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Prognostic value of serum microRNA-122 in hepatocellular carcinoma is dependent on coexisting clinical and laboratory factors

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World Journal of Gastroenterology 2020年第1期26卷 86-96页

作者： Martin Franck Kerstin schütte peter Malfertheiner Alexander Link Department of Gastroenterology Hepatology and Infectious DiseasesOtto-von-Guericke University MagdeburgMagdeburg 39120Germany Department of Gastroenterology Hepatology and EndocrinologyHannover Medical SchoolHannover 30625Germany Department of Internal Medicine and Gastroenterology Niels-Stensen-Kliniken MarienhospitalOsnabrück 49074Germany

BACKGROUND There is ongoing search for new noninvasive biomarkers to improve management of patients with hepatocellular carcinoma(HCC).Studies,mostly from the Asian-Pacific region,demonstrated differential expression of liverspecific microRNA-122(miR-122)in tissue as well as in sera of patients with hepatitis B virus-and hepatitis C virus-induced *** To evaluate prognostic value of miR-122 in patients with HCC in a European population and determine potential factors related to alteration of miR-122 in *** Patients with confirmed HCC(n=91)were included in the study over a two-year *** were characterized according to Child-Pugh score,Barcelona clinic liver cancer(BCLC)staging system,etiology of liver disease,laboratory parameters and overall ***-122 was measured in sera using TaqMan assay normalized to spiked-in *** Serum miR-122 quantity was independent of the Child-Pugh score,the BCLC stage or the underlying *** positive correlation was found between miR-122 and alanine aminotransferase(P<0.0001),aspartate aminotransferase(P=0.0001),alpha-fetoprotein(AFP)(P=0.0034)and hemoglobin concentration(P=0.076).Negative correlation was observed between miR-122 level and creatinine concentration(P=0.0028).AFP,Child-Pugh score and BCLC staging system were associated with survival *** overall cohort low miR-122 in sera was only associated with a trend for a better overall survival without reaching statistical *** analysis revealed that low miR-122 was significantly associated with better prognosis in patients with advanced cirrhosis(Child-Pugh class B/C),advanced tumor stage(BCLC B/C/D)and normal AFP(<7 ng/mL).CONCLUSION Our results strongly support the value of miR-122 as potential biomarker of liver injury and probably ***,the value of miR-122 in prediction of prognosis of HCC patients was limited to certain patients’*** circulating miR-122 may be influ

关键词： Hepatocellular carcinoma MicroRNA Prognosis MicroRNA-122 Influencing factors

Microstructure evolution and interface structure of Al-40 wt% Si composites produced by high-energy ball milling

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Journal of Materials Science & Technology 2019年第4期35卷 512-519页

作者： Yuanyuan Chen Zhangping Hu Yifei Xu Jiangyong Wang peter schützendübe Yuan Huang Yongchang Liu Zumin Wang school of Materials Science and Engineering Tianjin University Department of Physics Shantou University Max Planck Institute for Intelligent Systems

High silicon content Al-Si composites with a composition of Al-40 wt% Si were fabricated via a highenergy ball milling method. The microstructure evolution of Al-40 wt% Si milled powders and sintered composites has been thoroughly studied by scanning electron microscopy, X-ray diffraction, energydispersive spectrometry and high-resolution transmission electron microscopy. The mechanism of ball milling Al-40 wt% Si powders has been disclosed in detail: fracture mechanism dominating in the early stages, followed by the agglomeration mechanism, finally reaching the balance between the fragments and the agglomerates. It has been found that the average particle sizes of mixed Al-Si powders can be refined to the nanoscale, and the crystallite sizes of Al and Si have been reduced to 10nm and 62nm upon milling for 2h–50h, respectively. The finally formed Al-Si interfaces after ball milling for 50h are wellcohesive. A dense and homogenous Al-40 wt% Si composite have been achieved by solid-state sintering at550?C. The results thus provide an effective support for producing bulk nanostructured Al-Si composites.

关键词： Al-Si composites Interface structure High-energy ball milling Nanocrystalline powders

Effect of atomic structure on preferential oxidation of alloys:amorphous versus crystalline Cu-Zr

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Journal of Materials Science & Technology 2020年第5期40卷 128-134页

作者： Yifei Xu Lars P.H.Jeurgens peter schützendübe Shengli Zhu Yuan Huang Yongchang Liu Zumin Wang State Key Lab of Hydraulic Engineering Simulation and Safety School of Materials Science and EngineeringTianjin UniversityTianjin 300350China Swiss Federal Laboratories for Materials Science and Technology Laboratory for Joining Technologies and CorrosionUeberlandstrasse 1298600 DuebendorfSwitzerland Max Planck Institute for Intelligent Systems Heisenbergstrasse 3D-70569 StuttgartGermany

The effect of structural order in the parent alloy substrate on the oxidation kinetics and oxide phase evolution was investigated for the thermal oxidation of amorphous Cu33at.%Zr67at.%and crystalline CuZr2 alloys of identical compositions in the temperature range of 200–250?*** was found that,besides the strong preferential oxidation of Zr in both alloys,the lack of structural order in the amorphous Cu33at.%Zr67at.%alloy results in much slower oxidation kinetics,as well as in distinctly different microstructures of the oxide overgrowth and its Zr-depletion zone in the wake of the ZrO2 overlayer growth *** experimental findings can be rationalized on the basis of the strikingly different atomic mobilities of Cu,Zr and dissolved O in the amorphous and crystalline alloys,which also results in different nucleation barriers for crystalline oxide *** thus obtained knowledge on the underlying oxidation mechanisms provides new and profound insights into the surface engineering of metallic alloys.

关键词： Oxidation Atomic structure Amorphous alloys Cu-Zr HRTEM

Value of three-dimensional reconstructions in pancreatic carcinoma using multidetector CT:Initial results

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World Journal of Gastroenterology 2009年第46期15卷 5827-5832页

作者： Miriam Klauβ Max schbinger Ivo Wolf Jens Werner Hans-peter Meinzer Hans-Ulrich Kauczor Lars Grenacher Department of Diagnostic and Interventional Radiology University of Heidelberg Department of Medical and Biological Informatics German Cancer Research Center(DKFZ) Surgical Clinic University of Heidelberg

AIM:To evaluate the use of three-dimensional imaging of pancreatic carcinoma using multidetector computed tomography(CT)in a prospective ***:Ten patients with suspected pancreatic tumors were examined prospectively using multidetec-tor CT(Somatom Sensation 16,Siemens,Erlangen,Germany).The images were evaluated for the pres-ence of a pancreatic carcinoma and invasion of the peripancreatic vessels and surrounding *** the isotropic CT data sets,a three-dimensional image was created with automatic vascular analysis and semi-automatic segmentation of the organs and pancreatic tumor by a *** CT examinations and the three-dimensional images were presented to the sur-geon directly before and during the patient's operation using the Medical Imaging Interaction Toolkit-based software "ReLiver".Immediately after surgery,the value of the two images was judged by the *** operation and the histological results served as the gold ***:Nine patients had a pancreatic carcinoma(all pT3),and one patient had a serous *** tumor inf iltrated the superior mesenteric *** inf iltration was correctly *** carcinomas were *** comparison to the CT image with axial and coronal reconstructions,the three-dimensional image was judged by the surgeons as better for operation planning and consistently described as ***:A 3D-image of the pancreas repre-sents an invaluable aid to the ***,the 3D-software must be further developed in order to be integrated into daily clinical routine.

关键词： Pancreatic carcinoma 3D-reconstruction Multidetector computed tomography Pancreatic carcinomainvasion Segmentation

Long-term outcome and prognostic factors of patients with hilar cholangiocarcinoma

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World Journal of Gastroenterology 2007年第9期13卷 1422-1426页

作者： Andreas Weber Sonja Landrock Jochen schneider Manfred Stangl Bruno Neu peter Born Meinhard Classen Thomas Rsch Roland M schmid Christian Prinz Department of Internal Medicine Ⅱ Technical University of Munich Germany Department of Surgery Technical University of Munich Germany Department of Internal Medicine Rudolf Virchow Klinikum Charite Berlin Germany

AIM： To evaluate the long-term outcome and prognostic factors of patients with hilar cholangiocarinoma. METHODS： Ninety-six consecutive patients underwent treatment for malignant hilar bile duct tumors during 1995-2005. Of the 96 patients, 20 were initially treated with surgery （n = 2 R0 / n = 18 R1）. In non-operated patients, data analysis was performed retrospectively. RESULTS： Among the 96 patients, 76 were treated with endoscopic transpapillary （ERC, n = 45） and/or percutaneous transhepatic biliary drainage （PTBD, n = 31）. The mean survival time of these 76 patients undergoing palliative endoscopic and/or percutaneous drainage was 359 ± 296 d. The mean survival time of patients with initial bilirubin levels 〉 10 mg/dL was significantly lower （P 〈 0.001） than patients with bilirubin levels 〈 10 mg/dL. The mean survival time of patients with Bismuth stage Ⅱ （n = 8）, Ⅲ （n = 28） and Ⅳ （n = 40） was 496 =1= 300 d, 441 ± 385 d and 274 ± 218 d, respectively. Thus, patients with advanced Bismuth stage showed a reduced mean survival time, but the difference was not significant. The type of biliary drainage had no significant benefidal effect on the mean survival time （ERC vs PTBD, P = 0.806）. CONCLUSION： Initial bilirubin level is a significant prognostic factor for survival of patients. In contrast, age, tumor stage according to the Bismuth-Corlette classification, and types of intervention are not significant prognostic parameters for survival. Palliative treatment with endoscopic or percutaneous biliary drainage is still suboptimal, new diagnostic and therapeutic tools need to be evaluated.

关键词： Klatskin tumor Cholangiocarcinoma Bilirubin Prognostic factors Endoscopic therapy Operative therapy Survival Bismuth stage

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高档涂布纸和纸板的红外线干燥

中华纸业 2005年第6期26卷 28-30页

作者： Hans-peter schpping Krieger GmbH&Co.KG Krieger GmbH&Co.KG

介绍了VoithKrieger近期开发的用于涂布纸生产的红外线干燥系统的分类、原理、作用和效果。

关键词：红外线干燥纸板高档涂布纸生产干燥系统

The Optimal Suture Technique for Mitral Valve Replacement in an <i>Ex Vivo</i>Animal Model

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Open Journal of Thoracic Surgery 2021年第1期11卷 36-45页

作者： Emilie schultz Hougaard Marie schäfer Lars peter Riber Department of Cardiac Thoracic and Vascular Surgery at Odense University Hospital Odense Denmark

Objective: This study compared and evaluated three suture methods in order to find the method with the best durability for mitral valve replacement. The methods evaluated are horizontal mattress suture with subanular pledgets, horizontal mattress suture with supraanular pledgets and continuous running suture. Methods: Thirty hearts were explanted from newly terminated pigs. The hearts were randomized in the three groups. After an atriotomy, the mitral valve was cut out, and a patch was sutured into its place. An air pump model was connected to a balloon which was placed in the left ventricle through aorta and continuously filled with air to a maximum of 300 mmHg. The peak pressure at rupture was noted. If no rupture occurred before reaching 300 mmHg, the suture was found competent. Results: Two out of ten hearts in the continuous running suture-group had myocardial rupture within a pressure of 300 mmHg. In the remaining eight hearts there were no ruptures within 300 mmHg. In the two groups sutured with horizontal mattress with pledgets placed either subanular or supraanular, no rupture of myocardium occurred. When comparing continuous running suture with the horizontal mattress with subanular pledgets or the horizontal mattress with supraanular pledgets, the 1-sided Fishers’ exact was 0.237. At 5% significance level, there was no difference between the three suture methods. Conclusion: There was no statistically significant difference between the durability of the three suture methods, though rupture was only evident in the continuous running suture line. Since it is the surgeon’s choice to select the optimal suture technique, our study should be a reminder for the surgeon to reflect on the suturing factors that have an influence on successful mitral valve replacement.

关键词： Mitral Valve Mitral Valve Replacement Suture Technique

Pancreatic cancer–Endosonography

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The Chinese-German Journal of Clinical Oncology 2007年第2期6卷 123-128页

作者： Stefan Kahl Kerstin schütte peter Malfertheiner Department of Gastroenterology Municipal Hospital Magdeburg Birkenallee 39130 Magdeburg Germany

EUS is the most sensitive imaging procedure for the detection of small solid pancreatic masses and is accurate in determining vascular invasion of the portal venous system. Even compared to the new CT-techniques EUS provides excellent results in preoperative staging of solid pancreatic tumors. Compared to helical CT-techniques EUS is less accurate in detecting tumor involvement of superior mesenteric artery. EUS staging and EUS-guided FNA can be performed in a single-step procedure, to establish the diagnosis of cancer. There is no known negative impact of tumor cell seeding due to EUS-FNA. Without FNA EUS and additional methods are not able to reliably distinguish between inflammatory and malignant masses.

关键词： adenocarcinoma diagnosis digestive system neoplasms endosonography neoplasm staging pancreatic neoplasms pancreatitis review literature surgery ultrasonography, interventional

Biomineralization of Zinc-Phosphate-Based Nano Needles by Living Microalgae

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Journal of Biomaterials and Nanobiotechnology 2012年第3期3卷 362-370页

作者： Giulia Santomauro Vesna Srot Birgit Bussmann peter A. van Aken Franz Brümmer Horst Strunk Joachim Bill Institute for Biology Depart- ment of Zoology University of Stuttgart Stuttgart Germany 4Institute for Materials Science Chair in Material Physics University of Stuttgart Stuttgart Germany. Institute for Materials Science Chair in Chemical Material Synthesis University of Stuttgart Stuttgart Germany Institute for Materials Science University of Stuttgart Stuttgart Germany Stuttgart Center for Electron Microscopy – StEM Max Planck Institute for Intelligent Systems Stuttgart Germany Stuttgart Center for Electron Microscopy–StEM Max Planck Institute for Intelligent Systems Stuttgart Germany

Up to now, chemical synthesis routes only provide restricted opportunities for the formation of structured nano particles. In contrast, living microorganisms generate nano materials of well defined shapes by the precise control of biomineralization. Here we reveal new principles for the generation of functional nano materials through the process of biomineralization. We used the detoxification mechanism of the unicellular alga Scenedesmus obliquus to generate a techno logically interesting zinc-phosphate-based nano material. The algae were incubated in media with a sublethal zinc concentration (6.53 mg Zn dm-3) for 4 weeks. Using BF-and ADF-STEM imaging combined with analytical XEDS we could show that nano needles containing phosphorus and zinc were formed inside the living cells. Further more, the cells incubated with zinc show a strong fluorescence. Our findings indicate that the algae used polyphosphate bodies for detoxification of the zinc ions, leading to the generation of intracellular zinc-phosphate-based nano needles. Beside the technological application of this material, the fluorescent cells can be used for labeling of e.g. biological probes. This new experimental protocol for the production of an inorganic functional material can be applied also for other substances.

关键词： Nano Needles Biomineralization Zinc Phosphate Microalgae Fluorescence