卷 1-5页

作者： peter M.dracatos Stefanie Lück dimitar K.douchkov department of Animal Plant and Soil SciencesAgriBioLa Trobe UniversityBundooraVIC 3086Australia Leibniz Institute of Plant Genetics and Crop Plant Research(IPK)Gatersleben Corrensstrasse 306466 Seeland OT GaterslebenGermany

hole-grain cereals,including wheat,barley,oat,rye,corn,rice,millet,and triticale,are a rich source of calories,essential vitamins,minerals,and phytochemicals that both nourish and protect humans and animals from diseases such as heart attack and cancer[1].However,susceptibility to foliar diseases caused by necrotrophic or biotrophic fungal pathogens continues to reduce yield potential or lead to total crop failure and famine in developing nations[2].Historically,foliar diseases of cereals have been controlled using either fungicide treatment[3]or plant breeding[4].

关键词： breeding cereal corn

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Control systems and data management for high-power laser facilities

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High Power Laser Science and Engineering 2023年第5期11卷 51-75页

作者： Scott Feister Kevin Cassou Stephen dann Andreas döpp Philippe Gauron Anthony J.Gonsalves Archis Joglekar Victoria Marshall Olivier Neveu Hans-peter Schlenvoigt Matthew J.V.Streeter Charlotte A.J.Palmer California State University Channel Islands CamarilloCaliforniaUSA UniversitéParis-Saclay CNRS/IN2P3IJCLabOrsayFrance Central Laser Facility STFC Rutherford Appleton LaboratoryDidcotUK Ludwig–Maximilians–Universität München GarchingGermany BELLA Center Lawrence Berkeley National LaboratoryBerkeleyCaliforniaUSA department of Nuclear Engineering and Radiological Sciences University of MichiganAnn ArborMichiganUSA Ergodic LLC San FranciscoCaliforniaUSA Helmholtz-Zentrum dresden–Rossendorf DresdenGermany Queen’s University Belfast BelfastUK

The next generation of high-power lasers enables repetition of experiments at orders of magnitude higher frequency than what was possible using the prior *** requiring human intervention between laser repetitions need to adapt in order to keep pace with the new laser technology.A distributed networked control system can enable laboratory-wide automation and feedback control *** higher-repetition-rate experiments will create enormous quantities of data.A consistent approach to managing data can increase data accessibility,reduce repetitive data-software development and mitigate poorly organized *** opportunity arises to share knowledge of improvements to control and data infrastructure currently being *** compare platforms and approaches to state-of-the-art control systems and data management at high-power laser facilities,and we illustrate these topics with case studies from our community.

关键词： big data community organization control systems data management feedback loops high-power lasers high repetition rate metadata stabilization standards

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医用TC4钛合金激光-化学复合抛光及表面形貌演化

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中国表面工程 2024年第2期37卷 227-237页

作者：邵勇孙树峰王萍萍蒙卡·彼得·帕沃尔陈博文张丰云王茜孙维丽青岛理工大学机械与汽车工程学院青岛266520 青岛理工大学信息与控制工程学院青岛266520 斯洛伐克科希策技术大学制造技术学院普雷绍夫08001 青岛黄海学院智能制造学院青岛266427

表面粗糙度是医疗器械构件最重要的质量特征之一,然而现有的激光抛光、化学抛光等单一表面抛光技术存在一定局限性。针对医用TC4钛合金表面的精密抛光需求,设计并搭建一套激光-化学复合抛光系统,通过激光-化学复合加工材料去除机理分析... 详细信息

表面粗糙度是医疗器械构件最重要的质量特征之一,然而现有的激光抛光、化学抛光等单一表面抛光技术存在一定局限性。针对医用TC4钛合金表面的精密抛光需求,设计并搭建一套激光-化学复合抛光系统,通过激光-化学复合加工材料去除机理分析和开展TC4钛合金的激光-化学复合抛光试验,深入探究复合抛光过程中不同抛光阶段材料表面形貌的演变过程及粗糙度变化并进行分析,进而明确激光-化学复合抛光机理。研究结果表明,激光-化学复合抛光材料去除是基于激光热-力效应与激光诱导化学腐蚀溶解共同作用的结果,而且两者具有一定协同效应,在适当的工艺窗口内,化学腐蚀溶解可以完全去除激光烧蚀产生的残渣和重熔物。激光辐照会在工件表面“峰-谷”区域产生温度差,进而导致化学溶解速率差异,即“山峰”区域溶解速率快,“山谷”区域溶解速率慢,从而实现表面粗糙度的降低。最后采用合适的工艺参数,优化了抛光效果,实现了医用TC4钛合金的选择性精密抛光,激光辐照区域表面粗糙度Ra由初始的5.230μm下降至0.225μm,Sa由初始的8.630μm下降至0.571μm,分别下降95.7%和93.4%。研究结果可为钛合金或其他自钝化金属的精密抛光提供参考。

关键词：激光钛合金抛光表面形貌化学腐蚀

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Ti-Zr-Hf-Nb-Ta-Sn high-entropy alloys with good properties as potential biomaterials

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Rare Metals 2022年第7期41卷 2305-2315页

作者： Wei Yang Shu-Jie Pang Guan Wang Ying Liu peter KLiaw Tao Zhang Key Laboratory of Aerospace Materials and Performance(Ministry of Education) School of Materials Science and EngineeringBeihang UniversityBeijing 100191China Beijing Advanced Innovation Center for Biomedical Engineering Beihang UniversityBeijing 100191China AVIC Manufacturing Technology Institute Beijing 100024China department of Materials Science and Engineering The University of TennesseeKnoxville TN 37996USA

(Ti_(0.2)Zr_(0.2)Hf_(0.2)Nb_(0.2)Ta_(0.2))_(100-x)Sn_(x)(x=3,5,and 7;at%)high-entropy alloys(HEAs)with good mechanical properties,corrosion resistance,and biocompatibility were developed as potential *** effects of Sn additions on the microstructure and properties of the HEAs were ***(Ti_(0.2)Zr_(0.2)Hf_(0.2)Nb_(0.2)Ta_(0.2))_(100-x)Sn_(x) with x=3 at%exhibited the single body-centered-cubic(BCC)*** HEAs with the further increased Sn contents of x=5 at%and 7 at%were composed of a BCC phase and a hexagonal-close-packed(HCP)-(Sn,Zr)ordered *** addition of Sn improved the compres-sive yield strengths and hardness of the HEAs to 1068-1259 MPa and HV 315-HV 390,*** HEAs also possessed relatively low Young's moduli of 80-91 *** the present Ti-Zr-Hf-Nb-Ta-Sn HEAs,the(Ti_(0.2)Zr_(0.2)Hf_(0.2)Nb_(0.2)Ta_(0.2))97Sn3 HEA exhibited the good combination of high yield strength of~1068 MPa,relatively low Young's modulus of 80 GPa,and good plasticity(~45%).The HEAs also possess good bio-corrosion resistance and biocompatibility,parallel to the Ti-6Al-4V *** Ti-Zr-Hf-Nb-Ta-Sn HEAs with the integration of the high yield strength,relatively low Young's modulus,and good corrosion resistance and bio-compatibility are promising for biomedical applications.

关键词： High-entropy alloys Biomaterials Microstructure Mechanical properties Corrosion Biocompatibility

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