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Integrative Zoology 2016年第2期11卷 111-127页

作者： Jenny H.E.BURGMAN Jennifer LEICHLITER Nico L.AVENANT peter s.UNGAR Environmental Dynamics Program University of ArkansasFayettevilleArkansasUSA Department of Anthropology University of Colorado BoulderBoulderColoradoUSA National Museum and University of the Free state BloemfonteinSouth Africa Department of Anthropology University of ArkansasFayettevilleArkansasUSA

Dental microwear textures have proven to be a valuable tool for reconstructing the diets of a wide assortment of fossil ***,some studies have recently questioned the efficacy of this approach,suggesting that aspects of habitat unrelated to food preference,especially environmental grit load,might have a confounding effect on microwear patterning that obscures the diet *** we evaluate this hypothesis by examining microwear textures of 3 extant sympatric rodent species that vary in diet breadth and are found in a variety of habitat types:Mastomys coucha,Micaelamys namaquensis and Rhabdomys *** sample each of these species from 3 distinct environmental settings in southern Africa that differ in rainfall and vegetative cover:Nama-Karoo shrublands(semi-desert)and Dry Highveld grasslands in the Free state Province of south Africa,and Afromontane(wet)grasslands in the highlands of *** differences between habitat types are evident for some of the species,inconsistency in the pattern suggests that the microwear signal is driven by variation in foods eaten rather than grit-level per *** is clear that,at least for species and habitats sampled in the current study,environmental grit load does not swamp diet-related microwear signatures.

关键词： diet grit tooth wear

Absent MicroRNAs in Different Tissues of Patients with Acquired Cardiomyopathy

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Genomics, Proteomics & Bioinformatics 2016年第4期14卷 224-234页

作者： Christine s. siegismund Maria Rohde Uwe Kiihl Felicitas Escher Heinz peter schultheiss Dirk Lassner Institute for Cardiac Diagnostics and Therapy(IKDT) 12203 BerlinGermany Department of Cardiology Campus VirchowCharite-University Hospital Berlin13353 BerlinGermany

MicroRNAs （miRNAs） can be found in a wide range of tissues and body fluids, and their specific signatures can be used to determine diseases or predict clinical courses. The miRNA profiles in biological samples （tissue, serum, peripheral blood mononuelear cells or other body fluids） differ significantly even in the same patient and therefore have their own specificity for the presented condition. Complex profiles of deregulated miRNAs are of high interest, whereas the importance of non-expressed miRNAs was ignored. since miRNAs regulate gene expression rather negatively, absent miRNAs could indicate genes with unaltered expression that therefore are normally expressed in specific compartments or under specific disease situations. For the first time, non-detectable miRNAs in different tissues and body fluids from patients with different diseases （cardiomyopathies, Alzheimer＇s disease, bladder cancer, and ocular cancer） were analyzed and compared in this study, miRNA expression data were generated by microarray or TaqMan PCR-based platforms. Lists of absent miRNAs of primarily cardiac patients （myocardium, blood cells, and serum） were clustered and analyzed for potentially involved pathways using two prediction platforms, i.e., miRNA enrichment analysis and annotation tool （miEAA） and DIANA miRPath. Extensive search in biomedical publication databases for the relevance of non-expressed miRNAs in predicted pathways revealed no evidence for their involvement in heart-related pathways as indicated by software tools, confirming proposed approach.

关键词： Cardiomyopathy Heart muscle biopsy Absent mi RNAs Peripheral blood mononuclear cell serum

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Bulbocavernosus muscle area measurement： a novel method to assess androgenic activity

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Asian Journal of Andrology 2014年第4期16卷 618-622页

作者： Ali A Dabaja Matthew s Wosnitzer Anna Mielnik Alexander Bolyakov peter N schlegel Darius A Paduch Department of Urology and Reproductive Medicine Weill Cornell Medical College New York USA.

serum testosterone does not correlate with androgen tissue activity, and it is critical to optimize tools to evaluate such activity in males. Ultrasound measurement of bulbocavernosus muscle （BCM） was used to assess the relationship between the number of CAG repeats （CAGn） in the androgen receptor （AR） and the BCM size; the changes in the number of CAGn over age were also evaluated. Transperineal ultrasound measurement of the BCM was also performed. AR CAGn were determined by high performance liquid chromatography, and morning hormone levels were determined using immunoassays. Forty-eight men had CAG repeat analysis. Twenty-five were 〈30 years of age, mean 23.7 years （s.d, = 3.24） and 23 were 〉45 years of age, mean 53years （s.d. = 5.58）. The median CAGn was 21 （13-29）. BCM area was greater when the number of CAGn were 〈18 as compared to the number of CAGn 〉24 （P= 0.04）. There was a linear correlation between the number of CAGn and the BCM area R^2= 16% （P= 0.01）. In the 45 to 65-years-old group, a much stronger negative correlation （R^2 = 29%, P= 0.01） was noticed. In the 19 to 29-years-old group, no such correlation was found （R2 = 4%, P = 0.36）. In older men, the number of CAGn increased with age （R^2 = 32%, P= 0.01）. The number of CAGn in the AR correlates with the area of the BCM. Ultrasound assessment of the BCM is an effective surrogate to evaluate end-organ activity of androgens. The number of CAGn may increase with age.

关键词： age androgen activity androgen receptor androgen sensitivity bulbocavernosus muscle CAG repeats

Cirrhotic portal hypertension: From pathophysiology to novel therapeutics

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World Journal of Gastroenterology 2020年第40期26卷 6111-6140页

作者： Lakmie s Gunarathne Harinda Rajapaksha Nicholas shackel peter W Angus Chandana B Herath Department of Medicine Melbourne Medical SchoolThe University of MelbourneHeidelbergVIC 3084Australia school of Molecular science College of ScienceHealth and EngineeringLa Trobe UniversityBundooraVIC 3086Australia ANZAC Research Institute ConcordNSW 2139Australia Department of Gastroenterology Austin HealthHeidelbergVIC 3084Australia south Western sydney Clinical school Faculty of MedicineUniversity of New South WalesIngham Institute for Applied Medical Research1 Campbell StreetLiverpoolNSW 2170Australia

Portal hypertension and bleeding from gastroesophageal varices is the major cause of morbidity and mortality in patients with cirrhosis. Portal hypertension is initiated by increased intrahepatic vascular resistance and a hyperdynamic circulatory state. The latter is characterized by a high cardiac output, increased total blood volume and splanchnic vasodilatation, resulting in increased mesenteric blood flow. Pharmacological manipulation of cirrhotic portal hypertension targets both the splanchnic and hepatic vascular beds. Drugs such as angiotensin converting enzyme inhibitors and angiotensin Ⅱ type receptor 1 blockers, which target the components of the classical renin angiotensin system(RAs), are expected to reduce intrahepatic vascular tone by reducing extracellular matrix deposition and vasoactivity of contractile cells and thereby improve portal hypertension. However, these drugs have been shown to produce significant offtarget effects such as systemic hypotension and renal failure. Therefore, the current pharmacological mainstay in clinical practice to prevent variceal bleeding and improving patient survival by reducing portal pressure is non-selective-blockers(NsBBs). These NsBBs work by reducing cardiac output and splanchnic vasodilatation but most patients do not achieve an optimal therapeutic response and a significant proportion of patients are unable to tolerate these *** statins, used alone or in combination with NsBBs, have been shown to improve portal pressure and overall mortality in cirrhotic patients, further randomized clinical trials are warranted involving larger patient populations with clear clinical end points. On the other hand, recent findings from studies that have investigated the potential use of the blockers of the components of the alternate RAs provided compelling evidence that could lead to the development of drugs targeting the splanchnic vascular bed to inhibit splanchnic vasodilatation in portal hypertension. This rev

关键词： Portal hypertension Cirrhosis Intrahepatic vascular resistance Hyperdynamic circulatory state splanchnic vasodilatation Portal blood flow Non-selective betablockers Alternate renin angiotensin system

Vibrotactile coordinated reset stimulation for the treatment of Parkinson's disease

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Neural Regeneration Research 2022年第7期17卷 1495-1497页

作者： peter A.Tass Department of Neurosurgery Stanford University School of MedicineStanfordCAUSA

Introduction of the treatment concept:Regular deep brain stimulation(rDBs)is the standard therapy for the treatment of medically refractory Parkinson’s disease(PD)(Benabid et al.,2009).Notwithstanding its significant therapeutic effects,rDBs may cause side effects,characterized as rDBsinduced movement disorders(BaizabalCarvallo and Jankovic,2016).

关键词： stimulation al. treatment

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Untangling the history of oroclines and mountain belts

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National science Review 2022年第5期9卷 179-180页

作者： peter A.Cawood school of Earth Atmosphere and Environment Monash University

Oro clines are map-view bends of the Earth’s lithosphere formed by rotation of originally quasilinear linear rock units about a sub-vertical axis [1].They can have amplitudes and wavelengths on the order of hundreds of kilometres and are a significant feature of many active and ancient mountain belts(Fig.1,*** orocline,Bolivian orocline,Betic-Rif Belt,

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Resistivity of reservoir sandstones and organic rich shales on the Barents shelf: Implications for interpreting CsEM data

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Geoscience Frontiers 2021年第6期12卷 411-427页

作者： Kim senger Thomas Birchall peter Betlem Kei Ogata sverre Ohm snorre Olaussen Renate s.Paulsen Department of Arctic Geology The University Centre in SvalbardLongyearbyenNorway Department of Geosciences University of OsloOsloNorway Department of Earth science Vrije UniversiteitAmsterdamNetherlands Now at Dipartimento di scienze Della Terra Dell’Ambiente e Delle Risorse(DISTAR)Universita Degli Studi diNapoli Federico IINapoliItaly Department of Energy Resources University of StavangerStavangerNorway Department of Geosciences University of Tromsø–the Arctic University of NorwayTromsøNorway

Marine controlled source electromagnetic(CsEM) data have been utilized in the past decade during petroleum exploration of the Barents shelf, particularly for de-risking the highly porous sandstone reservoirs of the Upper Triassic to Middle Jurassic Realgrunnen subgroup. In this contribution we compare the resistivity response from CsEM data to resistivity from wireline logs in both water-and hydrocarbon-bearing wells. We show that there is a very good match between these types of data, particularly when reservoirs are shallow. CsEM data, however, only provide information on the subsurface resistivity. Careful, geology-driven interpretation of CsEM data is required to maximize the impact on exploration success. This is particularly important when quantifying the relative resistivity contribution of high-saturation hydrocarbon-bearing sandstone and that of the overlying cap rock. In the presented case the cap rock comprises predominantly organic rich Upper Jurassic–Early Cretaceous shales of the Hekkingen Formation(i.e. a regional source rock). The resistivity response of the reservoir and its cap rock become merged in CsEM data due to the transverse resistance equivalence principle. As a result of this, it is imperative to understand both the relative contributions from reservoir and cap rock, and the geological significance of any lateral resistivity variation in each of the units. In this contribution, we quantify the resistivity of organic rich mudstone, i.e. source rock, and reservoir sandstones, using 131 exploration boreholes from the Barents shelf. The highest resistivity(>10,000 Ωm) is evident in the hydrocarbon-bearing Realgrunnen subgroup which is reported from 48 boreholes, 43 of which are used for this study. Pay zone resistivity is primarily controlled by reservoir quality(i.e. porosity and shale fraction) and fluid phase(i.e. gas, oil and water saturation).In the investigated wells, the shale dominated Hekkingen Formation exhibits enhanced resistivity c

关键词： Barents shelf Petroleum Electromagnetic Exploration source rocks

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seroprevalence of celiac disease among United Arab Emirates healthy adult nationals: A gender disparity

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World Journal of Gastroenterology 2014年第42期20卷 15830-15836页

作者： Yousif A Abu-Zeid Waheeba s Jasem Benjamin Lebwohl peter H Green Gehad ElGhazali Department of Biology College of Science United Arab Emirates University Ambulatory Healthcare services Abu Dhabi Health Services Company Celiac Disease Center at Columbia University Department of Medicine Columbia University College of Physicians and Surgeons Mafraq Hospital and sheikh Khalifa Medical City

AIM: To determine celiac disease (CD) prevalence and associated manifestations or risk factors in healthy adult Emiratis.

关键词： Celiac disease Epidemiology serology Prevalence Gender United Arab Emirates

Climate change and its consequences for water and wastewater management

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Frontiers of Environmental science & Engineering 2009年第1期3卷 2-11页

作者： peter A.WILDERER Institute of Advanced studies on sustainability Amalienstr7580799 MunichGermany

Life,in combination with solar radiation and abiotic processes,is most probably the reason why liquid water has existed on Earth for over billions of years,and the global mean temperature has remained in a lifeenabling *** to limit or even reverse global warming must be derived from the knowledge of the Earth’s complex life-support *** this context,the balance between liquid and gaseous water plays a crucial role,and water management becomes an important field of innovation and action,globally,on the scale of watersheds but also on the very local *** use,reuse,and temporary storage of water in urban settings must be considered to limit over-extraction of water from natural resources,and to maintain the life supporting function of *** the same time,public health requirements,cost efficiency,and reliability demands are to be met.

关键词： ecosystem management tools self-regulation urbanization water-climate relationship water reuse

Pitfalls and promises of bile duct alternatives:There is plenty of room in the regenerative surgery

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World Journal of Gastroenterology 2023年第30期29卷 4701-4705页

作者： Ilya D Klabukov Denis s Baranovskii peter V shegay Andrey D Kaprin Department of Regenerative Medicine National Medical Research Radiological Center of the Ministry of Health of the Russian FederationObninsk 249036Russia Center for Innovative Radiological and Regenerative Technologies National Medical Research Radiological Center of the Ministry of Health of the Russian FederationObninsk 249036Russia

Current abdominal surgery has several approaches for biliary ***,the creation of functional and clinically applicable bile duct substitutes still represents an unmet *** the paper by Miyazawa and colleagues,approaches to the creation of bile duct alternatives were summarized,and the reasons for the lack of development in this area were *** history of bile duct surgery since the nineteenth century was also traced,leading to the conclusion that the use of bioabsorbable materials holds promise for the creation of bile duct substitutes in the *** suggest three ideas that may stimulate progress in the field of bile duct substitute ***,a systematic analysis of the causative factors leading to failure or success in the creation of bile duct substitutes may help to develop more effective ***,the regeneration of a bile duct is delicately balanced between epithelialization and subsequent submucosal maturation within limited time frames,which may be more apparent when using quantitative models to estimate ***,the utilization of the organism’s endogenous regeneration abilities may enhance the creation of bile duct *** are convinced that an interdisciplinary approach,including quantitative methods,machine learning,and deep retrospective analysis of the causes that led to success and failure in studies on the creation of bile duct substitutes,holds great ***,more attention should be directed towards the balance of epithelialization and submucosal maturation rates,as well as induced *** ideas deserve further investigation to pave the way for bile duct restoration with physiologically relevant outcomes.

关键词： Bile duct alternative Bile duct substitute Regenerative medicine Regene rative surgery Theoretical surgery Quantitative human physiology