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Projection on Segre varieties and determination of holomorphic mappings between real submanifolds Dedicated to Professor Sheng GONG on the occasion of his 75th birthday

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Science China mathematics 2006年第11期49卷 1611-1624页

作者： BAOUENDI m S EBENFELT peter ROTHSCHILD Linda P Department of mathematics University of California at San Diego La JollaCA 92093-0112USA

It is shown that a germ of a holomorphic mapping sending a real-analytic generic submanifold of finite type into another is determined by its projection on the Segre variety of the target manifold. A necessary and sufficient condition is given for a germ of a mapping into the Segre variety of the target manifold to be the projection of a holomorphic mapping sending the source manifold into the target. An application to the biholomorphic equivalence problem is also given.

关键词： Segre variety, generic submanifold, Segre mappings, finite type, biholomorphic equivalence.

Semantic linking of complex properties,monitoring processes and facilities in web-based representations of the environment

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International Journal of Digital Earth 2016年第3期9卷 300-324页

作者： Adam m.Leadbetter peter N.Vodden marine Institute Co.GalwayIreland Centre for Ecology and Hydrology Lancaster Environment CentreLancasterUK

Where a virtual representation of the Earth must contain data values observed within the physical Earth system,data models are required that allow the integration of data across the silos of various Earth and environmental sciences *** a mapping between the well-defined terminologies of these silos is a stubborn *** paper presents a generalised ontology for use within Web 3.0 services,which builds on European Commission spatial data infrastructure *** presented ontology acknowledges that there are many complexities to the description of environmental properties which can be observed within the physical Earth *** ontology is shown to be flexible and robust enough to describe concepts drawn from a range of Earth science disciplines,including ecology,geochemistry,hydrology and *** paper also demonstrates the alignment and compatibility of the ontology with existing systems and shows applications in which the ontology may be deployed.

关键词： observable properties monitoring properties environmental monitoring facilities semantic web geospatial data integration

A Novel ABA Insensitive mutant of Lotus japonicus with a Wilty Phenotype Displays Unaltered Nodulation Regulation

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molecular Plant 2009年第3期2卷 487-499页

作者： Bandana Biswas Pick Kuen Chan peter m Gresshoff ARC Centre of Excellence for Integrative Legume Research The University of Queensland St Lucia Brisbane QId 4072 Australia

An ABA insensitive mutant, Beyma, was isolated in Lotus japonicus mG-20 from an EmS mutagenesis population using root growth inhibition to applied ABA as the screening criterion. （The name ＂Beyma＂ was taken from the Australian Aboriginal language, Wagiman, beyma, meaning ‘drying up＇.） The stable mutant that segregates as a dominant mendelian mutation is insensitive to ABA induced inhibition of germination, vegetative growth, stomatal opening, as well as nodulation. Tissue ABA levels were normal, suggesting a sensitivity rather than biosynthesis mutation. It is slow-growing （50-70% of wild-type mG-20） and has a near-constitutive wilty phenotype associated with its inability to regulate stomatal opening. Whilst showing a wide range of ABA insensitive phenotypes, Beyma did not show alteration of nodule number control, as, in the absence of added ABA, the number and patterning （but not size） of nodules formed in the mutant were similar to that of mG-20. Split root experiments on mG-20 showed that application of ABA on one side of the root inhibited nodulation locally but not systemically. We propose that ABA is not involved directly in systemic autoregulation of nodulation （AON）.

关键词： hormone biology water relations genetics development symbiosis legume.

The genetics and biology of KRAS in lung cancer

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Chinese Journal of Cancer 2013年第2期32卷 63-70页

作者： peter m.K.Westcott minh D.To Pharmaceutical Sciences and Pharmacogenomics Program University of California SanFrancisco Helen Diller Comprehensive Cancer Center University of California SanFrancisco Thoracic Oncology Program Department of SurgeryUniversity of California SanFrancisco

mutational activation of KRAS is a common oncogenic event in lung cancer and other epithelial cancer *** to develop therapies that counteract the oncogenic effects of mutant KRAS have been largely unsuccessful,and cancers driven by mutant KRAS remain among the most refractory to available *** undertaken over the past decades have produced a wealth of information regarding the clinical relevance of KRAS mutations in lung *** Kras-driven mouse models of cancer,together with cellular and molecular studies,have provided a deeper appreciation for the complex functions of KRAS in ***,a much more thorough understanding of these complexities is needed before clinically effective therapies targeting mutant KRAS-driven cancers can be achieved.

关键词： RAS基因肺癌生物学遗传学基因突变致癌作用临床意义小鼠模型

On some aspects of minimum redundancy maximum relevance feature selection

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Science China(Information Sciences) 2020年第1期63卷 89-103页

作者： peter BUGATA peter DROTAR Intelligent Information Systems Lab Technical University of Kosice

The feature selection is an important challenge in many areas of machine learning because it plays a crucial role in the interpretations of machine-driven decisions. There are various approaches to the feature selection problem and methods based on the information theory comprise an important ***, the minimum redundancy maximum relevance(m RmR) feature selection is undoubtedly the most popular one with widespread application. In this paper, we prove in contrast to an existing finding that the m RmR is not equivalent to max-Dependency criterion for first-order incremental feature selection. We present another form of equivalence leading to a generalization of m RmR feature selection. Additionally,we compare several feature selection methods based on m RmR, max-Dependency, and feature ranking,employing different measures of dependency. The results on high-dimensional real-world datasets show that the distance correlation is the suitable measure for dependency-based feature selection methods. The results also indicate that the max-Dependency incremental algorithm combined with distance correlation appears to be a promising feature selection approach.

关键词： big data information theory feature selection dimensionality reduction minimum redundancy maximum relevance m RmR

A generic and extensible model for the martensite start temperature incorporating thermodynamic data mining and deep learning framework

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Journal of materials Science & Technology 2022年第33期128卷 31-43页

作者： Chenchong Wang Kaiyu Zhu peter Hedström Yong Li Wei Xu State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819China Department of materials Science and Engineering KTH Royal Institute of TechnologyStockholm 10044Sweden

The martensite start temperature is a critical parameter for steels with metastable *** numerous models have been developed to predict the martensite start(ms)temperature,the complexity of the martensitic transformation greatly limits their performance and *** this work,we apply deep data mining of thermodynamic calculations and deep learning to develop a generic model for *** data mining was used to establish a hierarchical database with three levels of ***,a convolutional neural network model,which can accurately treat the hierarchical data structure,was used to obtain the final *** integrating thermodynamic calculations,traditional machine learning and deep learning modeling,the final predictor model shows excellent generalizability and extensibility,*** performance both within and beyond the composition range of the original *** effects of 15 alloying elements were considered successfully using the proposed *** work suggests that,with the help of deep data mining considering the physical mechanisms,deep learning methods can partially mitigate the challenge with limited data in materials science and provide a means for solving complex problems with small databases.

关键词： martensite transformation Data mining Deep learning Extensibility Small-sample problem

Claudin-11 and occludin are major contributors to Sertoli cell tight junction function, in vitro

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Asian Journal of Andrology 2016年第4期18卷 620-626页

作者： mark J mcCabe Caroline FH Foo marcel E Dinger peter m Smooker peter G Stanton male Fertility Regulation Laboratory Hudson Institute of Medical Research Monash Medical Centre Clayton Victoria 3168 Australia School of Applied Sciences Royal Melbourne Institute of Technology University Bundoora Victoria 3088 Australia Kinghorn Centre for Clinical Genomics Garvan Institute of Medical Research Darlinghurst New South Wales 2010 Australia St Vincent's Clinical School UNSW Sydney New South Wales 2052 Australia.

The Sertoli cell tight junction （T J） is the key component of the blood-testis barrier, where it sequesters developing germ cells undergoing spermatogenesis within the seminiferous tubules. Hormonally regulated claudin-11 is a critical transmembrane protein involved in barrier function and its murine knockout results in infertility. We aimed to assess quantitatively the significance of the contribution of claudin-11 to TJ function, in vitro, using siRNA-mediated gene silencing. We also conducted an analysis of the contribution of occludin, another intrinsic transmembrane protein of the TJ. Silencing of claudin-11 and/or occludin was conducted using siRNA in an immature rat Sertoli cell culture model. Transepithelial electrical resistance was used to assess quantitatively TJ function throughout the culture. Two days after siRNA treatment, cells were fixed for immunocytochemical localization of junction proteins or lyzed for RT-PCR assessment of mRNA expression. Silencing of claudin-11, occludin, or both resulted in significant decreases in TJ function of 55% （P 〈 0.01）, 51% （P 〈 0.01）, and 62% （P 〈 0.01）, respectively. Data were concomitant with significant decreases in mRNA expression and marked reductions in the localization of targeted proteins to the Sertoli cell TJ. We provide quantitative evidence that claudin-11 contributes significantly （P 〈 0.01） to Sertoli cell TJ function in vitro. Interestingly, occludin, which is hormonally regulated but not implicated in infertility until late adulthood, is also a significant （P 〈 0.01） contributor to barrier function. Our data are consistent with in vivo studies that clearly demonstrate a role for these proteins in maintaining normal TJ barrier structure and function.

关键词： blood-testis barrier claudin-11 occludin Sertoli cell tight junction siRNA

Echo-enhanced ultrasound with pulse inversion imaging: A new imaging modality for the differentiation of cystic pancreatic tumours

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World Journal of Gastroenterology 2006年第14期12卷 2205-2208页

作者： Steffen Rickes Klaus mnkemüller peter malfertheiner Department of Gastroenterology Hepatology and Infectious Diseases Otto-von-Guericke-UniversityMagdeburgGermany

AIm： To describe and discuss echo-enhanced sonography in the differential diagnosis of cystic pancreatic lesions. mETHODS： The pulse inversion technique （with intravenous injection of 2.4 mL SonoVue） or the power-Doppler mode under the conditions of the 2^nd harmonic imaging （with intravenous injection of 4 g Levovist） was used for echo-enhanced sonography. RESULTS： Cystadenomas frequently showed many vessels along fibrotic strands. On the other hand, cystadenocarcinomas were poorly and chaotically vascularized. ＂Young pseudocysts＂ were frequently found to have a highly vascularised wall. However, the wall of the ＂old pseudocysts＂ was poorly vascularized. Data from prospective studies demonstrated that based on these imaging criteria the sensitivities and specificities of echoenhanced sonography in the differentiation of cystic pancreatic masses were 〉 90%. CONCLUSION： Cystic pancreatic masses have a different vascularization pattern at echo-enhanced sonography. These characteristics are useful for their differential diagnosis, but histology is still the gold standard.

关键词： Cystic pancreatic lesions Differentia diagnosis Echo-enhanced sonography

Classical Ethylene Insensitive mutants of the Arabidopsis EIN2 Orthologue Lack the Expected‘hypernodulation’ Response in Lotus japonicus

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Journal of Integrative Plant Biology 2013年第4期55卷 395-408页

作者： Pick Kuen Chan Bandana Biswas peter m. Gresshoff Australian Research Council (ARC) Centre of Excellence for Integrative Legume Research The University of Queensland ARC Centre of Excellence for Integrative Legume Research and School of Agriculture and Food Sciences The University of Queensland

Three independent ethylene insensitive mutants were selected from an EmS- mutagenized population of Lotus japonicus mG-20 （miyakojima）. The mutants, called ＇Enigma＇, were mutated in the LjEIN2a gene from Lotus chromosome 1, sharing significant homology with Arabidopsis EIN2 （ethylene-insensitive2）. All three alleles showed classical ethylene insensitivity phenotypes （e.g., Triple Response）, but lacked the increased nodulation phenotype commonly associated with ethylene insensitivity. Indeed, all showed a marginal reduction in nodule number per plant, a phenotype that is enigmatic to sickle, an ethylene- insensitive EIN2 mutant in medicago truncatula. In contrast to wild type, but similar to an ETRI-1 ethylene ethylene-insensitive transgenic of L. japonicus, enigma mutants formed nodules in between the protoxylem poles, demonstrating the influence of ethylene on radial positioning. Suppression of nodule numbers by nitrate and colonisation by mycorrhizal fungi in the enigma-1 mutant were indistin- guishable from the wild-type mG-20. However, reflecting endogenous ethylene feedback, the enigma-1 mutant released more than twice the wild-type amount of ethylene, enigma-1 had a moderate reduction in growth, greater root mass （and lateral root formation）, delayed flowering and ripening, smaller pods and seeds. Expression analysis of ethylene-regulated genes, such as ETR1, NRL1 （neverripe-like 1）, and ElL3 in shoots and roots of enigma-1 and mG-20 illustrated that the ethylene-insensitive mutation strongly affected transcriptional responses in the root. These mutants open the possibility that EIN2 in L. japonicus, a determinate nodulating legume, acts in a more complex fashion possibly through the presence of a duplicated copy of LjEIN2.

关键词： ABA development ethylene legume nodulation symbiosis.