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Skeletal muscle as a molecular and cellular biomarker of disease progression in amyotroph.c lateral sclerosis:a narrative review

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Neural Regeneration Research 2024年第4期19卷 747-753页

作者： peter h.King Department of Neurology and Center for Neurodegeneration and Experimental Th.rapeutics The University of Alabama at BirminghamBirminghamALUSA Birmingh.m Veterans Affairs Medical Center BirminghamALUSA

Amyotroph.c lateral sclerosis is a fatal multisystemic neurodegenerative disease with.motor neurons being a primary *** progressive weakness is a h.llmark feature of amyotroph.c lateral sclerosis,th.re is considerable h.terogeneity,including clinical presentation,progression,and th. underlying triggers for disease *** on longitudinal studies with.families h.rboring amyotroph.c lateral sclerosis-associated gene mutations,it h.s become apparent th.t overt disease is preceded by a prodromal ph.se,possibly in years,wh.re compensatory mech.nisms delay symptom *** 85-90%of amyotroph.c lateral sclerosis is sporadic,th.re is a strong need for identifying biomarkers th.t can detect th.s prodromal ph.se as motor neurons h.ve limited capacity for *** Food and Drug Administration-approved th.rapies work by slowing th. degenerative process and are most effective early in th. *** muscle,including th. neuromuscular junction,manifests abnormalities at th. earliest stages of th. disease,before motor neuron loss,making it a promising source for identifying biomarkers of th. prodromal *** accessibility of muscle th.ough.biopsy provides a lens into th. distal motor system at earlier stages and in real *** advent of“omics”tech.ology h.s led to th. identification of numerous dysregulated molecules in amyotroph.c lateral sclerosis muscle,ranging from coding and non-coding RNAs to proteins and *** tech.ology h.s opened th. door for identifying biomarkers of disease activity and providing insigh. into disease mech.nisms.A major ch.llenge is correlating th. myriad of dysregulated molecules with.clinical or h.stological progression and understanding th.ir relevance to presymptomatic ph.ses of *** are two major goals of th.s *** first is to summarize some of th. biomarkers identified in h.man amyotroph.c lateral sclerosis muscle th.t h.ve a clinicopath.logical correlation with.disease activi

关键词： amyotroph.c lateral sclerosis biomarkers clinicopath.logical correlation disease progression muscle biomarkers neurogenic atroph. neuromuscular junction non-coding RNAs presymptomatic stages skeletal muscle SOD1G93A mouse model

Immunological Exploration of h.licobacter pylori Serotype O_(2) O-Antigen by Using a Synth.tic Glycan Library

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Ch.nese Journal of Ch.mistry 2024年第3期42卷 243-251页

作者： Ming Zh.o Guangzong Tian Ch.njun Qin Xiaopeng Zou peter h. Seeberger Jing h. Jian Yin Key Laboratory of Carboh.drate Ch.mistry and Biotech.ology Ministry of EducationSchool of Biotechnology & School of Life Sciences and Health EngineeringJiangnan UniversityLihu Avenue 1800WuxiJiangsu214122 China Biomolecular Systems Department Max Planck Institute of Colloids and InterfacesAm Mühlenberg 1Potsdam14476 Germany Wuxi Sch.ol of Medicine Jiangnan UniversityLihu Avenue 1800WuxiJiangsu214122 China

h.licobacter pylori(***)infection is a th.eat to h.man *** lipopolysacch.ride(LPS)O-antigen h.lds promise for developing *** is meaningful to explore th. immunological activity of oligosacch.rides with.different length. and framesh.fts for antigen ***,a glycan library of *** O2 O-antigen containing eigh. fragments is *** screening with.*** O2 LPS sera and patients’sera by glycan microarray,th. disacch.ride h.O2G-2b and trisacch.ride h.O2G-3a sh.w strong antigenicity and th.n are separately conjugated with.carrier protein *** glycoconjugates elicit a robust immunoglobulin G(IgG)immune response in *** anti-h.O2G-3a IgG antibodies possess a much.stronger binding affinity with.th. LPS and bacteria of *** O2 th.n th. anti-h.O2G-2b IgG *** is no cross-reaction between both.sera IgG antibodies with.LPS and bacteria of *** O1,O6,and *** results demonstrate th. trisacch.ride h.O2G-3a is a promising candidate for *** vaccine development.

关键词： Glycoconjugates h.licobacter pylori Immunology Microarrays O-antigen Oligosacch.rides

Assessment of four different dietary amino acid profiles recommended for ISA Brown layer h.ns: A validation study

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Animal Nutrition 2024年第2期17卷 438-446页

作者： Meh.i Togh.ani Sh.mil Macelline Juliano C.de Paula Dorigam peter V.Ch.ystal peter h.Selle Sonia Y.Liu Sch.ol of Life and Environmental Sciences Faculty of Science The University of Sydney Poultry Research.Foundation The University of Sydney Evonik Operations Gmbh

Th. current feeding study was designed to validate th. two dietary essential amino acid profiles(EAAP)establish.d based on linear broken-line(LBL) and quadratic broken-line(QBL) models, in a previous study, against Evonik(AMINOh.n) and breeder recommendations for ISA Brown layers for peak production(PP, 20 to 44 weeks of age), and post peak production(post PP, 44 to 75 weeks of age). Th. EAAP based on LBL models on average h.d 19.5% and 26.0% lower digestible AA(Lys, Met + Cys, Th., Trp, Ile and Val), th.n th. EAAP based on QBL models for PP and post PP, respectively. Th. EAAP based on AMINOh.n and breeder recommendation h.d lower digestible AA th.n QBL, and h.gh.r EAAP th.n LBL models for both.production ph.ses. At 20 weeks of age, 224 ISA Brown layer h.ns were weigh.d and randomly allocated to individual battery cages. Each.of th. four diets was replicated 8 times with.7 birds per replicate. Egg production was recorded daily, and egg weigh.s were measured at th. end of each.week. Feed consumption was measured at th. end of each.period. Th. egg production rate was not significantly affected by th. diets and remained at around 98.0%(PP) and 95.0%(post PP)(P > 0.05). Birds fed diets based on LBL recommendation consistently laid smaller eggs, resulting in a lower egg mass(59.8 vs. 62.0 g egg/h.n per day during PP, and 60.3 vs. 63.0 g egg/h.n per day during post PP; P h.d no significant effect on feed intake and body weigh.(P > 0.05). Th. h.gh.st feed conversion ratio(FCR) during PP(P = 0.067) and post PP(P h. birds offered diets based on LBL recommendation. In conclusion, all four EAAP tested in th.s study support an above average egg production rate. h.wever, th. EAAP based on LBL models may potentially decrease th. input feed cost per kilogram of eggs but are not set to optimise FCR and maximise egg mass.

关键词： Ideal amino acid profile Regression model Egg production Egg mass

Th. potential of glutamine supplementation in reduced-crude protein diets for ch.cken-meat production

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Animal Nutrition 2024年第3期18卷 49-56页

作者： peter h.Selle Sh.mil P.Macelline Meh.i Togh.ani Sonia Yun Liu Poultry Research.Foundation with.n th. University of Sydney CamdenNSW 2570Australia Sydney Sch.ol of Veterinary Science The University of SydneyCamdenNSW 2570Australia Sch.ol of Life and Environmental Sciences Faculty of ScienceThe University of SydneyCamdenNSW 2570Australia

Th.s review explores th. potential of including glutamine,a so-called non-essential amino acid,in th. formulation of reduced-crude protein(CP)diets for broiler *** is a precedent for benefits wh.n including glycine and serine in reduced-CP *** th.s is due to decreases in non-essential amino acid concentrations in reduced-CP diets—an unavoidable consequence of reducing CP with.ut amino acid *** situation for glutamine is complicated because analysed dietary concentrations are very rarely provided as standard assays do not differentiate between glutamine and glutamate and are reported on a combined basis as glutamic *** dietary requirement for glutamic acid is approximately 36.3 g/kg but it is increasingly unlikely th.t th.s requirement will be met as dietary CP levels are progressively *** is an abundant and versatile amino acid and constitutes 50.5 mg/g of wh.le-body ch.cken protein and is th. dominant free amino acid in systemic plasma wh.re it h.s been sh.wn to provide 22.6%(139.9 of 620.3μg/mL)of th. total in birds offered 215 g/kg CP,wh.at-based *** addition to dietary intakes,glutamine biosynth.sis is derived mainly from th. condensation of glutamate and ammonia(Nh.)catalysed by glutamine synth.tase,a reaction th.t is pivotal to Nh. *** and Nh. are converted to glutamine by ph.sph.te-dependent glutaminase in th. reciprocal reaction;th.s,glutamine and glutamate are interch.ngeable amino ***,th. rate of glutamine biosynth.sis may not be adequate in rapidly growing broiler ch.ckens and exogenous and endogenous glutamine levels are probably insufficient in birds offered reduced-CP *** many functional roles of glutamine,including Nh. detoxification and maintenance of acid-base h.meostasis,th.n become *** feeding studies were identified wh.re dietary glutamine supplementation,usually 10 g/kg,was evaluated in birds kept under th.rmoneutral ***

关键词： Broiler ch.cken Glutamate Glutamic acid Glutamine

h.(2)mediated mixed culture microbial electrosynth.sis for h.gh.titer acetate production from CO_(2)

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Environmental Science and Ecotech.ology 2024年第3期19卷 125-131页

作者： Yanh.ng Bian Aaron Leininger h.rold D.may Zh.yong Jason Ren Department of Civil and Environmental Engineering Princeton University86 Olden StPrincetonNJ08544United States Andlinger Center for Energy and th. Environment Princeton University86 Olden St.PrincetonNJ08544United States

Microbial electrosynth.sis(MES)converts CO_(2)into value-added products such.as volatile fatty acids(VFAs)with.minimal energy use,but low production titer h.s limited scale-up and *** electron transfer via h.(2)on th. MES cath.de h.s sh.wn a h.gh.r conversion rate th.n th. direct biofilm-based approach.as it is tunable via cath.de potential control and accelerates electrosynth.sis from CO_(2).h.re we report h.gh.acetate titers can be ach.eved via improved in situ h.(2)supply by nickel foam decorated carbon felt cath.de in mixed community MES *** concentration of 12.5 g L^(-1)was observed in 14 days with.nickel-carbon cath.de at a poised potential of-0.89 V(*** h.drogen electrode,Sh.),wh.ch.was much.h.gh.r th.n cath.des using stainless steel(5.2 g L^(-1))or carbon felt alone(1.7 g L^(-1))with.th. same projected surface area.A h.gh.r acetate concentration of 16.0 g L^(-1)in th. cath.de was ach.eved over long-term operation for 32 days,but crossover was observed in batch.operation,as additional acetate(5.8 g L^(-1))was also found in th. abiotic anode *** observed th. low Faradaic efficiencies in acetate production,attributed to partial h.(2)utilization for *** selective acetate production with.h.gh.titer demonstrated in th.s study sh.ws th. h.(2)-mediated electron transfer with.common cath.de materials carries good promise in MES development.

关键词： Microbial electrosynth.sis Indirect electron transfer CO_(2)electrolysis VFAs production

碰撞激活诱导的双势阱势能面可以实现9-甲基-8-氧鸟嘌呤-9-甲基腺嘌呤碱基对阳离子自由基的质子转移

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Ch.nese Journal of Ch.mical Ph.sics 2024年第2期37卷 330-340,I0022-I0039,I0104页

作者： may Myat Moe 刘剑波美国纽约城市大学皇后学院化学与生物化学系纽约11367 美国纽约城市大学研究生院纽约10016

8-氧鸟嘌呤(OG)是最常见的核碱基氧化损伤,它在复制过程中可以用h.ogsteen的模式与腺嘌呤(A)错误配对.0G.A碱基对不仅可以诱发G·C→T·A的颠换突变,而且由于OG的电离势和氧化电位低于天然DNA碱基更容易受到电离辐射和单电子氧化的影响... 详细信息

8-氧鸟嘌呤(OG)是最常见的核碱基氧化损伤,它在复制过程中可以用h.ogsteen的模式与腺嘌呤(A)错误配对.0G.A碱基对不仅可以诱发G·C→T·A的颠换突变,而且由于OG的电离势和氧化电位低于天然DNA碱基更容易受到电离辐射和单电子氧化的影响,本文报道了[9MOG·9MA]^(·+)碱華对阳离子自由基的形成.和碰撞诱导解离,该碱基对利用9-甲基8-氧鸟嘌呤(9MOG)和9-甲基腺嘌呤(9MA)模拟相对应的核苷酸.实验通过电喷雾产生Cu(Ⅱ)碱基复合物继之以氧化分离产生[9MOG·9MA]^(·+),并使用导向离子束串级质谱仪检测[9MOG·9MA]^(·+)的碰撞诱导解离、通过测量在不同碰撞能量下的解离产物和反应截面,可以得出[9MOG-h.+[9MA+h.^(+)(主要解离通道)和9MOG^(·+)+9MA(次要通道)的0 K解离阈能分别为1.8和1.65 eV.使用密度泛函理论对[9MOG·9MA]^(·+)的结构计算发现其所有重要构象都发生了质子转移生成[9MOG-h.^(·)·[9MA+h.^(+).另一方面,9MOG^(·+)+9MA的解离通道却需要9MOG^(·+)9MA作为中间体.看似矛盾的结果可以用碰撞活化后反应势能面上出现的双重势阱和由此触发的激发态质子转移平衡([9MOG-h.^(·)·[9MA+h.^(+))^(*)→←(9MOG6(·+)·9MA)^(*)来解释.本文实验和理论研究揭示了这种生物学上重要的非规范碱基对如何在氧化和电离损伤时发生解离.

关键词：碱基对阳离子自由基碰撞诱导解离碱基对内质子转移反应势能面电喷雾电离质谱导向离子束散射

Dual Additives for Stabilizing Li Deposition and SEI Formation in Anode-Free Li-Metal Batteries

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Energy & Environmental Materials 2024年第3期7卷 84-92页

作者： Baolin Wu Ch.nguang Ch.n Dmitri L.Danilov Zh.qiang Ch.n Ming Jiang Rüdiger-A.Eich.l peter h.L.Notten Forsch.ngszentrum Jülich.IEK-9) D-52425Jülich Germany RWTh.Aach.n University D-52074Aachen Germany LNM Institute of MechanicsChinese Academy of SciencesBeijing 100190China Sch.ol of Engineering Sciences University of Chinese Academy of SciencesBeijing 100049China Eindh.ven University of Tech.ology P.O.Box 5135600 MBEindhoven The Netherlands Sch.ol of Electronics and Information Institute of Carbon Neutrality and New EnergyHangzhou Dianzi UniversityHangzhou 310018China University of Tech.ology Sydney BroadwaySydney NSW 2007Australia

Anode-free Li-metal batteries are of significant interest to energy storage industries due to th.ir intrinsically h.gh.***,th. accumulative Li dendrites and dead Li continuously consume active Li during *** results in a sh.rt lifetime and low Coulombic efficiency of anode-free Li-metal *** effective electrolyte additives can improve th. Li deposition h.mogeneity and solid electrolyte interph.se(SEI)stability for anode-free Li-metal ***,we reveal th.t introducing dual additives,composed of LiAsF6 and fluoroeth.lene carbonate,into a low-cost commercial carbonate electrolyte will boost th. cycle life and average Coulombic efficiency of NMC‖Cu anode-free Li-metal *** NMC‖Cu anode-free Li-metal batteries with.th. dual additives exh.bit a capacity retention of about 75%after 50 cycles,much.h.gh.r th.n th.se with.bare electrolytes(35%).Th. average Coulombic efficiency of th. NMC‖Cu anode-free Li-metal batteries with.additives can maintain 98.3%over 100 *** contrast,th. average Coulombic efficiency with.ut additives rapidly decline to 97%after only 50 *** situ Raman measurements reveal th.t th. prepared dual additives facilitate denser and smooth.r Li morph.logy during Li *** dual additives significantly suppress th. Li dendrite growth.enabling stable SEI formation on anode and cath.de *** results provide a broad view of developing low-cost and h.gh.effective functional electrolytes for h.gh.energy and long-life anode-free Li-metal batteries.

关键词： anode-free lith.um metal battery dual additives in situ Raman Li growth SEI formation

Ultrafast magneto-optical dynamics in nickel(111)single crystal studied by th. integration of ultrafast reflectivity and polarimetry probes

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Ch.nese Ph.sics B 2024年第3期33卷 65-69页

作者：匡皓余军潇陈洁 h.E.Elsayed-Ali 李润泽 peter M.Rentzepis Sch.ol of Ph.sical Science and Tech.ology ShanghaiTech UniversityShanghai 201210China Center for Transformative Science ShanghaiTech UniversityShanghai 201210China Center for Ultrafast Science and Tech.ology Key Laboratory for Laser Plasmas (Ministry of Education)Collaborative Innovation Center of IFSA (CICIFSA)School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Department of Electrical and Computer Engineering Old Dominion UniversityNorfolkVirginia 23529USA Department of Electrical and Computer Engineering Texas A&M UniversityCollege StationTexas 77843USA

With.th. integration of ultrafast reflectivity and polarimetry probes,we observed carrier relaxation and spin dynamics induced by ultrafast laser excitation of Ni(111)single *** carrier relaxation time with.n th. linear excitation range reveals th.t electron-ph.non coupling and dissipation of ph.ton energy into th. bulk of th. crystal take tens of *** th. oth.r h.nd,th. observed spin dynamics indicate a longer time of about 120 *** furth.r understand h.w th. lattice degree of freedom is coupled with.th.se dynamics may require th. integration of an ultrafast diffraction probe.

关键词： ultrafast spin dynamics non-equilibrium dynamics multi-probe

Rbfox1 controls alternative splicing of focal adh.sion genes in cardiac muscle cells

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Journal of Molecular Cell Biology 2024年第1期16卷 54-65页

作者： peter Zorn Jaime Calvo Sánch.z Tala Alakh.as Barbara Sch.eier Mich.el Gekle Stefan h.ttelmaier Marcel Köh. Junior Group‘Non-coding RNAs and RBPs in h.man Diseases’ Medical FacultyUniversity of Halle–Wittenberg06120 Halle(Saale)Germany Julius Bernstein Institute of Ph.siology Medical FacultyUniversity of Halle–Wittenberg06112 Halle(Saale)Germany Institute of Molecular Medicine Medical FacultyUniversity of Halle–Wittenberg06120 Halle(Saale)Germany

Alternative splicing is one of th. major cellular processes th.t determine th. tissue-specific expression of protein ***,it remains ch.llenging to identify ph.siologically relevant and tissue-selective proteins th.t are generated by alternative ***,we investigated th. target spectrum of th. splicing factor Rbfox1 in th. cardiac muscle context in more *** using a combination of in silico target prediction and in-cell validation,we identified several focal adh.sion proteins as alternative splicing targets of *** focused on th. alternative splicing patterns of vinculin(metavinculin isoform)and paxillin(extended paxillin isoform)and identified both.as potential Rbfox1 *** analyses suggested th.t both.isoforms are promoted by Rbfox1 due to binding in th. *** adh.sions play an important role in th. cardiac muscle context,since th.y mainly influence cell sh.pe,cytoskeletal organization,and cell–matrix *** data confirmed th.t depletion of Rbfox1 ch.nged cardiomyoblast morph.logy,cytoskeletal organization,and multinuclearity after differentiation,wh.ch.migh. be due to ch.nges in alternative splicing of focal adh.sion ***,our results indicate th.t Rbfox1 promotes alternative splicing of focal adh.sion genes in cardiac muscle cells,wh.ch.migh. contribute to h.art disease progression,wh.re downregulation of Rbfox1 is frequently observed.

关键词： Rbfox1 alternative splicing focal adh.sion cardiac muscle cells