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Survival after inflammatory bowel disease-associated colorectal cancer in the Colon Cancer Family Registry

World Journal of Gastroenterology 2013年第21期19卷 3241-3248页

作者： Scott V Adams Dennis J Ahnen John A Baron peter t campbell Steven Gallinger William M Grady Loic LeMarchand Noralane M Lindor John D Potter Polly A Newcomb Cancer Prevention Public Health SciencesFred Hutchinson Cancer Research CenterSeattleWA 98109United States Department of Medicine Denver VA Medical Center and University of Colorado School of MedicineDenverCO 80045United States Department of Medicine University of North CarolinaChapel HillNC 27599United States Epidemiology Research Program Department of Intramural ResearchAmerican Cancer SocietyAtlantaGA 30303United States Division of General Surgery University of TorontoTorontoON M5G2C4Canada Cancer Research Center of Hawaii University of HawaiiHonoluluHI 96813United States Department of Health Science Research Mayo Clinic ArizonaScottsdaleAZ 85259United States

AIM: to investigate the survival of individuals with colorectal cancer (CRC) with inflammatory bowel disease (IBD-associated CRC) compared to that of individuals without IBD diagnosed with CRC. MEtHODS: Epidemiologic, clinical, and follow-up data were obtained from the Colon Cancer Family Registry (Colon CFR). IBD-associated cases were identified from self-report of physician diagnosis. For a subset of participants, medical records were examined to confirm self-report of IBD. Cox proportional hazards regression was applied to estimate adjusted hazard ratios (aHR) and 95%CI of mortality, comparing IBD-associated to non-IBD-associated CRC, adjusted for age at CRC diagnosis, sex, Colon CFR phase, and number of prior endoscopies. Following imputation to complete CRC stage information, adjustment for CRC stage was examined. RESULtS: A total of 7202 CRC cases, including 250 cases of IBD-associated CRC, were analyzed. Over a twelve year follow-up period following CRC diagnosis, 2013 and 74 deaths occurred among non-IBD associated CRC and IBD-associated CRC patients, respectively. the difference in survival between IBD-associated and non-IBD CRC cases was not statistically significant (aHR = 1.08; 95%CI: 0.85-1.36). However, the assumption of proportional hazards necessary for valid inference from Cox regression was not met over the entire follow-up period, and we therefore limited analyses to within five years after CRC diagnosis when the assumption of proportional hazards was met. Over this period, there was evidence of worse prognosis for IBD-associated CRC (aHR = 1.36; 95%CI: 1.05-1.76). Results were similar when adjusted for CRC stage, or restricted to IBD confirmed in medical records. CONCLUSION: these results support the hypothesis that IBD-associated CRC has a worse prognosis than non-IBD-associated CRC.

关键词： Colorectal cancer Inflammatory bowel disease Outcomes research Cancer survival Inflammation

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A product version of the Hilton-Milner-Frankl theorem

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Science China Mathematics 2024年第2期67卷 455-474页

作者： peter Frankl Jian Wang Alfréd Rényi Institute of Mathematics Hungarian Academy of SciencesBudapest H-1053Hungary Department of Mathematics Taiyuan University of TechnologyTaiyuan 030024China

two families F and G of k-subsets of {1, 2,..., n} are called non-trivial cross t-intersecting if|F ∩ G|≥t for all F ∈ F, G ∈ G and | ∩ {F : F ∈ F}| < t, | ∩ {G : G ∈ G}| < t. In the present paper,we determine... 详细信息

two families F and G of k-subsets of {1, 2,..., n} are called non-trivial cross t-intersecting if|F ∩ G|≥t for all F ∈ F, G ∈ G and | ∩ {F : F ∈ F}| t, | ∩ {G : G ∈ G}| t. In the present paper,we determine the maximum product of the sizes of two non-trivial cross t-intersecting families of k-subsets of{1, 2,..., n} for n≥4(t + 2)2k2, k≥5, which is a product version of the Hilton-Milner-Frankl theorem.

关键词： extremal set theory cross t-intersecting family product version non-trivial

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China, Malaysia, and an Emerging New World Order

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China Report ASEAN 2024年第7期9卷 32-33页

作者： peter t C Chang Institute of China Studies University of Malaya

the strong relationship between China and Malaysia can be a catalyst for advancing a more stable and representative world *** leveraging their close ties,both nations can collaborate on diplomatic initiatives,economic... 详细信息

关键词： order stability catalyst

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Benchmarking visual SLAM methods in mirror environments

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Computational Visual Media 2024年第2期10卷 215-241页

作者： peter Herbert Jing Wu Ze Ji Yu-Kun Lai School of Computer Science and Informatics Cardiff UniversityAbacws BuildingSenghennydd RdCardiff CF244AGUK School of Engineering Cardiff UniversityQueen’s BuildingsThe ParadeCardiff CF243AAUK

Visual simultaneous localisation and mapping(vSLAM)finds applications for indoor and outdoor navigation that routinely subjects it to visual complexities,particularly mirror *** effect of mirror presence(time visible and its average size in the frame)was hypothesised to impact localisation and mapping performance,with systems using direct techniques expected to perform ***,a dataset,MirrEnv,of image sequences recorded in mirror environments,was collected,and used to evaluate the performance of existing representative *** ORB-SLAM3 and BundleFusion appear to show moderate degradation of absolute trajectory error with increasing mirror duration,whilst the remaining results did not show significantly degraded localisation *** mesh maps generated proved to be very inaccurate,with real and virtual reflections colliding in the reconstructions.A discussion is given of the likely sources of error and robustness in mirror environments,outlining future directions for validating and improving vSLAM performance in the presence of planar *** MirrEnv dataset is available at https://***/10.17035/d.2023.0292477898.

关键词： visual simultaneous localisation and mapping(vSLAM) mirror localisation mapping reflection datase

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temporal trends and practice variation of paediatric diagnostic tests in primary care:retrospective analysis of 14 million tests

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Family Medicine and Community Health 2024年第4期12卷 1-8页

作者： Elizabeth t thomas Diana R Withrow Cynthia Wright Drakesmith peter J Gill Rafael Perera-Salazar Carl Heneghan Centre for Evidence-Based Medicine Nuffield Department of Primary Care Health SciencesUniversity of OxfordOxfordUK Nuffield Department of Primary Care Health Sciences University of OxfordOxfordUK Department of Pediatrics University of TorontoTorontoOntarioCanada Hospital for Sick Children TorontoOntarioCanada

Objective the primary objective was to investigate temporal trends and between-practice variability of paediatric test use in primary *** and analysis this was a descriptive study of population-based data from Clinical Practice Research Datalink Aurum primary care consultation records from 1 January 2007 to 31 December *** aged 0–15 who were registered to one of the eligible 1464 general practices and had a diagnostic test code in their clinical record were *** primary outcome measures were(1)temporal changes in test rates measured by the average annual percent change,stratified by test type,gender,age group and deprivation level and(2)practice variability in test use,measured by the coefficient of *** 14299598 diagnostic tests were requested over 27.8 million child-years of observation for 2542101 *** test use increased by 3.6%/year(95%CI 3.4 to 3.8%)from 399/1000 child-years to 608/1000 child-years,driven by increases in blood tests(8.0%/year,95%CI 7.7 to 8.4),females aged 11–15(4.0%/year,95%CI 3.7 to 4.3),and children from the most socioeconomically deprived group(4.4%/year,95%CI 4.1 to 4.8).tests subject to the greatest temporal increases were faecal calprotectin,fractional exhaled nitric oxide and vitamin *** classified as high-use and high-practice variability were iron studies,coeliac testing,vitamin B12,folate,and vitamin *** In this first nationwide study of paediatric test use in primary care,we observed significant temporal increases and practice variability in *** reflects inconsistency in practice and diagnosis rates and a scarcity of evidence-based *** test use generates more clinical activity with significant resource implications but conversely may improve clinical *** research should evaluate whether increased test use and variability are warranted by exploring test indications and test results and directly examine how increased test use impacts

关键词： vitamin nationwide stratified

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Rehabilitation of Semi-Arid Grasslands through the Perennialization of Lots by Implementing Perennial Forage Exotic Grass

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Phyton-International Journal of Experimental Botany 2024年第8期93卷 2115-2125页

作者： Delfina Arancio Sidoti Juan Manuel Zeberio Guadalupe peter Universidad Nacional de Río Negro Sede AtlánticaCEANPaViedma8500Argentina Consejo Nacional de Investigaciones Científicas y técnicas CONICETCABABuenos Aires1425Argentina Chacra Experimental Patagones Ministerio de Desarrollo Agrario de la Provincia de Buenos AiresCarmen de Patagones8504Argentina

Argentina is the country with the highest proportion of arid and semi-arid ecosystems in Latin *** the rangelands of Southwestern Buenos Aires(Patagones Department),there is a clear advancement of the agricultural frontier to the detriment of the native forest in this *** to rainfall variation and seed acquisition,thinopyrum ponticum is cultivated as a forage perennial crop in this *** objective was to evaluate the performance of *** as a facilitating crop for the medium-term rehabilitation of natural grasslands in semi-arid *** working hypotheses were that:1)native perennial grass cover increases over the years and 2)diversity and specific richness of the vegetation are enhanced by the duration of tall Wheatgrass *** were collected from commercial plots where *** was shown:recent implantation(5–8 years,RI);medium implantation(13–15 years,MI);and old implantation(20–22 years,OI).thirty-four species were identified and classified into seven functional groups:Annual grasses,annual herbs,perennial herbs,exotic perennial herbs,perennial forage grasses,exotic perennial forage grasses,perennial forage exotic grasses,and nonforage perennial *** ponticum’s total cover was between RI and *** cover,species richness,and Shannon-Weaver diversity index showed no differences among *** forage grasses exhibited higher cover values in sites with greater implantation age and annual grasses showed the opposite *** results indicated that *** does not invade the sampled plots and enhances the colonization of the planted plots by perennial forage native ***,even though the herbaceous cover had been recovered,the woody layer which could provide environmental services and specific values for conservation was not.

关键词： Wheatgrass clearing vegetation monte thinopyrum ponticum

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Enhancing prognostic accuracy in predicting rectal neuroendocrine neoplasms

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World Journal of Gastroenterology 2024年第37期30卷 4087-4089页

作者： Renin peter AA Raj Abdulqadir J Nashwan Department of Medicine Aston Medical SchoolBirmingham B47ETUnited Kingdom Department of Nursing&Midwifery Research Hamad Medical CorporationDoha 3050Qatar

the recently published retrospective study introduces the GAtIS score,a new predictive model for rectal neuroendocrine *** analyzing data from a large Chinese multicenter cohort,the study shows that the GAtIS score,incor-porating tumor grade,t stage,tumor size,age,and prognostic nutritional index,demonstrates superior predictive power for overall survival and progression-free survival compared to traditional World Health Organization grade and tumor,nodes and metastases staging *** editorial aims to discuss the impor-tance of the GAtIS score,its potential impact on clinical practice,and the strengths and limitations of the ***,it explores the significance,methodology,and clinical implications of these findings.

关键词： Rectal neuroendocrine neoplasm Nomogram Random forest Prognosis Overall survival Progression-free survival

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In vitro bench testing using patient-specific 3D models for percutaneous pulmonary valve implantation with Venus P-valve

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Chinese Medical Journal 2024年第8期137卷 990-996页

作者： Yu Han Zehua Shao Zirui Sun Yan Han Hongdang Xu Shubo Song Xiangbin Pan peter P.t.de Jaegere taibing Fan Gejun Zhang Department of Structure Heart Disease Central China Fuwai Hospital of Zhengzhou UniversityZhengzhouHenan 451460China Children’s Heart Center Central China Fuwai Hospital of Zhengzhou UniversityZhengzhouHenan 451460China Department of Anesthesiology Central China Fuwai Hospital of Zhengzhou UniversityZhengzhouHenan 451460China Department of Structure Heart Disease Fuwai Hospital Chinese Academy of Medical SciencesBeijing 100037China Department of Cardiology Erasmus MCRotterdam 3015 GDNetherlands

Background:Due to the wide variety of morphology,size,and dynamics,selecting an optimal valve size and location poses great difficulty in percutaneous pulmonary valve implantation(PPVI).this study aimed to report our experience with in vitro bench testing using patient-specific three-dimensional(3D)-printed models for planning PPVI with the Venus ***:Patient-specific 3D soft models were generated using PolyJet printing with a compliant synthetic material in 15 patients scheduled to undergo PPVI between July 2018 and July 2020 in Central China Fuwai Hospital of Zhengzhou ***:3D model bench testing altered treatment strategy in all patients(100%).One patient was referred for surgery because testing revealed that even the largest Venus P-valve would not anchor *** the remaining 14 patients,valve size and/or implantation location was altered to avoid valve migration and/or compression coronary *** four patients,it was decided to change the point anchoring because of inverted cone-shaped right ventricular outflow tract(RVOt)(n=2)or risk of compression coronary artery(n=2).Concerning sizing,we found that an oversize of 2-5 mm *** of the valve was dictated by the flaring of the in-and outflow portion in the pulmonary *** was successful in all 14 patients(absence of valve migration,no coronary compression,and none-to-mild residual pulmonary regurgitation[PR]).the diameter of the Venus P-valve in the 3D simulation group was significantly smaller than that of the conventional planning group(36[2]vs.32[4],Z=-3.77,Ptro testing indicated no need to oversize the Venus P-valve to the degree recommended by the balloon-sizing technique,as 2-5 mm sufficed.

关键词： Heart valve prosthesis implantation Percutaneous pulmonary valve intervention Pulmonary regurgitation bench testing 3D printing Venus P-valve

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High-Performance and Large-Area Inverted Perovskite Solar Cells Based on NiO_(x) Films Enabled with A Novel Microstructure-Control technology

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Energy & Environmental Materials 2024年第1期7卷 153-159页

作者： Guibin Shen Xin Li Yuqin Zou Hongye Dong Dongping Zhu Yanglin Jiang Xin Ren Ng Fen Lin peter Müller-Buschbaum Cheng Mu Key Laboratory of Advanced Light Conversion Materials and Biophotonics Department of ChemistryRenmin University of ChinaBeijing 100872China Solar Energy Research Institute of Singapore(SERIS) National University of SingaporeSingapore 117574Singapore Physik-Department Lehrstuhl für Funktionelle MaterialienTechnische Universität MünchenJames-Franck-Straße 185748Garching Germany Heinz Maier-Leibnitz Zentrum(MLZ) Technische Universität MünchenLichtenbergstr.185748Garching Germany

the improvement in the efficiency of inverted perovskite solar cells(PSCs)is significantly limited by undesirable contact at the NiO_(x)/perovskite *** this study,a novel microstructure-control technology is proposed for fabrication of porous NiO_(x)films using Pluronic P123 as the structure-directing agent and acetylacetone(AcAc)as the coordination *** synthesized porous NiO_(x)films enhanced the hole extraction efficiency and reduced recombination defects at the NiO_(x)/perovskite ***,without any modification,the power conversion efficiency(PCE)of the PSC with MAPbl_(3)as the absorber layer improved from 16.50%to 19.08%.Moreover,the PCE of the device composed of perovskite Cs0.05(MA_(0.15)FA_(0.85))_(0.95)Pb(I_(0.85)Br_(0.15))_(3)improved from 17.49%to 21.42%.Furthermore,the application of the fabricated porous NiO_(x)on fluorine-doped tin oxide(FtO)substrates enabled the fabrication of large-area PSCs(1.2 cm^(2))with a PCE of 19.63%.this study provides a novel strategy for improving the contact at the NiO_(x)/perovskite interface for the fabrication of high-performance large-area perovskite solar cells.

关键词： interfacial contact inverted and large-area perovskite solar cells photovoltaic materials porous NiO_(x)films renewable energy

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Highly Active Interfacial Sites in SFt-SnO_(2) Heterojunction Electrolyte for Enhanced Fuel Cell Performance via Engineered Energy Bands:Envisioned theoretically and Experimentally

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Energy & Environmental Materials 2024年第3期7卷 384-397页

作者： Sajid Rauf Muhammad Bilal Hanif Faiz Wali Zuhra tayyab Bin Zhu Naveed Mushtaq Yatao Yang Kashif Khan peter D.Lund Martin Motola Wei Xu College of Electronic and Information Engineering and State Key Laboratory of Radio frequency Heterogeneous Integration Shenzhen UniversityShenzhen 518000China Department of Inorganic Chemistry Faculty of Natural SciencesComenius University in BratislavaIlkovicova 684215BratislavaSlovakia College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhen 518060China School of Energy and Environment Southeast UniversityNo.2 Si Pai LouNanjing 210096China School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 611731China New Energy technologies Group Department of Applied PhysicsAalto University School of ScienceP.O.Box 15100Fl-00076AaltoEspoo Finland

Extending the ionic conductivity is the pre-requisite of electrolytes in fuel cell technology for high-electrochemical *** this regard,the introduction of semiconductor-oxide materials and the approach of heterostructure formation by modulating energy bands to enhance ionic conduction acting as an electrolyte in fuel ***(n-type;SnO_(2))plays a key role by introducing into p-type SrFe_(0.2)ti_(0.8)O_(3-δ)(SFt)semiconductor perovskite materials to construct p-n heterojunction for high ionic ***,two different composites of SFt and SnO_(2)are constructed by gluing p-and n-type SFt-SnO_(2),where the optimal composition of SFt-SnO_(2)(6∶4)heterostructure electrolyte-based fuel cell achieved excellent ionic conductivity 0.24 S cm^(-1)with power-output of 1004 mW cm^(-2)and high OCV 1.12 V at a low operational temperature of 500℃.the high power-output and significant ionic conductivity with durable operation of 54 h are accredited to SFt-SnO_(2)heterojunction formation including interfacial conduction assisted by a built-in electric field in fuel cell ***,the fuel conversion efficiency and considerable Faradaic efficiency reveal the compatibility of SFt-SnO_(2)heterostructure electrolyte and ruled-out short-circuiting ***,the first principle calculation provides sufficient information on structure optimization and energy-band structure modulation of SFt-SnO_(2).this strategy will provide new insight into semiconductor-based fuel cell technology to design novel electrolytes.

关键词： high ionic conductivity interfacial conduction modulated energy band structure p-n heterojunction semiconductors

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