检索结果-南通市图书馆

Skeletal muscle as a molecular and cellular biomarker of disease progression in amyotrophic lateral sclerosis:a narrative review

引用

Neural Regeneration Research 2024年第4期19卷 747-753页

作者： peter h.king Department of Neurology and Center for Neurodegeneration and Experimental Therapeutics The University of Alabama at BirminghamBirminghamALUSA Birmingham Veterans Affairs Medical Center BirminghamALUSA

Amyotrophic lateral sclerosis is a fatal multisystemic neurodegenerative disease with motor neurons being a primary *** progressive weakness is a hallmark feature of amyotrophic lateral sclerosis,there is considerable heterogeneity,including clinical presentation,progression,and the underlying triggers for disease *** on longitudinal studies with families harboring amyotrophic lateral sclerosis-associated gene mutations,it has become apparent that overt disease is preceded by a prodromal phase,possibly in years,where compensatory mechanisms delay symptom *** 85-90%of amyotrophic lateral sclerosis is sporadic,there is a strong need for identifying biomarkers that can detect this prodromal phase as motor neurons have limited capacity for *** Food and Drug Administration-approved therapies work by slowing the degenerative process and are most effective early in the *** muscle,including the neuromuscular junction,manifests abnormalities at the earliest stages of the disease,before motor neuron loss,making it a promising source for identifying biomarkers of the prodromal *** accessibility of muscle through biopsy provides a lens into the distal motor system at earlier stages and in real *** advent of“omics”technology has led to the identification of numerous dysregulated molecules in amyotrophic lateral sclerosis muscle,ranging from coding and non-coding RNAs to proteins and *** technology has opened the door for identifying biomarkers of disease activity and providing insight into disease mechanisms.A major challenge is correlating the myriad of dysregulated molecules with clinical or histological progression and understanding their relevance to presymptomatic phases of *** are two major goals of this *** first is to summarize some of the biomarkers identified in human amyotrophic lateral sclerosis muscle that have a clinicopathological correlation with disease activi

关键词： amyotrophic lateral sclerosis biomarkers clinicopathological correlation disease progression muscle biomarkers neurogenic atrophy neuromuscular junction non-coding RNAs presymptomatic stages skeletal muscle SOD1G93A mouse model

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Kh型剪切调控蛋白:星形胶质细胞炎性细胞因子生成检测点

引用

神经损伤与功能重建 2012年第6期7卷 436-442,446页

作者： XUELIN LI WEI-JYE LIN ChING-YI ChEN YING SI XIAOWEN ZhANG LIANG LU ESThER SUSWAM LEI ZhENG peter h. king Department of Neurology University of Alabama Birmingham Alabama Departmentof Biochemistry University of Alabama Birmingham Alabama Department of Genetics Uni-versity of Alabama Birmingham Alabama Department of Cell Developmental and IntegrativeBiology University of Alabama Birmingham Alabama Department of Veterans Affairs Med-ical Center Birmingham Alabama Department of Neuroscience Mount Sinai School of Medi-cine New York New York

中枢神经系统(CNS)慢性炎性反应是许多神经退行性疾病和自身免疫性疾病的主要病理特点之一。作为免疫活性细胞,星形胶质细胞(Ast)在CNS炎性反应过程中发挥了重要作用。它可表达许多细胞因子,如肿瘤坏死因子-α(TNF-α)和白介素-1β(IL-1... 详细信息

中枢神经系统(CNS)慢性炎性反应是许多神经退行性疾病和自身免疫性疾病的主要病理特点之一。作为免疫活性细胞,星形胶质细胞(Ast)在CNS炎性反应过程中发挥了重要作用。它可表达许多细胞因子,如肿瘤坏死因子-α(TNF-α)和白介素-1β(IL-1β)等,这些细胞因子可直接或通过募集免疫细胞等途径间接促进炎性反应。检测点的存在可保证这些细胞因子的生成受到严密控制。细胞因子mRNA3’-非翻译区的腺苷酸/尿苷酸富含元件(ARE)由于可调节mRNA稳定性和翻译效率而扮演着主要检测点的角色。Kh型剪切调控蛋白(KSRP)是一种RNA结合蛋白,可通过与ARE结合降低mRNA的稳定性。本研究检测了KSRP对Ast细胞因子表达和旁分泌表型的影响。笔者发现了一个包括TNF-α和L-1β在内的炎性介质网络。与同窝出生的对照小鼠相比,KSRP-/-小鼠Ast上述炎性介质的表达在RNA水平增高了2～4倍。而这种KSRP-/-小鼠Ast激活后产生的TNF-α和IL-1β甚至能达到对照组的15倍以上。离体情况下,KSRP-/-Ast条件性培养液有趋化作用且能诱导神经元死亡。令人惊讶的是,笔者发现仅通过特定途径激活Ast后才能观察到部分mRNA半衰期延长。荧光素酶报告系统研究显示KSRP可在转录水平和转录后水平调节细胞因子基因的表达。本研究提示KSRP在促炎介质的调控方面发挥重要作用,因此在CNS炎性和自身免疫性疾病中有广泛意义。

关键词： RNA稳定性 AU富含元件肿瘤坏死因子-α 白介素-1β

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

神经胶质细胞炎症反应的RNA调控及其作为中枢神经系统疾病治疗靶点的潜力

引用

神经损伤与功能重建 2023年第2期18卷 F0003-F0003页

作者： Abhishek Guha Mohammed Amir husain Ying Si L Burt Nabors Natalia Filippova Grace Promer Reed Smith peter h king 杜一星(编译) Department Neurology The University of Alabama at BirminghamBirminghamAlabamaUSA Department Cell Developmentaland Integrative BiologyThe University of Alabama at BirminghamBirminghamAlabamaUSA Birmingham Department of Veterans health Care System BirminghamAlabamaUSA Center for Neurodegeneration and Experimental Therapeutics The University of Alabama at BirminghamBirminghamUSA 不详

神经炎症的一个主要标志是小胶质细胞和星形胶质细胞的激活以及炎症介质(如IL-1β、TNF-α、iNOS和IL-6)的诱导。神经炎症会导致从急性中枢神经系统创伤到慢性神经退行性疾病等多种神经系统疾病的进展。mRNA稳定性的转录后调控途径和翻... 详细信息

神经炎症的一个主要标志是小胶质细胞和星形胶质细胞的激活以及炎症介质(如IL-1β、TNF-α、iNOS和IL-6)的诱导。神经炎症会导致从急性中枢神经系统创伤到慢性神经退行性疾病等多种神经系统疾病的进展。mRNA稳定性的转录后调控途径和翻译效率是这些炎症介质表达的主要驱动因素。这一调节水平的一个共同元素以富含腺嘌呤和尿苷的元素(ARE)为中心,该元素存在于编码这些炎症介质的mRNA的3’非翻译区(UTR)中。(ARE)-结合蛋白(AUBPs)——如人类抗原R(huR)、三四脯氨酸(TTP)和Kh型剪接调节蛋白(KSRP)——是指导这些转录后通路的关键节点,可以促进(huR)或抑制(TTP和KSRP)胶质细胞产生炎症介质。本综述将讨论ARE介导的RNA调节的基本概念及其对胶质细胞驱动的神经炎症性疾病的影响。还将讨论针对这种新的基因调控水平以达到治疗效果的策略,并对其治疗神经系统疾病潜力的初步研究进行回顾性分析。

关键词：富含AU元件人类抗原R 趋化因子细胞因子神经胶质细胞神经炎症转录后调控

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

GPS monitoring of the crustal motion in southwestern China

引用

Chinese Science Bulletin 1999年第19期44卷 1804-1807页

作者： B.Clark Burchfiel Robert W.king Leigh h.Royden Massachusetts Institute of Technology CambridgeMA 02139USAMassachusetts Institute of TechnologyCambridgeMA 02139USAMassachusetts Institute of TechnologyCambridgeMA 02139USA

Through GPS carrier phases observation in southwestern China during 1991-1997,the velocity field within eastern Qinghai-Xizang (Tibet) and its neighbour regions has been es-’tablished. The velocity of those sites in and west of Chuan-Dian block is mostly 5-10 mm·a-1relative to the fiduciary station ChDU (Chengdu), and the motion in Chuan-Qing and

关键词： eastern Tibetan Plateau global positioning system (GPS) crustal motion and deformation.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

3D Printing of Polylactic Acid Bioplastic–Carbon Fibres and Twisted Kevlar Composites Through Coextrusion Using Fused Deposition Modeling

引用

Journal of Renewable Materials 2020年第12期8卷 1671-1680页

作者： J.Y.Tey W.h.Yeo Y.J.king W.O.Ding Department of Mechanical and Material Engineering Lee Kong Chian Faculty of Engineering and ScienceUniversiti Tunku Abdul RahmanJalan Sungai LongBandar Sungai LongCheras43000 KajangSelangorMalaysia

Polylactic acid(PLA)bioplastic is a common material used in Fused Deposition Modeling(FDM)3D *** is biodegradable and environmentally friendly biopolymer which made out of ***,it exhibits weak mechanical properties which reduced its usability as a functional prototype in a real-world *** the present study,two PLA composites are created through coextruded with 3K carbon fibres and twisted Kevlar string(as core fibre)to form a fibre reinforced parts(FRP).The mechanical strength of printed parts was examined using ASTM D638 standard with a strain rate of 1 mm/*** has been demonstrated that the FRPs coextruded with 3K carbon fibres had achieved significant improvement in Young’s modulus(+180.6%,9.205 GPa),ultimate tensile strength(+175.3%,103 MPa)and maximum tensile strain(+21.6%,1.833%).Although the Young’s modulus of Kevlar FRP was found to be similar to as compared to unreinforced PLA(~3.29 GPa),it has gained significant increment in terms of maximum tensile strain(+179.7%,104.64 MPa),and maximum tensile strain(+257%,5.384%).Thus,this study revealed two unique composite materials,in which the 3K carbon FRP can offer stiff and high strength structure while Kevlar FRP offers similar strength but at a higher elasticity.

关键词： 3D printing Kevlar fibre 3K carbon fibre coextruded reinforced plastic polylactic acid bioplastic

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A chromatin modulator sustains self-renewal and enables differentiation of postnatal neural stem and progenitor cells

引用

Journal of Molecular Cell Biology 2020年第1期12卷 4-16页

作者： Kushani Shah Gwendalyn D.king hao Jiang Department of Biochemistry and Molecular Genetics University of Alabama at BirminghamBirminghamAL 35294USA Department of Neurobiology University of Alabama at BirminghamBirminghamAL 3529AUSA Department of Biochemistry and Molecular Genetics University of VirginiaCharlottesvilleVA 22908USA

It remains unknown whether h3K4 methylation,an epigenetic modification associated with gene activation,regulates fate determination of the postnatal neural stem and progenitor cells(NSPCs).By inactivating the Dpy30 subunit of the major h3K4 methyltransferase complexes in specific regions of mouse brain,we demonstrate a crucial role of efficient h3K4 methylation in maintaining both the self-renewal and differentiation capacity of postnatal ***30 deficiency disrupts development of hippocampus and especially the dentate gyrus and subventricular zone,the major regions for postnatal NSC ***30 is indispensable for sustaining the self-renewal and proliferation of NSPCs in a cell-intrinsic manner and also enables the differentiation of mouse and human neural progenitor cells to neuronal and glial ***30 directly regulates h3K4 methylation and the induction of several genes critical in *** findings link a prominent epigenetic mechanism of gene expression to the fundamental properties of NSPCs and may have implications in neurodevelopmental disorders.

关键词： neural stem cell self-renewal differentiation epigenetics h3K4 methylation Dpy30

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

human Invasion by Lesser Known Medically Important Trematodes in the Proximity of Tshwane,Gauteng Province,South Africa

引用

地学前缘 2009年第S1期16卷 78-79页

作者： E.B.E.Moema P.h.king C.Baker Department of Biology University of Limpopo EM-Unit University of Limpopo

It is well-documented that digenetic trematodes exhibit complex life cycles where the definitive hosts are vertebrates—mostly birds,other mammals and *** is also known that digenetic trematodes are host specific,but changes in our feeding habits, agricultural and social practices,have led to human beings infected with parasites that were previously regarded to be of no or insignificant medical importance. The objective of this study was to identify the less known digenetic parasites in the water bodies around Tshwane that may result in possible

关键词： digenetic trematodes life cycles medical importance control measures

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Suppression of Self-Discharge in Aqueous Supercapacitor Devices Incorporating highly Polar Nanofiber Separators

引用

Energy & Environmental Materials 2023年第3期6卷 74-86页

作者： Wesley G.Buxton Simon G.king Vlad Stolojan Advanced Technology Institute University of SurreyGuildford SurreyGU27XHUK

One of the major problems limiting the applications of electric double-layer(EDLC)supercapacitor devices is their inability to maintain their cell voltage over a significant ***-discharge is a spontaneous decay in charged energy,often resulting in fully depleted devices in a matter of ***,a new method for suppressing this self-discharge phenomenon is proposed by using directionally polarized piezoelectric electrospun nanofiber films as separator *** engineering of polyvinylidene fluoride(PVDF)nanofiber films containing a small concentration of sodium dodecyl sulfate(SDS)results in a high proportion of polarβphases,reaching 380.5%of the total *** polarity into the separator material provides a reverse-diode mechanism in the device,such that it drops from an initial voltage of 1.6 down to 1 V after 10 h,as opposed to 0.3 V with a nonpolarized,commercial separator ***,the energy retained for the polarized separator is 37%and 4%for the nonpolarized separator,making supercapacitors a more attractive solution for long-term energy storage.

关键词： piezoelectric polar nanofibers PVDF separators self-discharge supercapacitors

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A comparative study between ionic liquid coating and counterparts in bulk for toluene absorption

引用

Green Chemical Engineering 2020年第2期1卷 147-154页

作者： Ventura Castillo Ramos Wei han king Lun Yeung Division of Environment and Sustainability Hong Kong SARChina Department of Chemical and Biological Engineering The Hong Kong University of Science and TechnologyClear Water BayKowloonHong Kong SARChina

The structure-activity relationship(SAR)for toluene absorption and desorption in ionic liquids(ILs)has been investigated for seven commercial ILs in bulk and thin liquid *** with imidazolium cations of different alkyl chain lengths and a hofmeister series of anions including[Ch3COO],[I],[BF4],[hSO4],and[PF6]were *** capacity for toluene increases with increasing kosmotropicity of the cation and anion,while the absorption rate in bulk ILs is governed by viscosity and that in thin ILs layer by the oil-water partition coefficient(Kow).A regenerability coefficient(Rp)measures toluene desorption and IL *** release rate as measured by dRp/dt correlates well with the Kow and viscosity of the ILs and tx,the time required to completely desorb toluene is related to its ionic strength as measured from v(C2h)of the imidazolium *** properties are in turn governed by the kosmotropicity of the cation and anion pair forming the IL.

关键词： Ionic liquids Volatile organic compounds Absorption Air purification Structure-activity relationship

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

行人膝关节韧带的建模及验证研究

引用

汽车工程 2012年第1期34卷 57-61,75页

作者：张冠军曹立波官凤娇张勇 Yang king h. 湖南大学汽车车身先进设计制造国家重点实验室长沙410082 华侨大学机电及自动化学院厦门361021 Bioengineering Center Wayne State Universitydetroitus48201

基于人体模型ThUMS中的膝韧带模型,改进了材料参数和单元属性。采用近年较新的生物力学实验数据,逐个验证韧带模型在不同应变率下的生物逼真度。结果表明,膝韧带ACL、PCL、MCL和LCL在不同应变率下的拉力与位移关系曲线与试验结果吻合较... 详细信息

基于人体模型ThUMS中的膝韧带模型,改进了材料参数和单元属性。采用近年较新的生物力学实验数据,逐个验证韧带模型在不同应变率下的生物逼真度。结果表明,膝韧带ACL、PCL、MCL和LCL在不同应变率下的拉力与位移关系曲线与试验结果吻合较好,说明模型具有较好的生物逼真度,能较准确地模拟韧带的损伤和拉伸响应。

关键词：汽车与行人碰撞膝关节韧带有限元模型验证

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：