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Advancing Malaria Prediction in Uganda through AI and Geospatial Analysis Models

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Journal of Geographic Information System 2024年第2期16卷 115-135页

作者： Maria Assumpta Komugabe Richard Caballero Itamar Shabtai simon peter Musinguzi Center for Information Systems & Technology Claremont Graduate University Claremont California USA Department of Information Technology Faculty of Business and ICT University of Kisubi Entebbe Uganda Faculty of Health Sciences University of Kisubi Entebbe Uganda Department of Agriculture Production Faculty of Agriculture Kyambogo University Kyambogo Uganda Department of Agriculture and Natural Sciences Faculty of Agriculture Uganda Martyrs University Kampala Uganda

The resurgence of locally acquired malaria cases in the USA and the persistent global challenge of malaria transmission highlight the urgent need for research to prevent this disease. Despite significant eradication efforts, malaria remains a serious threat, particularly in regions like Africa. This study explores how integrating Gregor’s Type IV theory with Geographic Information Systems (GIS) improves our understanding of disease dynamics, especially Malaria transmission patterns in Uganda. By combining data-driven algorithms, artificial intelligence, and geospatial analysis, the research aims to determine the most reliable predictors of Malaria incident rates and assess the impact of different factors on transmission. Using diverse predictive modeling techniques including Linear Regression, K-Nearest Neighbor, Neural Network, and Random Forest, the study found that;Random Forest model outperformed the others, demonstrating superior predictive accuracy with an R2 of approximately 0.88 and a Mean Squared Error (MSE) of 0.0534, Antimalarial treatment was identified as the most influential factor, with mosquito net access associated with a significant reduction in incident rates, while higher temperatures correlated with increased rates. Our study concluded that the Random Forest model was effective in predicting malaria incident rates in Uganda and highlighted the significance of climate factors and preventive measures such as mosquito nets and antimalarial drugs. We recommended that districts with malaria hotspots lacking Indoor Residual Spraying (IRS) coverage prioritize its implementation to mitigate incident rates, while those with high malaria rates in 2020 require immediate attention. By advocating for the use of appropriate predictive models, our research emphasized the importance of evidence-based decision-making in malaria control strategies, aiming to reduce transmission rates and save lives.

关键词： Malaria Predictive Modeling Geospatial Analysis Climate Factors Preventive Measures

Advancing Malaria Prediction in Uganda through AI and Geospatial Analysis Models

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Sepsis during short bowel syndrome hospitalizations:Identifying trends,disparities,and clinical outcomes in the United States

Journal of Geographic Information System（地理信息系统） 2024年第2期 115页

作者： Maria Assumpta Komugabe Richard Caballero Itamar Shabtai simon peter Musinguzi

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World Journal of Gastrointestinal Pathophysiology 2024年第1期15卷 26-36页

作者： Dushyant Singh Dahiya Jennifer Wachala Shantanu Solanki Dhanshree Solanki Asim Kichloo Samantha Holcomb Uvesh Mansuri Khwaja Saad Haq Hassam Ali Manesh Kumar Gangwani Yash R Shah Teresa Varghese Hafiz Muzaffar Akbar Khan simon peter Horslen Thomas D Schiano Syed-Mohammed Jafri Division of Gastroenterology Hepatology&MotilityThe University of Kansas School of MedicineKansas CityKS 66160United States Department of Internal Medicine Samaritan Medical CenterWatertownNY 13601United States Division of Gastroenterology Hepatology&Nutrition The University of Texas MD Anderson Cancer CenterHoustonTX 77030United States Department of Medicine Institute for Foreign Medical Graduate EducationHoustonTX 77030United States Department of Internal Medicine MedStar Harbor HospitalBaltimoreMD 21225United States Department of Internal Medicine WellStar Spalding Regional HospitalGriffinGA 30224United States Division of Gastroenterology Hepatology and NutritionEast Carolina University/Brody School of MedicineGreenvilleNC 27858United States Department of Gastroenterology and Hepatology University of Arkansas for Medical SciencesLittle RockAR 72205United States Department of Internal Medicine Trinity Health Oakland/Wayne State UniversityPontiacMI 48341United States Division of Gastroenterology and Hepatology SUNY Upstate Medical UniversitySyracuseNY 13210United States Department of Pediatrics School of Medicine and UPMC Children’s Hospital of PittsburghUniversity of PittsburghPittsburghPA 15219United States Division of Liver Diseases Icahn School of Medicine at Mount SinaiNew YorkNY 10029United States Division of Gastroenterology and Hepatology Henry Ford HospitalDetroitMI 48202United States

BACKGROUND Short bowel syndrome(SBS)hospitalizations are often complicated with *** is a significant paucity of data on adult SBS hospitalizations in the United States and across the *** To assess trends and outcomes of SBS hospitalizations complicated by sepsis in the United *** The National Inpatient Sample was utilized to identify all adult SBS hospitalizations between *** study cohort was further divided based on the presence or absence of *** were identified,and hospitalization characteristics and clinical outcomes were *** of mortality for SBS hospitalizations complicated with sepsis were *** Of 247097 SBS hospitalizations,21.7%were complicated by *** SBS hospitalizations had a rising trend of hospitalizations from 20.8%in 2005 to 23.5%in 2014(P trend<0.0001).Compared to non-septic SBS hospitalizations,septic SBS hospitalizations had a higher proportion of males(32.8%vs 29.3%,P<0.0001),patients in the 35-49(45.9%vs 42.5%,P<0.0001)and 50-64(32.1%vs 31.1%,P<0.0001)age groups,and ethnic minorities,i.e.,Blacks(12.4%vs 11.3%,P<0.0001)and Hispanics(6.7%vs 5.5%,P<0.0001).Furthermore,septic SBS hospitalizations had a higher proportion of patients with intestinal transplantation(0.33%vs 0.22%,P<0.0001),inpatient mortality(8.5%vs 1.4%,P<0.0001),and mean length of stay(16.1 d vs 7.7 d,P<0.0001)compared to the non-sepsis cohort.A younger age,female gender,White race,and presence of comorbidities such as anemia and depression were identified to be independent predictors of inpatient mortality for septic SBS *** Septic SBS hospitalizations had a rising trend between 2005-2014 and were associated with higher inpatient mortality compared to non-septic SBS hospitalizations.

关键词： Short bowel syndrome Sepsis Outcomes Mortality Trends

Human epidermal growth factor receptor targeted inhibitors for the treatment of ovarian cancer

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Cancer Biology & Medicine 2018年第4期15卷 375-388页

作者： Maria Bonello ANDrew Harvey Sims simon peter Langdon Cancer Research UK Edinburgh Center and Division of Pathology Laboratory MRC Institute of Genetics and Molecular Medicine University of Edinburgh

Ovarian cancer is the second most lethal gynecological cancer worldwide and while most patients respond to initial therapy, they often relapse with resistant disease. Human epidermal growth factor receptors(especially HER1/EGFR and HER2/ERBB2) are involved in disease progression; hence, strategies to inhibit their action could prove advantageous in ovarian cancer patients,especially in patients resistant to first line therapy. Monoclonal antibodies and tyrosine kinase inhibitors are two classes of drugs that act on these receptors. They have demonstrated valuable antitumor activity in multiple cancers and their possible use in ovarian cancer continues to be studied. In this review, we discuss the human epidermal growth factor receptor family; review emerging clinical studies on monoclonal antibodies and tyrosine kinase inhibitors targeting these receptors in ovarian cancer patients; and propose future research possibilities in this area.

关键词： Tyrosine kinase monoclonal antibodies ovarian cancer inhibitors HER receptors

Global Electronic Dominance with Spatial Grasp

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International Journal of Communications, Network and System Sciences 2012年第11期5卷 724-735页

作者： peter simon Sapaty Institute of Mathematical Machines and Systems National Academy of Sciences Kiev Ukraine

A high-level control technology will be revealed that can dynamically establish overwhelming dominance over distributed networked systems with embedded electronic devices and any communications between them. It is based on implanting of universal control modules (that may be concealed) into key system points which collectively interpret complex but compact mission scenarios in a special high-level Distributed Scenario language (DSL). Self-evolving and self-spreading in networks, matching them in a super-virus mode, DSL scenarios can analyze their structures and states and set up any behavior needed, including creation of benign or elimination of unwanted infrastructures. The scalable technology allows us to convert any distributed networked systems into a sort of integral spatial brain capable of analyzing and withstanding unpredictable situations in a variety of important domains.

关键词： Electronic Dominance Distributed Dynamic Worlds Asymmetric Situations and Threats Spatial Grasp Technology Distributed Scenario Language Parallel Networked Interpretation Global Awareness Multi-Robot Systems

Audience-Performer Interface as a Battlefield of Expression： A Study of Ateso Oral Narratives

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Journal of Literature and Art Studies 2014年第4期4卷 318-323页

作者： simon peter Ongodia Makerere University Kampala Uganda

The purpose of the study was to investigate and illustrate the challenges faced by performers and audiences during Ateso oral narratives in Ateso speaking communities in Uganda. The study used ethnographic and discurssive analyses methods of research. The topic was Audience-Performer Interface as a Battlefield of Expression： A Study of Ateso Oral Narratives. Ethnographic method of study was used in Ateso speaking communities of Serere, Ngora, Bukedea and Pallisa districts of Uganda. The author stayed with communities for four to seven days in 2009, 2010 and 2011. The study analysed the interpretational dimensions of the oral narrative episodes. Questionnaires and focused group discussions were used to solicit data from a total of 20 （33.3%） out of 60 persons. The study saw that there was dire need to revive the cultural media of communication in Teso. In Serere, Bukedea and Ngora there was more of unpleasant intrusion than in Pallisa and Serere. Performers should consider their audiences complementary to the narration and establish rapport. Audiences should appreciate the efforts of the narrators to keep the cultural norm of story-telling alive in Teso. The Ministry of Education and Sports in Uganda should encourage local languages at all levels of education.

关键词： Ateso audience-performer interface battlefield of expression cultural media Etesot interpretationaldimensions Iteso retrogressive Teso unpleasant intrusion

Air and Missile Defense Under Spatial Grasp Technology

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International Relations and Diplomacy 2017年第5期5卷 287-303页

作者： peter simon Sapaty National Academy of Sciences of Ukraine Kiev Ukraine

A novel control ideology and technology for solving tasks in large distributed networked systems will be briefed. Based on active scenarios self-navigating and self-matching distributed spaces in a highly organized super-virus mode, it can effectively establish global control over large systems of any natures. The technology can use numerous scattered and dissimilar facilities in an integral and holistic way, allowing them to work together in goal-driven supercomputer mode. The approach can be useful for advanced air and missile defense in a variety of ways which is described and explained in this paper.

关键词： air and missile defense distributed dynamic systems spatial grasp technology holistic control solutions.

Distributed Human Terrain Operations for Solving National and International Problems

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International Relations and Diplomacy 2014年第9期2卷 597-622页

作者： peter simon Sapaty National Academy of Sciences of Ukraine Kiev Ukraine

With the world conflicts steadily moving from kinetics to cultural dimensions, the author will be discussing here a new, promising, trend allowing for effective solutions of complex national and international problems by intelligent and predominantly peaceful means using the concept of Human Terrain （HT）. A novel ideology and supporting high-level networking technology will be revealed that can effectively implement HT ideas in large networked spaces. The technology is based on holistic and gestalt principles in dealing with complex distributed systems in opposition to traditional multi-agent and interoperability organizations. This allows researchers to grasp nonlocal social, cultural, ethnic, religious, and, if needed, military problems with their integral solutions on top semantic level and expresses them in a special high-level language suitable for implementation in manned, unmanned, or combined systems.

关键词： social organizations networked systems human terrain spatial grasp technology spatial grasp language networked interpretation spatial scenarios system integrity.

Distributed Air &Missile Defense with Spatial Grasp Technology

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Intelligent Control and Automation 2012年第2期3卷 117-131页

作者： peter simon Sapaty Institute of Mathematical Machines and Systems National Academy of Sciences Kiev Ukraine

A high-level technology is revealed that can effectively convert any distributed system into a globally programmable machine capable of operating without central resources and self-recovering from indiscriminate damages. Integral mission scenarios in Distributed Scenario Language (DSL) can be injected from any point, runtime covering & grasping the whole system or its parts, setting operational infrastructures, and orienting local and global behavior in the way needed. Many operational scenarios can be simultaneously injected into this spatial machine from different points, cooperating or competing over the shared distributed knowledge as overlapping fields of solutions. Distributed DSL interpreter organization and benefits of using this technology for integrated air and missile defense are discussed along with programming examples in this and other fields.

关键词： Distributed Systems Spatial Grasp Technology Integral Mission Scenarios Distributed Scenario Language Parallel Networked Interpretation Air and Missile Defense Directed Energy Systems Cooperative Robotics