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Effects and safety of natriuretic peptides as treatment of cirrhotic ascites:A systematic review and meta-analysis

World Journal of Hepatology 2022年第4期14卷 827-845页

作者： Rasmus Hvidbjerg Gantzel Mikkel Breinholt Kjær peter jepsen Niels Kristian Aagaard Hugh Watson Lise Lotte Gluud Henning Grønbæk Department of Hepatology and Gastroenterology Aarhus University HospitalAarhus N 8200Denmark Gastroenterology Unit Copenhagen University HospitalHvidovre 2650Denmark Department of Clinical Medicine University of CopenhagenHvidovre 2650Denmark

BACKGROUND Natriuretic peptides are involved in the cascade of pathophysiological events occurring in liver cirrhosis,counterbalancing vasoconstriction and anti-natriuretic factors.The effects of natriuretic peptides as treatment of cirrhotic ascites have been investigated only in small studies,and definitive results are lacking.AIM To examine the effects and safety of natriuretic peptides in cirrhosis patients with ascites.METHODS We searched MEDLINE,Web of Science,Scopus,Cochrane Library and Embase for all available studies applying intravenous administration of any natriuretic peptide to patients suffering from cirrhotic ascites.Inclusion was not limited by treatment duration or dose,or by follow-up duration.Both randomised controlled trials and non-randomised studies were eligible for inclusion.The primary outcome was change in renal sodium excretion.Secondary outcomes included safety measures and changes in renal water excretion,plasma aldosterone concentration,and plasma renin activity.RESULTS Twenty-two studies were included.Atrial natriuretic peptide(ANP)was the only intensively studied treatment.Sodium excretion increased in response to continuous ANP infusion and was more pronounced when infusion rates of>30 ng/kg/min were administered compared with≤30 ng/kg/min(P<0.01).Moreover,natriuresis was significantly higher in study subgroups with mild/moderate ascites compared with moderate/severe and refractory ascites(P<0.01).ANP infusions increased renal water excretion,although without reaching a statistically significant dose-response gradient.Plasma aldosterone concentration and plasma renin activity were significantly lower at baseline in study subgroups achieving a negative sodium balance in response to an ANP administration compared with treatment non-responders(P<0.01).Blood pressure decreases occurred less frequently when ANP doses≤30 ng/kg/min were applied.The quality of evidence for a natriuretic response to ANP was low,mainly due to small sample sizes and considerable between-study heterogeneity.D

关键词： Atrial natriuretic peptide B-type natriuretic peptide Urodilatin Cirrhosis Ascites Refractory ascites

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Comorbidity in cirrhosis

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World Journal of Gastroenterology 2014年第23期20卷 7223-7230页

作者： peter jepsen Department of Hepatology and Gastroenterology Aarhus University HospitalDK-8000 Aarhus CDenmark Department of Clinical Epidemiology Aarhus University HospitalDK-8000 Aarhus CDenmark

Cirrhosis patients’comorbidities are their other diseases than cirrhosis.Comorbidities are neither causes nor consequences of cirrhosis,but they can increase mortality and are therefore clinically important.They are also an important source of confounding in epidemiologic studies.Comorbidity scoring systems have been developed as tools to measure the cirrhosis patient’s total burden of comorbidity,and they are useful in the clinic and for epidemiologic studies.The recently developed CirCom score is the only comorbidity scoring system developed specifically for cirrhosis patients,and it may be preferred over the older,generic,and more complex Charlson comorbidity index.Studies of individual comorbid diseases can provide insight into the interactions between cirrhosis and other diseases and thus into the pathophysiology of cirrhosis.This article reviews the literature on comorbidity in cirrhosis.

关键词： Liver cirrhosis Comorbidity Prognosis Epidemiology

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Time-resolved terahertz spectroscopy of charge carrier dynamics in the chalcogenide glass As_(30)Se_(30)Te_(40)[Invited]

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Photonics Research 2016年第3期4卷 22-28页

作者： Tianwu Wang Elena A.Romanova Nabil Abdel-Moneim David Furniss Anna Loth Zhuoqi Tang Angela Seddon Trevor Benson Andrei Lavrinenko peter Uhd jepsen Department of Photonics Engineering (DTU Fotonik) Technical University of Denmark Saratov State University Department of Physics Faculty of Engineering University of Nottingham

Broadband(1.6–18 THz) terahertz time-domain spectroscopy(THz-TDS) and time-resolved terahertz spectroscopy(TRTS) were performed on a 54 μm thick chalcogenide glass(As_(30)Se_(30)Te_(40)) sample with a two-color laser-induced air plasma THz system in transmission and reflection modes, respectively. Two absorption bands at 2–3 and 5–8 THz were observed. TRTS reveals an ultrafast relaxation process of the photoinduced carrier response, well described by a rate equation model with a finite concentration of mid-bandgap trap states for self-trapped excitons.The photoinduced conductivity can be well described by the Drude–Smith conductivity model with a carrier scattering time of 12–17 fs, and we observe significant carrier localization effects. A fast refractive index change was observed 100 fs before the conductivity reached its maximum, with 2 orders of magnitude larger amplitude than expected for the optically induced THz Kerr effect, indicating that free carriers are responsible for the transient index change.

关键词： Te Invited Se Time-resolved terahertz spectroscopy of charge carrier dynamics in the chalcogenide glass As

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飘海中国六年录——来自丹麦SorΦ水手的回忆(1862—1868)（英文）

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国家航海 2017年第1期 88-117页

作者： Karsten Hermansen Benedicte Busk-jepsen 丹麦马斯塔尔海事博物馆

19世纪,很多国家对中国贸易产生了兴趣。1842年,英国根据与清廷签署的条约在中国开放了五个通商口岸,这为其他国家(包括丹麦)提供了新的机会。丹麦商船已经到达了世界的许多地区,但它们需要开拓新的市场,比如中国。年轻的丹麦水手彼得... 详细信息

19世纪,很多国家对中国贸易产生了兴趣。1842年,英国根据与清廷签署的条约在中国开放了五个通商口岸,这为其他国家(包括丹麦)提供了新的机会。丹麦商船已经到达了世界的许多地区,但它们需要开拓新的市场,比如中国。年轻的丹麦水手彼得·斯汀借以'阿波罗'号的航行来增广见闻,结果一走便是六年。这六年里,他以北欧人的规范和理想来观察、记录中国人的生活和文化,体验了一个完全陌生的世界。

关键词：彼得·斯汀中国 1862年至1868年外国文化欧洲视角下的中国

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