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Vibrotactile coordinated reset stimulation for the treatment of Parkinson's disease

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Neural Regeneration Research 2022年第7期17卷 1495-1497页

作者： peter A.Tass Department of Neurosurgery Stanford University School of MedicineStanfordCAUSA

Introduction of the treatment concept:Regular deep brain stimulation(rDBS)is the standard therapy for the treatment of medically refractory Parkinson’s disease(PD)(Benabid et al.,2009).Notwithstanding its significant therapeutic effects,rDBS may cause side effects,characterized as rDBSinduced movement disorders(BaizabalCarvallo and Jankovic,2016).

关键词： stimulation al. treatment

Untangling the history of oroclines and mountain belts

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National Science Review 2022年第5期9卷 179-180页

作者： peter A.Cawood School of Earth Atmosphere and Environment Monash University

Oro clines are map-view bends of the Earth’s lithosphere formed by rotation of originally quasilinear linear rock units about a sub-vertical axis [1].They can have amplitudes and wavelengths on the order of hundreds of kilometres and are a significant feature of many active and ancient mountain belts(Fig.1,*** orocline,Bolivian orocline,Betic-Rif Belt,

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Climate change and its consequences for water and wastewater management

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Frontiers of Environmental Science & Engineering 2009年第1期3卷 2-11页

作者： peter A.WILDERER Institute of Advanced Studies on Sustainability Amalienstr7580799 MunichGermany

Life,in combination with solar radiation and abiotic processes,is most probably the reason why liquid water has existed on Earth for over billions of years,and the global mean temperature has remained in a lifeenabling *** to limit or even reverse global warming must be derived from the knowledge of the Earth’s complex life-support *** this context,the balance between liquid and gaseous water plays a crucial role,and water management becomes an important field of innovation and action,globally,on the scale of watersheds but also on the very local *** use,reuse,and temporary storage of water in urban settings must be considered to limit over-extraction of water from natural resources,and to maintain the life supporting function of *** the same time,public health requirements,cost efficiency,and reliability demands are to be met.

关键词： ecosystem management tools self-regulation urbanization water-climate relationship water reuse

The evolution and refinement of vasoepididymostomy techniques

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Asian Journal of Andrology 2013年第1期15卷 49-55页

作者： peter T Chan Department of Urology Royal Victoria Hospital McGill University Health Center Montreal Quebec H3A 1A1 Canada

Obstructive azoospermia secondary to epididymal obstruction can be corrected by microsurgical reconstruction with vasoepididymostomy （VE）. Although alternative management such as epididymal or testicular sperm aspiration in conjunction with intracytoplasmic sperm injection is feasible, various studies have established the superior cost-effectiveness of VE as a treatment of choice. Microsurgical VE is considered one of the most technically challenging microsurgeries. Its success rate is highly dependent on the skills and experience of the surgeons. Various techniques have been described in the literature for VE. We have pioneered a technique known as longitudinal intussusception VE （LIVE） in which the epididymal tubule is opened longitudinally to obtain a larger opening to allow its tubular content to pass through the anastomosis. Our preliminary data demonstrated a patency rate of over 90%. This technique has been widely referenced in the recent literature including robotic-assisted microsurgery. The history of the development of different VE approaches, the oreoDerative evaluation along with the techniaues of various VE will be described in this article.

关键词： longitudinal intussusception vasoepididymostomy (LIVE) intracytoplasmic sperm injection (ICSI) male infertility microsurgery obstructive azoospermia vasoepididymostomy (VE)

Maintaining biodiversity will define our long-term success

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Plant Diversity 2020年第4期42卷 211-220页

作者： peter Raven Mathis Wackernagel Missouri Botanical Garden 4344 Shaw BlvdSt.LouisMO63110USA Global Footprint Network 1528 Webster StreetSuite 11OaklandCA94612USA

Human beings are not only a part of our planet's ecosystems,but also,they are massively overusing *** makes ecosystem protection,including biodiversity preservation,vital for humanity's *** speed and scale of the threat are unprecedented in human *** long arch of evolution has been confronted with such a high level of human impact,that we are now facing the sixth mass extinction event,66 million years after the last *** threat heightens the imperative for bold human *** paper identifies three strategies for such an ***,and possibly most challenging,human demand needs to be curbed so it fits within the bounds of what Earth's ecosystems can *** meeting this quantitative goal,biodiversity preservation efforts will not be able to get ***,in the transition time,we must focus on those locations and areas where most biodiversity is *** a focus on‘hotspots’will help safeguard the largest portion of biodiversity with least ***,to direct biodiversity preservation strategies,we need to much better document the existence and distribution of biodiversity around the *** information technologies could help with this critical *** conclusion,biodiversity preservation is no longer just a concern for specialized biologist but is becoming a societal necessity if humanity wants to have a stable future.

关键词： Biodiversity Hotspots Biocapacity Conservation strategy

Emerging and Innovative Materials for Hydropower Engineering Applications:Turbines,Bearings,Sealing,Dams and Waterways,and Ocean Power

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Engineering 2022年第1期8卷 148-158页

作者： Emanuele Quaranta peter Davies European Commission Joint Research Centre Ispra 21027Italy Marine Structures Laboratory IFREMER Centre BretagnePlouzané29280France

The hydropower sector is currently experiencing several technological *** technologies and practices are emerging to make hydropower more flexible and more *** materials have also been recently developed to increase performance,durability,and reliability;however,no systematic discussions can be found in the ***,in this paper,novel materials for hydropower applications are presented,and their performance,advantages,and limitations are *** example,composites can reduce the weight of steel equipment by 50%to 80%,polymers and superhydrophobic materials can reduce head losses by 4%to 20%,and novel bearing materials can reduce bearing wear by 6%.These improvements determine higher efficiencies,longer life span,waste reduction,and maintenance needs,although the initial cost of some materials is not yet competitive with respect to the costs of traditional *** novel materials are described here based on the following categories:novel materials for turbines,dams and waterways,bearings,seals,and ocean hydropower.

关键词： Bearing Composite Dam Hydropower Material Ocean Seal Turbine

Spatial and Temporal Validation of In-Situ and Satellite Weather Data for the South West Agricultural Region of Australia

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Journal of Meteorological Research 2022年第1期36卷 175-192页

作者： Tristan CAMPBELL peter FEARNS Centre for Mine Site Restoration Curtin University of TechnologyWA 6102Australia Remote Sensing and Satellite Research Group Curtin University of TechnologyWA 6102Australia

Seasonal variations in weather have significant impacts on crop *** accuracy of weather data is an important consideration for crop yield *** study uses an independent in-situ weather station network to validate the accuracy of monthly temperature and precipitation data from the in-situ weather station network operated by the Bureau of Meteorology(BOM),interpolated gridded data from this network,and satellite weather data for the South West Agricultural Region of *** region covers five classes of the K?ppen-Geiger climate classification system and is responsible for 10 billion AUD of agricultural produce annually.A strong bias was found for the maximum temperatures in the Copernicus LST(land surface temperature)satellite *** bias was linearly correlated with the in-situ temperature and exceeded 20℃in warmer *** to the bias’s linear nature,a linear correction was able to reduce the root-mean-square error(RMSE)of the Copernicus LST product by 82%.This process was tested for other regions of Australia and,despite some regional differences,a linear correction consistently reduced RMSE by 80%.The validation process demonstrated that the dataset with reliably the lowest RMSE is the gridded weather data calculated from BOM’s in-situ weather *** neighbor in-situ weather stations generally had the next lowest RMSE,followed by weather-station corrected satellite products and lastly the non-weather station corrected satellite *** the in-situ gridded product generally had the lowest RMSE,there were spatial and seasonal *** maximum temperatures were more accurately measured by the bias-corrected Copernicus LST product in the northern and eastern extents(where there is a lower density of BOM in-situ stations).Monthly minimum temperatures from the Copernicus LST product had similar to slightly better RMSE than the Australian Water Availability Project(AWAP)product for the southern half of the study ar

关键词： Australian Water Availability Project land surface temperature satellite precipitation validation

Skeletal muscle as a molecular and cellular biomarker of disease progression in amyotrophic lateral sclerosis:a narrative review

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Neural Regeneration Research 2024年第4期19卷 747-753页

作者： peter H.King Department of Neurology and Center for Neurodegeneration and Experimental Therapeutics The University of Alabama at BirminghamBirminghamALUSA Birmingham Veterans Affairs Medical Center BirminghamALUSA

Amyotrophic lateral sclerosis is a fatal multisystemic neurodegenerative disease with motor neurons being a primary *** progressive weakness is a hallmark feature of amyotrophic lateral sclerosis,there is considerable heterogeneity,including clinical presentation,progression,and the underlying triggers for disease *** on longitudinal studies with families harboring amyotrophic lateral sclerosis-associated gene mutations,it has become apparent that overt disease is preceded by a prodromal phase,possibly in years,where compensatory mechanisms delay symptom *** 85-90%of amyotrophic lateral sclerosis is sporadic,there is a strong need for identifying biomarkers that can detect this prodromal phase as motor neurons have limited capacity for *** Food and Drug Administration-approved therapies work by slowing the degenerative process and are most effective early in the *** muscle,including the neuromuscular junction,manifests abnormalities at the earliest stages of the disease,before motor neuron loss,making it a promising source for identifying biomarkers of the prodromal *** accessibility of muscle through biopsy provides a lens into the distal motor system at earlier stages and in real *** advent of“omics”technology has led to the identification of numerous dysregulated molecules in amyotrophic lateral sclerosis muscle,ranging from coding and non-coding RNAs to proteins and *** technology has opened the door for identifying biomarkers of disease activity and providing insight into disease mechanisms.A major challenge is correlating the myriad of dysregulated molecules with clinical or histological progression and understanding their relevance to presymptomatic phases of *** are two major goals of this *** first is to summarize some of the biomarkers identified in human amyotrophic lateral sclerosis muscle that have a clinicopathological correlation with disease activi

关键词： amyotrophic lateral sclerosis biomarkers clinicopathological correlation disease progression muscle biomarkers neurogenic atrophy neuromuscular junction non-coding RNAs presymptomatic stages skeletal muscle SOD1G93A mouse model

SE Asian Cenozoic Larger Foraminifera:Taxonomic Questions,Apparent Radiation and Abrupt Extinctions

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Journal of Earth Science 2022年第6期33卷 1378-1399页

作者： peter Lunt Xiwu Luan College of Earth Science and Engineering Shandong University of Science and Technology(SDUST)Qingdao266579China Stratos Energy Advisors Kuala LumpurMalaysia

The Cenozoic larger foraminifera are important for biostratigraphy in SE *** review examines the taxonomic inconsistencies of this group and especially the confusion over concepts of evolution,migration,radiation and *** is proposed that from the Mediterranean to Indo-Pacific,Latest Eocene through Miocene,larger foraminifera populations were more homogenous than previously *** show a slow morphological radiation interrupted by several *** pattern is superimposed on a long-term decline in larger foraminiferal *** dating of the major biostratigraphic events are *** main lineages of larger foraminifera can be classified by their evolutionary *** classically“large”genera have highly peramorphic trends achieved through strong orthoselection,and these lineages were the most severely hit by a series of Mid-Eocene to Mid-Miocene extinction *** carbonate facies taxa that are traditionally grouped with the larger foraminifera are characterised by weak paramorphism,and these were much less affected by the extinction *** of these weakly peramorphic forms underwent Latest Miocene to recent radiation to and locally become rock-forming *** three major and one minor larger foraminiferal extinction events since the Mid Eocene coincide with abrupt tectonic events across SE ***,there are probably multiple causes for these extinctions,including global climatic changes.

关键词： larger foraminifera evolution biostratigraphy extinction