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Immunobiology of congenital cytomegalovirus infection of the central nervous system--the murine cytomegalovirus model

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Cellular & Molecular Immunology 2015年第2期12卷 180-191页

作者： Irena Slavuljica Daria Kvestak peter csaba huszthy Kate Kosmac William J Britt Stipan Jonjic Department of Histology and Embryology School of Medicine University of Rijeka Rijeka Croatia Department of Infectious Diseases School of Medicine University of Rijeka Rijeka Croatia Department of Immunology Institute of Clinical Medicine University of Oslo Oslo Norway Department of Microbiology University of Alabama at Birmingham Birmingham AL USA

Congenital human cytomegalovirus infection is a leading infectious cause of long-term neurodevelopmental sequelae, including mental retardation and hearing defects. Strict species specificity of cytomegaloviruses has restricted the scope of studies of cytomegalovirus infection in animal models. To investigate the pathogenesis of congenital human cytomegalovirus infection, we developed a mouse cytomegalovirus model that recapitulates the major characteristics of central nervous system infection in human infants, including the route of neuroinvasion and neuropathological findings. Following intraperitoneal inoculation of newborn animals with mouse cytomegalovirus, the virus disseminates to the central nervous system during high-level viremia and replicates in the brain parenchyma, resulting in a focal but widespread, non-necrotizing encephalitis. Central nervous system infection is coupled with the recruitment of resident and peripheral immune cells as well as the expression of a large number of pro-inflammatory cytokines. Although infiltration of cellular constituents of the innate immune response characterizes the early immune response in the central nervous system, resolution of productive infection requires virus-specific CD8＋ T cells. Perinatal mouse cytomegalovirus infection results in profoundly altered postnatal development of the mouse central nervous system and long-term motor and sensory disabilities. Based on an enhanced understanding of the pathogenesis of this infection, prospects for novel intervention strategies aimed to improve the outcome of congenital human cytomegalovirus infection are proposed.

关键词： central nervous system congenital infection cytomegalovirus immune response

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Niche differentiation among facultative filter feeders: Insights from invasive Ponto-Caspian mysids

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Current Zoology 2024年第4期70卷 513-521页

作者： Péter Borza Varsha Rani csaba F.Vada Institute of Aquatic Ecology Centre for Ecological ResearchKarolina ut 29.1113 BudapestHungary Doctoral School of Biology Institute of BiologyEotvos Lorand UniversityPazmany Péter sétany 1/C1117 BudapestHungary

The degree of dietary specialization has a fundamental impact on the ecological function and interactions of suspension *** niche differentiation by food particle size is common among obligate suspension feeders,its role is not evident in facultative *** this study,we aimed at providing new insights on the matter by focusing on sympatric mysid *** mysids use different mechanisms for raptorial and filter-feeding,they represent a more adequate model system than for example,the more extensively studied *** made morpholog-ical measurements on the 4 coexisting invasive Ponto-Caspian mysid species to determine the areas and mesh sizes of their *** also quantified their clearance rates on the microalga Cryptomonas *** a laboratory experiment to reveal how morphological differences manifest in their overall filtering *** found relatively small but consistent differences in the primary filter area among the species,indicating that morphological constraints due to the enclosed position of the setae might limit the possibility for *** primary filter mesh sizes were small in all 4 species(0.69-2.73μm)with moderate but consistent intraspecific differences,suggesting that the benefit of being able to capture small particles might outweigh the pressure for *** observed clearance rates were in accordance with the morphological characteristics of the species,highlighting that auxiliary filters(present in one of the species,Limnomysis benedeni)are needed to increase filtering capacity *** study confirmed that food particle size can contribute to the niche differentiation of facultative filter feeders,but also indicated that they can tolerate a higher overlap than obligate *** observed differences were related to the habitat preferences and predatory potentials of the species,suggesting that complementarity among the different niche axes might further facilitate theircoexistence.

关键词： clearance rate coexistence filter area filtermesh size.

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Infrared neural stimulation and inhibition using an implantable silicon photonic microdevice

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Microsystems & Nanoengineering 2020年第1期6卷 939-950页

作者： Agoston csaba Horvath Sandor Borbely Ors Csanad Boros Lili Komaromi Pal Koppa peter Bartho Zoltan Fekete Research Group for Implantable Microsystems Faculty of Information Technology&BionicsPazmany Peter Catholic UniversityBudapestHungary Microsystems Laboratory Institute for Technical Physics&Material ScienceCentre for Energy ResearchBudapestHungary Obuda University Doctoral School on Materials Sciences and Technologies BudapestHungary MTA TTK NAP Sleep Oscillations Research Group BudapestHungary Department of Physiology and Neurobiology Eotvos Lorand UniversityBudapestHungary Department of Atomic Physics Budapest University of Technology&EconomicsBudapestHungary

Brain is one of the most temperature sensitive *** the fundamental role of temperature in cellular metabolism,thermal response of neuronal populations is also significant during the evolution of various neurodegenerative *** such critical environmental factor,thorough mapping of cellular response to variations in temperature is desired in the living *** far,limited efforts have been made to create complex devices that are able to modulate temperature,and concurrently record multiple features of the stimulated *** our work,the in vivo application of a multimodal photonic neural probe is ***,thermal,and electrophysiological functions are monolithically integrated in a single *** system facilitates spatial and temporal control of temperature distribution at high precision in the deep brain tissue through an embedded infrared waveguide,while it provides recording of the artefact-free electrical response of individual cells at multiple locations along the probe *** distribution of the optically induced temperature changes is evaluated through in vitro measurements and a validated multi-physical *** operation of the multimodal microdevice is demonstrated in the rat neocortex and in the hippocampus to increase or suppress firing rate of stimulated neurons in a reversible manner using continuous wave infrared light(λ=1550 nm).Our approach is envisioned to be a promising candidate as an advanced experimental toolset to reveal thermally evoked responses in the deep neural tissue.

关键词： stimulation metabolism organs

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Peeling off the surface: Pt-decoration of WSe 2 nanoflakes results in exceptional photoelectrochemical HER activity

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SusMat 2022年第6期2卷 749-760页

作者： peter S.Toth Gabor Szabo Gabor Bencsik Gergely F.Samu Krishnan Rajeshwar csaba Janaky Department of Physical Chemistry and Materials Science Interdisciplinary Excellence CenterUniversity of SzegedSzegedHungary Department of Chemistry and Biochemistry The University of Texas at ArlingtonArlingtonTexasUSA

Photoelectrochemical(PEC)hydrogen evolution reaction(HER)was studied on exfoliated,pristine and Pt-decorated tungsten diselenide(p-WSe_(2))nanoflake samples,using a previously developed microdroplet PEC microscopy *** WSe 2 nanoflakes had well-defined thicknesses as measured by atomic force microscopy,and the Pt nanoparticles(NPs)were deposited by a variable num-ber of atomic layer deposition(ALD)*** exceptionally high photocurrent density of 49.6 mA cm^(−2)(under 220 mW cm^(−2) irradiation)and internal-photon-to-electron-conversion efficiency(∼90%at 550 nm)were demonstrated on these Pt-decorated WSe_(2)(WSe_(2)-Pt)*** Pt NP loading and thickness of WSe_(2) nanoflakes(in the 24–235 nm range)were used to fine-tune their PEC activity for *** found similar charge transfer and surface recombination kinetics of pristine and WSe_(2)-Pt specimens(as assessed by intensity-modulated photocurrent spectroscopy),which indicated significant differences in their bulk properties.X-ray and ultraviolet photoelectron spectroscopies were performed to identify defect states and quantify the density of states around the valence band of WSe_(2).The elevated temperature of the ALD process and the evolving Pt NP phase conspired to passivate the sub-surface(i.e.,bulk)defects in the WSe_(2) nanoflakes,resulting in their vastly improved PEC performance.

关键词： atomic layer deposition defect migration density of states hydrogen evolution layered semiconductor photoelectrochemical kinetics

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Evolution of disease phenotype in adult and pediatric onset Crohn's disease in a population-based cohort

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World Journal of Gastroenterology 2013年第14期19卷 2217-2226页

作者： Barbara Dorottya Lovasz Laszlo Lakatos Agnes Horvath Istvan Szita Tunde Pandur Michael Mandel Zsuzsanna Vegh Petra Anna Golovics Gabor Mester Mihaly Balogh csaba Molnar Erzsebet Komaromi Lajos Sandor Kiss peter Laszlo Lakatos First Department of Medicine Semmelweis University Department of Medicine Csolnoky F Province Hospital Department of Pediatrics Csolnoky F Province Hospital Department of Medicine Grof Eszterhazy Hospital Department of Infectious Diseases Magyar Imre Hospital Department of Gastroenterology Municipal Hospital

AIM:To investigate the evolution of disease phenotypein adult and pediatric onset Crohn's disease(CD) populations,diagnosed between 1977 and ***:Data of 506 incident CD patients were analyzed(age at diagnosis:28.5 years,interquartile range:22-38 years).Both in-and outpatient records were collected prospectively with a complete clinical follow-up and comprehensively reviewed in the population-based Veszprem province database,which included incident patients diagnosed between January 1,1977 and December 31,2008 in adult and pediatric onset CD *** phenotype according to the Montreal classification and long-term disease course was analysed according to the age at onset in time-dependent univariate and multivariate ***:Among this population-based cohort,seventy-four(12.8%) pediatric-onset CD patients were identified(diagnosed ≤ 17 years of age).There was no significant difference in the distribution of disease behavior between pediatric(B1:62%,B2:15%,B3:23%) and adult-onset CD patients(B1:56%,B2:21%,B3:23%) at diagnosis,or during ***,the probability of developing complicated disease behaviour was 49.7% and 61.3% in the pediatric and 55.1% and 62.4% in the adult onset patients after 5-and 10-years of ***,time to change in disease behaviour from non stricturing,non penetrating(B1) to complicated,stricturing or penetrating(B2/B3) disease was not significantly different between pediatric and adult onset CD in a Kaplan-Meier *** year of diagnosis(P = 0.04),ileal location(P < 0.001),perianal disease(P < 0.001),smoking(P = 0.038) and need for steroids(P < 0.001) were associated with presence of,or progression to,complicated disease behavior at diagnosis and during follow-up.A change in disease location was observed in 8.9% of patients and it was associated with smoking status(P = 0.01),but not with age at ***:Long-term evolution of disease behavior was not different in pediatric-a

关键词： Crohn’s disease Age at diagnosis Disease behavior Disease course

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Is early limited surgery associated with a more benign disease course in Crohn's disease?

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World Journal of Gastroenterology 2013年第43期19卷 7701-7710页

作者： Petra Anna Golovics Laszlo Lakatos Attila Nagy Tunde Pandur Istvan Szita Mihaly Balogh csaba Molnar Erzsebet Komaromi Barbara Dorottya Lovasz Michael Mandel Gabor Veres Lajos S Kiss Zsuzsanna Vegh peter Laszlo Lakatos First Department of Medicine Semmelweis UniversityH-1083 BudapestHungary Department of Medicine Csolnoky F Province HospitalH-8200 VeszpremHungary Department of Surgery Csolnoky F Province HospitalH-8200 VeszpremHungary Department of Medicine Grof Eszterhazy HospitalH-8500 PapaHungary Department of Infectious Diseases Magyar Imre HospitalH-8400 AjkaHungary Department of Gastroenterology Municipal HospitalH-8100 VarpalotaHungary First Department of Pediatrics Semmelweis UniversityH-1083 BudapestHungary

AIM:To analyze the difference in disease course and need for surgery in patients with Crohn’s disease(CD).METHODS:Data of 506 patients with incident CD were analyzed(age at diagnosis:31.5±13.8 years).Both hospital and outpatient records were collected prospectively with a complete clinical follow-up and comprehensively reviewed in the population-based Veszprem province database,which includes incident CD patients diagnosed between January 1,1977 and December 31,***-up data were collected until December 31,*** patients included had at least 1year of follow-up *** with indeterminate colitis at diagnosis were excluded from the ***:Overall,73 patients(14.4%)required resective surgery within 1 year of *** exposure and need for biological therapy were lower in patients with early limited surgery(P<0.001 and P=0.09).In addition,surgery rates during follow-up in patients with and without early surgery differed significantly after matching on propensity scores(P<0.001,HR=0.23).The need for reoperation was also lower in patients with early limited resective surgery(P=0.038,HR=0.42)in a Kaplan-Meier and multivariate Cox regression(P=0.04)***,this advantage was not observed after matching on propensity scores(PLogrank=0.656,PBreslow=0.498).CONCLUSION:Long-term surgery rates and overall exposure to steroids and biological agents were lower in patients with early limited resective surgery,but reoperation rates did not differ.

关键词： Crohn’s disease Early surgery Disease course Disease behavior Treatment strategy

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Association of extraintestinal manifestations of inflammatory bowel disease in a province of western Hungary with disease phenotype:Results of a 25-year follow-up study

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World Journal of Gastroenterology 2003年第10期9卷 2300-2307页

作者： Laszlo Lakatos Tunde Pandur Gyula David Zsuzsanna Balogh Pal Kuronya Arpad Tollas peter Laszlo Lakatos 1~(st) Department of Medicine Csolnoky F.Province HospitalVeszprem Department of Medicine Grof Eszterhazy HospitalPapa Department of Infectious Diseases Magyar Imre HospitalAjka Department of Medicine Mumcipal HospitalVarpalota 1~(st) Department of Medicine Semmelweis UniversityBudapestHungary

AIM:IBD is a systemic disease associated with a large number of extraintestinal manifestations (EIMs).Our aim was to determine the prevalence of EIMs in a large IBD cohort in Veszprem Province in a 25-year follow-up study. METHODS:Eight hundred and seventy-three IBD patients were enrolled (ulcerative colitis/UC/:619,m/f:317/302, mean age at presentation:38.3 years,average disease duration:11.2 years;Crohn's disease/CD/:254,m/f:125/129, mean age at presentation:32.5 years,average disease duration:9.2 years).Intestinal,extraintestinal signs and laboratory tests were monitored *** alteration suggesting an EIMs was investigated by a specialist. RESULTS:A total of 21.3% of patients with IBD had EIM (UC:15.0%,CD:36.6%).Age at presentation did not affect the likelihood of *** of EIMs was higher in women and in CD,ocular complications and primary sclerosing cholangitis (PSC) were more frequent in *** UC there was an increased tendency of EIM in patients with a more extensive *** complications were more frequent in CD (22.4% vsUC 10.2%,P<0.01).In UC positive family history increased the risk of joint complications (OR:3.63).In CD the frequency of type-1 peripheral arthritis was increased in patients with penetrating disease (P=0.028).PSC was present in 1.6% in UC and 0.8% in *** complications were present in 3.8% in UC and 10.2% in CD,the rate of ocular complications was around 3% in both *** complications were glomerulonephritis,autoimmune hemolytic anaemia and celiac disease. CONCLUSION:Prevalence of EIM in Hungarian IBD patients is in concordance with data from Western *** high number of EIM supports a role for complex follow-up in these patients.

关键词： Adolescent Adult Age Distribution Aged Aged, 80 and over Anemia, Iron-Deficiency Bile Duct Diseases Child Colitis, Ulcerative Crohn Disease Eye Diseases Female Follow-Up Studies Humans Hungary Joint Diseases Liver Diseases Male Middle Aged Phenotype Prevalence

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母亲暴露于常规空气污染物与后代的先天性心脏缺陷:来自全国出生缺陷预防研究的结果

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环境与职业医学 2014年第12期31卷 929-929页

作者： Jeanette A.Stingone Thomas J.Luben Julie L.Daniels Montserrat Fuentes David B.Richardson Arthur S.Aylsworth Amy H.Herring Marlene Anderka Lorenzo Botto Adolfo Correa Suzanne M.Gilboa peter H.Langlois Bridget Mosley Gary M.Shaw csaba Siffel Andrew F.Olshan National Birth Defects Prevention Study

[背景]流行病学文献表明,空气污染物暴露与胎儿的发育相关联。[目的]探讨产妇在妊娠2-8周期间的空气污染物暴露及其与先天性心脏缺陷的关联。[方法]此项出生缺陷预防研究是一项由9个州参加的病例对照研究。给参加这项研究的妊娠妇女分配... 详细信息

[背景]流行病学文献表明,空气污染物暴露与胎儿的发育相关联。[目的]探讨产妇在妊娠2-8周期间的空气污染物暴露及其与先天性心脏缺陷的关联。[方法]此项出生缺陷预防研究是一项由9个州参加的病例对照研究。给参加这项研究的妊娠妇女分配1周和7周里一氧化碳、二氧化氮、臭氧、二氧化硫的每日最高浓度平均值,以及细颗粒物和粗颗粒物的24 h测量值,采用的方法是在妊娠早期收集这些妇女住所50 km内最接近的空气监测点的测量值。根据不同的污染物,最多4 632例活产对照和3 328例活产、死胎或流产病例有空气污染暴露的数据。应用分层回归模型,并以产妇的人口统计学、烟草和酒精使用情况进行调整。对于多污染物共同暴露的情况,则采用主成分分析来评估这些关联。[结果]二氧化氮暴露与主动脉缩窄及肺动脉瓣狭窄之间存在正性关联。细颗粒物暴露与左室发育不良心脏综合征呈正性相关,但与房间隔缺损呈负性相关。检测个体的暴露周数表明,使用7周的平均水平未观察到污染物与缺陷之间的关联。多污染物分析的结果支持左室流出道阻塞与二氧化氮之间、左室发育不良心脏综合征与颗粒物之间存在关联,尽管在最高的暴露水平时估计值是下降的。[结论]采用每日最高污染物水平探讨个体暴露周数揭示了某些污染物与心脏缺陷之间存在一些正向关联,并且提示在妊娠期间存在潜在的敏感性窗口期。

关键词：先天性心脏缺陷空气污染物出生缺陷预防母亲暴露病例对照研究心脏综合征细颗粒物后代

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CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

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