检索结果-南通市图书馆

Time to clinical response and remission for therapeutics in inflammatory bowel diseases: what should the clinician expect, what should patients be told?

引用

World Journal of Gastroenterology 2017年第35期23卷 6385-6402页

作者： Abhinav Vasudevan peter R gibson Daniel R van Langenberg Department of Gastroenterology and Hepatology Eastern HealthBox Hill Hospital Monash University Eastern Health Clinical School Department of Gastroenterology Alfred Health and Monash University

An awareness of the expected time for therapies to induce symptomatic improvement and remission is necessary for determining the timing of follow-up, disease(re)assessment, and the duration to persist with therapies, yet this is seldom reported as an outcome in clinical trials. In this review, we explore the time to clinical response and remission of current therapies for inflammatory bowel disease(IBD) as well as medication, patient and disease related factors that may influence the time to clinical response. It appears that the time to therapeutic response varies depending on the indication for therapy(Crohn's disease or ulcerative colitis). Agents with the most rapid time to clinical response included corticosteroids, calcineurin inhibitors, exclusive enteral nutrition, aminosalicylates and anti-tumor necrosis factor therapy which will work in most patients within the first 2 mo. Vedolizumab,methotrexate and thiopurines had a longer time to clinical response and can take several months to achieve maximal efficacy. Factors affecting the time to clinical response of therapies included use of concomitant therapy, disease duration, smoking status, disease phenotype and advanced age. There appears to be marked variation in time to clinical response for therapies used in IBD which is further influenced by disease and patient related factors. Understanding the expected time to therapeutic response is integral to inform further decision making, maintain a patientcentered approach and ensure treatment is given an appropriate timeframe to achieve maximal benefit prior to cessation.

关键词： Crohn’s disease Clinical pharmacology Ulcerative colitis Thiopurines Inflammatory bowel disease Biologics nutrition

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Probiotic effects on intestinal fermentation patterns in patients with irritable bowel syndrome

引用

World Journal of Gastroenterology 2008年第32期14卷 5020-5024页

作者： Jacqueline S Barrett Kim EK Canale Richard B Gearry peter M Irving peter R gibson Monash University Department of Medicine and Department of Gastroenterology Box Hill Hospital

AIM： To determine whether Lactobacillus casei strain Shirota （Yakult） can alter small intestinal bacterial overgrowth （SIBO）, as tested by the lactulose breath test, and whether this is associated with changes in symptoms in irritable bowel syndrome （IBS）. METHODS： 18 patients with IBS （Rome Ⅱ criteria）, who showed an early rise in breath hydrogen with lactulose （ERBHAL）, consumed 65 mL of Yakult daily for 6 wk. Lactulose breath test was repeated at the end of the treatment period. Symptoms were recorded daily using a 10 cm visual analogue scale. RESULTS： 14 patients completed the study, 9 （64%） had reversal of ERBHAL, with the median time of first rise in breath hydrogen increasing from 45 to 75 min （P = 0.03）. There was no significant improvement in the symptom score with probiotic therapy, except for wind （P = 0.04）. Patients commencing with at least moderate symptoms and who no longer had ERBHAL at the end of treatment, showed improvement in the overall symptoms scores [median final score 5.3 （IQR 3.9-5.9）, 55% reduction; n = 6] to a greater extent than those who had had persisting ERBHAL [final score 6.9 （5.0-7.0）, 12% reduction; n = 5; P = 0.18]. CONCLUSION： Yakult is effective in altering fermentation patterns in the small bowel, consistent with reducing SIBO. The loss of ERBHAL was associated with reduced symptoms. The true interpretation of these findings awaits a randornised, controlled trial.

关键词： Probiotics Small intestinal bacterial overgrowth Breath hydrogen testing Functional gut symptoms

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A Methodology for Bridge Condition Evaluation

引用

Journal of Civil Engineering and Architecture 2012年第9期6卷 1149-1157页

作者： Maria Rashidi peter gibson Faculty of Engineering University of Wollongong NSW 2522 Australia

Due to the substantial role of bridges in transportation networks and in accordance with the limited funding for bridge management, remediation strategies have to be prioritised. A conservative bridge assessment will result in unnecessary actions, such as costly bridge strengthening or repairs. On the other hand, any bridge maintenance negligence and delayed actions may lead to heavy future costs or degraded assets. The accuracy of decisions developed by any manager or bridge engineer relies on the accuracy of the bridge condition assessment which emanates from visual inspection. Many bridge rating systems are based on a very subjective procedure and are associated with uncertainty and personal bias. The developing condition rating method described herein is an important step in adding more holism and objectivity to the current approaches. Structural importance and material vulnerability are the two main factors that should be considered in the evaluation of element structural index and the causal factor as the representative of age, environment, road class and inspection is implemented as a coefficient to the OSCI （overall structural condition index）. The AHP （analytical hierarchy process） has been applied to evaluate the priority vector of the causal parameters.

关键词： Bridge inspection condition assessment structural importance material vulnerability causal factor AHP OSCI.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

One fifth of hospitalizations for peptic ulcer-related bleeding are potentially preventable

引用

World Journal of Gastroenterology 2014年第30期20卷 10504-10511页

作者： Ray Boyapati Sim Ye Ong Bei Ye Anuk Kruavit Nora Lee Rhys Vaughan Sanjay Nurkar peter gibson Mayur Garg Gastroenterology and Liver Transplant Unit Austin HospitalMelbourneVictoria 3128Australia Department of Gastroenterology and Hepatology Eastern Health and Monash UniversityMelbourneVictoria 3128Australia Department of Gastroenterology The Alfred Hospital and Monash UniversityMelbourneVictoria 3128Australia

AIM: To calculate the proportion of potentially preventable hospitalizations due to peptic ulcer disease (PUD), erosive gastritis (EG) or duodenitis (ED).

关键词： Peptic ulcer Gastrointestinal hemorrhage Prevention Non-steroidal anti-inflammatory drug Proton pump inhibitor Gastroprotection

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Food,fibre,bile acids and the pelvic floor: An integrated low risk low cost approach to managing irritable bowel syndrome

引用

World Journal of Gastroenterology 2015年第40期21卷 11379-11386页

作者： Hamish Philpott Sanjay Nandurkar John Lubel peter R gibson Monash University Eastern HealthThe Alfred Hospital

Patients presenting with abdominal pain and diarrhea are often labelled as suffering from irritable bowel syndrome,and medications may be used often without success. Advances in the understanding of the causes of the symptoms(including pelvic floor weakness and incontinence,bile salt malabsorption and food intolerance) mean that effective,safe and well tolerated treatments are now available.

关键词： Bile acids Pelvic floor Food intolerance Irritable

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Management of severe asthma:from stepwise approach to therapy to treatable traits?

引用

Precision Clinical Medicine 2021年第4期4卷 293-296页

作者： Gang Wang Vanessa M.McDonald peter G.gibson Department of Respiratory and Critical Care Medicine Clinical Research Center for Respiratory DiseaseWest China HospitalSichuan UniversityChengdu 610041China Laboratory of Pulmonary Immunology and Inflammation Frontiers Science Center for Disease-Related Molecular NetworkSichuan UniversityChengdu 610041China Department of Respiratory and Sleep Medicine John Hunter HospitalHunter Medical Research InstituteNewcastle 2305Australia Centre of Excellence in Severe Asthma and Priority Research Centre for Asthma and Respiratory Disease the University of NewcastleNewcastle 2308Australia School of Nursing and Midwifery the University of NewcastleNewcastle 2308Austral

Dear Editor,Asthma is a heterogeneous disease,usually characterized by chronic airway *** disease affects more than 300 million individualsworldwide,and poses a significant ongoing health burden,especially for patients with poorly controlled and severe asthma.1 The stepwise approach to therapy recommended in asthma management guidelines is effective.

关键词： asthma stepwise airway

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Evidence‐based Respiratory Medicine 1st

引用

2005年

作者： peter G. gibson Michael Abramson Richard Wood‐Baker Jimmy Volmink Michael Hensley Ulrich Costabel

ISBN: (数字)9780470987377

ISBN: (纸本)9780727916051

First major evidence-based text in adult respiratory medicine Comprehensive, authoritative summary of the best treatments for the major respiratory diseases Compiled by specialists from the Cochrane Airways Management Group Easy-to-use format, with key clinical implications summarised in each chapter Kept up-to-date online Compiled by specialists from the Cochrane Collaboration Airways Management Group, Evidence-based Respiratory Medicine is the first major evidence-based text in adult respiratory medicine. Providing a comprehensive summary of the best treatments for the most important respiratory diseases, some of the world's leading physicians review the evidence for a broad range of treatments using evidence-based principles. Essential information is presented in an easy-to-understand format, with the most important clinical implications summarised in each chapter. Evidence-based Respiratory Medicine tackles the big clinical questions in diagnosis and treatment, presenting treatment options which take into account the individual patient's needs. Evidence-Based Series: Evidence-based Respiratory Medicine, part of the acclaimed series BMJ Evidence-based medicine textbooks that have revolutionised clinical medicine literature, comes with a fully searchable CD-ROM of the whole text. Note: CD-ROM/DVD and other supplementary materials are not included as part of eBook file.

关键词： LungsDiseases.

来源：畅想之星图书光盘版（南... 评论

在线全文

畅想之星图书光盘版（南通市图书馆镜像）

学校读者我要写书评

暂无评论

火线驰骋

引用

汽车生活 2008年第6期 74-85页

作者： Oliver Marriage peter gibson 臧赟华

全新的梅赛德斯C63 AMG和雷克萨斯IS F信誓旦旦,扬言要瓜分顶级豪车的市场。我们将它们同宝马最新的4门M3和目前该车系的佼佼者Audi RS4放到一起同场竞技,看看哪一台可以让驾驶者最为吃惊。

关键词：变速箱引擎驾驶宝马方向盘奥迪排气管人民币扭矩经济性

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

慢性难治性咳嗽的管理

引用

英国医学杂志中文版 2016年第6期19卷 325-338页

作者： peter G gibson,director Anne E Vertigan,speech pathologist 戴钰梁志欣 Centre for Asthmaand RespiratoryDisease University ofNewcastle Department ofRespiratory andSleep Medicine JohnHunter Hospital Hunter Medical Research Institute Newcastle NSW2010 Australia Centre for Asthmaand RespiratoryDisease University of Newcastle Speech Pathology Department JohnHunter Hospital Hunter Region MailCentre HunterMedical Research 解放军总医院呼吸内科

慢性难治性咳嗽（chronic refractory cough，CRC）是指按照指南治疗后仍持续存在的咳嗽。至咳嗽专科门诊就诊的患者中，有20％～46％患有慢性难治性咳嗽，这些患者的生活质量及健康水平受到较大影响。许多术语被用来描述慢性难治性咳... 详细信息

慢性难治性咳嗽（chronic refractory cough，CRC）是指按照指南治疗后仍持续存在的咳嗽。至咳嗽专科门诊就诊的患者中，有20％～46％患有慢性难治性咳嗽，这些患者的生活质量及健康水平受到较大影响。许多术语被用来描述慢性难治性咳嗽，包括最近介绍的咳嗽高敏综合征。它的核心症状为局限于喉部附近区域的刺激性干咳。其症状并不仅限于咳嗽，还可包括癔球症、呼吸困难和发声困难。慢性难治性咳嗽与喉高敏综合征和慢性疼痛综合征具有相同的影响因素，这些相似点有助于我们理解其病理生理机制。慢性难治性咳嗽的病理生理学机制复杂，包括咳嗽反射敏感、中枢敏化、外周敏化和声带矛盾运动，通常发生于病毒感染之后。当导致慢性咳嗽的主要病因被排除（或治疗），而咳嗽症状对于治疗反应不佳时可以诊断为慢性难治性咳嗽。针对慢性难治性咳嗽的治疗，过去的十年中有一些新的发现，包括从功能性发声障碍治疗方法借鉴而来的言语病理学干预，以及作用于神经中枢的神经调节剂（例如加巴喷丁和普瑞巴林）的使用。此外，一些尚在研究中的潜在新型治疗方法也显示出较好的前景。

关键词：治疗咳嗽慢性

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Workup of difficult-to-treat asthma:implications from treatable

引用

Precision Clinical Medicine 2023年第1期6卷 30-37页

作者： Qing Zhang Wen Wen Wu Lei Li Vanessa M.McDonald Yu Cheng Chen Gang Wang peter G.gibson Department of Respiratory and Critical Care Medicine Clinical Research Center for Respiratory DiseaseWest China HospitalSichuan UniversityChengdu 610041SichuanChina Laboratory of Pulmonary Immunology and Inflammation Frontiers Science Center for Disease-related Molecular NetworkSichuan UniversityChengdu 610041SichuanChina Center of Excellence in Severe Asthma and Priority Research Center for Asthma and Respiratory Disease the University of NewcastleNewcastle 2308Australia National Health and Medical Research Council Center for Research Excellence in Severe Asthma and Treatable Traits the University of NewcastleNewcastle 2308Australia Cardiology Division Department of MedicineWest China HospitalSichuan UniversityChengdu 610041SichuanChina Department of Respiratory and Sleep Medicine John Hunter HospitalHunter Medical Research InstituteNewcastle 2305Australia

Traditional stepwise approach usually adjusts the treatment regimen based on changes in asthma symptoms and severity to achieve good asthma ***,due to the generalized heterogeneity and complexity of asthma,its therapeutic efficacy in difficultto-treat asthma is ***,a precision medicine approach based on the identification and intervention of treatable traits of chronic airway disease has been proposed and appears to be of greater benefit to *** reported a 71-year-old male with uncontrolled asthma and multiple exacerbations over the past *** complained of persistent dyspnea despite high-dose of inhaled corticosteroids plus other *** this patient have some potential treatable traits contributing to difficult-to-treat asthma?Through a multidimensional assessment of three domains including pulmonary,extrapulmonary,and behavioral/risk factors,15 treatable traits were identified in the patient,mainly including airflow limitation,eosinophilic airway inflammation,small airway dysfunction,exacerbation prone,dilated cardiomyopathy,diabetes mellitus,inhaler device polypharmacy,smoking,and the absence of an asthma action *** targeted treatment for these treatable traits,the patient experienced significant improvement in dyspnea and he could maintain good asthma control with low-dose inhaled corticosteroids and long-acting β_(2)-*** study shows that,in response to the limitation of a stepwise approach to therapy,treatable traits is a new strategy where patients are individually assessed for a specified set of treatable problems,and an individualized treatment program is developed and implemented based on this multidimensional assessment,especially for difficult-to-treat asthma.

关键词： difficult-to-treat asthma treatable traits multidimensional assessment comorbidity stepwise approach

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：