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工程建设与设计 2003年第5期 6-8页

作者： Dr.peter kuhn Dr.kuhn咨询公司瑞士伯尔尼82347

依据对9.11恐怖袭击造成世贸大厦倒塌事实的分析,提出了钢结构防火的重要性和改进消防工程思路的一些建议。

关键词：建筑物消防钢结构防火防火保护设计

The JCIMPT - Innovative New Technologies for Membrane Protein Structural Biology

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The JCIMPT - Innovative New Technologies for Membrane Protei...

The 4th ISGO International Conference on Structural Genomics

作者： Raymond C.Stevens peter kuhn Geoffrey Chang Kurt Wüthrich Mark Yeager M.G.Finn Department of Molecular Biology10550 North Torrey Pines Road La JollaCA 92037USA Department of Chemistry The Scripps Research Institute 10550 North Torrey Pines RoadLa JollaCA 92037USA Department of Cell Biology 10550 North Torrey Pines Road La JollaCA 92037USA Department of Molecular Biology 10550 North Torrey Pines Road La JollaCA 92037USA Department of Molecular Biology 10550 North Torrey Pines Road La JollaCA 92037USA Department of Chemistry The Scripps Research Institute10550 North Torrey Pines RoadLa JollaCA 92037USA Department of Cell Biology 10550 North Torrey Pines Road La JollaCA 92037 USA Department of Chemistry The Scripps Research Institute 10550 North Torrey Pines Road La JollaCA 92037 USA

＜正＞The mission of the Joint Center for Innovative Membrane Protein Technologies （JCIMPT;http://***） is to develop and disseminate methods and technologies for structure-grade production and stabilization of integral membrane proteins. Miniaturization and automation are major components in the systematic investigation of membrane proteins and in the development of novel genetically engineered expression systems and sample preparation technologies.

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非小细胞肺癌中的循环肿瘤细胞

国际病理科学与临床杂志 2013年第6期33卷 478-480页

作者： Rogier Boshuizen peter kuhn Michel van den Heuvel 郭晓纲 Department of Thoracic Oncology The Netherlands Cancer Institute Department of Cell Biology The Scripps Research Institute Department of The oracic Oncology The Netherlands Cancer Institute 浙江大学医学院附属第一医院心内科杭州310003

肺癌是世界上最致命的癌症类型。仅仅在美国，每年就有超过225000人被确诊为肺癌，2012年预计死于肺癌的患者大约有16万。与癌胚抗原（carcinoembryonic antigen，CEA）在结肠癌以及前列腺特异抗原（prostate specific antigen，PSA）... 详细信息

肺癌是世界上最致命的癌症类型。仅仅在美国，每年就有超过225000人被确诊为肺癌，2012年预计死于肺癌的患者大约有16万。与癌胚抗原（carcinoembryonic antigen，CEA）在结肠癌以及前列腺特异抗原（prostate specific antigen，PSA）在前列腺癌中的作用不同，在肺癌患者诊治过程中，肿瘤标志物的应用并不广泛。肺癌的诊断依赖于影像学检查，而不是体液中的肿瘤标志物。然而在最近的研究中，循环肿瘤细胞（circulating tumor cells，CTCs）的潜在价值被发现。基于CTCs的分析已经被视作“液相活组织检查”，它将有助于我们对恶性肿瘤进行定性和定量的分析。

关键词：非小细胞肺癌循环肿瘤细胞前列腺特异抗原肿瘤标志物肺癌患者影像学检查 cells 活组织检查

Community assembly of ectomycorrhizal fungi along a subtropical secondary forest succession

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Community assembly of ectomycorrhizal fungi along a subtropi...

中国菌物学会2015年学术年会

作者： Gao Cheng Zhang Yu Shi Nan-Nan Zheng Yong Chen Liang Wubet Tesfaye Bruelheide Helge Both Sabine Buscot Francois Ding Qiong Erfmeier Alexander kuhn peter Nadrowski Karin Scholten Thomas Guo Liang-Dong State Key Laboratory of Mycology Institute of MicrobiologyChinese Academy of Sciences College of Life Science and Engineering Qiqihar University University of Chinese Academy of Sciences Department of Soil Ecology UFZ-Helmholtz Centre for Environmental Research Institute of Biology Martin Luther University Institute of Biology Leipzig University Department of Geoscieneces Research Area GeographyUniversity of Tubingen

Environmental selection and dispersal limitation are two of the primary processes structuring biotic communities in ecosystems, but little is known about these processes in shaping soil microbial communities during secondary forest succession. We examined the communities of ectomycorrhizal（EM） fungi in young, intermediate and old forests in a Chinese subtropical ecosystem, using 454 pyrosequencing. The EM fungal community consisted of 393 operational taxonomic units（OTUs）, belonging to 21 EM fungal lineages, in which three EM fungal lineages and 11 EM fungal OTUs showed significantly biased occurrence among the young, intermediate and old forests. The EM fungal community was structured by environmental selection and dispersal limitation in old forest, but only by environmental selection in young, intermediate, and whole forests. Furthermore, the EM fungal community was affected by different factors in the different forest successional stages, and the importance of these factors in structuring EM fungal community dramatically decreased along the secondary forest succession series. This study suggests that different assembly mechanisms operate on the EM fungal community at different stages in secondary subtropical forest succession.

关键词： 454 pyrosequencing dispersal limitation ectomycorrhizal(EM) fungal community ITS2 plant community subtropical secondary forest succession

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招聘广告中的性别歧视:来自中国的证据

新产经 2012年第9期 12-12页

作者： peter kuhn 沈凯玲美国加州大学圣巴巴拉校区厦门大学王亚南研究院

据最近一次人口普查,女性中"白领"工作者的比例都低于男性。但是,"白领"工作者的平均受教育年限,女性高于男性。且女性在高工资行业就业的比例都低于男性。也就是说,与男性相比,女性要得到相同工资或进入相同行业,花费的成本要比男性多... 详细信息

据最近一次人口普查,女性中"白领"工作者的比例都低于男性。但是,"白领"工作者的平均受教育年限,女性高于男性。且女性在高工资行业就业的比例都低于男性。也就是说,与男性相比,女性要得到相同工资或进入相同行业,花费的成本要比男性多,或者说,在女性花费相同成本的情况下,企业会拒绝女性或给与女性较低的工资报酬。

关键词：招聘广告工资报酬性别歧视平均受教育年限用人单位性中高工资理论模型性别偏好交互项

FAIR Convergence Matrix:Optimizing the Reuse of Existing FAIR-Related Resources

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Data Intelligence 2020年第1期2卷 158-170,313页

作者： Hana Pergl Sustkova Kristina Maria Hettne peter Wittenburg Annika Jacobsen Tobias kuhn Robert Pergl Jan Slifka peter McQuilton Barbara Magagna Susanna-Assunta Sansone Markus Stocker Melanie Imming Larry Lannom Mark Musen Erik Schultes GO FAIR International Support and Coordination Office LeidenThe Netherlands Centre for Digital Scholarship Leiden University LibrariesLeidenThe Netherlands Max Planck Computing and Data Facility Gießenbachstraße 285748 GarchingGermany Leiden University Medical Center Leiden2333 ZAThe Netherlands Department of Computer Science Vrije Universiteit AmsterdamDe Boelelaan 11051081 HV AmsterdamThe Netherlands Czech Technical University in Prague Faculty of Information Technology(FIT CTU)16000 Prague 6Czech Republic Oxford e-Research Centre Department of Engineering SciencesUniversity of OxfordOxford OX13PJUK Environment Agency Austria A-1090 ViennaAustria TIB Leibniz Information Centre for Science and Technology HannoverGermany SURF Utrecht 3511 EPThe Netherlands Corporation for National Research Initiatives(CNRI) RestonVirginia 20191USA Stanford Center for Biomedical Informatics Research StanfordCA 94305USA

The FAIR principles articulate the behaviors expected from digital artifacts that are Findable,Accessible,Interoperable and Reusable by machines and by *** by now widely accepted,the FAIR Principles by design do not explicitly consider actual implementation choices enabling FAIR *** different communities have their own,often well-established implementation preferences and priorities for data reuse,coordinating a broadly accepted,widely used FAIR implementation approach remains a global *** an effort to accelerate broad community convergence on FAIR implementation options,the GO FAIR community has launched the development of the FAIR Convergence *** Matrix is a platform that compiles for any community of practice,an inventory of their self-declared FAIR implementation choices and *** Convergence Matrix is itself a FAIR resource,openly available,and encourages voluntary participation by any self-identified community of practice(not only the GO FAIR Implementation Networks).Based on patterns of use and reuse of existing resources,the Convergence Matrix supports the transparent derivation of strategies that optimally coordinate convergence on standards and technologies in the emerging Internet of FAIR Data and Services.

关键词： FAIR Implementation Choices and Challenges Convergence FAIR Communities

Estimating the Level of Asymptomatic COVID-19 Infections in Northern Ireland in 2020

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Open Journal of Modelling and Simulation 2022年第2期10卷 190-218页

作者： peter A. Hall Gabor Kiss Tilman kuhn Salissou Moutari Ellen Patterson Emily Smith Mathematical Sciences Research Centre School of Mathematics & Physics Queen’s University Belfast Belfast UK School of Biological Sciences Queen’s University Belfast Belfast UK Heidelberg Institute of Global Health (HIGH) Heidelberg University Hospital Heidelberg Germany

The identification and understanding of COVID-19 potential routes of transmission are fundamental to informing policies and strategies to successfully control the outbreak. Various studies highlighted asymptomatic infections as one of the silent drivers of the epidemic. An accurate estimation of the asymptomatic cases and the understanding of their contribution to the spread of the disease could enhance the effectiveness of current control strategies, mainly based on the symptom onset, to curb transmission. We investigate the dynamics of the COVID-19 epidemic in Northern Ireland during the period 1st March 25th to December 2020 to estimate the proportion of the asymptomatic infections in the country. We extended our previous model to include the stage of the asymptomatic infection, and we implement the corresponding deterministic model using a publicly available dataset. We partition the data into 11 sets over the period of study and fit the model parameters on the consecutive intervals using the cumulative number of confirmed positive cases for each interval. Moreover, we assess numerically the impacts of uncertainty in testing and we provide estimates of the reproduction numbers using the fitted parameters. We found that the proportion of asymptomatically infectious subpopulations, in Northern Ireland during the period of study, ranged between 5% and 25% of exposed individuals. Also, the estimate of the basic reproduction number, R0, is 3.3089. The lower and upper estimates for herd immunity are (0.6181, 0.7243) suggesting that around 70% of the population of Northern Ireland should acquire immunity via infection or vaccination, which is in line with estimates reported in other studies.

关键词： Pandemic Epidemic SARS-CoV-2 COVID-19 Compartmental Model SEIAR Model Basic Reproduction Number Effective Reproduction Number Parameter Estimates Fitted Model Testing Uncertainty Asymptomatic Infection Northern Ireland

Mathematical Modelling of the COVID-19 Epidemic in Northern Ireland in 2020

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Open Journal of Modelling and Simulation 2021年第2期9卷 91-110页

作者： peter A. Hall Gabor Kiss Tilman kuhn Salissou Moutari Ellen Patterson Emily Smith Mathematical Science Research Centre School of Mathematics & Physics Queen’s University Belfast Belfast Northern Ireland United Kingdom School of Biological Sciences Queen’s University Belfast Belfast Northern Ireland United Kingdom Heidelberg Institute of Global Health (HIGH) Heidelberg University Hospital Heidelberg Germany

In this study, we investigate the dynamics of the COVID-19 epidemic in Northern Ireland from 1st March 2020 up to 25th December 2020, using several copies of a Susceptible-Exposed-Infectious-Recovered (SEIR) compartmental model, and compare it to a detailed publicly available dataset. We split the data into 10 time intervals and fit the models on the consecutive intervals to the cumulative number of confirmed positive cases on each interval. Using the fitted parameter estimates, we also provide estimates of the reproduction number. We also discuss the limitations and possible extensions of the employed model.

关键词： Pandemic Epidemic SARS-CoV-2 COVID-19 Compartmental Model SEIR Model Basic Reproduction Number Effective Reproduction Number Parameter Estimates Fitted Model

Silicon microcavity arrays with open access and a finesse of half a million

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Light(Science & Applications) 2019年第1期8卷 862-868页

作者： Georg Wachter Stefan kuhn Stefan Minniberger Cameron Salter peter Asenbaum James Millen Michael Schneider Johannes Schalko Ulrich Schmid Andre Felgner Dorothee Huser Markus Arndt Michael Trupke Faculty of Physics University of ViennaVCQBoltzmanngasse 51090 ViennaAustria Institute for Atomic and Subatomic Physics TU WienVCQStadionallee 21020 ViennaAustria Institute for Sensor and Actuator Systems TU Wien1040 ViennaAustria Physikalisch-Technische Bundesanstalt Bundesallee 100D-38116 BraunschweigGermany Department of Physics King’s College LondonStrandLondon WC2R 2LSUK

Optical resonators are essential for fundamental science,applications in sensing and metrology,particle cooling,and quantum information *** can significantly enhance interactions between light and *** many applications they perform this task best if the mode confinement is tight and the photon lifetime is *** access to the mode center is important in the design to admit atoms,molecules,nanoparticles,or solids into the light ***,we demonstrate how to machine microcavity arrays of extremely high quality in pristine *** to an almost perfect parabolic shape with a surface roughness on the level of 2A and coated to a finesse exceeding F=500,000,these new devices can have lengths below 17μm,confining the photons to 5μm waists in a mode volume of 88λ^(3).Extending the cavity length to 150μm,on the order of the radius of curvature,in a symmetric mirror configuration yields a waist smaller than 7μm,with photon lifetimes exceeding 64 *** cleanroom fabrication delivers an entire microcavity array in a single *** precision furthermore yields alignment structures that result in mechanically robust,pre-aligned,symmetric microcavity arrays,representing a lightmatter interface with unprecedented performance.

关键词： process field. exceeding

FAIR Principles:Interpretations and Implementation Considerations

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Data Intelligence 2020年第1期2卷 10-29,293-302,322页

作者： Annika Jacobsen Ricardo de Miranda Azevedo Nick Juty Dominique Batista Simon Coles Ronald Cornet Melanie Courtot Merce Crosas Michel Dumontier Chris T.Evelo Carole Goble Giancarlo Guizzardi Karsten Kryger Hansen Ali Hasnain Kristina Hettne Jaap Heringa Rob W.W.Hooft Melanie Imming Keith G.Jeffery Rajaram Kaliyaperumal Martijn GKersloot Christine R.Kirkpatrick Tobias kuhn Ignasi Labastida Barbara Magagna peterMcQuilton Natalie Meyers Annalisa Montesanti Mirjam van Reisen Philippe Rocca-Serra Robert Pergl Susanna-Assunta Sansone Luiz Olavo Bonino da Silva Santos Juliane Schneider George Strawn Mark Thompson Andra Waagmeester Tobias Weigel Mark D.Wilkinson Egon L.Willighagen peter Wittenburg Marco Roos Barend Mons Erik Schultes Leiden University Medical Center Leiden2333 ZAThe Netherlands Institute of Data Science Maastricht UniversityUniversiteitssingel 60Maastricht 6229 ERThe Netherlands Department of Computer Science The University of ManchesterOxford RoadManchester M139PLUK Oxford e-Research Centre Department of Engineering SciencesUniversity of OxfordOxford OX13PJUK School of Chemistry Faculty of Engineering and Physical SciencesUniversity of SouthamptonSO171BJUK Amsterdam UMC University of AmsterdamAmsterdam 1000 GGThe Netherlands European Bioinformatics Institute(EMBL-EBI) HinxtonCambridgeCB101SDUK Harvard University CambridgeMassachusetts 02138USA Department of Bioinformatics–BiGCaT NUTRIMMaastricht UniversityMaastricht 6229 ERThe Netherlands Conceptual and Cognitive Modeling Research Group(CORE) Free University of Bozen-BolzanoBolzano 39100Italy Aalborg University Aalborg DK-9220Denmark Insight Centre for Data Analytics National University of Ireland GalwayH91 TK33Ireland Centre for Digital Scholarship Leiden University LibrariesLeiden2333 ZAThe Netherlands Department of Computer Science Vrije Universiteit AmsterdamDe Boelelaan 11051081 HV AmsterdamThe Netherlands Dutch Techcentre for Life Sciences(DTL) UtrechtThe Netherlands SURF Utrecht 3511 EPThe Netherlands Keith G Jeffery Consultants FaringdonUK Castor EDC Paasheuvelweg 25Wing 5D1105 BPAmsterdamThe Netherlands San Diego Supercomputer Center University of California San DiegoLa JollaCalifornia 92093USA Learning and Research Resources Centre(CRAI) Universitat de Barcelona08007 BarcelonaSpain Environment Agency Austria A-1090 ViennaAustria University of Notre Dame 75004 ParisFrance Health Research Board(HRB) Dublin 2DO2 H638Ireland Liacs Institute of Advanced Computer Science Leiden University2311 GJ LeidenThe Netherlands Czech Technical University in Prague Faculty of Information Technology(FIT CTU)16000 Prague 6Czech Republic GO FAIR International Support&Coordination Office(GFISCO) LeidenThe Netherlands Harvard Catalys

The FAIR principles have been widely cited,endorsed and adopted by a broad range of stakeholders since their publication in *** intention,the 15 FAIR guiding principles do not dictate specific technological implementations,but provide guidance for improving Findability,Accessibility,Interoperability and Reusability of digital *** has likely contributed to the broad adoption of the FAIR principles,because individual stakeholder communities can implement their own FAIR ***,it has also resulted in inconsistent interpretations that carry the risk of leading to incompatible ***,while the FAIR principles are formulated on a high level and may be interpreted and implemented in different ways,for true interoperability we need to support convergence in implementation choices that are widely accessible and(re)-*** introduce the concept of FAIR implementation considerations to assist accelerated global participation and convergence towards accessible,robust,widespread and consistent FAIR *** self-identified stakeholder community may either choose to reuse solutions from existing implementations,or when they spot a gap,accept the challenge to create the needed solution,which,ideally,can be used again by other communities in the ***,we provide interpretations and implementation considerations(choices and challenges)for each FAIR principle.

关键词： FAIR guiding principles FAIR implementation FAIR convergence FAIR communities choices and challenges