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Automatic Data Reduction and Quantification of X-Ray Computed Tomography Images of Sedimentary Cores: Method and Illustration

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Open Journal of Geology 2020年第8期10卷 874-899页

作者： Philippe Gaillot Mathieu J. Duchesne peter blum ExxonMobil Exploration Company Business Development Spring Texas USA Formerly at Center for Deep Earth Exploration—CDEX Yokohama Japan Geological Survey of Canada-Québec Division INRS Centre Eau Terre et Environnement Quebec Canada Integrated Ocean Drilling Program College Station Texas USA

This paper presents a procedure from which information contained in 3-Dimensional single energy X-ray computed tomography (XR-CT) images of sedimentary rocks is converted into sub-mm scale resolution core scalar and core image logs. This new data provide a quantitative and compact (data volume reduction of ~90%) description of the XR-CT images. Density-related outputs are calibrated through automatic integration with continuous digital visual core description (VCD) and discrete moisture and density (MAD) property index measurements of selected samples. After lithology-based calibration of the X-ray attenuation coefficients into density values, quantitative displays include: 1) histogram of the distribution of density values and its related statistical parameters, 2) radial and angular distributions of core density values, 3) volume, average density and mass contributions of three core fractions defined by density thresholds corresponding to voids or vugs (VV, density ≤ ~1 g•cm−3), and a break in the histogram of distribution of the density values showing the limit between the damaged (DM) and non-damaged (ND) fractions of the core material, and so, 4) providing a sub-mm scale bulk density core log free of any drilling disturbance. The procedure is illustrated on data from the 365 m deep Hole C9001C drilled off-shore Shimokita (northeast coast of Honshu, Japan). Usage of the outputs include: 1) derivation of sub-mm scale porosity core log, 2) correction of volume sensitive measurements in case of poor core quality and partially filled core liner, and 3) seismic modeling and well ties.

关键词： Core image Multi-Sensor Core Logger Ocean Drilling Shimokita (Japan) Diatomaceous Silty Clays Upper Miocene to Holocene

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自动化领域的联盟合作

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流程工业 2010年第21期 36-37页

作者： Jochen Eissler Harts—peter blum 德国Wangen市Waldner公司德国Bodnegg市Hecht自动化技术系统公司

如何才能真正建立起用户与供应商之间的良好合作伙伴关系呢？答案就是通过相互合作实现共赢。本文所介绍的仪器仪表厂商Waldner过程控制系统公司与自动化技术公司Hecht公司之间的合作关系就是最好的实例。

关键词：合作伙伴关系自动化技术联盟过程控制系统合作关系仪器仪表供应商厂商

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EXPLORING THE ASIAN MONSOON THROUGH DRILLING IN THE SOUTH CHINA SEA

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地学前缘 2000年第S1期7卷 377-377页

作者： Wang Pinxian 1,Warren Prell 2,peter blum 3(1 Tongji University, Shanghai 200092, China 2 Brown University, Providence, RI, USA 3 Ocean Drilling Program, Texas A & M University, College Station, TX,the Leg 184 Scientific Party,USA)

Both evolution of the Asian monsoon system and the Cenozoic global cooling are thought to be closely linked to the Himalayan—Tibetan orogen. The South China Sea (SCS) with its high sedimentation rates of carbonate\|rich hemipelagic sediments offers a unique opportunity to study the variability of the East Asian monsoon, the erosion and weathering of tectonic orogens as well as its possible impact on global and regional *** 184, the first deep\|sea drilling leg to the seas off China, cored 17 holes at 6 sites in the northern and southern parts of the SCS and recovered 5463m of sediment. The drilling of hemipelagic sediments was exceptionally successful, with core recovery averaging 83%～101%. The 32Ma sequence of deep\|sea sediments recovered during Leg 184 covers almost the entire environmental history of the SCS since its opening. The abnormally high sediment accumulation rates in the Oligocene section are correlative with the incipient sea floor spreading. The bathyal nature of the Oligocenefauna implies that rifting occurred in the Eocene or earlier. Faunal changesfrom the early to late Oligocene are indicative of basin deepening, a trend thatis even more evident in the Miocene section. Sediment deformation, abruptlithologic changes, and a hiatus occur near the Oligocene/Miocene boundary,representing one of the most significant events in the tectonic andenvironmental history of the SCS.

关键词： Asian monsoon drilling South China Sea core Cenozoic global cooling

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Pseudomonas exotoxin antisense RNA selectively kills hepatitis B virus infected cells

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World Journal of Gastroenterology 2008年第18期14卷 2810-2817页

作者： peter Hafkemeyer Ulrich Brinkmann Elizabeth Brinkmann Ira Pastan Hubert E blum Thomas F Baumert Department of Medicine Ⅱ University Hospital Freiburg Hugstetterstrasse 55 Freiburg D-79106 Germany Roche Diagnostics Nonnenwald 2 Penzberg D-82377 Germany National Cancer Institute National Institutes of Health Bethesda United States Inserm unit 748 Université Louis Pasteur 3 Rue Koeberle Strasbourg F-67000 France

AIM: To present an approach for selectively killing retrovirus-infected cells that combines the toxicity of Pseudomonas exotoxin (PE) and the presence of reverse transcriptase (RT) in infected cells. METHODS: PE antisense toxin RNA has palindromic stem loops at its 5' and 3' ends enabling self-primed generation of cDNA in the presence of RT. The RT activity expressed in retrovirus-infected cells converts "antisense-toxin-RNA" into a lethal toxin gene exclusively in these cells. RESULTS: Using cotransfection studies with PE-expressing RNAs and β-gal expressing reporter plasmids, we show that, in HepG2 and HepG2.2.15 hepatoma cells as well as in duck hepatitis B virus (DHBV) infected cells, HBV or DHBV-polymerase reverse transcribe a lethal cDNA copy of an antisense toxin RNA, which is composed of sequences complementary to a PE gene and eukaryotic transcription and translation signals. CONCLUSION: This finding may have important implications as a novel therapeutic strategy aimed at the elimination of HBV infection.

关键词： Gene therapy Pseudomonas exotoxin Retrovirus Reverse transcription

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Combined TACE and PEI for palliative treatment of unresectable hepatocellular carcinoma

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World Journal of Gastroenterology 2005年第39期11卷 6104-6109页

作者： Gerhild Becker Tarik Soezgen Manfred Olschewski Joerg Laubenberger Hubert Erich blum Hans-peter Allgaier for the Hcc Study Group Department of Medicine Ⅱ Department of Medical Biometry and Statistics and Department of RadiologyUniversity Hospital FreiburgGermany

AIM： To assess whether the effectiveness of a combination of transarterial chemoembolization （TACE） and percutaneous ethanol injection （PEI） in the treatment of unresectable hepatocellular carcinoma （HCC） is superior to TACE alone a randomized controlled trial was performed. METHODS： The effect of combination therapy on longterm survival rates and duration of hospitalization was evaluated in 52 previously untreated HCCs, randomly allocated to TACE-PEI （27 pts） or TACE alone （25 pts）. RESULTS： The cumulative survival rate of the TACE group was 75.8% at 6 mo, 62.9% at 12 mo, and 18.0% at 24 mo and of the TACE-PEI group 76.9%, 61.5%, and 38.7%, respectively. Comparison of overall survival in both groups showed no statistically significant difference. Regarding the patients with HCCs Okuda stage I （n = 26）, the median survival of the TACE-PEI group was significantly longer （〉24 mo, median not yet reached in the study period） compared to the TACE group （18.4 mo [range 11.6-21.7 mo]; P = 0.04）. TACE-PEI reduced the relative risk for mortality to 0.4 （95% CI 0.15-0.96） compared to patients who received TACE alone. Median survival in patients with HCCs Okuda stage Ⅱ or Ⅲ was 5.0 mo in the TACE group （1.7 rno-not defined） compared to 10.4 mo in the TACE-PEI group. CONCLUSION： The combination TACE-PEI improved survival time compared to TACE alone. Our study revealed a statistically significant improved survival in HCCs Okuda stage I. Side effects were minor and the combination therapy did not prolong duration of hospitalization considerably.

关键词： Hepatocellular carcinoma Chemoembolization Ethanol injection Combination therapy

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系统性与盘状性红斑狼疮的活动性血清指标:可溶性白介素-2受体

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德国医学 1994年第2期11卷 81-82页

作者： Carmen blum Detlef Zilikens Hans-peter Tony Albert A.Hartmann Günter Burg 许彤华 tUniversitgts-Hautklinik Josef-Schneider-Str.D-97080 Wiirzburg Germany Medizinisch.e Poliklin k.der Universit.gtt Wi~.rzburg Germany Universitts-Hautklinik Josef-Schneider-Str. D-97080 Würzburg Germany Dermatologisehe Klinik Universittsspital ZürichCH-8091 Zürich.Switzerland 同济医科大学

红斑性狼疮是一发病原因不明疾病,由于免疫调控失常形成针对自身物质的自身抗体。可分为只有局限皮肤受累的盘状性红斑狼疮(DLE)和系统性红斑狼疮(SLE)。判断病情的活动性对确定治疗具有重要意义。然而,依据临床表现对疾病的活动性作出... 详细信息

红斑性狼疮是一发病原因不明疾病,由于免疫调控失常形成针对自身物质的自身抗体。可分为只有局限皮肤受累的盘状性红斑狼疮(DLE)和系统性红斑狼疮(SLE)。判断病情的活动性对确定治疗具有重要意义。然而,依据临床表现对疾病的活动性作出判断并不可靠。

关键词：红斑狼疮白细胞介素2 受体血清

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北京侨福芳草地

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城市环境设计 2013年第8期 232-237页

作者：徐腾 Ulrich blum Nicole Ip Alicia Tan Pusey Chan Stephane Lacroix Moses Tan Kin Choy Christa Lange Jochen Tombers Howard Chung peter Liu Louisa Williams Colin Foster Rosita Nicknafs Patrick Yue Simon Griffiths Ed peter Connie Ho William Tam IDA建筑设计事务所

2000年岁末,北京市中心,来自香港的侨福集团为一座地标性建筑提出了一项挑战性的策划,旨在改变大型综合商业开发项目的成规。它所引得的回应,也是一项时尚、节能且环保的设计,由徐腾(Winston Shu)领衔的香港建筑事务所IDA一手命制。整... 详细信息

2000年岁末,北京市中心,来自香港的侨福集团为一座地标性建筑提出了一项挑战性的策划,旨在改变大型综合商业开发项目的成规。它所引得的回应,也是一项时尚、节能且环保的设计,由徐腾(Winston Shu)领衔的香港建筑事务所IDA一手命制。整个开发项目有微气候调节,运用与北京季候变化相一致的可持续自然手段,实现了水准空前的热舒适度与灵活的使用空间。项目由四座建筑组成,位于一座下沉庭园之中,低于毗邻街道地平面9m。所有的建筑彼此独立,中间是一个L形的满光中庭,宽达24m;其中有空中花园、露台、廊桥彼此穿插错落,均在一道

关键词：精品酒店廊桥商业微气候微小气候办公楼零售商场绿色建筑绿地集团 LEED 北京庭园园林中庭空中花园露台园林建筑设计团队

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应用善宁治疗原发性肝细胞癌的研究

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Oncology and Translational Medicine 2000年第6期17卷 32-32页

作者： Hans-peter Allgaier,G.Becker,H.E.blum,易继林 Medizinische Universittsklinik Abteilung Innere Medizin Ⅱ Hugstetter Str.55 D-79106 Freiburg Germany Medizinische Universittsklinik Abteilung Innere Medizin Ⅱ Hugstetter Str.55 D-79106 Freiburg Germany Medizinische Universittsklinik Abteilung Innere Medizin Ⅱ Hugstetter Str.55 D-79106 Freiburg Germany 同济医科大学附属同济医院

肝细胞性肝癌(HCC)在世界范围内都是一种常见的恶性肿瘤。在德国和其他一些西方国家每年的肝癌发病率约为40～60例10万人,其中在德国每年约有4000～6000例新增肝癌患者。最近的研究表明肝细胞性肝癌在发达国家的发病率有所上升。肝细胞... 详细信息

肝细胞性肝癌(HCC)在世界范围内都是一种常见的恶性肿瘤。在德国和其他一些西方国家每年的肝癌发病率约为40～60例10万人,其中在德国每年约有4000～6000例新增肝癌患者。最近的研究表明肝细胞性肝癌在发达国家的发病率有所上升。肝细胞性肝癌的临床恶性程度很高,病人的预后较差。

关键词：肝细胞性肝癌进展期肝癌患者善宁

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