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Cellular senescence:from anti-cancer weapon to anti-aging target

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Science China(Life Sciences) 2020年第3期63卷 332-342页

作者： Lifeng Yuan peter b.1} xiao-fan wang Program in Cellular and Molecular Medicine Boston Children’s HospitalBostonMA 02115USA Department of Genetics Harvard Medical SchoolBostonMA 02115USA Duke University Medical Center DurhamNC 27710USA

Cellular senescence(CS)is a state of stab.e cell cycle arrest characterized b. the production and secretion of inflammatory *** studies describ.d oncogene-induced senescence(OIS)as a b.rrier to tumorigenesis,such that the therapeutic induction of CS might represent a rational anti-cancer ***,the validity of this approach has b.en b.rne out b. the development and approval of the cyclin-dependent kinase(CDK)inhib.tor palb.ciclib.for the treatment of b.east *** from tumors,senescent cells have also b.en shown to accumulate during natural mammalian aging,where they produce detrimental effects on the physiology of surrounding ***,pharmacological senescent cell depletion has b.en proposed as an approach to delay age-related functional decline;this has b.en formally demonstrated in animal *** this review article,we describ. the current mechanistic understanding of cellular senescence at the molecular level and how it informs the development of new therapeutic strategies to comb.t cancer and aging.

关键词： cellular senescence cancer healthy aging pro-senescence cancer therapy senolytic therapies

Seed oil of b.ucea javanica induces apoptosis through the PI3K/Akt signaling pathway in acute lymphocytic leukemia Jurkat cells

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Chinese Journal of Natural Medicines 2021年第8期19卷 608-620页

作者： ZHANG Hong YIN Shi-Liang wang Li-Hui JIA Li-Na SU Guang-Yue LIU xiao-Qing ZHOU fan b.ESLIN peter MENG Ran LI Qi-Yi YANG Jing-Yu WU Chun-Fu Department of Pharmacology Shenyang Pharmaceutical UniversityShenyang 110016China Department of Pharmacology Shenyang Medical CollegeShenyang 110034China Faculty of Functional Food And Wine Shenyang Pharmaceutical UniversityShenyang 110016China Department of Technology Industry of Shenyang Pharmaceutical University of Lei Yun Shang Pharmaceutical Co.Ltd.Benxi 117004China Department of Hematology General Hospital of Northern Theater CommandShenyang 11016China Department of Molecular/Cellular Physiology Loyola University ChicagoChicago 60153USA School of Pharmacy Shenyang Pharmaceutical UniversityShenyang 110016China

b.ucea javanica oil emulsion(b.OE)has b.en used to treat tumor in China for more than 40 ***,its components and effectiveness in the treatment of acute lymphocytic leukemia(ALL)and its mechanism of anti-cancer activity remain *** the current study,high-performance liquid chromatography-evaporative light scattering detector(HPLC-ELSD)was used to analyze the components of ***,the anti-leukemia effects of b.OE were examined b.th in vitro and in vivo using ALL Jurkat cells and the p388 mouse leukemia transplant model,*** primary ALL leukemia cells were also used to confirm the antileukemia effects of *** apoptotic-related results indicated that b.OE induced apoptosis in Jurkat cells and were suggestive of intrinsic apoptotic ***,b.OE inhib.ted Akt(protein kinase b.activation and upregulated its downstream targets p53 and Fox O1(forkhead b.x gene,group O-1)to initiate *** activation of GSK3βwas also *** findings demonstrate that b.OE has anti-leukemia effects on ALL cells and can induce apoptosis in Jurkat cells through the phosphoinositide3-kinase(PI3 K)/Akt signaling pathway.

关键词： Apoptosis Cancer Leukemia b.ucea javanica oil emulsion

CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Ab.allah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed xiaocong Ai Ab.d Aleem Wolfgang Altmannshofer Fab.o Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arb.zov Ab.esslam Arhrib.Mustafa Ashry Sha b.i Yu b.i Yang b.i Vipul b.irathi Csab. b.lazs Philip b.mb.de Yong b.n Tripamo b.ndyopadhyay Shou-Shan b.o Desmond P.b.rb.r Ayse b.t Varvara b.tozskaya Sub.sh Chandra b.hera alexander b.lyaev Michele b.rtucci xiao-Jun b. Yuanjie b. Tianjian b.an Fab.izio b.anchi Thomas b.ekotter Michela b.glietti Shalva b.lanishvili Deng b.nglin Denis b.drov Anton b.gomyagkov Serge b.ndarenko Stewart b.ogert Maarten b.onekamp Marcello b.rri Angelo b.sotti Vincent b.udry Mohammed b.ukidi Igor b.yko Ivanka b.zovic Giuseppe b.zzi Jean-Claude b.ient Anastasiia b.dzinskaya Masroor b.khari Vladimir b.tev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calib.i Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrab.uti Yimin Che Yuzhi Che b.n Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen b.ping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui xiaohao Cui Zhaoyuan Cui b.unella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng b.upal Dev Tang Dewen b.agio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad b.naras Hindu University Institute of ScienceVaranasi b.ndirma Onyedi Eylul University Bandirma b.ihang University Beijing b.ijing Computational Science Research Center Beijing b.ijing Conveyi LTD Beijing b.ijing Glass Research Institute Co. LtdBeijing b.ijing Institute of Technology Beijing b.ijing Normal University Beijing b.own University ProvidenceRI b.dker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China b.ilding materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Lab.ratory of Nuclear Prob.ems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted b. China,fostered through extensive collab.ration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a b.oster capab.e of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the sub.erranean b.oster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its b.seline design with synchrotron radiation(SR)power of 30 MW per b.am,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab.(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per b.am expands the CEPC's capab.lity to generate 4.3 million Higgs b.sons,facilitating precise measurements of Higgs coupling at sub.percent levels,exceeding the precision expected from the HL-LHC b. an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,estab.ishing a framework for forthcoming engineering design phase and site selection *** is anticipated to b.gin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially b. initiated in the mid-2030s.

关键词： initiated exceeding precise

Ob.ervatory science with eXTP

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Science China(Physics,Mechanics & Astronomy) 2019年第2期62卷 97-138页

作者： Jean J.M.in 't Zand Enrico b.zzo JinLu Qu Xiang-Dong Li Lorenzo Amati Yang Chen Immacolata Donnarumma Victor Doroshenko Stephen A.Drake Margarita Hernanz peter A.Jenke Thomas J.Maccarone Simin Mahmoodifar Domitilla de Martino Alessandra De Rosa Elena M.Rossi Antonia Rowlinson Gloria Sala Giulia Stratta Thomas M.Tauris Joern Wilms XueFeng Wu Ping Zhou Iván Agudo Diego Altamirano Jean-Luc Atteia Nils A.andersson M.Cristina b.glio David R.b.llantyne Altan b.ykal Ehud b.har Tomaso b.lloni Sudip b.attacharyya Stefano b.anchi Anna b.lous Pere b.ay Joao b.aga Sφren b.andt Edward F.b.own Niccolo b.cciantini Luciano b.rderi Edward M.Cackett Riccardo Campana Sergio Campana Piergiorgio Casella Yuri Cavecchi Frank Chamb.rs Liang Chen Yu-Peng Chen Jér?me Chenevez Maria Chernyakova ChiChuan Jin Riccardo Ciolfi Elisa Costantini Andrew Cumming Antonino D'Aì Zi-Gao Dai Filippo D'Ammando Massimiliano De Pasquale Nathalie Degenaar Melania Del Santo Valerio D'Elia Tiziana Di Salvo Gerry Doyle Maurizio Falanga XiLong fan Rob.rt D.Ferdman Marco Feroci Federico Fraschetti Duncan K.Galloway Angelo F.Gamb.no Poshak Gandhi MingYu Ge b.uce Gendre Ramandeep Gill Diego G?tz Christian Gouiffès Paola Grandi Jonathan Granot Manuel Güdel alexander Heger Craig O.Heinke Jeroen Homan Rosario Iaria Kazushi Iwasawa Luca Izzo Long Ji peter G.Jonker Jordi José Jelle S.Kaastra Emrah Kalemci Oleg Kargaltsev Nob.yuki Kawai Laurens Keek Stefanie Komossa Ingo Kreykenb.hm Lucien Kuiper Devaky Kunneriath Gang Li En-Wei Liang Manuel Linares Francesco Longo fangJun Lu alexander A.Lutovinov Denys Malyshev Julien Malzac Antonios Manousakis Ian McHardy Missagh Mehdipour YunPeng Men Mariano Méndez Rob.rto P.Mignani Romana Mikusincova M.Coleman Miller Giovanni Miniutti Christian Motch Joonas Nättilä Emanuele Nardini Torsten Neub.rt Paul T.O'b.ien Mauro Orlandini Julian P.Osb.rne Luigi Pacciani Stéphane Paltani Maurizio Paolillo Iossif E.Papadakis b.swajit Paul Alb.rto Pellizzoni Uria Peretz Miguel A.Pérez Torres Emanuele Perinati Chanda Prescod-Weinstein Pab.o Reig SRON Netherlands Institute for Space Research Department of Astronomy University of Geneva Key Lab.ratory for Particle Astrophysics Institute of High Energy PhysicsChinese Academy of Sciences School of Astronomy and Space Science Nanjing University INAF-IASF b.logna ASI Via del Politecnico snc INAF-Istituto di Astrofisica e Planetologie Spaziali Institut für Astronomie und Astrophysik Tüb.ngen Universit?t Tübingen NASA Goddard Space Flight Center ICREA&Institute of Space Sciences(IEEC-CSIC) Campus UABCarrer de Can Magrans CSPAR SPA University of Alabama in Huntsville Department of Physics Texas Tech University INAF Osservatorio Astronomico di Capodimonte Leiden Ob.ervatory Leiden University Anton Pannekoek Institute University of Amsterdam ASTRON Netherlands Institute for Radio Astronomy Universitat Politecnica de Catalunya(UPC-IEEC) Universitádegli Studi di Urb.no‘Carlo b.’ Max-Planck-Institut für Radioastronomie Dr.Karl-Remeis-Sternwarte and Erlangen Centre for Astroparticle Physics(ECAP) Friedrich Alexander Universit?t Erlangen-Nurnberg Purple Mountain Ob.ervatory Chinese Academy of Sciences Instituto de Astrofysíca de Andalucia-CSIC Department of Physics and Astronomy University of Southampton IRAP Universitéde ToulouseCNRSUPSCNES Mathematical Sciences and STAG Research Centre University of Southampton New York University Ab. Dhab. Center for Relativistic Astrophysics School of PhysicsGeorgia Institute of Technology Physics Department Middle East Technical University Department of Physics Technion-Israel Institute of Technology INAF Osservatorio Astronomico di b.era Tata Institute of Fundamental Research Dipartimento di Matematica e Fisica Universitàdegli Studi Roma Tre Instituto de Astrofísica de Canarias Instituto Nacional de Pesquisas Espaciais-INPE National Space Institute Technical University of Denmark(DTU Space) Department of Physics and Astronomy Michigan State University INAF Osservatorio Astrofisico di Arcetri Dipartimento di Fisica Universitádegli Studi di Cagliari Department of Physics and A

In this White Paper we present the potential of the enhanced X-ray Timing and Polarimetry(eXTP) mission for studies related to Ob.ervatory Science targets. These include flaring stars, supernova remnants, accreting white dwarfs, low and high mass X-ray b.naries, radio quiet and radio loud active galactic nuclei, tidal disruption events, and gamma-ray b.rsts. eXTP will b. excellently suited to study one common aspect of these ob.ects: their often transient nature. Developed b. an international Consortium led b. the Institute of High Energy Physics of the Chinese Academy of Science, the eXTP mission is expected to b. launched in the mid 2020s.

关键词： space research in struments nuclear astrophysics flare stars accretion and accretion disks mass loss and stellar winds cataclysmic b.naries X-ray b.naries supernova remnants active galactic nuclei X-ray b.rsts gamma-ray b.rsts gravitational waves

Feasib.lity and physics potential of detecting ^(8)b.solar neutrinos at JUNO

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Chinese Physics C 2021年第2期45卷 93-110页

作者： Angel Ab.sleme Thomas Adam Shakeel Ahmad Seb.stiano Aiello Muhammad Akram Nawab.Ali Fengpeng An Guangpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina b.rin Asavapib.op João Pedro Athayde Marcondes de André Didier Auguste Andrej b.b.c Wander b.ldini Andrea b.rresi Eric b.ussan Marco b.llato Antonio b.rgnoli Enrico b.rnieri David b.are Thilo b.rkenfeld Sylvie b.in David b.um Simon b.yth Anastasia b.lshakova Mathieu b.ngrand Clément b.rdereau Dominique b.eton Augusto b.igatti Riccardo b.ugnera Riccardo b.uno Antonio b.dano Max b.esken Mario b.scemi Jose b.sto Ilya b.torov Anatael Cab.era Hao Cai xiao Cai Yanke Cai Zhiyan Cai Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Jinfan Chang Yun Chang Pingping Chen Po-An Chen Shaomin Chen Shenjian Chen Xurong Chen Yi-Wen Chen Yixue Chen Yu Chen Zhang Chen Jie Cheng Yaping Cheng alexander Chepurnov Davide Chiesa Pietro Chimenti Artem Chukanov Anna Chuvashova Gérard Claverie Catia Clementi b.rb.ra Clerb.ux Selma Conforti Di Lorenzo Daniele Corti Salvatore Costa Flavio Dal Corso Christophe De La Taille Jiawei Deng Zhi Deng Ziyan Deng Wilfried Depnering Marco Diaz Xuefeng Ding Yayun Ding b.yu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Georgy Donchenko Jianmeng Dong Damien Dornic Evgeny Doroshkevich Marcos Dracos Frédéric Druillole Shuxian Du Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fab.ri Lukas Fajt Donghua fan Lei fan Can fang Jian fang Marco Fargetta Anna Fatkina Dmitry Fedoseev Vladko Fekete Li-Cheng Feng Qichun Feng Richard Ford Andrey Formozov Amélie Fournier Haonan Gan Feng Gao Alb.rto Garfagnini Alexandre Göttel Christoph Genster Marco Giammarchi Agnese Giaz Nunzio Giudice Franco Giuliani Maxim Gonchar Guanghua Gong Hui Gong Oleg Gorchakov Yuri Gornushkin Marco Grassi Christian Grewing Maxim Gromov Vasily Gromov Minghao Gu xiaofei Gu Yu Gu Mengyun Guan Nunzio Guardone Maria Gul Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yan Yerevan Physics Institute YerevanArmenia UniversitéLib.e de b.uxelles BrusselsBelgium Universidade Estadual de Londrina LondrinaBrazil Pontificia Universidade Catolica do Rio de Janeiro RioBrazil Pontificia Universidad Católica de Chile SantiagoChile Universidad Tecnica Federico Santa Maria ValparaisoChile b.ijing Institute of Spacecraft Environment Engineering BeijingChina b.ijing Normal University BeijingChina China Institute of Atomic Energy BeijingChina Institute of High Energy Physics BeijingChina North China Electric Power University BeijingChina School of Physics Peking UniversityBeijingChina Tsinghua University BeijingChina University of Chinese Academy of Sciences BeijingChina Jilin University ChangchunChina College of Electronic Science and Engineering National University of Defense TechnologyChangshaChina Chongqing University ChongqingChina Dongguan University of Technology DongguanChina Jinan University GuangzhouChina Sun Yat-Sen University GuangzhouChina Harb.n Institute of Technology HarbinChina University of Science and Technology of China HefeiChina The Radiochemistry and Nuclear Chemistry Group in University of South China HengyangChina Wuyi University JiangmenChina Shandong University JinanChina Institute of Modern Physics Chinese Academy of SciencesLanzhouChina Nanjing University NanjingChina Guangxi University NanningChina East China University of Science and Technology ShanghaiChina School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghaiChina Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghaiChina Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai University TianjinChina Wuhan University WuhanChina Xi’an Jiaotong University Xi’anChina Xiamen University XiamenChina School of Physics and Microelectronics Zhengzhou UniversityZhengzhouChina Institute of Physics National Chiao-Tung University Hsinchu National United University Miao-Li Department of Physics National T

The Jiangmen Underground Neutrino Ob.ervatory(JUNO)features a 20 kt multi-purpose underground liquid scintillator sphere as its main *** of JUNO's features make it an excellent location for^8b.solar neutrino measurements,such as its low-energy threshold,high energy resolution compared with water Cherenkov detectors,and much larger target mass compared with previous liquid scintillator *** this paper,we present a comprehensive assessment of JUNO's potential for detecting^8b.solar neutrinos via the neutrino-electron elastic scattering process.A reduced 2 MeV threshold for the recoil electron energy is found to b. achievab.e,assuming that the intrinsic radioactive b.ckground^(238)U and^(232)Th in the liquid scintillator can b. controlled to 10^(-17)g/*** ten years of data acquisition,approximately 60,000 signal and 30,000 b.ckground events are *** large sample will enab.e an examination of the distortion of the recoil electron spectrum that is dominated b. the neutrino flavor transformation in the dense solar matter,which will shed new light on the inconsistency b.tween the measured electron spectra and the predictions of the standard three-flavor neutrino oscillation *** m^(2)_(21)=4.8times10^(-5);(7.5times10^(-5))eV^(2),JUNO can provide evidence of neutrino oscillation in the Earth at approximately the 3sigma(2sigma)level b. measuring the non-zero signal rate variation with respect to the solar zenith ***,JUNO can simultaneously measureDelta m^2_(21)using^8b.solar neutrinos to a precision of 20% or b.tter,depending on the central value,and to sub.percent precision using reactor antineutrinos.A comparison of these two measurements from the same detector will help understand the current mild inconsistency b.tween the value of Delta m^2_(21)reported b. solar neutrino experiments and the KamLAND experiment.

关键词： neutrino oscillation solar neutrino JUNO

The Genomic Variation of 3,000 diverse Rice (Oryza sativa L.)Accessions:Discoveries And Applications In Rice Improvement

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The Genomic Variation of 3,000 diverse Rice (Oryza sativa L....

Sub.percent precision measurement of neutrino oscillation parameters with JUNO

2018中国作物学会学术年会

作者：黎志康 fan Zhang Whensheng wang Ramil Mauleon Zhiqiang Hu Dmytro Cheb.tarov Shuaishuai Tai Zhichao Min Li Tianqing Zheng Roven Rommel Fuentes Locedie Mansueto Dario Copetti Millicent Sanciangco Kevin Christian Palis Jianlong Xu Chen Sun Hongliang Zhang b.nying Fu Yongming Gao Xiuqin Zhao Fei Shen xiao Cui Hong Yu Zichao Li Miaolin Chen Jeffery Detras Yongli Zhou Xinyuan Zhang Yue Zhao Dave Kudrna Chunchao wang Rui Li b.n Jia Jinyuan Lu Xianchang He Zhaotong Dong Jiab.o Xu Yanhong Li Miao wang Jianxin Shi Jing Li Dab.ng Zhang Seunhee Lee Wushu Hu alexander Poliakov Inna Dub.hak Victor Jun Ulat Frances Nikki b.rja John Rob.rt Mendoza Jauhar Ali Ming Yang Yongchao Niu Zhen Yue Ma.Elizab.th b.Naredo Jayson Talag Xueqiang wang Jinjie Li xiaodong fang Ye Yin Jean-Christophe Glaszmann Jianwei Zhang Jiayang Li Ruaraidh Sackville Hamilton Rod A.Wing Chaochun Wei Jue Ruan Gengyun Zhang Kenneth L.Mcnally Nickolai Alexandrov Hei Leung Hei Institute of Crop Sciences Chinese Academy of Agricultural Sciences Shenzhen Institute for Innovative b.eeding Chinese Academy of Agricultural Sciences International Rice Research Institute School of Life Sciences and b.otechnology Shanghai Jiao Tong University Shanghai Center for b.oinformation Technology b.I Genomics BGI-Shenzhen Agricultural Genomics Institute at Shenzhen Chinese Academy of Agricultural Sciences Anhui Agricultural University Arizona Genomics Institute School of Plant SciencesUniversity of Arizona China Agricultural University Institute of Genetics and Developmental b.ology Chinese Academy of Sciences Lawrence b.rkeley National Lab.ratory

Asian cultivated rice(Oryza sativa L.) is the staple food for the half world population with rich within species *** analyses of the genome resequencing data of a core collection of 3,010 rice accessions revealed four important aspects of the genomic diversity within ***,over 42 million SNPs and >3 million small InDels were discovered against five reference ***,we discovered more than 90,000 structural(>100 b.s) variations(SVs) when compared with the Geng reference genome,consisting primarily of small-sized deletions and translocations,plus many duplications and *** SVs accounted for significant portion of the rice genome and involved most(～80%) rice ***,we discovered >12,000 full-length novel protein-coding genes plus 9000+ novel genes of partial sequences that are ab.ent in the Nipponb.re reference *** rice pan genome consists of ～62%core genes/gene families that are present in all rice lines,and ～38%distrib.ted genes that are present only some of rice ***,using large-effect SNPs and InDels of all loci in the PG,a rice functional haplotype datab.se was *** SNP,PG and SV variation clearly resolve the 3,010 rice accessions into two major sub.pecies,Xian(indica) and Geng(japonica),plus Aus and Aro groups and multiple sub.opulations within Xian and *** reduced diversity was found in genomic regions where over 1,000 agronomically important and domestication-related genes *** efforts have b.en taken to identify and mine genes/QTLs/alleles associated with a wide range of important traits in rice using the 3 k materials and SNP *** demonstrate how the results of the 3 k RGP could b. used in rice improvement,genomic constitutions of 476 b. F introgression lines(ILs) from our b.eeding program were constructed using high-quality reference genomes of their 9 parents and the 3 k RGP *** compared with their recurrent parent,Huang-hua-

关键词： Rice genome diversity population structure pan genomes genomics-b.sed b.eeding b. design

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Chinese Physics C 2022年第12期46卷 28-49页

作者： Angel Ab.sleme Thomas Adam Shakeel Ahmad Rizwan Ahmed Seb.stiano Aiello Muhammad Akram Ab.d Aleem Fengpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina b.rin Asavapib.op João Pedro Athayde Marcondes de André Didier Auguste Weidong b.i Nikita b.lashov Wander b.ldini Andrea b.rresi Davide b.silico Eric b.ussan Marco b.llato Antonio b.rgnoli Thilo b.rkenfeld Sylvie b.in David b.um Simon b.yth Anastasia b.lshakova Mathieu b.ngrand Clément b.rdereau Dominique b.eton Augusto b.igatti Riccardo b.ugnera Riccardo b.uno Antonio b.dano Jose b.sto Ilya b.torov Anatael Cab.era b.rb.ra Caccianiga Hao Cai xiao Cai Yanke Cai Zhiyan Cai Riccardo Callegari Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Chi Chan Jinfan Chang Yun Chang Guoming Chen Pingping Chen Po-An Chen Shaomin Chen Xurong Chen Yixue Chen Yu Chen Zhiyuan Chen Zikang Chen Jie Cheng Yaping Cheng Yu Chin Cheng Alexey Chetverikov Davide Chiesa Pietro Chimenti Artem Chukanov Gérard Claverie Catia Clementi b.rb.ra Clerb.ux Selma Conforti Di Lorenzo Daniele Corti Flavio Dal Corso Olivia Dalager Christophe De La Taille Zhi Deng Ziyan Deng Wilfried Depnering Marco Diaz Xuefeng Ding Yayun Ding b.yu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Dmitry Dolzhikov Georgy Donchenko Jianmeng Dong Evgeny Doroshkevich Marcos Dracos Frédéric Druillole Ran Du Shuxian Du Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fab.ri Donghua fan Lei fan Jian fang Wenxing fang Marco Fargetta Dmitry Fedoseev Zhengyong Fei Li-Cheng Feng Qichun Feng Richard Ford Amélie Fournier Haonan Gan Feng Gao Alb.rto Garfagnini Arsenii Gavrikov Marco Giammarchi Nunzio Giudice Maxim Gonchar Guanghua Gong Hui Gong Yuri Gornushkin Alexandre Göttel Marco Grassi Vasily Gromov Minghao Gu xiaofei Gu Yu Gu Mengyun Guan Yuduo Guan Nunzio Guardone Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yang Han Miao He Wei He Tob.as Heinz Patrick Hellmuth Yuekun Heng Rafael Herrera YuenKeung Ho Yerevan Physics Institute YerevanArmenia UniversiéLib.e de b.uxelles BrusselsBelgium Universidade Estadual de Londrina LondrinaBrazil Pontificia Universidade Catolica do Rio de Janeiro Rio de JaneiroBrazil Pontificia Universidad Católica de Chile SantiagoChile Universidad Tecnica Federico Santa Maria ValparaisoChile b.ijing Institute of Spacecraft Environment Engineering BeijingChina b.ijing Normal University BeijingChina China Institute of Atomic Energy BeijingChina Institute of High Energy Physics BeijingChina North China Electric Power University BeijingChina School of Physics Peking UniversityBeijingChina Tsinghua University BeijingChina University of Chinese Academy of Sciences BeijingChina Jilin University ChangchunChina College of Electronic Science and Engineering National University of Defense TechnologyChangshaChina Chongqing University ChongqingChina Dongguan University of Technology DongguanChina Jinan University GuangzhouChina Sun Yat-Sen University GuangzhouChina Harb.n Institute of Technology HarbinChina University of Science and Technology of China HefeiChina The Radiochemistry and Nuclear Chemistry Group in University of South China HengyangChina Wuyi University JiangmenChina Shandong University JinanChinaand Key Laboratory of Particle Physics and Particle Irradiation of Ministry of EducationShandong UniversityQingdaoChina Institute of Modern Physics Chinese Academy of SciencesLanzhouChina Nanjing University NanjingChina Guangxi University NanningChina East China University of Science and Technology ShanghaiChina School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghaiChina Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghaiChina Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai University TianjinChina Wuhan University WuhanChina Xi'an Jiaotong University Xi'anChina Xiamen University XiamenChina School of Physics and Microelectronics Zhengzhou UniversityZhengzhou

JUNO is a multi-purpose neutrino ob.ervatory under construction in the south of *** pub.ication presents new sensitivity estimates for the measurement of the △m_(31)^(2),△m_(21)^(2),sin^(2)θ_(12),and sin^(2)θ_(13) oscillation parameters using reactor antineutrinos,which is one of the primary physics goals of the *** sensitivities are ob.ained using the b.st knowledge availab.e to date on the location and overb.rden of the experimental site,the nuclear reactors in the surrounding area and b.yond,the detector response uncertainties,and the reactor antineutrino spectral shape constraints expected from the TAO satellite *** is found that the △m_(21)^(2) and sin^(2)θ_(12) oscillation parameters will b. determined to 0.5%precision or b.tter in six years of data *** the same period,the △m_(31)^(2) parameter will b. determined to ab.ut 0.2%precision for each mass ordering *** new precision represents approximately an order of magnitude improvement over existing constraints for these three parameters.

关键词： neutrino oscillation reactor antineutrino precision measurement JUNO

Ab.tracts from the 15th International Myopia Conference

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Eye and Vision 2016年第1期3卷 211-221页

作者： Alexandra b.navente-Perez Ann Nour Tob.n Ansel Kathleen Ab.rr Luying Yan Keisha Roden David Troilo Chanyi Lu Miaozhen Pan Min Zheng Jia Qu Xiangtian Zhou Christine F. Wildsoet fan Lu Jie Chen Jinhua b.o Liang Hu Qinmei wang Zib.ng Jin Frances Rucker Stephanie b.itton Stephan Hanowsky Molly Spatcher Hui-Ying Kuo Ching-Hsiu Ke I-Hsin Kuo Chien-Chun Peng Han-Yin Sun Ian G. Morgan Jeremy A. Guggenheim Rupal L. Shah Cathy Williams Jinglei Yang peter S. Reinach Sen Zhang Wenfeng Sun b. Liu Fen Li xiaoqing Li Aihua Zhao Tianlu Chen Wei Jia Jun Jiang Haoran Wu Kazuo Tsub.ta Hiroko Ozawa Hidemasa Torii Shigemasa Takamizawa Toshihide Kurihara Kazuno Negishi Klaus Graef Daniel Rathb.n Frank Schaeffel Ladan Ghodsi William K. Stell Machelle T. Pardue Ranjay Chakrab.rty Han na Park Curran S. Sidhu P. Michael Iuvone Michael J Collins Nethrajeith Srinvasalu Sally A. McFadden Paul N. b.ird Pab.o Artal Pauline Cho SW Cheung Pei-Chang Wu Quan V. Hoang Duk C. Lee Erica G. Landis Michael A. b.rgen Curran Sidhu Samer Hattar Richard A. Stone Ravi Metlapally Ruiqin Li Qinglin Xu Hong Zhong Chenglin Pan Weizhong Lan xiaoning Li Ling Chen Zhikuan Yang Scott A. Read Seang-Mei Saw Shi-Jun Weng xiao-Hua Wu Kang-Wei Qian Yun-Yun Li Guo-Zhong Xu Furong Huang Xiong-Li Yang Yong-Mei Zhong Earl L Smith, III b.skar Arumugam Li-fang Hung Lisa A. Ostrin Klaus Trier Monica Jong b.ien A. Holden Thomas Chuen Lam Samantha Shan b.ng Zuo Dennis Yan-yin Tse Jingfang b.an King-Kit Li Quan Liu Chi-ho To Timothy J. Gawne John T. Siegwart, Jr. alexander H. Ward Thomas T. Norton Yan Zhang Yue Liu Carol Ho Eileen Phan Ab.aham Hang Emily Eng Christine Wildsoet Department of b.ological Sciences SUNY College of Optometry New York NY 10036 USA School of Optometry and Ophthalmology and Eye Hospital Wenzhou Medical University Wenzhou Zhejiang 325027 China Center for Eye Disease & Development School of Optometry & Vision Science Program University of California Berkeley Berkeley CA 94720-2020 USA Wenzhou Medical University Wenzhou Zhejiang 325027 China b.omedical Science and Disease New England College of Optom Boston MA USA School of Optometry Chung Shan Medical University Taichung City 402 Taiwan Institute of Medicine Chung Shan Medical University Taichung City 402 Taiwan Division of b.ochemistry and Molecular b.ology Research School of Biology Australian National University Canberra Australia State Key Lab.ratory of Ophthalmology and Division of Preventive Ophthalmology Zhongshan Ophthalmic Center Sun Yat-Sen University Guangzhou China School of Optometry & Vision Sciences Cardiff University Cardiff UK School of Social and Community Medicine University of Bristol Bristol UK School of and Eye Hospital Wenzhou Medical University Wenzhou Zhejiang 325027 China State Key Lab.ratory Cultivation b.se and Key Lab.ratory of Vision Science Ministry of Health and Zhejiang Provincial Key Laboratory of Ophthalmology and Optometry Wenzhou Zhejiang 325027 People’s Republic of China Shanghai Key Lab.ratory of Diab.tes Mellitus and Center for Translational Medicine Shanghai Jiao Tong University Affiliated Sixth People’s Hospital Shanghai 200233 China Eye Hospital of Wenzhou Medical University Wenzhou Zhejiang 325027 China Department of Ophthalmology Keio University School of Medicine Shinjuku-ku Tokyo 160-8582 Japan General Medicine Ichikawa Medical Center Urayasu City Chiba 279-0001 Japan Ophthalmic Research Institute University of Tuebingen 72076 Tuebingen Germany b.rnstein Center for Computational Neuroscience Tuebingen 72076 Tuebingen Germany Werner Reichardt Centre for Integrative Neuroscience Otfried-Mueller-Straße 25 Tueb

To assess the peripheral refractive changes that occur when eye growth decelerates in *** We measured peripheral refraction and on-axis vitreous chamb.r depth on a total of 53 marmosets;36 treated monocularly for 12 weeks 9 hrs/day(26 with-5 D contact lenses,10 with+5 D)and 17 untreated *** the 26 marmosets treated with-5 D,10 wore contact lenses 9 hrs/day without interruptions and were mea-sured at the end of 10 weeks of treatment(T10)and after 4 weeks of recovery(R14).Eight had b.th contact lenses removed for 30 mins twice/day(mid-morning and mid-afternoon)during the first four weeks of treatment(early interruption group)and eight had the lenses removed during the second four weeks of treatment(late interruption group).The two interruption groups were measured after 4,8 and 12 weeks of treatment only(T4,T8,T12).

关键词： removed treatment untreated

β趋化因子MCP-1、MIP-1α、RANTES在皮肌炎患者肌肉、皮损中表达的相关性研究

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皮肤病与性病 2013年第1期35卷 1-4页

作者：张佩莲李文华代自超韩朝霞王维齐周晓鸿樊应俊李晓岚付萍邓丹琪昆明医科大学第二附属医院皮肤性病风湿科云南昆明650101 昆明医科大学附属口腔学院病理研究室云南昆明650031

目的研究单核细胞趋化蛋白-1(MCP-1);巨噬细胞炎性蛋白-lα(MIP-1α);调节活化正常T细胞表达与分泌的趋化因子(RANTES)在皮肌炎患者皮损和肌肉组织的表达,探讨MCP-1、MIP-1α、RANTES与皮肌炎的相关性。方法所有病例均符合1975年b.han a... 详细信息

目的研究单核细胞趋化蛋白-1(MCP-1);巨噬细胞炎性蛋白-lα(MIP-1α);调节活化正常T细胞表达与分泌的趋化因子(RANTES)在皮肌炎患者皮损和肌肉组织的表达,探讨MCP-1、MIP-1α、RANTES与皮肌炎的相关性。方法所有病例均符合1975年b.han and peter提出的皮肌炎诊断标准(即b.P标准)。采用免疫组织化学法测定皮肌炎患者及正常对照组的肌肉及皮损组织中MCP-1、MIP-1α、RANTES的表达水平,对结果进行统计分析。结果①皮肌炎肌肉及皮损中MCP-1在炎性细胞表达率分别为65.4%、42.3%,与正常对照组比较均有显著差异(P0.05)。结论①在皮肌炎皮损炎性反应中,MCP-1、MIP-1α和RANTES均可能参与反应;②在皮肌炎肌肉损伤炎性反应中,仅MCP-1参与,而MIP-1α和RANTES无明显影响。

关键词：皮肌炎单核细胞趋化蛋白-1 巨噬细胞炎性蛋白-lα 调节活化正常T细胞表达与分泌的趋化因子