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The antioxidant Trolox restores mitochondrial membrane potential and Ca2+-stimulated ATP production in human complex Ⅰ deficiency

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世界最新医学信息文摘 2017年第30期 281-281页

作者： Felix Distelmaier Henk-Jan Visch Jan A.M.Smeitink ertan Mayatepek Werner J.H.Koopman peter H.G.M.Willems

Malfunction of mitochondrial complex I caused by nuclear gene mutations causes early-onset neurodegenerative *** work using cultured fibroblasts of complex-I-deficient patients revealed elevated levels of reactive oxygen species（ROS） and reductions in both total Ca2+content of the endoplasmic reticulum(erCa) and bradykinin（Bk）-induced increases in cytosolic and mitochondrial free Ca2+([Ca2+]C;[Ca2+]M) and ATP（[ATP]C;[ATP]M） ***,we determined the mitochondrial membrane potential（Aw） in patient skin fibroblasts and show significant correlations with cellular ROS levels and erCa,i.e.,the less negative Aw,the higher these levels and the lower *** with 6-hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid（Trolox） normalized △Ψ and Bk-induced increases in[Ca2+]Mand[ATP]*** effects were accompanied by an increase in erCaand Bkinduced increase in[Ca2+]***,these results provide evidence for an integral role of increased ROS levels in complex I deficiency and point to the potential therapeutic value of antioxidant treatment.

关键词： Reactive oxygen species Oxidative stress Mitochondrial membrane potential Endoplasmic reticulum Ca2+ content Mitochondrial disease Antioxidant Human skin fibroblasts

The antioxidant Trolox restores mitochondrial membrane potential and Ca2+-stimulated ATP production in human complex I deficiency

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世界最新医学信息文摘 2016年第11期 8-8页

作者： Felix Distelmaier Henk-Jan Visch Jan A.M.Smeitink ertan Mayatepek Werner J.H.Koopman peter H.G.M.Willems

Malfunction of mitochondrial complex I caused by nuclear gene mutations causes early-onset neurodegenerative diseases. Previous work using cultured fibroblasts of complex-I-deficient patients revealed elevated levels of reactive oxygen species（ros） and reductions in both total Ca2+content of the endoplasmic reticulum(erCa) and bradykinin（Bk）-induced increases in cytosolic and mitochondrial free Ca2+([Ca2+]c; [Ca2+]M) and ATP（[ATP]C; [ATP]M） concentration. Here, we determined the mitochondrial membrane potential（Δψ） in patient skin fibroblasts and show significant correlations with cellular ros levels and erCa, i.e., the less negative Δψ, the higher these levels and the lower erCa. Treatment with 6-hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid（Trolox） normalized Δψ and Bk-induced increases in [Ca2+]Mand [ATP]M. these effects were accompanied by an increase in erCaand Bkinduced increase in [Ca2+]c. together, these results provide evidence for an integral role of increased ROS levels in complex I deficiency and point to the potential therapeutic value of antioxidant treatment.

关键词： Reactive oxygen species Oxidative stress Mitochondrial membrane potential Endoplasmic reticulum Ca2+ content Mitochondrial disease Antioxidant Human skin fibroblasts

Association of mineral and bone biomarkers with adverse cardiovascular outcomes and mortality in the German Chronic Kidney Disease(GCKD)cohort

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Bone Research 2023年第4期11卷 764-771页

作者： Katharina Charlotte Reimer Jennifer Nadal Heike Meiselbach Matthias Schmid Ulla T.Schultheiss Fruzsina Kotsis Helena Stockmann Nele Friedrich Matthias Nauck Vera Krane Kai-Uwe Eckardt Markus P.Schneider Rafael Kramann Jürgen Floege Turgay Saritas Department of Nephrology Rheumatologyand Clinical ImmunologyUniversity Hospital RWTH AachenAachenGermany Institute of Experimental Medicine and Systems Biology RWTH Aachen UniversityAachenGermany Institute for Cell and Tumor Biology RWTH Aachen UniversityAachenGermany Institute of Medical Biometry Informatics and EpidemiologyUniversity Hospital of BonnBonnGermany Department of Nephrology and Hypertension University of Erlangen-NürnbergErlangenGermany Institute of Genetic Epidemiology Faculty of Medicine and Medical Center-University of FreiburgFreiburgGermany Department of Medicine IV-Nephrology and Primary Care Faculty of Medicine and Medical Center-University of FreiburgFreiburgGermany Department of Nephrology and Medical Intensive Care Charité-Universitätsmedizin BerlinBerlinGermany Department of Nephrology University Medical Center RegensburgRegensburgGermany Institute of Clinical Chemistry and Laboratory Medicine University Medicine GreifswaldGreifswaldGermany DZHK(German Centre for Cardiovascular Research) Partner Site GreifswaldUniversity MedicineGreifswaldGermany Department of Medicine I Division of NephrologyUniversity Hospital WürzburgWürzburgGermany

Mineral and bone disorder(MBD)in chronic kidney disease(CKD)is tightly linked to cardiovascular disease(CVD).In this study,we aimed to compare the prognostic value of nine MBD biomarkers to determine those associated best with adverse cardiovascular(CV)outcomes and *** 5217 participants of the German CKD(GCKD)study enrolled with an estimated glomerular filtration rate(eG FR)between 30–60 mL·min-1 per 1.73 m2 or overt proteinuria,serum osteoprotegerin(OPG),C-terminal fibroblast growth factor-23(FGF23),intact parathyroid hormone(iP TH),bone alkaline phosphatase(BAP),cross-linked C-telopeptide of type 1 collagen(CTX1),procollagen 1intact N-terminal propeptide(P1NP),phosphate,calcium,and 25-OH vitamin D were measured at *** with missing values among these parameters(n=971)were excluded,leaving a total of 4246 participants for *** a median follow-up of6.5 years,387 non-CV deaths,173 CV deaths,645 nonfatal major adverse CV events(MACEs)and 368 hospitalizations for congestive heart failure(CHF)were *** and FGF23 were associated with all outcomes,with the highest hazard ratios(HRs)for *** the final Cox regression model,adjusted for CV risk factors,including kidney function and all other investigated biomarkers,each standard deviation increase in OPG was associated with non-CV death(HR 1.76,95%CI:1.35–2.30),CV death(HR 2.18,95%CI:1.50–3.16),MACE(HR 1.38,95%CI:1.12–1.71)and hospitalization for CHF(HR 2.05,95%CI:1.56–2.69).Out of the nine biomarkers examined,stratification based on serum OPG best identified the CKD patients who were at the highest risk for any adverse CV outcome and mortality.

关键词： Kidney cardiovascular vitamin

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Fungal diversity notes 1036-1150:taxonomic and phylogenetic contributions on genera and species of fungal taxa

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Fungal Diversity 2019年第3期96卷 1-242页

作者： Kevin D.Hyde Danushka S.Tennakoon Rajesh Jeewon DJayarama Bhat Sajeewa S.N.Maharachchikumbura Walter Rossi Marco Leonardi Hyang Burm Lee Hye Yeon Mun Jos Houbraken Thuong T.T.Nguyen Sun Jeong Jeon Jens Christian Frisvad Dhanushka N.Wanasinghe Robert Lucking Andre Aptroot Marcela E.S.Caceres Samantha C.Karunarathna Sinang Hongsanan Rungtiwa Phookamsak Nimali Ide Silva Kasun M.Thambugala Ruvishika S.Jayawardena Indunil C.Senanayake Saranyaphat Boonmee Jie Chen Zong-Long Luo Chayanard Phukhamsakda Olinto L.Pereira Vanessa P.Abreu Andre Wilson Campos Rosado Buyck Bart Emile Randrianjohany Vale rie Hofstetter Tatiana B.Gibertoni Adriene Mayrada Silva Soares Helio Longoni Plautz Jr Helen Maria Pontes Sotao William Kalhy Silva Xavier Jadson Diogo Pereira Bezerra Thays Gabrielle Linsde Oliveira Cristina Mariade Souza-Motta Oliane Maria Correia Magalhaes Digvijayini Bundhun Dulanjalee Harishchandra Ishara S.Manawasinghe Wei Dong Sheng-Nan Zhang Dan-Feng Bao Milan C.Samarakoon Dhandevi Pem Anuruddha Karunarathna Chuan-Gen Lin Jing Yang Rekhani H.Perera Vinit Kumar Shi-Ke Huang Monika C.Dayarathne Anusha H.Ekanayaka Subashini C.Jayasiri Yuanpin Xiao Sirinapa Konta Tuula Niskanen Kare Liimatainen Yu-Cheng Dai Xiao-Hong Ji Xue-Mei Tian Armin Mesic Sanjay K.Singh Kunthida Phutthacharoen Lei Cai Touny Sorvongxay Vinodhini Thiyagaraja Chada Norphanphoun Napalai Chaiwan Yong-Zhong Lu Hong-Bo Jiang Jin-Feng Zhang Pranami D.Abeywickrama Janith V.S.Aluthmuhandiram Rashika S.Brahmanage Ming Zeng Thilini Chethana Deping Wei Martina Reblova Jacques Fournier Jana Nekvindova Renan do Nascimento Barbosa Jose Ewerton Felintodos Santos Neiva Tintide Oliveira Guo-Jie Li Damien ertz Qiu-Ju Shang Alan J.L.Phillips Chang-Hsin Kuo erio Camporesi Timur S.Bulgakov Saisamorn Lumyong E.B.Gareth Jones Putarak Chomnunti Eleni Gentekaki Frank Bungartz Xiang-Yu Zeng Sally Fryar Zdenko Tkalcec Junmin Liang Guangshuo Li Ting-Chi Wen Paras Nath Singh Yusufjon Gafforov Itthayakorn Promputtha erandi Yasanthika Ishani D.Goonasekara Rui-Lin Zhao Qi Zhao Paul M Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand East and Central Asia Regional Office World Agroforestry Centre(ICRAF)Kunming 650201YunnanPeople’s Republic of China Department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Mushroom Research Foundation 128 M.3 Ban Pa Deng T.Pa PaeA.Mae TaengChiang Mai 50150Thailand Department of Plant Medicine National Chiayi University300 Syuefu RoadChiayi City 60004TaiwanPeople’s Republic of China Department of Health Sciences Faculty of ScienceUniversity of MauritiusReduitMauritius Formerly Department of Botany Goa UniversityGoaIndia No.128/1-J Azad Housing SocietyCurcaGoa Velha 403108India Department of Crop Sciences College of Agricultural and Marine SciencesSultan Qaboos UniversityPO Box 8123 Al KhoudOman Sect.Environmental Sciences Dept.MeSVAUniversity of L’Aquila67100 CoppitoAQItaly Division of Food Technology Biotechnology&AgrochemistryCollege of Agriculture&Life SciencesChonnam National UniversityGwangju 61186Korea Fungal Resources Research Division NNIBRSangju-si 37242Korea Westerdijk Fungal Biodiversity Institute Uppsalalaan 83584 CT UtrechtThe Netherlands Department of Biotechnology and Biomedicine DTUBioengineeringTechnical University of Denmark2800 Kongens LyngbyDenmark Botanischer Garten und Botanisches Museum Berlin Freie Universitat BerlinKonigin-Luise-StraßBe 6-814195 BerlinGermany Laboratorio de Botanica/Liquenologia Instituto de BiocienciasUniversidade Federal de Mato Grosso do SulAvenida Costa e Silva s/nBairro UniversitarioCampo GrandeMatto Grosso do Sul CEP 79070-900Brazil Departamento de Biociencias Universidade Federal de SergipeItabaianaSergipe CEP:49500-000Brazil Shenzhen Key Laboratory of Microbial

This article is the tenth series of the Fungal Diversity Notes,where 114 taxa distributed in three phyla,ten classes,30 orders and 53 families are described and *** described in the present study include one new family(*** in Dothideomycetes),five new genera(Caatingomyces,Cryptoschizotrema,Neoacladium,Paramassaria and Trochilispora)and 71 new species,(*** thailandica,Amniculicola aquatica,***,Angustimassarina sylvatica,Blackwellomyces lateris,Boubovia gelatinosa,Buellia viridula,Caatingomyces brasiliensis,Calophoma humuli,Camarosporidiella mori,Canalisporium dehongense,Cantharellus brunneopallidus,***,Castanediella meliponae,Coprinopsis psammophila,Cordyceps succavus,Cortinarius minusculus,***,Diaporthe italiana,***,Diatrypella delonicis,Dictyocheirospora aquadulcis,***,Digitodesmium chiangmaiense,Distoseptispora dehongensis,***,Dothiorella styphnolobii,Ellisembia aurea,Falciformispora aquatic,Fomitiporia carpinea,***,Grammothele aurantiaca,***,Hermatomyces bauhiniae,Jahnula queenslandica,Kamalomyces mangrovei,Lecidella yunnanensis,Micarea squamulosa,Muriphaeosphaeria angustifoliae,Neoacladium indicum,Neodidymelliopsis sambuci,Neosetophoma miscanthi,***,Nodulosphaeria aquilegiae,***,Paramassaria samaneae,Penicillium circulare,***,***-pumilae,***,***,Phaeoisaria siamensis,Phaeopoacea asparagicola,Phaeosphaeria penniseti,Plectocarpon galapagoense,Porina sorediata,Pseudoberkleasmium chiangmaiense,Pyrenochaetopsis sinensis,Rhizophydium koreanum,Russula prasina,Sporoschisma chiangraiense,Stigmatomyces chamaemyiae,***,***,***,***,Thysanorea uniseptata,Torula breviconidiophora,***,Trochilispora schefflerae and Vaginatispora palmae).Further,twelve new combinations(*** cryptotrema,Prolixandromyces australi,***,***,***,P.

关键词： 71 new taxa Ascomycota Basidiomycota Dothideomycetes Eurotiomycetes Lecanoromycetes Leotiomycetes Pezizomycetes Phylogeny Taxonomy

Fungal diversity notes 491–602: taxonomic and phylogenetic contributions to fungal taxa

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Fungal Diversity 2017年第2期83卷 1-261页

作者： Saowaluck Tibpromma Kevin D.Hyde Rajesh Jeewon Sajeewa S.N.Maharachchikumbura Jian-Kui Liu D.Jayarama Bhat E.B.Gareth Jones eric H.C.McKenzie erio Camporesi Timur S.Bulgakov Mingkwan Doilom AndreLuiz Cabral Monteiro de Azevedo Santiago Kanad Das Patinjareveettil Manimohan Tatiana B.Gibertoni Young Woon Lim Anusha Hasini Ekanayaka Benjarong Thongbai Hyang Burm Lee Jun-Bo Yang Paul M.Kirk Phongeun Sysouphanthong Sanjay K.Singh Saranyaphat Boonmee Wei Dong K.N.Anil Raj K.P.Deepna Latha Rungtiwa Phookamsak Chayanard Phukhamsakda Sirinapa Konta Subashini C.Jayasiri Chada Norphanphoun Danushka S.Tennakoon Junfu Li Monika C.Dayarathne Rekhani H.Perera Yuanpin Xiao Dhanushka N.Wanasinghe Indunil C.Senanayake Ishani D.Goonasekara N.Ide Silva Ausana Mapook Ruvishika S.Jayawardena Asha J.Dissanayake Ishara S.Manawasinghe K.W.Thilini Chethana Zong-Long Luo Kalani Kanchana Hapuarachchi Abhishek Baghela Adriene Mayra Soares Alfredo Vizzini Angelina Meiras-Ottoni Armin Mesic Arun Kumar Dutta Carlos Alberto Fragoso de Souza Christian Richter Chuan-Gen Lin Debasis Chakrabarty Dinushani A.Daranagama Diogo Xavier Lima Dyutiparna Chakraborty Enrico ercole Fang Wu Giampaolo Simonini Gianrico Vasquez Gladstone Alves da Silva Helio Longoni Plautz Jr Hiran A.Ariyawansa Hyun Lee Ivana Kusan Jie Song Jingzu Sun Joydeep Karmakar Kaifeng Hu Kamal C.Semwal Kasun M.Thambugala Kerstin Voigt Krishnendu Acharya Kunhiraman C.Rajeshkumar Leif Ryvarden Margita Jadan MdIqbal Hosen Michal Miksık Milan C.Samarakoon Nalin N.Wijayawardene Nam Kyu Kim Neven Matocec Paras Nath Singh Qing Tian R.P.Bhatt Rafael JoseVilela de Oliveira Rodham E.Tulloss S.Aamir Saithong Kaewchai Sayali D.Marathe Sehroon Khan Sinang Hongsanan Sinchan Adhikari Tahir Mehmood Tapas Kumar Bandyopadhyay Tatyana YuSvetasheva Thi Thuong Thuong Nguyen Vladimır Antonın Wen-Jing Li Yong Wang Yuvraj Indoliya Zdenko Tkalcec Abdallah M.Elgorban Ali H.Bahkali Alvin M.C.Tang Hong-Yan Su Huang Zhang Itthayakorn Promputtha Jennifer Luangsa-ard Jianchu Xu Jiye Yan Kang Ji-Chuan Marc Stadler Pete Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand World Agroforestry Centre East and Central AsiaKunming 650201YunnanPeople’s Republic of China Mushroom Research Foundation 128 M.3 Ban Pa Deng T.Pa PaeA.Mae TaengChiang Mai 50150Thailand A.M.B.Gruppo Micologico Forlivese“Antonio Cicognani” Via Roma 18Forlı`Italy A.M.B.Circolo Micologico“Giovanni Carini” C.P.314BresciaItaly Societa`per gli Studi Naturalistici della Romagna C.P.144BagnacavalloRAItaly Formerly Department of Botany Goa UniversityTaleigaoGoaIndia No.128/1-J Azad Housing SocietyCurcaGoa VelhaIndia 33 B St.Edwards Road Southsea Hants Hampshire PO53DHUK Landcare Research Manaaki Whenua Private Bag 92170AucklandNew Zealand Department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Division of Applied Science College of International EducationThe Hong Kong Baptist UniversityHong Kong SARChina PostGraduate Program in Biology of Fungi Department of MycologyFederal University of PernambucoAv.Nelson Chavess/nRecifePE 50670-420Brazil Institute of Plant and Environment Protection Beijing Academy of Agriculture and Forestry SciencesBeijing 100097People’s Republic of China Environmental Microbiology Lab Division of Food TechnologyBiotechnology&AgrochemistryCollege of Agriculture and Life SciencesChonnam National UniversityYongbong-Dong 300Buk-GuGwangju 61186Korea Guizhou Key Laboratory of Agricultural Biotechnology Guizhou Academy of Agricultural SciencesGuiyang 550006GuizhouPeople’s Republic of China College of Agriculture and Biological Sciences Dali UniversityDali 671003YunnanPeople’s Republic of China Yunnan Institute of Food Safety Kunming University of Science&TechnologyKunming 650500YunnanPeople’s Republic

This is a continuity of a series of taxonomic and phylogenetic papers on the fungi where materials were collected from many countries,examined and *** addition to extensive morphological descriptions and appropriate asexual and sexual connections,DNA sequence data are also analysed from concatenated datasets to infer phylogenetic relationships and substantiate systematic positions of taxa within appropriate ***ever new species or combinations are proposed,we apply an integrative approach using morphological and molecular data as well as ecological features wherever *** on 112 fungal taxa are compiled in this paper including Biatriosporaceae and Roussoellaceae,Didysimulans ***.,81 new species,18 new host records and new country records,five reference specimens,two new combinations,and three sexual and asexual morph *** new species are Amanita cornelii,***,Angustimassarina alni,***,***,***,***,Ascochyta italica,***,Austroboletus appendiculatus,Barriopsis thailandica,Berkleasmium ariense,Calophoma petasitis,Camarosporium laburnicola,***,***,***,***,Colletotrichum sambucicola,Coprinopsis cerkezii,Cytospora gelida,Dacrymyces chiangraiensis,Didysimulans italica,***,Entodesmium italica,Entoloma magnum,Evlachovaea indica,Exophiala italica,Favolus gracilisporus,Femsjonia monospora,Fomitopsis flabellata,***,Gongronella brasiliensis,Helvella crispoides,Hermatomyces chiangmaiensis,***nae,Hysterium centramurum,Inflatispora caryotae,Inocybe brunneosquamulosa,***,***,Keissleriella cirsii,Lepiota cylindrocystidia,***,***,Lophiotrema guttulata,Marasmius luculentus,Morenoina calamicola,Moelleriella thanathonensis,Mucor stercorarius,Myrmecridium fluviae,Myrothecium septentrionale,Neosetophoma garethjonesii,Nigrograna cangshanensis,Nodulosphaeria guttulatum,***tata,***,Panus subf

关键词： Agaricomycetes Ascomycota Basidiomycota Dacrymycetes Dothideomycetes Eurotiomycetes New combination Mucoromycotina New genus New records New species Pezizomycetes Phylogeny Sordariomycetes Taxonomy