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An electrospun scaffold loaded with anti-androgen receptor com.ound for accelerating wound healing

Burns & Traum. 2013年第2期1卷 95-101页

作者： Cassandra Chong Yiwei Wang peter k. m. maitz Ulla Sim.nainen Zhe Li Burns & Reconstructive Surgery Research Group Concord Repatriation General Hospital Concord New South Wales 2139 Australia Burns & Reconstructive Surgery Research Group Concord Repatriation General Hospital Concord New South Wales 2139 Australia Burns Unit Concord Repatriation General Hospital Concord New South Wales 2139 Australia Andrology Group of ANZAC Research Institute Concord Repatriation General Hospital Concord New South Wales 2139 Australia

Current derm.l regenerative scaffolds provide wound coverage, and structural support and guidance for tissue repair, but usually lack.enough bio-signals needed for speeding up sk.n cell growth, m.gration, wound closure, and sk.n regeneration. In this study, an androgen receptor (AR) inhibitor called ASC-J9 is used to dem.nstrate the concept and feasibility of fabricating drug-loaded scaffolds via electrospinning. Inhibition of androgen is k.own to prom.te sk.n wound healing. The novel ASC-J9 - loaded porous scaffold was fabricated for sk.n wound repair using electrospun fibers of collagen and polycaprolactone (PCL) blend. Our prelim.nary results indicated that ASC-J9 - loaded scaffolds facilitated m.re efficient attachm.nt and ingrowth of derm.l fibroblasts, com.ared to the control collagen-PCL scaffold. A significant increase of cell proliferation was observed with the drug-loaded scaffold over a 28-day period. The drug-loaded scaffold also accelerated k.ratinocyte m.gration and wound closure in a contraction-inhibited m.use wound m.del over 21 days. The data indicated a sustained release of ASC-J9 from.the scaffold and its potential to accelerate wound healing by prom.ting cell proliferation and m.gration over an extended period of tim.. m.re im.ortantly, our results proved the concept and feasibility of fabricating drug-releasing or bioactive derm.l scaffolds for m.re effective wound healing.

关键词： Wound healing electrospun scaffold adrogen receptor inhibition ASC-J9

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Chem.cal short-range-order induced m.ltiscale strengthening in refractory m.dium.entropy alloys

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Acta m.chanica Sinica 2024年第6期40卷 41-49页

作者： Weizheng Lu Yang Chen Jia Li peter k.Liaw Qihong Fang State k.y Laboratory of Advanced Design and m.nufacturing for Vehicle Body College of Mechanical and Vehicle EngineeringHunan UniversityChangsha410082China Departm.nt of m.terials Science and Engineering The University of TennesseeKnoxvilleTN37996USA

High/m.dium.entropy alloys(H/m.As)are generally possible to exhibit chem.cal short-range order(SRO).However,the com.lex role of SRO on m.chanical properties from.nano-scale to m.so-scale is still challenging so ***,we study the strengthening m.chanism.and deform.tion behavior in a m.del body-centered-cubic HfNbTa m.A by using atom.c-scale m.lecular dynam.cs,m.cro-scale dislocation dynam.cs,and m.so-scale crystal plasticity finite *** SRO inhibits dislocation nucleation at the atom.c scale,im.roving the flow *** SRO-induced ultrastrong local stress fluctuation greatly im.roves the m.cro-scale dislocation-based strength by the significant dislocation forest ***,the Ta-rich locally ordered structure leads to an obvious heterogeneous strain and stress partitioning,which form. a strong strain gradient in the adjacent grain interiors and contributes to the strong back.stress-induced strain hardening.

关键词： High/m.dium.entropy alloys m.ltiscale strengthening Chem.cal short-range order

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Towards im.lem.ntation of alloy-specific therm.-fluid m.delling for laser powder-bed fusion of m. alloys

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Journal of m.gnesium.and Alloys 2024年第6期12卷 2327-2344页

作者： m.ham.ad Hoseini-Athar m.k.el Ersson peter Hedström Departm.nt of m.terial Science and Engineering KTH Royal Institute of TechnologyStockholmSE-10044 Sweden

m.lti-physics therm.-fluid m.deling has been extensively used as an approach to understand m.lt pool dynam.cs and defect form.tion as well as optim.zing the process-related param.ters of laser powder-bed fusion(L-PBF).However,its capabilities for being im.lem.nted as a reliable tool for m.terial design,where m.nor changes in m.terial-related param.ters m.st be accurately captured,is still in *** the present research,first,a therm.-fluid com.utational fluid dynam.cs(CFD)m.del is developed and validated against experim.ntal *** the predicted m.terial properties of the pure m. and com.ercial Zk.0 and WE43 m. alloys,param.tric studies are done attem.ting to elucidate how the difference in som. of the m.terial properties,i.e.,saturated vapor pressure,viscosity,and solidification range,can influence the m.lt pool *** is found that a higher saturated vapor pressure,associated with the Zk.0 alloy,leads to a deeper unstable k.yhole,increasing the k.yhole-induced porosity and evaporation m.ss *** viscosity and wider solidification range can increase the non-uniform.ty of tem.erature and velocity distribution on the k.yhole walls,resulting in increased k.yhole instability and form.tion of ***,the WE43 alloy showed the best behavior in term. of defect form.tion and evaporation m.ss loss,providing theoretical support to the extensive use of this alloy in *** sum.ary,this study suggests an approach to investigate the effect of m.terials-related param.ters on L-PBF m.lting and solidification,which can be extrem.ly helpful for future design of new alloys suitable for L-PBF.

关键词： m. alloys Laser powder-bed fusion(L-PBF) m.lt pool dynam.cs Com.utational fluid dynam.cs Fluid flow

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Effect of age on the standardized ileal am.no acid digestibility of soybean m.al and canola m.al in broilers

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Anim.l Nutrition 2024年第1期16卷 11-22页

作者： m.k.i Barua m.Reza Abdollahi Faegheh Zaefarian Tim.thy J.Wester Channarayapatna k.Girish peter V.Chrystal Velm.rugu Ravindran m.nogastric Research Center School of Agriculture and EnvironmentMassey UniversityPalmerston North 4442New Zealand Departm.nt of Anim.l Science and Nutrition Faculty of Veterinary MedicineChattogram Veterinary and Animal Sciences UniversityKhulshiChattogram 4225Bangladesh Nutrition and Care Animal NutritionEvonik(SEA)Pte.Ltd609927 Singapore Com.lete Feed Solutions Howick 2145AucklandNew Zealand

Standardized ileal digestibility coefficients(SIDC)of nitrogen(N)and am.no acids(AA)in two protein sources(soybean m.al[SBm.and canola m.al[Cm.)were investigated at six broiler ages(d 7,14,21,28,35,and 42).Two assay diets were form.lated to contain either SBm.413 g/k.)or Cm.553 g/k.)as the sole dietary AA *** dioxide(5 g/k.)was added as an indigestible m.rk.r.A total of 696 m.le broilers at 1 d old were allotted to 12 replicate cages per age *** assay diet was offered to birds for 4 d prior to the ileal digesta collection on d 7(14 birds/cage),14(12 birds/cage),21(10 birds/cage),28(8 birds/cage),35(8 birds/cage)and 42(6 birds/cage),*** apparent digestibility coefficients were standardized using age-specific basal endogenous AA *** the SBm.group,though the SIDC of N tended to be influenced(quadratic;P=0.075)by age,no linear or quadratic response of age effect was observed on the average SIDC of indispensable(IAA)and total AA(TAA).An age effect(quadratic;Pm.with the highest value recorded at d 7,followed by a decrease from.d 14 to 28,which increased beyond d *** SIDC of som. individual AA(Arg,Thr,Trp,Cys,Pro)were affected(Pm.nner by *** the Cm.the SIDC of N,average SIDC of IAA,DAA and TAA were influenced(quadratic;Pm.d 7 to 14,declined at d 21,and then increased beyond d *** average SIDC of IAA was low between d 7 and 28 and increased *** SIDC of individual AA were affected(linear or quadratic;Pm.gnitudes by *** age influence on the SIDC AA was variable,depending on the protein source and *** results dem.nstrate that age-specific SIDC AA data m.ght need consideration in broiler feed form.lations.

关键词： Age Am.no acid Broiler Digestibility Protein source

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Spatial and tem.oral patterns of sarcoptic m.nge in wom.ats using the citizen science tool,Wom.AT

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Integrative Zoology 2024年第3期19卷 387-399页

作者： Sujatha m.YADUNNAGE Hayley Jade STANNARD peter WEST Julie m.OLD School of Science Western Sydney UniversityHawkesburyNSWAustralia School of Agricultural Environmental and Veterinary SciencesCharles Sturt UniversityWagga WaggaNSWAustralia Departm.nt of Prim.ry Industries Orange Agricultural InstituteOrangeNSWAustralia

There is currently lim.ted inform.tion regarding the levels of infection and distribution of sarcoptic m.nge in the wom.at population throughout *** analyzed cases of sarcoptic m.nge in bare-nosed wom.ats reported into Wom.AT,a website and m.bile phone application where citizen scientists can upload sightings of wom.ats,burrows,and sarcoptic m.nge *** used m.xent software to predict locations and the environm.ntal factors associated with sarcoptic m.nge occurrence in bare-nosed wom.ats.A total of 1379 sarcoptic m.nge-infected and 3043 non-sarcoptic m.nge-infected wom.ats were reported by 674 and 841 citizen scientists,*** all the wom.ats reported to Wom.AT from.2015 to 2019,31.2%were infected with sarcoptic *** m.nge in bare-nosed wom.ats was reported in 502 suburbs across four *** South Wales had the highest num.er of sarcoptic m.nge cases reported to *** was no statistically significant seasonal variation of sarcoptic m.nge levels in bare-nosed *** m.del showed that Euclidean distance to urban areas was the highest contributing factor for sarcoptic m.nge *** distance to urban areas decreased,the suitability for sarcoptic m.nge *** precipitation was the next contributing factor in the m.del,with higher rainfall of 400–700 m. correlating to an increase in sarcoptic m.nge *** the data collected to date have provided the largest-scale contem.orary distribution of sarcoptic m.nge in wom.ats,data should continue to be collected by citizen scientists as it is an easy and low-cost m.thod of collecting data over large *** suggest targeting the identified hotspot areas and m.re site-specific studies for studying and m.tigating sarcoptic m.nge in bare-nosed wom.ats.

关键词： bare-nosed wom.ats habitat suitability m.xent m.deling

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Cannabinoids and endocannabinoids as therapeutics for nervous system.disorders:preclinical m.dels and clinical studies

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Neural Regeneration Research 2024年第4期19卷 788-799页

作者： R.Scott Duncan Sean m.Riordan m.tthew C.Gernon peter k.ulen Departm.nt of Ophthalm.logy School of MedicineUniversity of Missouri Departm.nt of Biom.dical Sciences School of MedicineUniversity of Missouri

Cannabinoids are lipophilic substances derived from.Cannabis sativa that can exert a variety of effects in the hum.n *** have been studied in cellular and anim.l m.dels as well as in hum.n clinical trials for their therapeutic benefits in several hum.n *** of these include central nervous system.CNS)diseases and dysfunctions such as form. of epilepsy,m.ltiple sclerosis,Park.nson’s disease,pain and neuropsychiatric *** addition,the endogenously produced cannabinoid lipids,endocannabinoids,are critical for norm.l CNS function,and if controlled or m.dified,m.y represent an additional therapeutic avenue for CNS *** review discusses in vitro cellular,ex vivo tissue and in vivo anim.l m.del studies on cannabinoids and their utility as therapeutics in m.ltiple CNS *** addition,the review provides an overview on the use of cannabinoids in hum.n clinical trials for a variety of CNS *** and endocannabinoids hold prom.se for use as disease m.difiers and therapeutic agents for the prevention or treatm.nt of neurodegenerative diseases and neurological disorders.

关键词： anandam.de cannabidiol cannabinoid endocannabinoid epilepsy m.ltiple sclerosis neurodegeneration neuroprotection tetrahydrocannabinol

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Adaptation in brain structure and respiratory and olfactory structures across environm.ntal gradients in African and North Am.rican m.roid rodents

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Integrative Zoology 2024年第1期19卷 165-181页

作者： peter J.TAYLOR Aluwani NENGOVHELA Christiane DENYS Graham.R.SCOTT Catherine m.IVY Departm.nt of Zoology School of Natural and Mathematical SciencesUniversity of VendaThohoyandouSouth Africa Afrom.ntane Unit Department of Zoology and EntomologyUniversity of the Free StatePhuthaditjhabaSouth Africa Departm.nt of m.m.alogy National MuseumBloemfonteinSouth Africa Institut de Systém.tique EvolutionBiodiversité(ISYEB)Muséum National d’Histoire NaturelleCNRSSorbonne UniversitéEPHEUniversitéDes AntillesParisFrance Departm.nt of Biology McMaster UniversityHamiltonOntarioCanada Guglielm. and Shoem.k.r Labs Advanced Facility for Avian ResearchUniversity of Western OntarioLondonOntarioCanada

m.rphom.tric studies of 3D m.cro CT-scanned im.ges can provide insights into the evolution of the brain and sensory structures but such data are still scarce for the m.st diverse m.m.alian order of *** reviewed and new data,we tested for convergence to extrem. aridity and high elevation in the sensory and brain m.rphology of rodents,from.m.rphom.tric data from.m.cro-CT X-ray scans of 174 crania of 16 species of three distantly re-lated African m.rid(soft-furred m.ce,Praom.ini,lam.nate-toothed rats,Otom.ini,and gerbils,Gerbillinae)clades and one North Am.rican cricetid(deer m.ce and white-footed m.ce,Perom.scus)*** studies dem.n-strated convergent evolution acting on the oval window area of the cochlea(enlarged in extrem.ly arid-adapted species of Otom.ini and Gerbillinae)and on endocranial volum.(reduced in high elevation taxa of Otom.ini and Perom.scus).However,contrary to our predictions,we did notfind evidence of convergence in brain struc-ture to aridity,or in the olfactory/respiratory system.turbinate bones)to high *** structure differed,particularly in the petrosal lobules of the cerebellum.and the olfactory bulbs,between Otom.ini and Gerbillinae,with extrem. arid-adapted species in each clade being highly divergent(not convergent)from.other species in the sam. *** observed greater“pack.ng”of the m.xillary turbinate bones,which have im.ortant respiratory functions,in Perom.scus m.ce from.high and low elevations com.ared to the high-elevation African Praom.ini,but m.re com.lex patterns within Perom.scus,probably related to trade-offs in respiratory physiology and heat exchange in the nasal epithelium.associated with high-elevation adaptation.

关键词： 3D m.rphom.trics Africa brain size North Am.rica Rodentia sensory evolution

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Highly-sensitive wafer-scale transfer-free graphene m.m. condenser m.crophones

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m.crosystem. & Nanoengineering 2024年第1期10卷 267-275页

作者： Roberto Pezone Sebastian Anzinger Gabriele Baglioni Hutom. Suryo Wasisto Pasqualina m.Sarro peter G.Steenek.n Sten Vollebregt Laboratory of Electronic Com.onents Technology and Materials(ECTM)Department of MicroelectronicsDelft University of TechnologyDelftThe Netherlands Infineon Technologies AG Am Campeon 1-15Neubiberg 85579Germany k.vli Institue of Nanoscience Department of Quantum NanoscienceDelft University of TechnologyDelftthe Netherlands Departm.nt of Precision and m.crosystem. Engineering(Pm.) Delft University of TechnologyDelftThe Netherlands

Since the perform.nce of m.cro-electro-m.chanical system.m.m.)-based m.crophones is approaching fundam.ntal physical,design,and m.terial lim.ts,it has becom. challenging to im.rove *** work. have dem.nstrated graphene’s suitability as a m.crophone *** potential for achieving sm.ller,m.re sensitive,and scalable onchip m.m. m.crophones is yet to be *** address large graphene sizes,graphene-polym.r heterostructures have been proposed,but they com.rom.se perform.nce due to added polym.r m.ss and *** work.dem.nstrates the first wafer-scale integrated m.m. condenser m.crophones with diam.ters of 2R=220-320μm.thick.ess of 7 nm.m.lti-layer graphene,that is suspended over a back.plate with a residual gap of 5μ*** m.crophones are m.nufactured with m.m. com.atible wafer-scale technologies without any transfer steps or polym.r layers that are m.re prone to contam.nate and wrink.e the *** designs,all electrically integrated are fabricated and characterized allowing us to study the effects of the introduction of a back.plate for capacitive *** devices show high m.chanical com.liances C_(m.=0.081-1.07μm.a^(−1)(10-100×higher than the silicon reported in the state-of-the-art diaphragm.)and pull-in voltages in the range of 2-9.5 *** addition,to validate the proof of concept,we have electrically characterized the graphene m.crophone when subjected to sound *** estim.ted sensitivity of S_(1k.z)=24.3-321 m. Pa^(−1)for a V_(bias)=1.5 V was determ.ned,which is 1.9-25.5×higher than of state-of-the-art m.crophone devices while having a~9×sm.ller area.

关键词： transfer plate approaching

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Achieving strength-ductility synergy in novel param.gnetic Fe-based m.dium.entropy alloys through deep cryogenic deform.tion

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Rare m.tals 2024年第9期43卷 4493-4507页

作者： Hu-Wen m. Yan-Chun Zhao Li Feng Tian-Zeng Liu Zhi-Qi Yu Bo Jin Wang-Chun Duan peter k.Liaw Dong m. State k.y Laboratory of Advanced Processing and Recycling of Non-Ferrous m.tals Lanzhou University of TechnologyLanzhou 730050China Wenzhou Pum. and Valve Engineering Research Institute Lanzhou University of TechnologyWenzhou 325105China Iron and Steel Research Institute Jiuquan Iron and Steel CorporationJiayuguan 735100China Lanzhou Resources and Environm.nt Voc-Tech University Lanzhou 730123China Departm.nt of m.terials Science and Engineering The University of TennesseeKnoxvilleTN 37996-2200USA Neutron Science Center Songshan Lake Materials LaboratoryDongguan 523808China

Cryogenic pre-deform.tion treatm.nt has been widely used to effectively im.rove the com.rehensive m.chanical properties of steels and novel ***,the dislocation evolution and phase transform.tion induced by different degrees of deep cryogenic deform.tion are not yet fully *** this study,the effects of m.ltiple cryogenic pre-treatm.nts on the m.chanical properties and deform.tion m.chanism. of a param.gnetic Fe_(63.3)m._(14-)Si_(9.1)Cr_(9.8)C_(3.8)m.dium.entropy alloy(m.A)were investigated,leading to the discovery of a pretreated m.A that exhibits exceptional m.chanical properties,including a fracture strength of 3.0 GPa,plastic strain of 26.1%and work.hardening index of *** addition,X-ray diffraction(XRD)and transm.ssion electron m.croscopy(TEm.analyses revealed that m.ltiple cryogenic pre-deform.tion treatm.nts significantly increased the dislocation density of the m.A(from.9×10^(15)to 4×10^(16)m.(-2)after three pretreatm.nts),along with a transition in the dislocation type from.predom.nantly edge dislocations to m.xed dislocations(including screw-and edge-type dislocations).Notably,this pretreated m.A retained its param.gnetic properties(μ_(r)m.nt can significantly reduce the stack.ng fault energy of the m.A by a factor of approxim.tely four(i.e.,from.9.7 to2.6 m.J·m.(-2)),thereby activating the synergistic effects of transform.tion-induced plasticity,twinning-induced plasticity and dislocation strengthening *** synergistic effects lead to sim.ltaneous strength and ductility enhancem.nt of the m.A.

关键词： Deep cryogenic transform.tion Iron-based m.dium.entropy alloys Dislocation evolution Phase transform.tion Stack.ng fault energy

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Ultrafast m.gneto-optical dynam.cs in nick.l(111)single crystal studied by the integration of ultrafast reflectivity and polarim.try probes

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Chinese Physics B 2024年第3期33卷 65-69页

作者：匡皓余军潇陈洁 H.E.Elsayed-Ali 李润泽 peter m.Rentzepis School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China Center for Transform.tive Science ShanghaiTech UniversityShanghai 201210China Center for Ultrafast Science and Technology Key Laboratory for Laser Plasmas (Ministry of Education)Collaborative Innovation Center of IFSA (CICIFSA)School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Departm.nt of Electrical and Com.uter Engineering Old Dominion UniversityNorfolkVirginia 23529USA Departm.nt of Electrical and Com.uter Engineering Texas A&M UniversityCollege StationTexas 77843USA

With the integration of ultrafast reflectivity and polarim.try probes,we observed carrier relaxation and spin dynam.cs induced by ultrafast laser excitation of Ni(111)single *** carrier relaxation tim. within the linear excitation range reveals that electron-phonon coupling and dissipation of photon energy into the bulk.of the crystal tak. tens of *** the other hand,the observed spin dynam.cs indicate a longer tim. of about 120 *** further understand how the lattice degree of freedom.is coupled with these dynam.cs m.y require the integration of an ultrafast diffraction probe.

关键词： ultrafast spin dynam.cs non-equilibrium.dynam.cs m.lti-probe

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