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Is the disease course predictable in inflammatory bowel diseases?

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World Journal of Gastroenterology 2010年第21期16卷 2591-2599页

作者： peter Laszlo Lakatos Lajos s Kiss 1st Department of Medicine Semmelweis UniversityH-1083 BudapestKoranyi S 2AHungary

During the course of the disease,most patients with Crohn's disease(CD) may eventually develop a stricturing or a perforating complication,and a significant number of patients with both CD and ulcerative colitis will undergo *** recent years,research has focused on the determination of factors important in the prediction of disease course in inflammatory bowel diseases to improve stratification of patients,identify individual patient profiles,including clinical,laboratory and molecular markers,which hopefully will allow physicians to choose the most appropriate management in terms of therapy and intensity of *** review summarizes the available evidence on clinical,endoscopic variables and biomarkers in the prediction of short and long-term outcome in patients with inflammatory bowel diseases.

关键词： Inflammatory bowel disease Crohn’s disease Ulcerative colitis Disease course Predictive markers Clinical serology Genetics

Current status of thiopurine analogues in the treatment in Crohn's disease

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World Journal of Gastroenterology 2011年第39期17卷 4372-4381页

作者： peter Laszlo Lakatos Lajos s Kiss 1st Department of Medicine Semmelweis University

In the last decades,with the development of biological therapy,the treatment paradigms in patients with Crohn＇s disease have continuously *** studies focusing on the optimal use of both traditional immunosuppressants and biological therapy have been published,investigating conventional,accelerated stepup and top-down *** addition,much emphasis has been placed in recent years on the de-termination of important predictive factors that could enable early patient stratification,which would lead to a tailored management *** this review,the authors try to highlight new evidence on the optimal timing,benefits,and risks of immunosupressants alone,or in combination,in patients with Crohn＇s disease.

关键词： Crohn's disease Immunosuppressives Azathioprine Thiopurine methyltrans ferase Biologicals

Effect of Osmotic stress in Early stages of Ontogenesis on Root Respiration, Growth, sugar Content,and Cell Injury in Maize seedlings Differing in Drought sensitivity

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Journal of Integrative Plant Biology 2006年第7期48卷 814-822页

作者： Lukás, Kolarovic Miroslava Luxová peter Valentovic Institute of Botany Slovak Academy of Sciences Dubravská cesta 14 Bratislava 84523 Slovakia

Cultivars of maize （Zea mays L.） with different sensitivity to drought were exposed to 0.3 mol/L sorbitol （-1.4 MPa water potential） for 24 h. Exposure to water deficiency significantly reduced the growth of both shoots （coleoptile and hypocotyl） and roots. shoot growth was inhibited more than the growth of roots. Osmotic stress enhanced accumulation of soluble sugars. Electrolyte leakage, a cell injury index, was slightly increased after 0.3 mol/L sorbitoh Respiration was measured in the presence and absence of 2,6-dlchloro-phenol indophenoh 2,6-Dichloro-phenol indophenol did not influence respiration rates, because statistically equal results were observed under both conditions. Total respiration （VT） decreased after osmoticum treatment. There were no significant differences in the VT among the cultlvars analysed. The decrease In VT was caused by a decline In the activities and capacities of both cytochrome （Vcyt, Vcyt） and alternative pathway （Valt, Valt） of respiration. A high residual respiration （Vres） was observed, up to 27% of total uninhibited respiration. The result of uncoupler use clearly indicated that coupling was maintained after 24 h of osmotic stress. The recovery of the respiration rate was comparable with that of non-stressed control rates. According to these observations, no possible mltochondrial damage is expected. Water deficiency did not induce a stimulation of the alternative oxidase, so we assume that the stimulation of the alternative pathway is not related to drought stress resistance; rather, the function of the alternative pathway is to balance carbon metabolism and electron transport in a response to a changing environment.

关键词： alternative oxidase (AOX) alternative respiration 2,6-dichloro-phenol indophenol (DCPIP) maize osmotic stress sugars uncoupler.

Imaging techniques used for the real-time assessment of angiogenesis in digestive cancers

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World Journal of Gastroenterology 2011年第1期17卷 7-8页

作者： Adrian sǎftoiu peter Vilmann Research Center of Gastroenterology and Hepatology Gastroenterology DepartmentUniversity of Medicine and Pharmacy CraiovaCraiovaDolj200349Romania Department of surgical Gastroenterology Copenhagen University Hospital HerlevEndoscopic Unit at Gentofte Hospital2900 HellerupDenmark

Angiogenesis has a critical role in primary tumor growth and the development of *** angiogenesis inhibitors were recently developed,being a very attractive target for digestive tumor ***,individualized therapy should not only be based on the pre-treatment imaging evaluation,but also on sensitive monitoring of microvascular changes during ***-of-theart imaging techniques have the potential to visualize and characterize angiogenesis,although the technology and methodologies employed are recent and need further *** aim of this series of reviews was to analyze and enhance current knowledge and future perspectives about the real-time assessment of angiogenesis in digestive cancers,used for the longitudinal monitoring of the effects of chemo-radiotherapy(including anti-angiogenic therapies),as well as for the precise targeting of drugs through molecular-based drug-delivery systems.

关键词： Angiogenesis Digestive cancers Chemoradiotherapy

Projection on segre varieties and determination of holomorphic mappings between real submanifolds Dedicated to Professor sheng GONG on the occasion of his 75th birthday

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science China Mathematics 2006年第11期49卷 1611-1624页

作者： BAOUENDI M s EBENFELT peter ROTHsCHILD Linda P Department of Mathematics University of California at san Diego La JollaCA 92093-0112USA

It is shown that a germ of a holomorphic mapping sending a real-analytic generic submanifold of finite type into another is determined by its projection on the segre variety of the target manifold. A necessary and sufficient condition is given for a germ of a mapping into the segre variety of the target manifold to be the projection of a holomorphic mapping sending the source manifold into the target. An application to the biholomorphic equivalence problem is also given.

关键词： segre variety, generic submanifold, segre mappings, finite type, biholomorphic equivalence.

Less common neoplasms of the pancreas

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World Journal of Gastroenterology 2006年第20期12卷 3180-3185页

作者： Abby L Mulkeen peter s Yoo Charles Cha Department of surgery Yale University school of Medicine New HavenCT and the VACT Healthcare SystemWest HavenCT330 Cedar StreetLH 118PO Box 208062New HavenCT06520-8062United States

Recently, there has been an increased recognition of neoplasms of the pancreas other than ductal adenocarcinorna. Although not as well studied or characterized as pancreatic adenocarcinorna there are many distinct lesions which exhibit diverse biological behaviors and varying degrees of malignancy. These lesions include： endocrine neoplasms, cystic tumors, solid pseudopapillary tumors, acinar cell carcinoma, squamous cell carcinoma, primary lymphoma of the pancreas, and metastatic lesions to the pancreas. These less common neoplasms are being diagnosed more frequently as the number and sensitivity of diagnostic imaging studies increase. This review article discusses the clinical course, diagnosis, and treatment of these less common, but quite relevant, neoplasms of the pancreas.

关键词： Pancreas Neoplasms Ductal adenocarcinoma

Cancer vaccines:shared tumor antigens return to the spotlight

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signal Transduction and Targeted Therapy 2020年第1期5卷 324-325页

作者： Lijin Li s.peter Goedegebuure William Gillanders Department of surgery Washington University School of MedicineSt LouisMOUSA The Alvin J.siteman Cancer Center at Barnes-Jewish Hospital and Washington University school of Medicine St LouisMOUSA

sahin et *** reported interim data from a phase 1 clinical trial(NCT02410733)treating melanoma patients with a RNAlipoplex vaccine(RNA-LPX),targeting melanoma TAA.1 The trial is a multicenter,non-randomized,open-label,dose-escalation trial designed to evaluate the safety and tolerability of BNT111 targeting four melanoma TAA(NY-EsO-1,MAGE-A3,tyrosinase,and TPTE).secondary endpoints include vaccine-induced immune responses and clinical response of patients with measurable disease.

关键词： vaccine melanoma clinical

Absolute characterization of high numerical aperture microscope objectives utilizing a dipole scatterer

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Light(science & Applications) 2021年第12期10卷 2342-2348页

作者： Jörg s.Eismann Martin Neugebauer Klaus Mantel peter Banzer Institute of Physics University of GrazNAWI GrazUniversitätsplatz 58010 GrazAustria Max Planck Institute for the science of Light Staudtstr.291058 ErlangenGermany Institute of Optics Information and PhotonicsUniversity Erlangen-NurembergStaudtstr.7/B291058 ErlangenGermany

Measuring the aberrations of optical systems is an essential step in the fabrication of high precision optical *** a characterization is usually based on comparing the device under investigation with a calibrated reference ***,when working at the cutting-edge of technology,it is increasingly difficult to provide an even better or well-known reference *** this manuscript we present a method for the characterization of high numerical aperture microscope objectives,functioning without the need of calibrated reference *** technique constitutes a nanoparticle,acting as a dipole-like scatterer,that is placed in the focal volume of the microscope *** light that is scattered by the particle can be measured individually and serves as the reference wave in our *** the well-characterized scattered light as nearly perfect reference wave is the main idea behind this manuscript.

关键词： characterization scatter scattered

Polymodal roles of transient receptor potential channels in the control of ocular function

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Eye and Vision 2015年第1期2卷 53-62页

作者： peter s Reinach Weiwei Chen stefan Mergler school of Ophthalmology and Optometry Wenzhou Medical UniversityWenzhouZhejiang 325027P.R.China Charité-Universitätsmedizin Berlin Campus Virchow-KlinikumKlinik für AugenheilkundeAugustenburger Platz 1D-13353 BerlinGermany

Maintenance of intracellular Ca^(2+)levels at orders of magnitude below those in the extracellular environment is a requisite for preserving cell *** channels contribute to such control through modulating their time-dependent opening and closing *** regulation requires Ca^(2+)to serve as a second messenger mediating receptor control of numerous life-sustaining *** receptor potential(TRP)channels signal transduce a wide variety of different sensory stimuli to induce responses modulating cellular *** channels are non-selective cation channels with variable Ca^(2+)selectivity having extensive sequence *** constitute a superfamily made up of 28 different members that are subdivided into 7 different subfamilies based on differences in sequence *** of these TRP channel isotypes are expressed in the eye and localized to both neuronal and non-neuronal cell *** activation generates intracellular Ca^(2+)transients and other downstream-linked signalling events that affect numerous responses required for visual *** there is an association between changes in functional TRP expression in various ocular diseases,there are efforts underway to determine if these channels can be used as drug targets to reverse declines in ocular *** review here our current knowledge about the expression,function and regulation of TRPs in different eye tissues in health and ***,some of the remaining hurdles are described to developing safe and efficacious TRP channel modulators for use in a clinical setting.

关键词： Transient receptor potential ion channels Calcium Retina Cornea Uvea Lens