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Open Journal of Modern Neurosurgery 2015年第3期5卷 76-83页

作者： peter yat ming woo Ka Wing Michael See Jason Kwan Ho Chow Yung Chan Hoi Tung Wong Kwong Yau Chan Department of Neurosurgery Kwong Wah Hospital Hong Kong China

Delayed cerebral ischemia (DCI) due to post-brain tumor resection vasospasm is an often unrecognized yet debilitating complication. We present a patient with DCI after the resection of glioblastoma multiforme (GBM). To our knowledge, this is the first report on DCI after GBM resection. A 52-year-old female patient with headache for one month underwent subtotal resection of a left temporal GBM encasing the proximal middle cerebral artery (MCA). She was well during the immediate postoperative period but developed right upper limb dense monoparesis on postoperative day four with computed tomographic angiography confirming left MCA vasospasm. Symptoms were significantly alleviated with weeklong hypertensive therapy and nimodipine administration;however they recurred soon after cessation of treatment. A high index of clinical suspicion is needed for the diagnosis of post-tumor resection DCI. Any new postoperative neurological deficit that cannot be explained by hemorrhage, seizures or infection should be expeditiously investigated by angiography or transcranial Doppler sonography. Prompt initiation of hypertensive and nimodipine therapy can possibly reverse neurological deficit. Treatment should be guided by Doppler, angiographic or perfusion imaging studies and not by clinical improvement alone.

关键词： Cerebral Vasospasm Delayed Cerebral Ischemia Glioblastoma Multiforme Hypertensive Therapy Nimodipine

Infectious intracranial aneurysm associated with Lactococcus garvieae: A case report and literature review

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Infectious Medicine

Infectious Medicine 2024年第3期3卷 78-86页

作者： Chung-Ho Lee peter yat-ming woo Calvin Ka-Lam Leung Ronald Li Jenny Kwan-Tsz Chan Kwan-Shun Ng Cindy Wing-Sze Tse Department of Pathology Kwong Wah HospitalHong Kong Special Administrative RegionChina Department of Neurosurgery Kwong Wah HospitalHong Kong Special Administrative RegionChina

Lactococcus garvieae is a known fish pathogen associated with numerous aquacultural *** humans,*** primarily causes infective endocarditis,but infections involving other organs have also been *** report the first case of ruptured infectious intracranial aneurysm associated with *** bacteraemia without concomitant infective *** diagnosis of a left distal posterior cerebral artery mycotic aneurysm was based on a computed tomography angiogram,catheter angiogram and histopathological examination of the resected ***,we review the literature on human *** infections and describe the clinical characteristics,risk factors,management and outcomes of the cases identified to date.

关键词： Lactococcus garvieae Bacteraemia Infectious intracranial aneurysm Mycotic aneurysm Subarachnoid haemorrhage

Evaluation of a Rapid Immunochromatographic Middle East Respiratory Syndrome Coronavirus Antigen Detection Assay

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Infectious Microbes & Diseases 2022年第4期4卷 175-177页

作者： Susanna Kar-Pui Lau Kenneth Sze-ming Li Jade Lee-Lee Teng Sunitha Joseph Hayes Kam-Hei Luk Joshua Fung Ulrich Wernery Patrick Chiu-yat woo Department of Microbiology School of Clinical MedicineLi Ka Shing Faculty of MedicineThe University of Hong KongPokfulamHong KongChina Central Veterinary Research Laboratory DubaiUnited Arab Emirates PhD Program in Translational Medicine and Department of Life Sciences National Chung Hsing UniversityTaichungTaiwan The iEGG and Animal Biotechnology Research Center National Chung Hsing UniversityTaichungTaiwan

Middle East respiratory syndrome coronavirus(MERS-CoV)infection in humans has a high mortality of>30%.Dromedaries are the reservoir of MERS-CoV and the main source of human ***,MERS-CoV infections in dromedaries are usually *** diagnosis of MERS-CoV infection in these animals is important in preventing camel-to-human transmission of the *** possible cross-reactivity of a previously reported rapid nucleocapsid protein-based antigen detection assay for MERS-CoV was examined with different CoVs,including Tylonycteris bat CoV HKU4,dromedary camel CoV UAE-HKU23,human CoV-229E,human CoV-OC43,severe acute respiratory syndrome CoV-2 and rabbit CoV HKU14,where none of them showed false-positive *** assay was further validated using quantitative real-time reverse transcription-polymerase chain reaction-confirmed MERS-CoV-positive and MERS-CoV-negative dromedary nasal samples collected in Dubai,the United Arab Emirates,which showed that the rapid antigen detection assay has a specificity of 100%and sensitivity of 91.7%.

关键词： MERS-CoV rapid antigen detection assay dromedary camels

Central Neurocytoma and Epidermoid Tumor Occurring as Collision Tumors: A Rare Association

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Open Journal of Modern Neurosurgery 2014年第1期4卷 31-35页

作者： peter Y. M. woo Ho Hung Cheung Calvin H. K. Mak Siu Ki Chan Kar ming Leung Kwong Yau Chan Department of Neurosurgery Kwong Wah Hospital Hong Kong China Department of Pathology Kwong Wah Hospital Hong Kong China

Different brain tumors of distinct histology can co-exist in the setting of phakomatoses or as a complication of radiotherapy. In the absence of these predisposing factors, this phenomenon is uncommon. When the lesions are in close proximity they are described as collision tumors and are extremely rare. A 58-year-old woman presented with persistent headache and cognitive decline for three months. Magnetic resonance imaging revealed a tumor arising from the atrium of the left lateral ventricle with heterogeneous contrast enhancement. This intraventricular lesion was adjacent to another extensive infiltrating tumor of the basal cisterns. Operative findings revealed a vascular ventricular tumor and gross total resection was achieved. An adjacent avascular basal cistern tumor with a pearly white sheen was encountered and partial excision was performed. The histopathological diagnosis was central neurocytoma and epidermoid tumor. There is only one documented description of a central neurocytoma co-existing with a tumor of different pathology. To our knowledge, this is the first reported collision tumor case involving central neurocytoma. Since the incidence of both lesions co-existing juxtaposed is extremely low, a chronic oncogenetic inflammatory process stimulated by the epidermoid tumor to the subventricular region is suggested. Other mechanisms for tumor collision are discussed and we suggest a classification system for this rare association to reflect their pathogenesis.

关键词： Collision Tumors Epidermoid Tumor Central Neurocytoma

peters’异常患者Sox11及CYP1B1基因变异分析

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中山大学学报（医学科学版） 2013年第4期34卷 633-637页

作者：贾秀华郭向明中山大学附属第三医院眼科广东广州510630 中山大学中山眼科中心广东广州510060

【目的】研究中国人peters’异常患者Sox11及CYP1B1基因变异情况。【方法】从眼遗传疾病库中选取13例peters’异常的先证者以及100例正常对照,采用直接测序的方法分析Sox11及CYP1B1基因的外显子及其相邻内含子基因变异情况;通过测序识... 详细信息

【目的】研究中国人peters’异常患者Sox11及CYP1B1基因变异情况。【方法】从眼遗传疾病库中选取13例peters’异常的先证者以及100例正常对照,采用直接测序的方法分析Sox11及CYP1B1基因的外显子及其相邻内含子基因变异情况;通过测序识别的基因突变,使用HA-SSCP分析的方法,在100例正常对照中做进一步评估。筛查中国人群peters’异常患者Sox11及CYP1B1基因基因变异,并研究其相关表型。【结果】在13例peters’异常的患者中检测到一个Sox11同义突变,一个CYP1B1错义突变,在正常对照中未发现此基因突变。【结论】本研究首次对peters’异常患者进行Sox11进行基因筛查,并验证了CYP1B1是peters’异常的致病基因之一,进一步扩大了peters’异常患者CYP1B1基因突变的突变频谱,增加了我们对基因型与表型之间关系的认识,并有望为将来该疾病致病机制的基因学及功能学方面的研究提供基础。

关键词： peters'异常 Sox11 CYP1B1 基因变异

Description of Pseudorhabdosynochus seabassi sp.n.(Monogenea:Diplectanidae) from Lates calcarifer and revision of the phylogenetic position of Diplectanum grouperi (Monogenea:Diplectanidae) based on rDNA sequence data

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Description of Pseudorhabdosynochus seabassi sp.n.(Monogenea...

International consensus on natural orifice specimen extraction surgery(NOSES)for gastric cancer(2019)

中国畜牧兽医学会家畜寄生虫学分会第五次代表大会暨第八次学术研讨会

作者： Xiang Y.Wu1 An X.Li1 Xing Q.Zhu2 ming Q.Xie1 1Center for Parasitic Organisms,School of Life Sciences,Sun yat-sen University,135 Xingang West Street,Haizhu District,Guangzhou 510275,Guangdong Province,The People’s Republic of China 2Laboratory of Parasitology,College of Veterinary Medicine,South China Agricultural University,483 Wushan Street,Tianhe District,Guangzhou 510642,Guangdong Province,The People’s Republic of China

Pseudorhabdosynochus seabassi sp.n.(Monogenea:Diplectanidae)from the gill filaments of Latescalcarifer Bloch,a marine teleost fish held in floating sea cages in Guangdong Province,China,wasdescribed based on morphological observations and molecular *** shapes of the male copulatoryorgans(MCO)of Pseudorhabdosynochus *** the focus of this *** typical proximal part ofthe MCO in most species of Pseudorhabdosynochus is reniform,heavily sclerotized,and divided intofour ***,the new species from *** has a bulbous proximal region with fourconcentric layers of apparent muscular origin,instead of reniform structure with four *** organ is also different in Diplectanum grouperi Bu,Leong,Wong,woo et Foo,1999,which issclerotized,cup-shaped,wide proximally with four concentric muscular layers and tubular ***3’terminal portion of the small subunit ribosomal RNA gene(ssrDNA)and the 5’terminal region(domains C1-D2)of the large subunit ribosomal RNA gene(lsrDNA)were used to reconstruct thephylogenetic relationship of *** and *** with related taxa utilizing maximum-parsimonyand neighbour-joining *** analyses unequivocally placed *** amongstPseudorhabdosynochus using either ssrDNA or lsrDNA *** species of Pseudorhabdosynochus(including ***)used in this study clustered together,inferring *** on molecularphylogenetic evidence,we propose that *** from Epinephelus coioides Hamilton be transferredto Pseudorhabdosynochus as *** comb.n..

关键词： Pseudorhabdosynochus seabassi sp.n Diplectanum grouperi PCR phylogeny Lates calcarifer

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Gastroenterology Report 2020年第1期8卷 5-10,I0001页

作者： Xu Guan Zheng Liu Amjad Parvaiz Antonio Longo Avanish Saklani Ali AShafik Jian-Chun Cai Charles Ternent Lin Chen Cuneyt Kayaalp Fatih Sumer Fernanda Nogueira Feng Gao Fang-Hai Han Qing-Si He Ho-Kyung Chun Chang-ming Huang Hai-Yang Huang Rui Huang Zhi-Wei Jiang Jim S Khan Joaquim Manuel da Costa Pereira JosephWNunoo-Mensah Jung Tack Son Liang Kang Keisuke Uehara Ping Lan Le-Ping Li Han Liang Bing-Rong Liu Juan Liu Dan Ma ming-Yin Shen Mohammad Rashidul Islam Narimantas Evaldas Samalavicius Kai Pan Petr Tsarkov Xin-Yu Qin Ricardo Escalante Sergey Efetov Seung Kyu Jeong Suk-Hwan Lee Dong-Hui Sun Li Sun Tatiana Garmanova Yan-Tao Tian Gui-Yu Wang Guo-Jun Wang Guo-Rong Wang Xiao-Qiang Wang William Tzu-Liang Chen woo Yong Lee Su Yan Zu-Li Yang Gang Yu Pei-Wu Yu Dan Zhao Yun-Shi Zhong Jian-Ping Wang Xi-Shan Wang The International Alliance of NOSES Department of Colorectal Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingP.R.China Poole Hospital NHS Trust PooleUK European Center of Coloproctology and Pelvic Diseases-Multimedica Hospital MilanItaly Department of GI Surgical Oncology Tata Memorial HospitalMumbaiIndia Department of Colorectal Surgery Cairo UniversityCairoEgypt Department of Gastrointestinal Surgery Zhongshan Hospital of Xiamen UniversityXiamenFujianP.R.China Section of Colon and Rectal Surgery Creighton University School of MedicineOmahaNEUSA Department of General Surgery Chinese People’s Liberation Army General HospitalBeijingP.R.China Department of Gastrointestinal Surgery Inonu UniversityMalatyaTurkey Department of Surgery Hospital de BragaBragaPortugal Department of Colorectal Cancer Surgery the Second Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiangP.R.China Department of Gastroenterological Surgery Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouGuangdongP.R.China Department of General Surgery Shandong University Qilu HospitalJinanShandongP.R.China Department of Surgery Kangbuk Samsung HospitalSungkyunkwan University School of MedicineSeoulSouth Korea Department of Gastric Surgery Fujian Medical University Union HospitalFuzhouFujianP.R.China Department of General Surgery Jiangsu Province Hospital of Traditional Chinese MedicineNanjingJiangsuP.R.China Department of Colorectal Surgery PortsmouthHospitals NHSTrustQueen Alexandra HospitalPortsmouthUK King’s College Hospital LondonUK Department of Colorectal Surgery The Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China Division of Surgical Oncology Department of SurgeryNagoya University School of MedicineNagoyaJapan Department of Gastrointestinal Surgery Shandong Provincial Hospital Affiliated to Shandong UniversityJinanShandongP.R.China Department of Gastric Cancer

At present,natural orifice specimen extraction surgery(NOSES)has attracted more and more attention worldwide,because of its great advantages including minimal cutaneous trauma and post-operative pain,fast post-operative recovery,short hospital stay,and positive psychological ***,NOSES for the treatment of gastric cancer(GC)is still in its infancy,and there is great potential to improve its theoretical system and clinical ***,several key points including oncological outcomes,bacteriological concerns,indication selection,and standardized surgical procedures are raised with this innovative ***,it is necessary to achieve an international consensus to regulate the implementation of GC-NOSES,which is of great significance for healthy and orderly development of NOSES worldwide.

关键词： gastric cancer natural orifice specimen extraction surgery transanal specimen extraction transvaginal specimen extraction transoral specimen extraction consensus

International guideline on natural orifice specimen extraction surgery(NOSES)for colorectal cancer(2023 version)

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Holistic Integrative Oncology 2023年第1期2卷 93-100页

作者： Zheng Liu Xu Guan mingguang Zhang Xiyue Hu ming Yang Junge Bai Jun Li Shaojun Yu Kefeng Ding Qingsi He Liang Kang Dan Ma Chuangang Fu Junhong Hu Ye Wei Donghui Sun Gang Yu Songbing He Changyou Wang Yanwei Gao Guiyu Wang Hongliang Yao Jian Peng Yangchun Zheng Bo Jiang Taiyuan Li Zhiguo Xiong Xuejun Sun Zhenning Wang William Meng William Tzu-Liang Chen ming-Yin Shen John H.Marks Charles A.Ternent Darcy DShaw Jim SKhan Petr Tsarkov Inna Tulina Sergey Efetov Joaquim Manuel da Costa Pereira Fernanda Nogueira Ricardo Escalante Joel Leroy Avanish Saklani Audrius Dulskas Cuneyt Kayaalp Atsushi Nishimura Kay Uehara woo-Yong Lee Sang-Hoo Kim Suk-Hwan Lee Xishan Wang Committee of Colorectal Cancer Society Chinese Anti-Cancer Association International NOSES Alliance Department of Colorectal Surgery National Cancer CenterNational Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100021China Department of Colorectal Surgery The Second Affiliated HospitalZhejiang University School of MedicineHangzhouChina Department of General Surgery Shandong University Qilu HospitalJinanShandongChina Department of Colorectal Surgery The Sixth Affiliated HospitalSun Yat-Sen UniversityGuangzhouChina Department of General Surgery Xinqiao HospitalThird Military Medical UniversityChongqingChina Department of Gastrointestinal Surgery Shanghai East HospitalTongji University School of MedicineShanghaiChina Department of Anorectal Surgery First Affiliated HospitalZhengzhou UniversityZhengzhouHenanChina Department of General Surgery Zhongshan HospitalFudan UniversityShanghaiChina Department of Gastric and Colorectal Surgery Jilin University First HospitalChangchunChina Department of General Surgery Qilu Hospital(Qingdao)Cheeloo College of MedicineShandong UniversityJinanChina Department of General Surgery the First Affiliated Hospital of Soochow UniversitySuzhouJiangsuChina Affiliated Hospital of North China University of Science and Technology TangshanHebeiChina Inner Mongolia Autonomous Region People’s Hospital HuhhotInner Mongolia Autonomous RegionChina Department of Colorectal Cancer Surgery the Second Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiangChina Department of General Surgery The Second Xiangya HospitalCentral South UniversityChangshaHunanChina Department of General Surgery Xiangya HospitalCentral South UniversityChangshaChina Department of Gastrointestinal Surgery Sichuan Cancer HospitalChengduChina Department of Colorectal and Anal Surgery Shanxi Cancer HospitalTaiyuanShanxiChina Department of General Surgery The First Affiliated Hospital of Nanchang UniversityNanchangChina Department of Gastrointestinal Surgery Hubei Provincial Cancer Hosp

Purpose In recent years,natural orifice specimen extraction surgery(NOSES)has gained widespread attention as an alternative *** the safety and feasibility of NOSES have been well documented,many questions remain open for *** aim of this guideline is to provide more evidence for the promotion of *** This guideline has been prepared by the CACA Committee of Colorectal Cancer Society and the International NOSES Alliance,based on the latest *** The guideline on NOSES for colorectal cancer include the definition,classification,technology requirement,indications,technical difficulties and clinical *** The guideline provides a full introduction of the theoretical and technical aspects of NOSES for colorectal cancer which will beneficial to development of NOSES.

关键词： Colorectal cancer Guideline Treatment Surgery Holistic integrative medicine Natural orifice specimen extraction surgery

CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen mingjun Chen mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise