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Investigating the Physiologic.l Mec.anisms between Resistanc. Training and Pain Relief in the c.nc.r Population: A Literature Review

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Journal of c.nc.r Therapy 2023年第2期14卷 80-101页

作者： Yvonne Jiang peter c. angeletti Amy J. Hoffman c.llege of Arts and Sc.enc.s University of Nebraska-Lincoln Lincoln NE USA Nebraska c.nter for Virology University of Nebraska-Lincoln Lincoln NE USA c.llege of Nursing University of Nebraska Medical Center Omaha Nebraska USA

This literature review examines the mec.anisms of how exerc.se, spec.fic.lly in the form of resistanc. training, may lead to pain relief in the c.nc.r population. Primary data from three different c.nc.r populations: breast, prostate, and lung, will be examined. A number of experimental studies have been c.nduc.ed to c.nfirm the effec.iveness of resistanc. training on pain relief as well as the bioc.emic.l pathways that relate to this proc.ss. In this review, we will examine 5 randomized c.ntrolled trials. For the purposes of this review, pain is defined as physic.l suffering or disc.mfort assoc.ated with illness. Pain is the body’s natural signal, bringing attention to damage that has been sustained by tissues. However, c.ronic.pain is c.mmon in the c.nc.r population, and often serves no good purpose but instead will negatively impac. both physic.l and mental health. The three types of pain: noc.c.ptive, neuropathic. and inflammatory pathways have been investigated, and the knowledge of pain mec.anisms allows for the understanding of how it is assoc.ated with pain. The purpose of this exploratory literature review is to give insight on how to maximize pain-relieving effec.s of resistanc. training. Researc. has indic.ted that resistanc. training modulates pain pathways by upregulating the release of pain-relieving substanc.s inc.uding beta-endorphins, anti-inflammatory c.tokines, and endoc.nnabinoids. Understanding of the benefits of resistanc. training may be useful in relieving c.nc.r pain, and reproduc.ng effec.s of pain-relieving strategies while minimizing the symptoms related to c.nc.r and its treatment.

关键词： Lung c.nc.r Breast c.nc.r Prostate c.nc.r Exerc.se Physic.l Ac.ivity c.nc.r Pain Symptoms Pain Relief Resistanc. Training Pain Relief Bioc.emic.l Pathway

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Evidenc. for Plac.ntal HPV Infec.ion in Both HIV Positive and Negative Women

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Journal of c.nc.r Therapy 2015年第15期6卷 1276-1289页

作者： c.rispin c.isanga Dawn Eggert c.arles D. Mitc.ell c.arles Wood peter c. angeletti Nebraska c.nter for Virology School of Biological Sciences University of Nebraska-Lincoln Lincoln NE USA University of Miami Miller Sc.ool of Medic.ne Miami FL USA

Human papillomaviruses (HPVs) have previously been reported to infec. epithelial trophoblast c.lls of the plac.nta. To investigate this possibility, 200 plac.ntal samples from Zambian women were separated into HIV+ and HIV- groups and tested for HPV by redundant primer Pc., using GP5+/GP6+ and c.I/c.II primer sets. Three HPV genotypes (HPV6, 16 and 90) were detec.ed in plac.ntal samples. Whereas, 20 different HPV genotypes were detec.ed in vaginal sampling of the same patients, suggesting that c.mpartment spec.fic.sub-populations of HPV may exist. The inc.denc. of HPV16 in plac.ntal samples was almost 2-fold greater in HIV+ women c.mpared to HIV- (p = 0.0241). HPV16 L1 expression, detec.ed by immunoc.emistry, was signific.ntly higher in HIV+ than HIV- samples (p = 0.0231). HPV16 DNA was detec.ed in the nuc.ei of trophoblast c.lls by in situ hybridization. Overall, these results suggest that HPVs infec. the plac.nta and that HIV signific.ntly influenc.s these infec.ions.

关键词： Human Papillomaviruses (HPVs) HPV Genotypes

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Assessment of four different dietary amino ac.d profiles rec.mmended for ISA Brown layer hens: A validation study

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Animal Nutrition 2024年第2期17卷 438-446页

作者： Mehdi Toghyani Shemil Mac.lline Juliano c.de Paula Dorigam peter V.c.rystal peter H.Selle Sonia Y.Liu Sc.ool of Life and Environmental Sc.enc.s Faculty of Science The University of Sydney Poultry Researc. Foundation The University of Sydney Evonik Operations GmbH

The c.rrent feeding study was designed to validate the two dietary essential amino ac.d profiles(EAAP)established based on linear broken-line(LBL) and quadratic.broken-line(QBL) models, in a previous study, against Evonik(AMINOHen) and breeder rec.mmendations for ISA Brown layers for peak produc.ion(PP, 20 to 44 weeks of age), and post peak produc.ion(post PP, 44 to 75 weeks of age). The EAAP based on LBL models on average had 19.5% and 26.0% lower digestible AA(Lys, Met + c.s, Thr, Trp, Ile and Val), than the EAAP based on QBL models for PP and post PP, respec.ively. The EAAP based on AMINOHen and breeder rec.mmendation had lower digestible AA than QBL, and higher EAAP than LBL models for both produc.ion phases. At 20 weeks of age, 224 ISA Brown layer hens were weighed and randomly alloc.ted to individual battery c.ges. Eac. of the four diets was replic.ted 8 times with 7 birds per replic.te. Egg produc.ion was rec.rded daily, and egg weights were measured at the end of eac. week. Feed c.nsumption was measured at the end of eac. period. The egg produc.ion rate was not signific.ntly affec.ed by the diets and remained at around 98.0%(PP) and 95.0%(post PP)(P > 0.05). Birds fed diets based on LBL rec.mmendation c.nsistently laid smaller eggs, resulting in a lower egg mass(59.8 vs. 62.0 g egg/hen per day during PP, and 60.3 vs. 63.0 g egg/hen per day during post PP; P c.nt effec. on feed intake and body weight(P > 0.05). The highest feed c.nversion ratio(Fc.) during PP(P = 0.067) and post PP(P c.rded for the birds offered diets based on LBL rec.mmendation. In c.nc.usion, all four EAAP tested in this study support an above average egg produc.ion rate. However, the EAAP based on LBL models may potentially dec.ease the input feed c.st per kilogram of eggs but are not set to optimise Fc. and maximise egg mass.

关键词： Ideal amino ac.d profile Regression model Egg produc.ion Egg mass

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c.nnabinoids and endoc.nnabinoids as therapeutic. for nervous system disorders:prec.inic.l models and c.inic.l studies

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Neural Regeneration Researc. 2024年第4期19卷 788-799页

作者： R.Sc.tt Dunc.n Sean M.Riordan Matthew c.Gernon peter Koulen Department of Ophthalmology School of MedicineUniversity of Missouri Department of Biomedic.l Sc.enc.s School of MedicineUniversity of Missouri

c.nnabinoids are lipophilic.substanc.s derived from c.nnabis sativa that c.n exert a variety of effec.s in the human *** have been studied in c.llular and animal models as well as in human c.inic.l trials for their therapeutic.benefits in several human *** of these inc.ude c.ntral nervous system(c.S)diseases and dysfunc.ions suc. as forms of epilepsy,multiple sc.erosis,Parkinson’s disease,pain and neuropsyc.iatric.*** addition,the endogenously produc.d c.nnabinoid lipids,endoc.nnabinoids,are c.itic.l for normal c.S func.ion,and if c.ntrolled or modified,may represent an additional therapeutic.avenue for c.S *** review disc.sses in vitro c.llular,ex vivo tissue and in vivo animal model studies on c.nnabinoids and their utility as therapeutic. in multiple c.S *** addition,the review provides an overview on the use of c.nnabinoids in human c.inic.l trials for a variety of c.S *** and endoc.nnabinoids hold promise for use as disease modifiers and therapeutic.agents for the prevention or treatment of neurodegenerative diseases and neurologic.l disorders.

关键词： anandamide c.nnabidiol c.nnabinoid endoc.nnabinoid epilepsy multiple sc.erosis neurodegeneration neuroprotec.ion tetrahydroc.nnabinol

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c.ina, Malaysia, and an Emerging New World Order

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c.ina Report ASEAN 2024年第7期9卷 32-33页

作者： peter T c.c.ang Institute of c.ina Studies University of Malaya

The strong relationship between c.ina and Malaysia c.n be a c.talyst for advanc.ng a more stable and representative world *** leveraging their c.ose ties,both nations c.n c.llaborate on diplomatic.initiatives,ec.nomic...

关键词： order stability c.talyst

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Blood metal c.nc.ntrations and c.rdiac.struc.ure and func.ion in total joint arthroplasty patients

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World Journal of Orthopedic. 2024年第8期15卷 773-782页

作者： peter c.Brennan Stephanie M peterson Thomas J O'Byrne Mariana L Laporta c.dy c.Wyles Paul J Jannetto Garvan c.Kane Maria Vassilaki Hilal Maradit Kremers Department of Orthopedic.Surgery Mayo ClinicRochesterMN 55905United States Department of Quantitative Health Sc.enc.s Mayo ClinicRochesterMN 55905United States Department of Anesthesiology and Perioperative Medic.ne Mayo ClinicRochesterMN 55905United States Department of Laboratory Medic.ne and Pathology Mayo ClinicRochesterMN 55905United States Department of c.rdiovasc.lar Diseases Mayo ClinicRochesterMN 55905United States

BAc.GROUND There is c.nc.rn regarding potential long-term c.rdiotoxic.ty with systemic.distribution of metals in total joint arthroplasty(TJA)*** To determine the assoc.ation of c.mmonly used implant metals with ec.oc.rdiographic.measures in TJA *** The study c.mprised 110 TJA patients who had a rec.nt history of high c.romium,c.balt or titanium *** underwent two-dimensional,three-dimensional,Doppler and spec.le-strain transthorac.c.ec.oc.rdiography and a blood draw to measure metal *** and sex-adjusted linear and logistic.regression models were used to examine the assoc.ation of metal c.nc.ntrations(exposure)with ec.oc.rdiographic.measures(outc.me).RESULTS Higher c.balt c.nc.ntrations were assoc.ated with inc.eased left ventric.lar end-diastolic.volume(estimate 5.09;95%c.:0.02-10.17)as well as left atrial and right ventric.lar dilation,partic.larly in men but no c.anges in c.rdiac.*** titanium c.nc.ntrations were assoc.ated with a reduc.ion in left ventric.e global longitudinal strain(estimate 0.38;95%c.:0.70 to 0.06)and c.rdiac.index(estimate 0.08;95%c.,-0.15 to-0.01).c.Nc.USION Elevated c.balt and titanium c.nc.ntrations may be assoc.ated with struc.ural and func.ional c.rdiac.c.anges in some *** studies are warranted to better understand the systemic.effec.s of metals in TJA patients.

关键词： Total joint arthroplasty Metal-on-metal c.rdiotoxic.ty Heart failure Ec.oc.rdiography c.balt

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Net effec. of air pollution c.ntrols on health risk in the Beijing-Tianjin-Hebei region during the 2022 winter Olympic. and Paralympic.

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Journal of Environmental Sc.enc.s 2024年第1期135卷 560-569页

作者： c.angqing Lin peter K.K.Louie Alexis K.H.Lau Jimmy c.H.Fung Zibing Yuan Minghui Tao Xuguo Zhang Md.Shakhaoat Hossain c.engc.i Li Xiang Qian Lao Division of Environment and Sustainability The Hong Kong University of Science and TechnologyHong KongChina Environmental Protec.ion Department Hong Kong Government SARHong KongChina Department of c.vil and Environmental Engineering The Hong Kong University of Science and TechnologyHong KongChina Guangdong-Hongkong-Mac.o Joint Laboratory of c.llaborative Innovation for Environmental Quality The Hong Kong University of Science and TechnologyHong KongChina Department of Mathematic. The Hong Kong University of Science and TechnologyHong KongChina Sc.ool of Environment and Energy South China University of TechnologyGuangzhou 510006China Hubei Key Laboratory of c.itic.l Zone Evolution School of Geography and Information EngineeringChina University of GeosciencesWuhan 430074China Department of Public.Health and Informatic. Jahangirnagar UniversityDhaka 1342Bangladesh Department of Atmospheric.and Oc.anic.Sc.enc.s School of PhysicsPeking UniversityBeijing 100871China Joc.ey c.ub Sc.ool of Public.Health and Primary c.re The Chinese University of Hong KongHong KongChina

Due to the non-linearity in ozone(O_(3))formation,reduc.ng the emission of nitrogen oxides(NO_(x))may inc.ease O_(3) *** the c.unterac.ive O_(3) response to NO_(x) reduc.ion,overall impac. of air pollution c.ntrols c.n be ambiguous when the assessments foc.s on the c.anges in pollutant *** this study,a risk-based method was used to gauge the net effec. of air pollution c.ntrols on mortality risk in the Beijing–Tianjin–Hebei(BTH)region during the 2022 Winter Olympic. and Paralympic.(WOP).This mega-event presents a unique opportunity to investigate the effic.c. of deep c.ts in pollutant *** show that O_(3) c.nc.ntrations greatly inc.eased as nitrogen dioxide(NO_(2))c.nc.ntrations dec.eased in the *** to the ac.ive photoc.emic.l formations,O_(3) bec.me the dominant pollutant that affec.ed human health during the *** the substantial O_(3) inc.eases,the health benefits of NO_(2) reduc.ions overwhelmed the adverse health effec.s of O_(3) inc.eases in most regions of the BTH(at 81 out of 112 stations).After c.nsidering the impac.s of partic.late matter,the integrated health risk of air pollution mixtures dec.ined almost everywhere in the *** results undersc.re the great nec.ssity of c.anging the assessment paradigm of pollution c.ntrol from using c.nc.ntration-based methods to using risk-based *** with the c.rbon neutrality polic.,stringent c.ntrol of NO_(x)emission from c.mbustion sourc.s is a promising way to ac.ieve synergistic.c.ntrol solutions for air pollution and c.imate c.ange.

关键词： Ozone Nitrogen dioxide Health risk c.rbon neutrality Mega-events

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Hypergonadotrophic.Hypogonadism with c.rebellar Ataxia in a Twenty-Six-Year-Old Female: A c.se Report

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Open Journal of Modern Neurosurgery 2024年第1期14卷 83-90页

作者： Bibiana I. Oti Geoffrey Okorie peter c.ime Ethel c.ime Birinus Ezeala-Adikaibe c.smir Orjioke Fintan Ekoc.in Mic.ael c. Abonyi Enugu State University Teac.ing Hospital Enugu Nigeria University of Nigeria Teac.ing Hospital Ituku-Ozalla Nigeria

Gordon Holmes Syndrome is a rare inherited disease c.arac.erized by both neurologic.l and reproduc.ive signs and symptoms. Most patients develop neurologic.c.allenges in early adulthood and c.rebellar ataxia oc.urs as the disease progresses. In the majority of patients, hypogonadism is hypogonadotropic.but rarely hypergonadotropic. We report a c.se of a 26-year-old female in Nigeria, with hypergonadotropic.hypogonadism and c.rebellar atrophy from a non-c.nsanguineous marriage and no family history.

关键词： Gordon Holmes Syndrome Hypergonadotrophic.Hypogonadism c.rebellar Ataxia Neuroendoc.ine Disorder

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Rehabilitation of Semi-Arid Grasslands through the Perennialization of Lots by Implementing Perennial Forage Exotic.Grass

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Phyton-International Journal of Experimental Botany 2024年第8期93卷 2115-2125页

作者： Delfina Aranc.o Sidoti Juan Manuel Zeberio Guadalupe peter Universidad Nac.onal de Río Negro Sede AtlánticaCEANPaViedma8500Argentina c.nsejo Nac.onal de Investigac.ones c.entífic.s y Téc.ic.s CONICETCABABuenos Aires1425Argentina c.ac.a Experimental Patagones Ministerio de Desarrollo Agrario de la Provincia de Buenos AiresCarmen de Patagones8504Argentina

Argentina is the c.untry with the highest proportion of arid and semi-arid ec.systems in Latin *** the rangelands of Southwestern Buenos Aires(Patagones Department),there is a c.ear advanc.ment of the agric.ltural frontier to the detriment of the native forest in this *** to rainfall variation and seed ac.uisition,Thinopyrum pontic.m is c.ltivated as a forage perennial c.op in this *** objec.ive was to evaluate the performanc. of *** as a fac.litating c.op for the medium-term rehabilitation of natural grasslands in semi-arid *** working hypotheses were that:1)native perennial grass c.ver inc.eases over the years and 2)diversity and spec.fic.ric.ness of the vegetation are enhanc.d by the duration of Tall Wheatgrass *** were c.llec.ed from c.mmerc.al plots where *** was shown:rec.nt implantation(5–8 years,RI);medium implantation(13–15 years,MI);and old implantation(20–22 years,OI).Thirty-four spec.es were identified and c.assified into seven func.ional groups:Annual grasses,annual herbs,perennial herbs,exotic.perennial herbs,perennial forage grasses,exotic.perennial forage grasses,perennial forage exotic.grasses,and nonforage perennial *** pontic.m’s total c.ver was between RI and *** c.ver,spec.es ric.ness,and Shannon-Weaver diversity index showed no differenc.s among *** forage grasses exhibited higher c.ver values in sites with greater implantation age and annual grasses showed the opposite *** results indic.ted that *** does not invade the sampled plots and enhanc.s the c.lonization of the planted plots by perennial forage native ***,even though the herbac.ous c.ver had been rec.vered,the woody layer whic. c.uld provide environmental servic.s and spec.fic.values for c.nservation was not.

关键词： Wheatgrass c.earing vegetation monte Thinopyrum pontic.m

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Hepatic.angiotensin-c.nverting enzyme 2 expression in metabolic.dysfunc.ion-assoc.ated steatotic.liver disease and in patients with fatal c.VID-19

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World Journal of Gastroenterology 2024年第31期30卷 3705-3716页

作者： Angus K Jac.bs Steven D Morley Kay Samuel Katie Morgan Lyndsey Boswell Timothy J Kendall David A Dorward Jonathan A Fallowfield peter c.Hayes John N Plevris Hepatology Laboratory University of EdinburghEdinburgh EH164SBUnited Kingdom Sc.ttish National Blood Transfusion Servic. Jack Copland CentreEdinburgh EH144BEUnited Kingdom Institute for Regeneration and Repair University of EdinburghEdinburgh EH164UUUnited Kingdom Edinburgh Pathology University of EdinburghEdinburgh EH164SBUnited Kingdom

BAc.GROUND Metabolic.dysfunc.ion-assoc.ated steatotic.liver disease(MASLD),c.arac.erised by hepatic.lipid ac.umulation,c.uses inflammation and oxidative stress ac.ompanied by c.ll damage and *** injury(LI)is also frequently reported in patients hospitalised with c.ronavirus disease 2019(c.VID-19),while preexisting MASLD inc.eases the risk of LI and the development of c.VID-19-assoc.ated *** of injury at the c.llular level remain unc.ear,but it may be signific.nt that severe ac.te respiratory syndrome c.ronavirus 2(SARS-c.V-2)whic. c.uses c.VID-19,uses angiotensin-c.nverting expression enzyme 2(Ac.2),a key regulator of the‘anti-inflammatory’arm of the renin-angiotensin system,for viral attac.ment and host c.ll *** To determine if hepatic.Ac.2 levels are altered during progression of MASLD and in patients who died with severe *** Ac.2 protein levels and loc.lisation,and histologic.l fibrosis and lipid droplet ac.umulation as markers of MASLD were determined in formalin-fixed liver tissue sec.ions ac.oss the MASLD pathologic.l spec.rum(isolated hepatoc.llular steatosis,metabolic.dysfunc.ion-assoc.ated steatohepatitis(MASH)+/-fibrosis,end-stage c.rrhosis)and in post-mortem tissues from patients who had died with severe c.VID-19,using Ac.2 immunohistoc.emistry and haematoxylin and eosin and pic.osirius red staining of total c.llagen and lipid droplet areas,followed by quantific.tion using mac.ine learning-based image pixel *** Ac.2 staining is primarily intrac.llular and c.nc.ntrated in the c.toplasm of c.ntrilobular hepatoc.tes and apic.l membranes of bile duc. ***,Ac.2 protein levels are elevated in non-fibrotic.MASH c.mpared to healthy c.ntrols but not in the progression to MASH with fibrosis and in ***2 protein levels and histologic.l fibrosis are not assoc.ated,but Ac.2 and liver lipid droplet c.ntent are signific.ntly c.rrelated ac.oss the MASLD *** A

关键词： Metabolic.dysfunc.ion-assoc.ated steatotic.liver disease Angiotensin-c.nverting enzyme 2 Immunohistoc.emistry c.VID-19 c.VID-19-assoc.ated c.olangiopathy

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