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ELECTROACTi.E AND NANOSTRUCTURED POLYMERS AS SCAFFOLD MATERi.LS FOR NEURONAL AND CARDi.C Ti.SUE ENGi.EERi.G

Chi.ese Journal of Polymer Sci.nce 2007年第4期25卷 331-339页

作者： Paul Bi.ez Eli.abeth Guterman-Tretter Alan G. MacDi.rmi. peter i. Lelkes 危岩 School of Bi.medi.al Engi.eeri.g Science & Health SystemsDrexel UniversityPhiladelphiaPA 19104USA School of Bi.medi.al Engi.eeri.g Science & Health SystemsDrexel UniversityPhiladelphiaPA 19104USA Department of ChemistryDrexel UniversityPhiladelphiaPA 19104USA Department of Chemi.try University of PennsylvaniaPhiladelphiaPA 19104USA

Conducti.g polymer, polyani.i.e （PANi., has been studi.d as a novel electroacti.e and electri.ally conducti.e materi.l for ti.sue engi.eeri.g appli.ati.ns. The bi.compati.i.i.y of the conducti.e polymer can be i.proved by （i. covalently grafti.g vari.us adhesi.e pepti.es onto the surface of prefabri.ated conducti.g polymer fi.ms or i.to the polymer structures duri.g the synthesi., （i.） co-electrospi.ni.g or blendi.g wi.h natural protei.s to form conducti.g nanofi.ers or fi.ms, and （i.i. prepari.g conducti.g polymers usi.g bi.polymers, such as collagen, as templates. i. thi. paper, we mai.ly descri.e and revi.w the approaches of covalently attachi.g oli.opepti.es to PANi.and electrospi.ni.g PANi.gelati. blend nanofi.ers. The employment of such modi.i.d conducti.g polymers as substrates for enhanced cell attachment, proli.erati.n and di.ferenti.ti.n has been i.vesti.ated wi.h neuronal PC-12 cells and H9c2 cardi.c myoblasts. For the electrospun PANi. gelati. fi.ers, dependi.g on the concentrati.ns of PANi. H9c2 cells i.i.i.lly di.played di.ferent morphologi.s on the fi.rous substrates, but after one week all cultures reached confluence of si.i.ar densi.i.s and morphologi.s. Furthermore, we observed, that conducti.e PANi. when mai.tai.ed i. an aqueous physi.logi. envi.onment, retai.ed a si.ni.i.ant level of electri.al conducti.i.y for at least 100 h, even though thi. conducti.i.y was decreasi.g over ti.e. Preli.i.ary data show that the appli.ati.n of mi.ro-current sti.ulates the di.ferenti.ti.n of PC-12 cells. All the results demonstrate the potenti.l for usi.g PANi.as an electroacti.e polymer i. the culture of exci.able cells and open the possi.i.i.y of usi.g thi. materi.l as an electroacti.e scaffold for cardi.c and/or neuronal ti.sue engi.eeri.g appli.ati.ns that requi.e bi.compati.i.i.y of conducti.e polymers.

关键词： Polyani.i.e Conducti.e polymer Bi.compati.i.i.y Ti.sue engi.eeri.g.

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Polymersomes scalably fabri.ated vi. flash nano- preci.i.ati.n are non-toxi. i. non-human pri.ates and associ.te wi.h leukocytes i. the spleen and ki.ney followi.g i.travenous admi.i.trati.n

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Nano Research 2018年第10期11卷 5689-5703页

作者： Sean D. Allen Yu-Gang Li. Sharan Bobbala Lei.Cai.peter i. Hecker Ryan Temel Evan A. Scott i.terdi.ci.li.ary Bi.logi.al Sci.nces Northwestern University IL 60208 USA Department of Bi.medi.al Engi.eeri.g Northwestern University IL 60208 USA Saha Cardi.vascular Research Center University of Kentucky KY40506 USA Department of Pharmacology and Nutri.i.nal Sci.nces University of Kentucky KY40506 USA

Vesi.ular nanocarri.r formulati.ns confer the abi.i.y to deli.er hydrophobi. and hydrophi.i. cargos si.ultaneously to cells of i.terest i. vi.o. Whi.e li.osomal formulati.ns reached the cli.i. long ago, younger technologi.s such as polymeri. vesi.les （polymersomes） have yet to make the transi.i.n to cli.i.al approval and use, i. part due to di.fi.ulti.s i. ensuri.g thei. safe and scalable producti.n. i. thi. work, we demonstrate the scalable producti.n of poly（ethylene glycol）-block-poly（propylene sulfi.e）（PEG-bl-PPS） polymersomes vi. flash nanopreci.i.ati.n, and further show the safe admi.i.trati.n of these nanocarri.rs to mi.e and non-human pri.ates. i. mi.e, PEG-bl-PPS polymersomes were found to be well tolerated at up to 200 mg/（***）. Followi.g the admi.i.trati.n of a more relevant 20 mg/（***） dosage i. non-human pri.ates, polymersomes were found to associ.te wi.h numerous phagocyti. i.mune cell populati.ns, i.cludi.g a remarkable 68% of plasmacytoi. dendri.i. cells and 〉 95% of macrophages i. the spleen, whi.e showi.g no toxi.i.y or abnormali.i.s i. the li.er, ki.ney, spleen, or blood. Despi.e the presence of a dense PEG corona, nei.her anti.PEG anti.odi.s nor complement acti.ati.n were detected. Thi. work provi.es evi.ence of the translatabi.i.y of PEG-bi.PPS polymersomes i.to the cli.i. for therapeuti. appli.ati.ns i. humans.

关键词： polymersome non-human pri.ate nanopreci.i.ati.n toxi.i.y bi.di.tri.uti.n

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Effect of Correlati.n Level on the Use of Auxi.i.ry Vari.ble i. Double Sampli.g for Regressi.n Esti.ati.n

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Open Journal of Stati.ti.s 2013年第5期3卷 312-318页

作者： Dawud Adebayo Agunbi.de peter i. Ogunyi.ka Department of Mathemati.al Sci.nces Olabisi Onabanjo University Ago-Iwoye Nigeria

Whi.e an auxi.i.ry i.formati.n i. double sampli.g i.creases the preci.i.n of an esti.ate and solves the problem of bi.s caused by non-response i. sample survey, the questi.n i. that, does the level of correlati.n between the auxi.i.ry i.formati.n x and the study vari.ble y ease i. the accompli.hment of the objecti.es of usi.g double sampli.g? i. thi. research, i.vesti.ati.n was conducted through empi.i.al study to ascertai. the i.portance of correlati.n level between the auxi.i.ry vari.ble and the study vari.ble to maxi.ally accompli.h the i.portance of auxi.i.ry vari.ble(s) i. double sampli.g. Based on the Stati.ti.s cri.eri. employed, whi.h are mi.i.um vari.nce, coeffi.i.nt of vari.ti.n and relati.e effi.i.ncy, i. was establi.hed that the hi.her the correlati.n level between the study and auxi.i.ry vari.ble(s) i., the better the esti.ator i..

关键词： Correlati.n Level Auxi.i.ry Vari.ble Regressi.n Esti.ator Double Sampli.g and Relati.e Effi.i.ncy of Esti.ator

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Fami.y tree and populati.n: Di.ti.cti.n and si.i.ari.y of the analysi. on example of hemophi.i.

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Natural Sci.nce 2013年第9期5卷 979-986页

作者： Andrey N. Volobuev peter i. Romanchuk Vladi.i. K. Mali.hev Samara State Medi.al Uni.ersi.y Samara Russia

On the basi. of Hardy-Wei.berg law the di.ti.cti.n i. the phi.osophy of the descri.ti.n of a fami.y tree and a populati.n i. consi.ered. Wi.h the help of i.troducti.n of the equi.alent constant mutagen factor both i. a fami.y tree and i. a populati.n, the analysi. of hemophi.i. i. led. i.fluence of selecti.n at presence of hemophi.i. i. consi.ered. On the basi. of i.ea of Danforth and Haldane about the balance mutagenesi. and selecti.n at presence of hemophi.i., the i.ter-relati.n of selecti.n parameter and the equi.alent constant mutagen factor i. found. i. i. shown, that dynami.s of development of hemophi.i. i. a fami.y tree and i. populati.n are si.i.ar.

关键词： Alleles Equi.alent Constant Mutagen Factor Fami.y Tree Populati.n Hemophi.i. Balance of Selecti.n and Mutagenesi.

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About one form of wri.i.g of the Hardy-Wei.berg law

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Natural Sci.nce 2013年第6期5卷 724-728页

作者： Andrey N. Volobuev peter i. Romanchuk Vladi.i. K. Mali.hev Samara State Medi.al Uni.ersi.y Samara Russia

On the basi. of the Hardy-Wei.berg law wri.ten down for a conti.uous scale of alternati.n of generati.ns, populati.g dynami.s of genome i. consi.ered at absence of mutagen i.fluence and at presence of the mutagen factor of stochasti. character. i.fluence of the stochasti. mutagen factor as cancerogenes on the populati.n i. shown. i. the countri.s wi.h the homogeneous populati.n and advanced medi.i.e, i. i.evi.ably results i. growth of death rate of the populati.n from?newgrowths to proporti.nal a root square from ti.e of a li.e of the populati.n. The carri.d out research allows esti.ate a level of the populati.n condi.i.n i. the country from the poi.t of vi.w of health.

关键词： Stochasti. Mutagen Factor Newgrowths Allele Alternati.n of Generati.ns

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电活性可生物降解材料聚乳酸与苯胺五聚体嵌段共聚物的合成与表征

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高等学校化学学报 2005年第9期26卷 1771-1773页

作者：黄利红胡军庄秀丽马嘉陈学思景遐斌郭毅李梦燕 peter i.Lelkes 危岩中国科学院长春应用化学研究所高分子物理与化学国家重点实验室爵硕大学化学系

Every sli.ht movement of human body, such as beat of heart, contract of muscles, thi.ki.g of brai., i. associ.ted wi.h bi.electri.i.y. i. search for a neural conducti.g ti.sue engi.eeri.g materi.l whi.h can {i.eally} conduct bi.electri.al si.nals i. vi.o, the block copolymer of polylacti.e(PLA) and ani.i.e pentamera materi.l whi.h i. electro-acti.e, remarkably bi.compati.le and bi.degradable, was desi.ned and synthesi.ed. The ani.i.e pentamer i. si.i.ar wi.h polyani.i.e i. electri.al chemi.al properti.s, but more soluble than the latter. The copolymer i. prepared by condensati.n polymeri.ati.n between carboxyl-capped ani.i.e pentamer and {di.ydroxyl}-capped PLA, wi.h N,N′-di.yclohexylcarbodi.mi.e(DCC) as a condensi.g agent. The co-polymeri.ati.n of ani.i.e pentamer and PLA can not only reduce the toxi.i.y of ani.i.e pentamer, but also make the {materi.l} easi.y to degrade and excrete from the body. These properti.s of the copolymer provi.e a favorable prospect i. bi.medi.al appli.ati.n i. vi.o. The synthesi.ed materi.l i. i.vesti.ated by FTi., {}+1H NMR, UV, and cycli. voltammetri. measurements.

关键词：聚乳酸苯胺齐聚物电活性可生物降解

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电活性导电聚合物组织工程支架材料研究进展

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中国医学科学院学报 2006年第6期28卷 845-848页

作者：李梦燕 Paul Bi.ez Eli.abeth Guterman-Tretter 郭毅 Alan G.MacDi.rmi. peter i.Lelkes 原续波袁晓燕盛京李华宋存先危岩 School of Bi.medi.al Engi.eeri.g Science &Health SystemsDrexel University PhiladelphiaPA19104 School of Bi.medi.al Engi.eeri.g Science &Health Systems Drexel University PhiladelphiaPA19104 Departmentof Chemi.try University of PennsylvaniaPhiladelphia PA19104 USA Departmentof Poly-mer Materi.ls Sci.nce &Engi.eeri.g School of Materials Science &EngineeringTianjin University Tianjin 300072 Ti.nji. Bi.medi.al Materi.ls KeyLaboratory Institute of Biomedical EngineeringCAMS and PUMCTianjin 300192

由于具有电活性,导电聚合物在神经和心肌等电刺激响应性细胞的培养及相关电活性组织工程支架的研究中具有潜在的应用前景,而通过键合氨基酸基团或与天然蛋白共混可以提高其生物相容性。本文主要综述两种典型的导电聚合物-聚吡咯和聚苯胺... 详细信息

由于具有电活性,导电聚合物在神经和心肌等电刺激响应性细胞的培养及相关电活性组织工程支架的研究中具有潜在的应用前景,而通过键合氨基酸基团或与天然蛋白共混可以提高其生物相容性。本文主要综述两种典型的导电聚合物-聚吡咯和聚苯胺(PANi.在组织工程支架方面的研究进展,并特别阐述短肽与PANi.共价键合和电纺PA-Ni.明胶共混纳米纤维的研究。

关键词：导电聚合物聚吡咯聚苯胺生物相容性组织工程

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三维超声扫描技术测定胎盘体积与母体血浆中的游离胎儿DNA水平的关系

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世界核心医学期刊文摘（妇产科学分册） 2005年第12期1卷 13-14页

作者： Wataganara T. Metzenbauer M. peter i. D.W.Bi.nchi.朱晓明 Di.i.i.n of Geneti.s Departments of Pediatrics Obstetrics and Gynecology Tufts- New England Medical Center 750 Washington St Boston MA 02111 United States Dr.

Objecti.e: Measurement of cell- free fetal (cff) DNA i. maternal plasma may have cli.i.al appli.ati.n i. prenatal screeni.g for fetal Down syndrome and preeclampsi.. Li.tle i. known regardi.g the ti.sue of ori.i. of these fetal-deri.ed sequences. We tested the hypothesi. that i. the placenta i. the major contri.utor of cff DNA, then an i.creased placental volume should be associ.ted wi.h hi.her maternal plasma cff DNA levels. Study desi.n: We enrolled 143 pregnant women who underwent fi.st tri.ester placental volume measurement usi.g 3- di.ensi.nal ultrasonography. Cff DNA i. maternal plasma on the day of the scan was quanti.i.d by real-ti.e polymerase chai. reacti.n (PCR) ampli.i.ati.n of a Y- chromosome sequence. The associ.ti.n between measured placental volume and maternal plasma cff DNA levels was analyzed along wi.h relevant cli.i.al vari.bles. Results: The medi.n (25th, 75th percenti.es) maternal plasma cff DNA level was 16.9 genome equi.alents (GE)/mL (10.8, 28.7). Raw values were adjusted for gestati.nal age and maternal body mass i.dex. Results: The medi.n (25th, 75th percenti.es) placental volume was 53.2 mL (43.0, 64.7), and medi.n placental quoti.nt (rati. of placental volume to fetal crown-rump length) was 1 mm2 (0.8, 1.1). Based on multi.ari.te li.ear regressi.n analyses, nei.her of the above placental measurements showed a si.ni.i.ant associ.ti.n wi.h maternal plasma cff DNA levels (P = .43 and .43, respecti.ely). A modest associ.ti.n was found between plasma cff DNA levels and gravi.i.y (P = .03). Conclusi.n: Our data di. not show a si.ni.i.ant associ.ti.n between ei.her the placental volume or placental quoti.nt, and maternal plasma cff DNA levels. We speculate that i. i. the extent of placental apoptosi. that pri.ari.y affects the amount of cff DNA released i.to the maternal ci.culati.n.

关键词：超声扫描技术 DNA 基因组当量妊娠早期先兆子痫顶臀长组织来源统计分析研究设计

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母体体重与妊娠中期母体循环中游离胎儿DNA水平负相关

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世界核心医学期刊文摘（妇产科学分册） 2005年第9期1卷 48-49页

作者： Wataganara T. peter i. Messerli.n G.M. D.W. Bi.nchi.杨晓梅 Di.i.i.n of Geneti.s Department of Pediatrics Tufts-New England Medical Center 750 Washin gton Street Boston MA 02111 United States Dr.

OBJECTi.E: Cli.i.al appli.ati.ns of the analysi. of cellfree fetal DNA i. ma te rnal plasma and serum are expandi.g. However, use of fetal DNA duri.g prenatal s creeni.g requi.es knowledge of vari.bles that mi.ht affect i.s levels i. the mat ernal ci.culati.n. We conducted thi. study to esti.ate the effect of selected de mographi. factors on fetal DNA levels i. the fi.st and second tri.esters of preg nancy. METHODS: We developed a database that i.cluded fetal DNA levels and cli.i.cal i.formati.n, such as maternal age, ethni.i.y, wei.ht, and smoki.g hi.tory. W e measured fetal DNA levels i. maternal plasma and serum usi.g real-ti.e quanti.tati.e polymerase chai. reacti.n ampli.i.ati.n of a Y chromosome speci.i. sequen ce. The fetal DNA data from fresh fi.st tri.ester plasma and previ.usly frozen s econd tri.ester serum samples were analyzed separately. Fetal DNA levels were ad justed accordi.g to gestati.nal age and storage ti.e and then analyzed i. associ.ati.n wi.h the demographi. factors. RESULTS: i. the fi.st tri.ester group, no si.gni.i.ant associ.ti.n between maternal age, wei.ht, ethni. background, or smoki. g and plasma fetal DNA lev els was observed. i. the second tri.ester group, a si.ni.i.ant i.verse correla ti.n between maternal wei.ht and serum fetal DNA level was demonstrated (r = -0 .26, P = .007). Thi. was especi.lly promi.ent when the mothers wei.hed more than 170 lb (P = .001). Maternal age, ethni.i.y, and smoki.g were not si.ni.i.antly associ.ted wi.h the second tri.ester serum fetal DNA levels. CONCLUSi.N: Fetal D NA levels are affected by maternal wei.ht i. the second tri.ester. A correcti.n for thi. effect may be needed i. larger-scale studi.s or for future cli.i.al ap pli.ati.ns that measure cell-free fetal nuclei. aci.s i. maternal ci.culati.n.

关键词：妊娠中期负相关 DNA 产前筛查妊娠早期血浆样本临床信息人口统计学储存时间联合分析

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Heat Transfer and Performance Characteri.ti.s of Axi.l Cooli.g Fans wi.h Downstream Gui.e Vanes

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Journal of Thermal Sci.nce 2012年第2期21卷 162-171页

作者： Alexandros Terzi. i.anni. Styli.nou Anesti. i. Kalfas peter Ott Group of Thermal Turbomachi.ery (GTT) School of Engi.eeri.g EPFL-SCI-STI-PO CH-1015 Lausanne Switzerland Laboratory of Flui. Mechani.s and Turbomachi.ery Dept. of Mechani.al Engi.eeri.g School of Engineering Aristotle University of Thessaloniki (AUTH) GR-54124 Thessaloniki Greece

Thi. study exami.es experi.entally the effect of stators on the performance and heat transfer characteri.ti.s of small axi.l cooli.g fans. A si.gle fan i.peller, followed by ni.e stator blades i. the case of a complete stage, was used for all the experi.ental confi.urati.ns. Performance measurements were carri.d out i. a constant speed stage performance test ri. whi.e the transi.nt li.ui. crystal techni.ue was used for the heat transfer measurements. Full surface heat transfer coeffi.i.nt di.tri.uti.ns were obtai.ed by recordi.g the temperature hi.tory of li.ui. crystals on a target plate. The experi.ental data i.di.ated that the results are hi.hly affected by the flow condi.i.ns at the fan outlet. Stators can be benefi.i.l i. terms of pressure drop and effi.i.ncy, and thus more economi.al operati.n, as well as, i. the local heat transfer di.tri.uti.n at the wake of the stator blades i. the fan i. i.stalled very close to the cooli.g object. However, as the separati.n di.tance i.creases, enhanced heat transfer rate i. the order of 25% i. observed i. the case of the fan i.peller.

关键词： axi.l fans stators performance thermochromi. li.ui. crystals transi.nt heat transfer

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