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股市晴雨表

作者：威廉·彼得·汉密尔顿(William peter hamilton)

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圣天秤星

圣天秤星

作者： (英)彼得·汉密尔顿(peter F. hamilton)

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圣天秤星

Cost-effectiveness of Crohn's disease post-operative care

2019年

作者： (英) 彼得·汉密尔顿

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World Journal of Gastroenterology 2016年第14期22卷 3860-3868页

作者： Emily K Wright Michael A Kamm peter Dr Cruz Amy L hamilton Kathryn J Ritchie Sally J Bell Steven J Brown William R Connell Paul V Desmond Danny Liew Department of Gastroenterology St Vincent's Hospital University of Melbourne Fitzroy VIC 3065 Melbourne Australia Imperial College London SW7 2AZ United Kingdom Melbourne EpiCentre University of Melbourne and Melbourne Health Parkville VIC 3010 Melbourne Australia

AIM: To define the cost-effectiveness of strategies, including endoscopy and immunosuppression, to prevent endoscopic recurrence of Crohn’s disease following intestinal ***: In the “POCER” study patients undergoing intestinal resection were treated with post-operative drug therapy. Two thirds were randomized to active care (6 mo colonoscopy and drug intensification for endoscopic recurrence) and one third to drug therapy without early endoscopy. Colonoscopy at 18 mo and faecal calprotectin (FC) measurement were used to assess disease recurrence. Administrative data, chart review and patient questionnaires were collected prospectively over 18 ***: Sixty patients (active care n = 43, standard care n = 17) were included from one health service. Median total health care cost was $6440 per patient. Active care cost $4824 more than standard care over 18 mo. Medication accounted for 78% of total cost, of which 90% was for adalimumab. Median health care cost was higher for those with endoscopic recurrence compared to those in remission [$26347 (IQR 25045-27485) vs $2729 (IQR 1182-5215), P < 0.001]. FC to select patients for colonoscopy could reduce cost by $1010 per patient over 18 mo. Active care was associated with 18% decreased endoscopic recurrence, costing $861 for each recurrence ***: Post-operative management strategies are associated with high cost, primarily medication related. Calprotectin use reduces costs. The long term cost-benefit of these strategies remains to be evaluated.

关键词： Crohn’ s disease Post-operative Health economics Health care cost Biologics

Counter Rotating Fans- An Aircraft Propulsion for the Future?

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Journal of Thermal Science 2003年第2期12卷 97-103页

作者： peter Schimming DLR Institute for Propulsion TechnologyCologneGermany

In the mid seventies a new propulsor for aircraft was designed and investigated - the so-called PROPFAN. With regard to the total pressure increase, it ranges between a conventional propeller and a turbofan with very high bypass ratio. This new propulsion system promised a reduction in fuel consumption of 15 to 25% compared to engines at that time.A lot of propfans (hamilton Standard, USA) with different numbers of blades and blade shapes have been designed and tested in wind tunnels in order to find an optimum in efficiency, Fig.1. Parallel to this development GE, USA, made a design of a counter rotating unducted propfan, the so-called UDF, Fig.2. A prototype engine was manufactured and investigated on an in-flight test bed mounted at the MD82 and the B727. Since that time there has not been any further development of propfans (except AN 70 with NK 90-engine, Ukraine, which is more or less a propeller design) due to relatively low fuel prices and technical obstacles. Only technical programs in different countries are still going on in order to prepare a data base for designing counter rotating fans in terms of aeroacoustics, aerodynamics and aeroelasticities. In DLR, Germany, a lot of experimental and numerical work has been undertaken to understand the physical behaviour of the unsteady flow in a counter rotating fan.

关键词： propfan counter rotation unsteady aerodynamics active noise control aeroelasticities.

Phosphorus Use Efficiency of Bio-Based Fertilizers:Bioavailability and Fractionation

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Pedosphere 2016年第3期26卷 310-325页

作者： Céline VANEECKHAUTE Joery JANDA peter A.VANROLLEGHEM Filip M.G.TACK Erik MEERS Laboratory for Analytical and Applied Ecochemistry Faculty of Bioscience EngineeringGhent University model EAU Département de Génie Civil et de Génie des EauxFaculté des Sciences et de GénieUniversité Laval

Although to date some technologies producing bio-based phosphorus(P) fertilizers have been proposed and implemented, the efficient use of the recovered products is still limited due to legislative constraints and lack of insights in the P release with time and in the corresponding mechanisms. The aim of this work was to evaluate the fertilizer performance in terms of P release and use efficiency of recovered struvite, FePO_4-sludge, digestate, and animal manure as compared to fossil reserve-based mineral triple superphosphate(TSP). First, product physicochemical characteristics and P fractions in the context of European fertilizer legislation were assessed. Next, a controlled greenhouse experiment was set up to evaluate plant reactions as well as changes of P availability in a sandy soil with high P status and a Rheinsand soil with low P status. Soil P fractions were determined in the extracts with water, ammonium lactate and CaCl_2, and in soil solution sampled with Rhizon soil moisture samplers. Based on all results, it is worth conducting long-term field trials to evaluate the P release effect of struvite and digestate as compared to animal manure and TSP on different soil types with varying P status. These products showed promise as sustainable substitutes for conventional P fertilizers and could contribute to a more efficient use of P in agriculture. A refined classification of P application standards/recommendations in terms of soil P status, soil texture, and fertilizer characteristics, next to the crop P demand, is recommended. Moreover, the additional use of Rhizon samplers for determination of direct available P, including dissolved organic P, is proposed for better understanding and categorization of different P fertilizers in environmental and fertilizer legislations.

关键词： chemical soil analysis digestate nutrient recovery Rhizon samplers struvite

An alternative approach for sustainable sheep meat production:implications for food security

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Journal of Animal Science and Biotechnology 2021年第2期12卷 791-805页

作者： Eric N.Ponnampalam Matthew I.Knight peter J.Moate Joe L.Jacobs Animal Production Sciences Agriculture Victoria ResearchDepartment of JobsPrecincts and RegionsBundooraVIC 3083Australia Animal Production Sciences Agriculture Victoria ResearchDepartment of JobsPrecincts and RegionsHamiltonVIC 3300Australia Animal Production Sciences Agriculture Victoria ResearchDepartment of JobsPrecincts and RegionsEllinbankVictoria 3821Australia Centre for Agricultural Innovation School of Agriculture and FoodFaculty of Veterinary and Agricultural SciencesThe University of MelbourneMelbourneVictoria 3010Australia

Background:A pelleted diet containing camelina hay(CAMH)or camelina meal(CAMM)as a supplement along with a control pellet(CONT)diet formulated with commonly available feeds during summer was used to investigate an alternative pathway for sustainable meat *** meat production was based on a simple estimation of income from meat produced versus feed costs if animals were fed for an extended period over summer compared to early slaughter at the beginning of *** maternal composite wether lambs(Composite)based on Coopworth genetics and 80 pure Merino wether yearlings were divided into 10 groups within breed(n=8)using stratified randomisation based on *** 1 week of adaptation to experimental diets,animals were fed experimental diets for up to10 ***:Animals were slaughtered after either 8,9 or 10 weeks of full feeding when the average liveweight of diet/genetic combination reached a weight appropriate for either‘heavy lamb’or‘heavy hogget’production,which occurred between 8 and 10 weeks of full *** was no diet×breed interactions except for dressing percentage(DP),where Composite lambs fed the CAMH diet had the greatest DP(48.1±0.35)and the Merino yearlings fed the CAMM diet the lowest DP(45.8±0.33).Composite lambs gained 17.6–20.3 kg and Merino yearlings gained 10.7–12.9 kg *** on their DP,this resulted in the production of approximately 8.3–9.5 kg additional carcass weight in Composites and 4.9–5.7 kg in Merinos,which in turn produced greater profit per Composite lamb and a small profit per Merino ***:Composite lambs fed CAMM and CAMH had 5%greater carcass weights at slaughter compared to the CONT group,but dietary treatments did not change carcass weight of Merino yearlings at *** extended feeding approach offered the producer an estimated economic gain of AUD$20.00 to$25.00 when yearly average prices were used(Method 1)and AUD$40.00 to$47.70 when pre-and post-summer

关键词： Animal welfare Environmental sustainability Global demand Livestock Sheep meat Summer feeding

Adaptation in brain structure and respiratory and olfactory structures across environmental gradients in African and North American muroid rodents

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Integrative Zoology 2024年第1期19卷 165-181页

作者： peter J.TAYLOR Aluwani NENGOVHELA Christiane DENYS Graham R.SCOTT Catherine M.IVY Department of Zoology School of Natural and Mathematical SciencesUniversity of VendaThohoyandouSouth Africa Afromontane Unit Department of Zoology and EntomologyUniversity of the Free StatePhuthaditjhabaSouth Africa Department of Mammalogy National MuseumBloemfonteinSouth Africa Institut de Systématique EvolutionBiodiversité(ISYEB)Muséum National d’Histoire NaturelleCNRSSorbonne UniversitéEPHEUniversitéDes AntillesParisFrance Department of Biology McMaster UniversityHamiltonOntarioCanada Guglielmo and Shoemaker Labs Advanced Facility for Avian ResearchUniversity of Western OntarioLondonOntarioCanada

Morphometric studies of 3D micro CT-scanned images can provide insights into the evolution of the brain and sensory structures but such data are still scarce for the most diverse mammalian order of *** reviewed and new data,we tested for convergence to extreme aridity and high elevation in the sensory and brain morphology of rodents,from morphometric data from micro-CT X-ray scans of 174 crania of 16 species of three distantly re-lated African murid(soft-furred mice,Praomyini,laminate-toothed rats,Otomyini,and gerbils,Gerbillinae)clades and one North American cricetid(deer mice and white-footed mice,Peromyscus)*** studies demon-strated convergent evolution acting on the oval window area of the cochlea(enlarged in extremely arid-adapted species of Otomyini and Gerbillinae)and on endocranial volume(reduced in high elevation taxa of Otomyini and Peromyscus).However,contrary to our predictions,we did notfind evidence of convergence in brain struc-ture to aridity,or in the olfactory/respiratory system(turbinate bones)to high *** structure differed,particularly in the petrosal lobules of the cerebellum and the olfactory bulbs,between Otomyini and Gerbillinae,with extreme arid-adapted species in each clade being highly divergent(not convergent)from other species in the same *** observed greater“packing”of the maxillary turbinate bones,which have important respiratory functions,in Peromyscus mice from high and low elevations compared to the high-elevation African Praomyini,but more complex patterns within Peromyscus,probably related to trade-offs in respiratory physiology and heat exchange in the nasal epithelium associated with high-elevation adaptation.

关键词： 3D morphometrics Africa brain size North America Rodentia sensory evolution

Apple dwarfing rootstocks exhibit an imbalance in carbohydrate allocation and reduced cell growth and metabolism

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Horticulture Research 2017年第1期4卷 311-323页

作者： Toshi M Foster peter A McAtee Chethi N Waite Helen L Boldingh Tony K McGhie The New Zealand Institute for Plant and Food Research Limited Palmerston North4474New Zealand The New Zealand Institute for Plant and Food Research Limited Auckland1142New Zealand The New Zealand Institute for Plant and Food Research Limited Hamilton3240New Zealand

Apple dwarfing rootstocks cause earlier shoot termination and reduced root and shoot *** identify physiological factors responsible for rootstock-induced growth restriction,we compared vascular-enriched gene expression between two dwarfing rootstocks(‘M27’and‘M9’)and the vigorous rootstock‘M793’using RNA sequencing and quantitative reverse transcriptase *** expressed genes common to both dwarfing rootstocks belonged to five main biological processes:(1)primary metabolism,(2)cell wall synthesis and modification,(3)secondary metabolism,(4)hormone signalling and response and(5)redox *** promoting the biosynthesis of amino acids,lipids and cell walls were downregulated in dwarfing rootstocks,whereas genes promoting the breakdown of these compounds were *** only exception to this trend was the upregulation of starch synthesis genes in dwarfing ***-structural carbohydrate analysis demonstrated that starch concentrations in‘M9’roots,stems and grafted‘Royal Gala’(‘RG’)scions were double that of equivalent tissues from‘RG’homo-grafted trees(‘RG’/‘RG’).Fructose and glucose concentrations were much lower in all three tissues of the‘RG’/‘M9’***,these data indicate that dwarfing rootstocks are in a state of sugar depletion and reduced cellular activity despite having large starch *** significant finding was the over-accumulation of flavonoids and the downregulation of auxin influx transporters MdAUX1 and MdLAX2 in dwarfing *** propose that both factors reduce polar auxin *** results of this study contribute novel information about the physiological state of dwarfing rootstocks.

关键词： walls roots dwarf