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Establishing a Cochlear Implant Program in a Rural Area of Germany with Special Respect to Older Patients

International Journal of Otolaryngology and Head & Neck Surgery 2018年第2期7卷 35-42页

作者： peter rolf issing Anja Michler Department of Otorhinolaryngology Head Neck & Plastic Facial Surgery Klinikum Bad Hersfeld GmbH Bad Hersfeld Germany

Objective: The present study aimed to demonstrate the patient outcomes after cochlear implantation in a rural area of Germany with special respect to older patients. Study Design: Retrospective Study. Setting: ENT-Department of Bad Hersfeld as an academic teaching hospital of the Justus-Liebig-University of Giessen. This is located in a rural county in Germany. Patients: A consecutive series of 217 patients implanted between 2003 and 2017. Intervention: Patients were implanted with different cochlear implant devices by the same surgeon in a standard procedure. In cases of chronic otitis media a middle ear obliteration was performed 6 months prior to cochlear implantation. Main Outcome Measures: Patients were divided in two groups: group 1 was 18 to 65 years of age and group 2 was older than 65 years. Pre- and postoperative hearing and speech understanding evaluated by the Freiburg monosyllable word test and the HSM-sentence test in the group of patients. Results: The mean preoperative speech understanding of group 1 was 0.5% for monosyllables at 60 dB and 2.7% at 80 dB. Group 2 showed similar results with 0.2% and 1.2%. In the HSM-test, group 1 had a speech understanding of 2.6% and group 2 of 3.2%. No statistically significant difference could be found between both groups. After cochlear implantation mean speech understanding at 60 dB increased in group 1 to 53.2% and 65.1% at 80 dB respectively. Group 2 had an improvement to 51.8% at 60 dB and 68.3% and 80 dB. The results in the HSM-sentence test were 77.8% in group 1 and 83.7% in group 2 (p = 0.47). Both groups had a significant increase in speech understanding concerning both tests after cochlear implantation (p = 0.0001) whereas we could not confirm any significant difference between the younger and older CI-recipients in the monosyllable word test. During the observation period no major complications had to be observed. Conclusion: Our data suggest that cochlear implantation in a rural area of Germany is feasi

关键词： Cochlear Implantation Rural Area Older Patients

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Facial Nerve Stimulation can Improve after Cochlear Reimplantation and Postoperative Advanced Programming Techniques: Case Report

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International Journal of Clinical Medicine 2012年第1期3卷 62-64页

作者： Fahd Ali Alharbi Martin Spreng peter rolf issing Department of Otolaryngology Head and Neck Surgery Bad Hersfeld Academic Teaching Hospital Giessen University Department of Otolaryngology Head and Neck Surgery Faculty of Medicine Jazan University

We had a case of 75-year old man with a history of progressive hearing loss on both side who implanted with a Nucleus 24 Contour Advance in the right ear. After 4 years from implantation, the patient started to complaint of right facial twitching when his cochlear implant was active. Despite undergoing numerous alterations in his implant programming, facial nerve stimulation (FNS) persisted. After increasing the pulse width and changing the stimulation mode, there was no facial nerve stimulation. However there was a deterioration in hearing and speech understanding. CT of the temporal bone showed good position of the implant electrodes und cochleomeatal scintigraphy (CMS) showed a highly positive activity with suspicion of otosclerosis, although the medical history was negative for otosclerosis. The FNS was managed with cochlea reimplantation and advanced programming techniques. FNS in cochlear implant patients may be managed through reimplantation and advanced programming techniques.

关键词： Facial Nerve Stimulation Cochlea Implant Reimplantation Otosclerosis

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Facial Nerve Stimulation Can Improve after Cochlear Reimplantation and Postoperative Advanced Programming Techniques: Case Report

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International Journal of Clinical Medicine（临床医学国际期刊） 2012年第1期

作者： Fahd Ali Alharbi Martin Spreng peter rolf issing

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Seed selections for crystallization of calcium phosphate for phosphorus recovery

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Journal of Environmental Sciences 2007年第5期19卷 591-595页

作者： SONG Yong-hui Dietfried DONNERT Ute BERG peter G. WEIDLER rolf NUEESCH Chinese Research Academy of Environmental Sciences Beijing 100012 China Institute for Technical Chemistry-Section of Water- and Geo-technology （ITC-WGT） Research Centre of Karlsruhe Karlsruhe D-76021 Germany

Seed induces and promotes the crystallization of calcium phosphate, and acts as carrier of the recovered phosphorus （P）. In order to select suitable seed for P recovery from wastewater, three seeds including Apatite （AP）, Juraperle （JP） and phosphate-modified Juraperle （M-JP） were tested and compared. Batch and fixed-bed column experiments of seeded crystallization of calcium phosphate were undertaken by using synthetic wastewater with 10 mg/L P phosphate. It shows that AP has bad enduring property in the crystallization process, while JP has better performance for multiple uses, and M-JP is a hopeful seed for P recovery by crystallization of calcium phosphate.

关键词： crystallization seed phosphorus recovery Juraperle Apatite

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Natural End Member Samples of Pyrope and Grossular:A Cathodoluminescence-Microscopy and-Spectra Case Study

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Journal of Earth Science 2018年第5期29卷 989-1004页

作者： Hans-peter Schertl Joana Polednia rolf D.Neuser Arne P.Willner Ruhr-University Bochum Institute of GeologyMineralogy and GeophysicsD-44780 BochumGermany College of Earth Science&Engineering Shandong University of Science and TechnologyQingdao 266590China Bayerisches Geoinstitut Universitat BayreuthD-95440 BayreuthGermany

Garnet is one of the most significant minerals in metamorphic rocks, that provides key information on prograde, peak-metamorphic and retrograde parts of the pressure-temperature （PT） path. Such results require a detailed knowledge of its different growth domains. For iron-poor compositions, the cathodoluminescence （CL） microscopy is an important and often overlooked method and allows to identify the internal structures of all garnet grains in one thin section within only a few seconds. The advantage of the CL-microscope is to deliver low magnification images in true color, not only of garnet but also, for instance, of other rock forming silicates, carbonates, sulfates, etc., of metamorphic, but also of sedimentary and magmatic origin, using polished thin sections. Internal structures of grossular from Mexico and pyrope from the Italian Alps were characterized and visualized by CL-microscopy. The different growth domains were additionally studied using CL-spectra and electron microprobe （EMP） analysis. Grossular shows a patchy zonation in its core while in mantle and rim zones oscillatory zoning is observed. It contains zones of anomalous birefringence, zones of orange and bluish luminescence and zones lacking luminescence. Different but low amounts of the activator elements Mn2＋ and Eu2＋ are responsible for the orange and bluish luminescent domains. Pyrope is also characterized by oscillatory growth zones, shows a dull luminescent core with a change of crystal morphology during growth, and displays an increase of brightness from core towards rim--the outermost rim, however, is lacking luminescence. The different luminescent zones are characterized by different amounts of Dy3＋, Tb3＋, Sm3＋ and Sm2＋ as activator elements. Because of slow diffusion rates of activators such as the REEs Sm, Dy and Tb, it can be still possible to visualize possible prograde and/or peak pressure stage growth domains of garnet, even if later high temperature events may have homogenized the m

关键词： pyrope grossular cathodoluminescence (CL) oscillatory zoning REE CL-spectra.

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Raman Optical Activity and Raman Spectra of Amphetamine Species--Quantum Chemical Model Calculations and Experiments

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American Journal of Analytical Chemistry 2012年第6期3卷 410-421页

作者： rolf Willestofte Berg Irene Shim peter Cyril White Salim Abdali Department of Chemistry Technical University of DenmarkLyngbyDenmark ReForensics LincolnUK Biophysical Chemistry Group Department of ChemistryH.C.Orsted Inst.University of CopenhagenCopenhagenDenmark

Theoretical calculations and preliminary measurements of vibrational Raman optical activity (ROA) spectra of different species of amphetamine (amphetamine and amphetamine-H+) are reported for the first time. The quantum chemical calculations were carried out as hybrid ab initio DFT-molecular orbital calculations by use of the Gaussian 03W program, based on complete geometry minimizations of the conformational energy of the S-(+)-amphetamine molecule, the S-(+)-amphetamine-H+ ion, and the R-(–)-amphetamine molecule. Following this, harmonic frequency calculations have been made, providing information about the cation vibrational bands, expected in salts of single anions (chlorides) as well as in salts of anions with internal bonds (sulfates, hydrogen phosphates, etc.). It shows that the kind of anion should be given better attention, as so far it has often not been the case, when the spectra are employed for identification purposes. The DFT calculations show that the most stable conformations are those allowing for close contact between the aromatic ring and the amine hydrogen atoms. The internal rotational barrier within the same amphetamine enantiomer has a considerable influence on the Raman and ROA spectra. As predicted the experimental ROA spectra were found to depend on the chirality. Two street samples, provided by the London Police, were also measured and compared to the calculated ROA spectra. The street samples were found to contain different enantiomers of the protonated amphetamine-H+ sulfate. According to the present study the AMPH+ ion in aqueous sulfate solution seems to adopt a conformation in which the phenyl and ammonium groups are in transpositions, similar to what has been found in the solid state.

关键词： Amphetamine Raman ROA DFT Molecular Orbital Drugs Forensic

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Domain Structure of the Selenocysteine-specific Translation Factor SelB in Prokaryotes

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Biomedical and Environmental Sciences 1997年第2期10卷 125-128页

作者： AUGUST B■CK rolf HILGENFELD peter TORMAY REINHARD WILTING, AND MATTHIAS KROMAYER (Lehrstuhl fur Mikrobiologie der Universitat uüunchen, MiriaWard-Strasse 1a, D-80638 Munchen, Germany Institut fur olekulare Biotechnologie, Beutenbergtrasse 11,D-0770 Lehrstuhl für Mikrobiologie Universität München Germany.

Translation factor SelB is the key component for the specific decoding of UGA codons with selenocysteine at the ribosome. SelB binds selenocysteyl-tRNASec, guanine nucleotides and a secondary structure of the selenoprotein mRNA following the UGA at the 3' side. A comparison of the amino acid sequences of SelB species from E. coli,Desulfomicrobium baculatum, Clostridium thermoaceticum and Haemophilus influenzae showed that the proteins consist of at least four structural domains from which the Nterminal three are well conserved and share homology with elongation factor Tu whereas the C-terminal one is more variable and displays no similarity to any protein known. With the aid of the coordinates of EF-Tu the N-terminal part has been modelled into a 3D structure which exhibits intriguing features concerning its interaction with guanine nucleotides and other components of the translational apparatus. Cloning and expression of fragments of SelB and biochemical analysis of the purified truncated proteins showed that the C-terminal 19 kDa protein fragment is able to specifically bind to the selenoprotein mRNA. SelB, thus, is a translation factor functionally homologous to EF-Tu hooked up to the mRNA with its C-terminal end. The formation by SelB of a quaternary complex in vivo has been proven by overexpression of truncated genes of SelB and by demonstration that fragments comprising the mRNA or the tRNA binding domain inhibit selenocysteine insertion

关键词： mRNA EF Ts tRNA Domain Structure of the Selenocysteine-specific Translation Factor SelB in Prokaryotes Nature

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