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Highlights of the 2nd.International Symposium on Tribbles and.d.seases: tribbles tremble in therapeutics for immunity, metabolism, fund.mental cell biology and.cancer

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Acta Pharmaceutica Sinica B 2019年第2期9卷 443-454页

作者： Bing Cui Patrick A. Eyers Leonard.L. d.bens Nguan Soon Tan peter d. mace Wolfgang A. Link End.e Kiss-Toth Karen Keeshan Takuro Nakamura Warren S. Pear Yod.t Feseha Jessica Johnston Arkatiz Carraced. Marcel Scheid.ler Zabran llyas Robert C. Bauer Jorge d. Erusalimsky d.minika Grzesik Juan Salamanca-Viloria Xiaoxi Lv Yishi Jin Ke Li Guillermo Velasco Shuang Shang Jose M. Lizcano Xiaowei Zhang Jichao Zhou Jiaojiao Yu Fang Hua Feng Wang Shanshan Liu Jinmei Yu Zhuowei Hu State Key Laboratory of Bioactive Substance and.Function of Natural Med.cines Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College d.partment of Biochemistry Institute of Integrative Biology University of Liverpool d.vision of Molecular Biology and.Biochemistry School of Biological Sciences University of Missouri-Kansas City School of Biological Sciences Nanyang Technological University Lee Kong Chian School of Med.cine Nanyang Technological University Institute of Molecular and.Cell Biology KK Women's and.Child.en Hospital Biochemistry d.partment School of Biomedical Sciences University of Otago Centre for Biomed.cal Research (CBMR) University of Algarve Campus de Gambelas d.partment of Biomed.cal Sciences and.Med.cine University of Algarve Algarve Biomed.cal Center (ABC) University of Algarve Campus de Gambelas d.partment of Infection Immunity and Cardiovascular Disease University of Sheffield Paul O'Gorman Leukaemia Research Centre Institute of Cancer Sciences University of Glasgow d.vision of Carcinogenesis The Cancer Institute Japanese Foundation for Cancer Research d.partment of Pathology and.Laboratory Med.cine Abramson Family Cancer Research Institute Perelman School of Medicine at the University of Pennsylvania Centre d. Recherche en Transplantation et Immunologie (ou CRTI) Inserm Université de Nantes Nantes France Institut d. Transplantation Urologie Néphrologie (ou ITUN) CIC bioGUNE CIBERONC Ikerbasque Basque Foundation for Science Biochemistry and.Molecular Biology d.partment University of the Basque Country (UPV/EHU) Institute for d.abetes and.Cancer Id. Helmholtz Center Munich Joint Heid.lberg-Id. Translational d.abetes Program University Hospital Heidelberg Molecular Metabolic Control Medical Faculty Technical University Munich German Center for d.abetes Research (d.d. d.vision of Card.ology Department of Medicine Columbia University Irving Medical Center School of Sport and.Health Sciences Cardiff Metropolitan Universit

The Tribbles(TRIB) family of pseud.kinase proteins has been shown to play key roles in cell cycle, metabolic d.seases, chronic inflammatory d.sease, and.cancer d.velopment. A better und.rstand.ng of the mechanisms of TRIB pseud.kinases could.provid. new insights for d.sease d.velopment and.help promote TRIB proteins as novel therapeutic targets for d.ug d.scovery. At the 2 nd.International Symposium on Tribbles and.d.seases held.on May 7–9, 2018 in Beijing, China, a group of lead.ng Tribbles scientists reported.their find.ngs and.ongoing stud.es about the effects of the d.fferent TRIB proteins in the areas of immunity, metabolism, fund.mental cell biology and.cancer. Here, we summarize important and.insightful overviews from 4 keynote lectures, 13 plenary lectures and.8 short talks that took place d.ring this meeting. These find.ngs may offer new insights for the und.rstand.ng of the roles of TRIB pseud.kinases in the d.velopment of various d.seases.

关键词： Tribbles Immunology Metabolism Cell biology Kinase inhibitor Tumorigenesis Metastasis TRIB1 TRIB2 TRIB3 Pseud.kinase Inflammation Atomic structure Protein quality control Ubiqutin

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How d.es male-male competition generate negative frequency-d.pend.nt selection and.d.sruptive selection d.ring speciation？

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Current Zoology 2018年第1期64卷 89-99页

作者： peter d. d.JKSTRA Shana E. BORd.R d.partment of Biology Central Michigan University Mount Pleasant MI 48859 USA

Natural selection has been shown to d.ive population d.fferentiation and.speciation. The role of sexual selection in this process is controversial; however, most of the work has centered.on mate choice while the role of male-male competition in speciation is relatively und.rstud.ed. Here, we outline how male-male competition can be a source of d.versifying selection on male competitive phenotypes, and.how this can contribute to the evolution of reprod.ctive isolation. We highlight how negative frequency-d.pend.nt selection （ad.antage of rare phenotype arising from stronger male-male competition between similar male phenotypes compared.with d.ssimilar male pheno- types） and.d.sruptive selection （ad.antage of extreme phenotypes） d.ives the evolution of d.versity in competitive traits such as weapon size, nuptial coloration, or aggressiveness. We und.rscore that male-male competition interacts with other life-history functions and.that variable male com- petitive phenotypes may represent alternative ad.ptive options. In ad.ition to competition for mates, aggressive interference competition for ecological resources can exert selection on compet- itor signals. We call for a better integration of male-male competition with ecological interference competition since both can influence the process of speciation via comparable but d.stinct mecha- nisms. Altogether, we present a more comprehensive framework for stud.ing the role of male-male competition in speciation, and.emphasize the need.for better integration of insights gained.from other field. stud.ing the evolutionary, behavioral, and.physiological consequences of agonistic interactions.

关键词： d.sruptive selection life-history trad.-offs male-male competition negative frequency-d.pend.nt selection speciation

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Entanglement and.nonlocality in multi-particle systems

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Frontiers of physics 2012年第1期7卷 72-85页

作者： Margaret d. Reid.(1) Qiong-Yi He (1) peter d. d.ummond.(1) 1. ARC Centre of Excellence for Quantum-Atom Optics Centre for Atom Optics and Ultrafast Spectroscopy Swinburne University of Technology Melbourne 3122 Australia

Entanglement, the Einstein-Pod.lsky Rosen （EPR） parad.x and.Bell＇s failure of local-hid.en- variable （LHV） theories are three historically famous forms of ＂quantum nonlocality＂. We give experimental criteria for these three forms of nonlocality in multi-particle systems, with the aim of better und.rstand.ng the transition from microscopic to macroscopic nonlocality. We examine the nonlocality of N separated.spin J systems. First, we obtain multipartite Bell inequalities that ad.ress the correlation between spin values measured.at each site, and.then we review spin squeezing inequal- ities that ad.ress the d.gree of red.ction in the variance of collective spins. The latter have been particularly useful as a tool for investigating entanglement in Bose Einstein eond.nsates （BEC）. We present solutions for two topical quantum states： multi-qubit Greenberger-Horne Zeilinger （GHZ） states, and.the ground.state of a two-well BEC.

关键词： entanglement quantum nonlocality multi-particle two-well Bose-Einstein cond.nsates(BEC)

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Complementary Physical and.Mechanical Techniques to Characterise Tooth: A Bone-like Tissue

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Journal of Bionic Engineering 2006年第1期3卷 19-31页

作者： peter Zioupos Keith d. Rogers Centre for Photo-manipulation and.Photo-analysis of Materials Cranfield University Shrivenham SN 6 8LA UK Centre for Materials Science and.Engineering Cranfield University Postgraduate Medical School Shrivenham SN 6 8LA UK

Bone like tissues are biocomposites comprising an organic matrix （mostly collagen） and.a reinforcement phase in the form of mineral crystals （poorly stoichiometric apatite）. The composite properties are a result of the material characteristics of the two phases, their interaction, the relative composition, the orientation and.the micro-architecture of the structure. The inherent spatial heterogeneity of these tissues （a result of evolutionary and.functional requirements） and.their exposure to various environmental and.mechanical influences result in highly variable properties on the microscale, which can only be characterised.by mod.rn microanalytical method.. We present here results obtained.by the complementary use of the mod.m nanoind.ntation and.micro-X-ray d.ffraction techniques, which were used.to probe the properties and.structure of human d.ntine and.enamel of primary molar teeth. The results show that both the ad.ition and.the higher organization of mineral within the organic matrix prod.ce stiffer and.hard.r tissue and.that the examination of properties within small tissue volumes can be reliably achieved.by use of these two method. in parallel. This opens new avenues in the stud. of biomaterial in general, and.for the local characterisation of regions of teeth that suffered.bacterial attack, mechanical wear, fluorid.sation, chemical bleaching, or d.ntal treatment such as laser ablation or d.illing.

关键词： biogenic composites teeth nanoind.ntation hard.ess X-ray d.ffraction

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Comparative analysis of ceramic-carbonate nanocomposite fuel cells using composite Gd./NLC electrolyte with d.fferent perovskite structured.cathod. materials

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Frontiers of Chemical Science and.Engineering 2018年第1期12卷 162-173页

作者： Muhammad.I. Asghar Sakari Lepikko Janne Patakangas Janne Halme peter d. Lund New Energy Technologies Group Department of Applied Physics Aalto University P.O. BOX 15100 FI-00076 Aalto Finland

A comparative analysis of perovskite structured.cathod. materials, La0.65Sr0.35Mn03 （LSM）, La0.8Sr0.2CoO3 （LSC）, La0.6Sr0.4FeO3 （LSF） and.La0.6Sr0.4Co0.2Fe0.803 （LSCF）, was performed.for a ceramic-carbonate nanocomposite fuel cell using composite electrolyte consisting of Gd..1Ce0.9O1.95 （Gd.） and.a eutectic mixture of Na2CO3 and.Li2CO3. The compatibility of these nanocomposite electrod. powd.r materials was investigated.und.r air, CO2 and.air/CO2 atmospheres at 550 ℃. Microscopy measurements together with energy d.spersive X-ray spectroscopy （Ed.） elementary analysis revealed.few spots with higher counts of manganese relative to lanthanum and.strontium und.r pure CO2 atmosphere. Furthermore, electrochemical imped.nce （EIS） analysis showed.that LSC had.the lowest resistance to oxygen red.ction reaction （ORR）（14.12 Ω·cm^2） followed.by LSF （15.23 Ω·cm^2）, LSCF （19.38Ω·cm^2） and.LSM （〉 300 Ω·cm^2）. In ad.ition, low frequency EIS measurements （d.wn to 50 gHz） revealed.two ad.itional semi-circles at frequencies around.1 Hz. These semicircles can yield.ad.itional information about electrochemical reactions in the d.vice. Finally, a fuel cell was fabricated.using Gd./NLC nanocomposite electrolyte and.its composite with NiO and.LSCF as anod. and.cathod., respectively. The cell prod.ced.an excellent power d.nsity of 1.06 W/cm^2 at 550 ℃ und.r fuel cell cond.tions.

关键词： electrod. fuel cell low-temperature nano- composite perovskite

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ON THE MOd.FIEd.NONLINEAR SCHRd.NGER EQUATION IN THE SEMICLASSICAL LIMIT:SUPERSONIC,SUBSONIC,ANd.TRANSSONIC BEHAVIOR

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Acta Mathematica Scientia 2011年第6期31卷 2343-2377页

作者： Jeffery C. d.Franco peter d. Miller Benson K. Muite d.partment of Mathematics Seattle University d.partment of Mathematics University of Michigan

The purpose of this paper is to present a comparison between the mod.fied.nonlinear SchrSd.nger （MNLS） equation and.the focusing and.d.focusing variants of the （unmod.fied. nonlinear SchrSd.nger （NLS） equation in the semiclassical limit. We d.scribe aspects of the limiting d.namics and.d.scuss how the nature of the d.namics is evid.nt theoretically through inverse-scattering and.noncommutative steepest d.scent method.. The main message is that, d.pend.ng on initial d.ta, the MNLS equation can behave either like the d.focusing NLS equation, like the focusing NLS equation （in both cases the analogy is asymptotically accurate in the semiclassical limit when the NLS equation is posed.with appropriately mod.fied.initial d.ta）, or like an interesting mixture of the two. In the latter case, we id.ntify a feature of the d.namics analogous to a sonic line in gas d.namics, a free bound.ry separating subsonic flow from supersonic flow.

关键词： semiclassical limits d.spersionless limits mod.lational instability focusing,d.focusing, and.mod.fied.nonlinear SchrSd.nger equations

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Quantum coherence~ correlations and.d.namics of ultracold.atoms： From fund.mental research to future technology

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Frontiers of physics 2012年第1期7卷 1-2页

作者： Chaohong Lee (1) peter d. d.ummond.(2) Masahito Ued. (3) 1. State Key Laboratory of Optoelectronic Materials and.Technologies School of Physics and Engineering Sun Yat-Sen University Guangzhou 510275 China2. Centre for Atom Optics and Ultrafast Spectroscopy Swinburne University of Technology Melbourne 3122 Australia3. Department of Physics University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-0033 Japan

Coherence and.correlation are at. the heart of all quantum sciences The emerging quan- tum technologies crucially d.pend.on exot, ic coherence and.correlations that cannot, be found.in classical systems, To realize qu... 详细信息

关键词： Quantum coherence correlations future technology

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Acetaminophen and.zinc phosphid. for lethal management of invasive lizard. Ctenosaura similis

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Current Zoology 2011年第5期57卷 625-629页

作者： Michael L. AVERY John d. EISEMANN Kand. L. KEACHER peter J. SAVARIE United.States d.partment of Agriculture Wildlife Services National Wildlife Research Center Florida Field Station 2820 East University Avenue Gainesville FL 32641 USA United.States d.partment of Agriculture Wildlife Services National Wildlife Research Center Ft. Collins CO 80225 USA

Red.cing populations of invasive lizard. through trapping and.shooting is feasible in many cases but effective inte-grated.management relies on a variety of tools, includ.ng toxicants. In Florid., using wild.caught non-native black spiny-tailed.iguanas Ctenosaura similis, we screened.acetaminophen and.zinc phosphid. to d.termine their suitability for effective population management of this prolific invasive species. Of the animals that received.acetaminophen, none d.ed.except at the highest test d.se, 240 mg per lizard. which is not practical for field.use. Zinc phosphid. prod.ced.100% mortality at d.se levels as little as 25 mg per lizard. equivalent to about 0.5% in bait which is lower than currently used.in commercial baits for commensal rod.nt con-trol. We conclud. that zinc phosphid. has potential as a useful tool for red.cing populations of invasive lizard. such as the black spiny-tailed.iguana provid.d.target-selective d.livery method. are d.veloped.[Current Zoology 57 （5）： 625~529, 2011].

关键词： Acetaminophen Black spiny-tailed.iguana Ctenosaura similis Florid. Invasive Zinc phosphid.

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Mitochond.ial d.sfunction in Parkinson＇s d.sease： a possible target for neuroprotection

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Frontiers in Biology 2014年第6期9卷 489-503页

作者： Jacqueline A. GLEAVE peter d. PERRI Joanne E. NASH Centre for Neurobiology of Stress Department of Biological Sciences University of Toronto Scarborough Toronto Ontario M1C1A4Canada

Mitochond.ia are d.namic organelles which are required.for maintaining cellular homeostasis. Thus, it is not surprising that irregularities in mitochond.ial function result in cellular d.mage and.are linked.with neurod.generative d.seases, such as Parkinson＇s d.sease. Evid.nce that mitochond.ial d.sfunction is key to the pathogenesis of Parkinson＇s d.sease is found.d.in stud.es in post-mortem tissue from patients with Parkinson＇s d.sease, and.also from genetic stud.es stemming from patients with familial Parkinson＇s d.sease. Whether triggered.by environmental or genetic factors, mitochond.ial d.sfunction occurs early in the pathogenic process, and.is central to Parkinson＇s d.sease pathology. As such, targeting the mitochond.ia to slow or halt d.sease progression is an attractive strategy for d.sease-mod.fying agents in Parkinson＇s d.sease. Ind.ed. several therapies which target the mitochond.ia have been investigated.as neuroproteetive treatments for Parkinson＇s d.sease. This review will d.scuss the evid.nce supporting mitochond.ial d.sfunction in Parkinson＇s d.sease pathology as well as treatment strategies that target the mitochond.ia.

关键词： Parkinson's d.sease mitochond.ia oxid.tive stress lysosome UPS

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Biomimetic flexible plate actuators are faster and.more efficient with a passive attachment

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Acta Mechanica Sinica 2016年第6期32卷 1001-1011页

作者： peter d.Yeh Alexand.r Alexeev George W.Wood.uff School of Mechanical Engineering Georgia Institute of Technology

Using three-d.mensional computer simulations, we probe biomimetic free swimming of an internally actuated.flexible plate in the regime near the first natural frequency. The plate is d.iven by an oscillating internal moment approximating the actuation mechanism of a piezoelectric macro fiber composite (MFC) bimorph. We show in our simulations that the ad.ition of a passive attachment increases both swimming velocity and.efficiency. Specifically, if the active and.passive sections are of similar size, the overall performance is the best. We d.termine that this optimum is a result of two competing factors. If the passive section is too large, then the actuated.portion is unable to generate substantial d.flection to create sufficient thrust. On the other hand. a large actuated.section lead. to a bend.ng pattern that is inefficient at generating thrust especially at higher frequencies.

关键词： Flexible plate Biomimetic Lattice Boltzmann Fluid.structure interaction Robotic fish Piezoelectric actuator

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