检索结果-南通市图书馆

Functional Magnetic Resonance Imaging Studies on Dopamine Receptor in Awake Normal and Parkinsonian Rhesus Monkeys

在线全文

学校读者我要写书评

暂无评论

Functional Magnetic Resonance Imaging Studies on Dopamine Re...

蝴蝶在生境和生物小区之间的移位伴随着对外来蜜源的利用(英文)

首届全国功能神经影像学和神经信息学研讨会

作者： Anders Andersen peter hardy Don Gash Department of Anatomy ＆ Neurobiology Morris K. Udall Parkinson Disease Research Center of Excellence Magnetic Resonance Imaging and Spectroscopy Center College of Medicine University of Kentucky Lexington KY 40536 4. Shandong University College of Medicine Jinan 250012 China. ) Department of Anatomy ＆ Neurobiology

＜正＞ Functional magnetic resonance imaging （fMRI） is increasingly recognized as being a non-invasive way to perform pharmacological investigations in experimental animal models and patients with neurotransmitter deficits such as in Parkinson’s disease （PD）. Previously, we have demonstrated in normal rhesus monkeys that pharmacological MRI （phMRI, i. e. functional MRI using drugs to evoke CNS responses） can be used to map age-associated changes in the nigrostriatal system following dopaminergic stimulation （NeuroImage 14: 1159 ?1167, 2001）. In the present study, phMRI was used to map dopamine （DA） receptor-mediated neuronal activity, specifically the D1 and D2 receptors in the basal ganglia of hemiparkinsonian rhesus monkeys. Twelve female rhesus monkeys rendered hemiparkinsonian via unilateral infusion of MPTP into the right carotid artery were used in this study. Three sec and age-matched normal controls were used for comparison. Apomor-phine, a mixed D1/D2 receptor agonist, evoked strong activations seen in the MPTP-lesoned putamen and substantia nigra. In parallel, a significant increase in movement speed was seen in these animals, as quantified using an automated video -tracking system. In normal monkeys, apomorphine evoked a small deactivation in the putamen, while no changes were seen in the SN. Accordingly, motor speed remained unchanged compared to baseline levels, in response to apomorphine challenge. Results suggest that phMRI is capable to detect MPTP-induced changes in the basal ganglia with dopaminergic stimulation and also prove that phMRI may be a potential powerful tool for Parkinson’s disease research in human.

关键词： Functional magnetic resonance imaging Dopamine receptor Parkinson disease Monkey

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

动物学报 2008年第1期54卷 77-83页

作者： peter B. hardy Roger L. H.DENNIS 81 Winstanley Road Sale Cheshire M33 2ATUK. NERC Centre for Ecology and Hydrology Monks Wood Abbots Ripton HuntingdonCambridgeshire PE28 2LS UK Institute for Environment Sustainability and Regeneration Mellor BuildingStaffordshire UniversityCollege RoadStoke onTrent ST4 2DE UK.

在发育成熟的温带环境中,植食性昆虫群落能迅速适应引入植物并将其作为幼虫的食物和花蜜。我们研究了经过森林砍伐的热带环境中蝴蝶对利用引入植物作为蜜源植物的适应快慢程度,并研究了蝴蝶-显花植物在新的生物小区中出现的范围,发现蝴... 详细信息

在发育成熟的温带环境中,植食性昆虫群落能迅速适应引入植物并将其作为幼虫的食物和花蜜。我们研究了经过森林砍伐的热带环境中蝴蝶对利用引入植物作为蜜源植物的适应快慢程度,并研究了蝴蝶-显花植物在新的生物小区中出现的范围,发现蝴蝶对引入显花植物的利用和探访多于本地植物,这与引入植物在调查地点、生物小区和植物丰度中的普遍性有关。此外,取食花蜜的蝴蝶和显花植物与正在形成的的生物小区有关,例如路边、农田、集约耕地以及花园。在这些新生物小区中,引入植物很重要,因为它们为蝴蝶提供了蜜源。

关键词：菲律宾生境花蜜开花植物森林砍伐资源蝴蝶群落

Biophysics inspired artificial intelligence for colorectal cancer characterization

在线全文

学校读者我要写书评

暂无评论

Artificial Intelligence in Gastroenterology 2021年第3期2卷 77-84页

作者： Niall P hardy Jeffrey Dalli Pól Mac Aonghusa peter M Neary Ronan A Cahill UCD Centre for Precision Surgery Dublin 7 D07 Y9AWIreland IBM Research IBM Research IrelandDublin 15 D15 HN66Ireland Department of Surgery University Hospital WaterfordUniversity College CorkWaterford X91 ER8EIreland Department of Surgery Mater Misericordiae University Hospital(MMUH)Dublin 7Ireland

Over the last ten years artificial intelligence(AI)methods have begun to pervade even the most common everyday tasks such as email filtering and mobile *** the necessary quality and safety standards may have understandably slowed the introduction of AI to healthcare when compared with other industries,we are now beginning to see AI methods becoming more available to the clinician in select *** this paper we discuss current AI methods as they pertain to gastrointestinal procedures including both gastroenterology and gastrointestinal *** current state of the art for polyp detection in gastroenterology is explored with a particular focus on deep leaning,its strengths,as well as some of the factors that may limit its application to the field of *** use of biophysics(utilizing physics to study and explain biological phenomena)in combination with more traditional machine learning is also discussed and proposed as an alternative approach that may solve some of the challenges associated with deep *** and present uses of biophysics inspired AI methods,such as the use of fluorescence guided surgery to aid in the characterization of colorectal lesions,are used to illustrate the role biophysicsinspired AI can play in the exciting future of the gastrointestinal proceduralist.

关键词： Gastroenterology Artificial intelligence Gastrointestinal surgery Deep learning Biophysics Machine learning

Family tree and population: Distinction and similarity of the analysis on example of hemophilia

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Natural Science 2013年第9期5卷 979-986页

作者： Andrey N. Volobuev peter I. Romanchuk Vladimir K. Malishev Samara State Medical University Samara Russia

On the basis of hardy-Weinberg law the distinction in the philosophy of the description of a family tree and a population is considered. With the help of introduction of the equivalent constant mutagen factor both in a family tree and in a population, the analysis of hemophilia is led. Influence of selection at presence of hemophilia is considered. On the basis of idea of Danforth and Haldane about the balance mutagenesis and selection at presence of hemophilia, the inter-relation of selection parameter and the equivalent constant mutagen factor is found. It is shown, that dynamics of development of hemophilia in a family tree and in population are similar.

关键词： Alleles Equivalent Constant Mutagen Factor Family Tree Population Hemophilia Balance of Selection and Mutagenesis

About one form of writing of the hardy-Weinberg law

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Natural Science 2013年第6期5卷 724-728页

作者： Andrey N. Volobuev peter I. Romanchuk Vladimir K. Malishev Samara State Medical University Samara Russia

On the basis of the hardy-Weinberg law written down for a continuous scale of alternation of generations, populating dynamics of genome is considered at absence of mutagen influence and at presence of the mutagen factor of stochastic character. Influence of the stochastic mutagen factor as cancerogenes on the population is shown. In the countries with the homogeneous population and advanced medicine, it inevitably results in growth of death rate of the population from?newgrowths to proportional a root square from time of a life of the population. The carried out research allows estimate a level of the population condition in the country from the point of view of health.

关键词： Stochastic Mutagen Factor Newgrowths Allele Alternation of Generations

Genetic association of rs7754840 and rs7756992 polymorphisms in the CDKAL1 gene and gestational diabetes mellitus in selected Filipino pregnant women

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian pacific Journal of Reproduction 2021年第4期10卷 155-161页

作者： Maria Ruth B.Pineda-Cortel Karlo Baybayan peter Louie Bello Latiffa Lois Camenforte Stefany Jane Ching Kathleen Conti Jeremiah Jose Ignacio Jiovanni Diaz Adrian Villavieja Jefferyl Kae Pandac Emilyn U.Alejandro Department of Medical Technology Faculty of PharmacyUniversity of Santo TomasManilaPhilippines The Graduate School University of Santo TomasManilaPhilippines Institute of Clinical Laboratory Sciences Silliman UniversityDumaguete CityPhilippines Research Center for the Natural and Applied Sciences University of Santo TomasManilaPhilippines Department of Integrative Biology and Physiology University of MinnesotaUSA

Objective:To investigate the possible association between rs7754840 and rs7756992 polymorphisms of CDKAL1 gene and susceptibility to gestational diabetes mellitus(GDM)in a Filipino pregnant ***:A total of 101 patients with GDM and 99 women without GDM were *** CDKAL1 gene single nucleotide polymorphisms(SNPs),namely rs7754840 and rs7756992,were genotyped by using TaqMan allelic discrimination ***-Whitney U test,median and interquartile range were used to describe physical and biochemical *** differences in the genotype and allele distribution of the target genetic variants among the two groups of participants were assessed by using Chi-square *** to hardy-Weinberg equilibrium was tested prior to conducting further *** logistic regression model was used to investigate the effects of the genotype models on GDM ***:There was no observed correlation between the genotypes of the rs7754840 SNP and oral glucose tolerance test ***,there was no significant association between genetic models of the rs7754840 SNP and GDM risk(additive OR 1.43,95%CI 0.82-2.50,P=0.21;dominant OR 1.21,95%CI 0.57-2.59,P=0.62;recessive OR 1.63,95%CI 0.86-3.09,P=0.13).Conclusions:The results of this study suggest no association between CDKAL1 gene variant rs7754840 and GDM development in Filipino pregnant *** studies with a larger population should be performed to validate our findings.

关键词： Gestational diabetes mellitus GDM Single nucleotide polymorphism SNP Genetic association rs7756992 rs7754840 CDKAL1 Filipino pregnant women

托马斯·哈代《声音》——抒情诗的叙事学分析

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

曲靖师范学院学报 2018年第1期37卷 1-5页

作者：彼得.霍恩谭君强汉堡大学英文系汉堡20146 云南大学文学院云南昆明650091

本文实践叙事学研究以阐明《声音》所牵涉的时间结构,并解释其功能。两个叙述序列的内在联系,即一方面按时间顺序进程展开的对过去爱情关系的回忆,这一关系的疏远和最终丧失;另一方面,则是在反向时间顺序的想象中重述对这一回忆的体验,... 详细信息

本文实践叙事学研究以阐明《声音》所牵涉的时间结构,并解释其功能。两个叙述序列的内在联系,即一方面按时间顺序进程展开的对过去爱情关系的回忆,这一关系的疏远和最终丧失;另一方面,则是在反向时间顺序的想象中重述对这一回忆的体验,追寻爱情关系从最初的幸福时光到逐渐恶化的发展。两个序列以时态、表现模式和它们在诗歌背景中的位置而加以区分:重新找回并浓缩的过去的故事镶嵌在眼下的叙述中,成为一个正在进行的回忆过程。诗歌的事件结构也是复杂的,两个序列都有否定性的事件。试图恢复幸福的过去,作为一个渴望中的有意义的积极转折,在失望和沮丧中结束,结果,回忆的过程引起抒情人更强烈地意识到他现在的凄凉和衰落。对失望和自我意识的强调可以归类为现代主义的特征。

关键词：跨学科叙事学框架脚本事件现代主义

华人GSTM1,CYP 1A1 与 2E1 和APOE等等位基因的基因型

在线全文

学校读者我要写书评

暂无评论

肿瘤 1998年第1期18卷 17-20页

作者：瞿永华石于波钟礼杰孙喜文孙璐林英姬程家蓉戴旭东项永兵高玉堂上海市肿瘤研究所哈尔滨医科大学肿瘤研究所

目的探讨华人ＧＳＴＭ１、ＣＹＰ１Ａ１与２Ｅ１，和ＡｐｏＥ等等位基因的基因型，将有助于研究肿瘤病因，环境有害物和机体的相互作用，以及药物代谢。方法收集９５例上海和８９例哈尔滨正常女性的血液，提取ＤＮＡ，作ＣＹＰ１Ａ１、... 详细信息

目的探讨华人ＧＳＴＭ１、ＣＹＰ１Ａ１与２Ｅ１，和ＡｐｏＥ等等位基因的基因型，将有助于研究肿瘤病因，环境有害物和机体的相互作用，以及药物代谢。方法收集９５例上海和８９例哈尔滨正常女性的血液，提取ＤＮＡ，作ＣＹＰ１Ａ１、２Ｅ１，ＧＳＴＭ１和ＡｐｏＥ等基因型的分析。结果ＧＳＴＭ１缺失占５２％。ＣＹＰ１Ａ１第７外显子Ａ┐Ｇ突变型纯合子（ｍｍ）占３．９％，突变型等位基因占２２．３％。ＣＹＰ２Ｅ１５′端调控区Ｃ┐Ｔｍｍ占１．６％，突变型等位基因占２３．６％；第六内含子Ｔ┐Ａｍｍ占５．１％，突变型等位基因占２６．４％。ＡｐｏＥ的ε２占８．４％，ε４占９．０％。２５０例ＣＹＰ２Ｄ６中仅１例为２Ｄ６Ａ杂合子，其余都是野生型纯合子。结论这些基因型的频率和等位基因分布在上海和哈尔滨人群中无差异。

关键词：等位基因基因型华人肿瘤发生