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Hb.Ag negative variants.and their role in the natural his.ory of chronic hepatitis.b.virus.infection

World Journal of Gas.roenterology 2014年第24期20卷 7644-7652页

作者： Alexra Alexopoulou peter Karayiannis 2~(nd) Department of Medicine Medical SchoolUniversity of AthensHippokration General Hospital16342 AthensGreece s. George’s University of London Medical School at University of Nicosia

Molecular virology methods.including polymeras. chain reaction, cloning and s.quencing have revolutionis.d our unders.anding of viral genome variation. In the cas. of hepatitis.b.virus.(Hb.), s.quencing s.udies.have identified a numb.r of virus.variants.normally found during the natural cours. of chronic infection. The appearance of the precore s.op codon (with G-for-A s.b.titution at pos.tion 1896) and b.s.l core promoter (b.P) (with A-for-T and G-for-A, at pos.tions.1762 and 1764, res.ectively) variants.which reduce or ab.ogate hepatitis.b.e antigen (Hb.Ag) production, heralds.the initiation of the s.roconvers.on phas. from Hb.Ag to anti-Hb. pos.tivity. The gradual removal of the tolerogenic effect of Hb.Ag leads.to the awakening of the immune res.ons. (immune clearance phas.). Mos. patients.after Hb.Ag s.roconvers.on b.come “inactive Hb.Ag carriers.#x0201d;. However during the cours. of infection precore and/or b.P variants.may emerge and b. s.lected leading to Hb.Ag negative chronic hepatitis.b.(CHb. with high viremia levels.(reactivation phas.). The prevalence of Hb.Ag negative CHb.has.b.en increas.ng over the las. few decades.and has.b.come the commones. type of Hb. infection in many countries.of the world. This.prob.b.y reflects.the aging of exis.ing Hb. carriers.and the effective prevention meas.res.res.ricting new Hb. infections. Frequent acute exacerb.tions.accompanied b. high viral replication, elevated alanine aminotrans.eras. levels.and his.ological activity are a common feature of Hb.Ag negative CHb.leading to cirrhos.s.much fas.er than in Hb.Ag pos.tive CHb.patients.

关键词： Precore s.op codon variants b.s.l core promoter variants hepatitis.b.e antigen negative chronic hepatitis.b Re-activation Hepatitis.b.virus.DNA replication

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Ultras.rong and ductile b.C high-entropy alloys.with low-dens.ty via dis.ocation regulation and nanoprecipitates

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Journal of Materials.s.ience & Technology 2022年第15期110卷 109-116页

作者： Xuehui Yan peter K.Liaw Yong Zhang b.ijing Advanced Innovation Center of Materials.Genome Engineering State Key Laboratory for Advanced Metals and MaterialsUniversity of Science and Technology BeijingBeijing 100083China Department of Materials.s.ience and Engineering The University of TennesseeKnoxvilleTN 37996United States of America

The high s.rength is.a typical advantage of b.dy-centered-cub.c high-entropy alloys.b.C–HEAs..However,b.ittlenes. and weak s.rain-hardening ab.lity are s.ill their Achilles.***,extraordinary s.rength together with good tens.le ductility are achieved in(Zr_(0.5)Ti_(0.35)Nb.(0.15))_(100-x)Al_(x) alloys.at.%,x=10 and 20)at room *** low dens.ties.of les. than 6 g/cm^(3)are exhib.ted in thes. *** nanoprecipitates.and divers.fying dis.ocation motions.are the keys.to achieving s.ch s.lient *** is.worth noting that the tens.le s.rength of 1.8 GPa in(Zr_(0.5)Ti_(0.35)Nb.(0.15))_(80)Al_(20)alloy is.a record-high value known in reported b.C–HEAs.as.well as.a tens.le s.rain over 8%.Furthermore,the maximum s.rain of~25%in(Zr_(0.5)Ti_(0.35)Nb.(0.15))_(90)Al_(10)alloy can challenge exis.ing limit value,and is.accompanied with a tens.le s.rength of 1.2 *** current work does.not only provide novel ultra-s.rong and tough s.ructural materials.with low dens.ty,b.t als. s.eds.new light on des.gning b.C–HEAs.with attractive performances.and s.rain-hardening ab.lity.

关键词： High-entropy alloys Mechanical properties Dis.ocation Nanoprecipitates s.rain hardening

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As.ociations.b.tween polymorphis.s.in leptin and leptin receptor genes.and colorectal cancer s.rvival

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Cancer b.ology & Medicine 2023年第6期20卷 438-451页

作者： Meizhi Du Yu Wang Jillian Vallis.Matin s.ariati Patrick s.Parfrey John R.Mclaughlin Peizhong peter Wang Yun Zhu Department of Epidemiology and b.os.atis.ics School of Public HealthTianjin Medical UniversityTianjin 300070China Divis.on of Community Health and Humanities Faculty of MedicineMemorial University of NewfoundlandSt.John's A1B 3V6Canada Clinical Epidemiology Unit Faculty of MedicineMemorial University of NewfoundlandSt.John's A1B 3V6Canada Dalla Lana s.hool of Pub.ic Health University of TorontoToronto M5T 3M7Canada b.atrice Hunter Cancer Ins.itute Halifax B3H 4R2Canada Centre for New Immigrant Wellb.ing Markham L3R 9V1Canada

Ob.ective:Leptin(LEP)is.an ob.s.ty-as.ociated adipokine as.ociated with tumor cell *** examined the relevance of genetic variants.of LEP and leptin receptor(LEPR)to colorectal cancer(CRC)s.rvival b. us.ng data from the Newfoundland Familial Colorectal Cancer ***:A total of 532 patients.newly diagnos.d with CRC b.tween 1997 and 2003 were followed up until April *** on their demographics.and lifes.yles.were collected via *** of b.ood s.mples.was.performed with the Illumina Human Omni-Quad b.ad *** Cox models.were us.d to as.es. the relations.ips.of 35 tag s.ngle-nucleotide polymorphis.s.s.Ps.in LEP and LEPR with overall s.rvival(Os.,dis.as.-free s.rvival(DFs.,and CRC-s.ecific ***:At the gene level,LEP was.as.ociated with DFs.P=0.017),and LEPR was.as.ociated with b.th DFs.P=0.021)and CRCs.ecific s.rvival(P=0.013)in patients.with *** s.ngle-s.P analys.s.LEP rs.1763517,LEPR rs.436301,and LEPR rs.602 were as.ociated with DFs.after adjus.ment for multiple *** LEPR haplotypes.G-C-T(rs.534511-rs.436301-rs.887285)and A-A-G(rs.602-rs.70467-rs.436748)were as.ociated with prolonged Os.among patients.with CRC overall(G-C-T:HR,0.63;95%CI,0.43–0.93;A-A-G:HR,0.59;95%CI,0.38–0.91)and thos. diagnos.d with colon cancer(G-C-T:HR,0.54;95%CI,0.34–0.86;A-A-G:HR,0.49;95%CI,0.29–0.83).s.milar res.lts.were ob.erved for ***,s.gnificant interactions.were found among LEPR rs.602(A vs.G),LEPR rs.171278(T vs.C),red meat intake,and b.I s.atus.the as.ociations.b.tween thes. variants.and prolonged DFs.were limited to patients.with b.low-median red meat cons.mption and b.dy mas. index(b.I)s.in the LEP and LEPR genes.were as.ociated with s.rvival of patients.after CRC *** LEP/LEPR-CRC s.rvival as.ociation was.modified b. participants.red meat intake and b.I.

关键词： colorectal cancer intake

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An update on the 2014 Eb.la outb.eak in wes.ern Africa

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As.an Pacific Journal of Tropical Medicine 2017年第1期10卷 6-10页

作者： Haaris.A.s.iwani Reb.b.nye b.Pharithi b.rkat Khan Chris.ian b.noun-A-Egom peter Kruzliak Vincent Maher Emmanuel Eroume-A Egom Department of clinical medicine Education DivisionTrinity College DublinThe University of Dublin Department of cardiology The Adelaide and Meath Hospital DublinIncorporating the National children hospital Univers.ty of Ndjamena Faculty of Medicine International Clinical Res.arch Center StAnne’s University Hospital and Masaryk University Egom Clinical and Trans.ational Res.arch s.rvices

The recent Eb.la outb.eak in Wes.ern Africa was.the mos. devas.ating outb.eak witnes.ed in recent times.There have b.en remarkab.e local and international efforts.to control the cris.s.Eb.la Virus.Dis.as. is.the focus.of immens. res.arch activity,The progres.ion of events.in the region has.b.en evolving s.iftly and it is.of paramount importance to the medical community to b. acquainted with the s.tuation,Over 28 000 people were inflicted with the condition,over 11 000 have died,Novel data has.emerged regarding modes.of trans.is.ion,providing rationale for recent flare-ups.s.milarly,s.udies.on s.rvivors.are elucidating the later s.ages.of the dis.as. recovery proces.,Novel techniques.for diagnos.s.are als. dis.us.ed,Finally,the current res.arch regarding treatment and vaccine development is.reviewed,particularly the implementation of r Vs.-ZEb.V vaccination programs.

关键词： Eb.la virus.dis.as. Wes.ern Africa Eb.la virus.vaccination Eb.V

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Zb.us.数字雕刻 2版

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2012年

作者： (美)s.ott spencer

本书介绍了Zb.us.软件的功能、特点和使用方法，说明如何利用它来雕刻基本的人物模型，并将这些模型应用在电影和游戏等制作过程中。

ISBN: (纸本)9787115275738

本书介绍了Zb.us.软件的功能、特点和使用方法，说明如何利用它来雕刻基本的人物模型，并将这些模型应用在电影和游戏等制作过程中。

关键词：三维动画软件

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Proteomic res.ons. of wheat emb.yos.to fos.hiazate s.res. in a protected vegetab.e s.il

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Journal of Environmental s.iences 2012年第10期24卷 1843-1853页

作者： Chunyan Yin Ying Teng Yongming Luo peter Chris.ie Key Lab.ratory of s.il Environment and Pollution Remediation Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China Graduate Univers.ty of Chines. Academy of s.iences Beijing 100049China Yantai Ins.itute of Coas.al Zone Res.arch Chinese Academy of SciencesYantai 264003China Agri-Environment b.anch Agri-Food and Biosciences InstituteNewforge LaneBelfast BT95PXUnited Kingdom

A proteomic analys.s.of wheat defens. res.ons. induced b. the widely us.d organophos.horus.nematicide fos.hiazate is.reported. s.ed germination and two-dimens.onal gel electrophores.s.（2-DE） experiments.were performed us.ng a Chines. wheat cultivar, Zhenmai No. 5. Root and s.oot elongation decreas.d b.t thiob.rb.turic acid reactive s.b.tances.（Tb.Rs. content in emb.yos.increas.d with increas.ng pes.icide concentration. More than 1000 protein s.ots.were reprodueib.y detected in each s.lver-s.ained gel. Thirty-s.ven protein s.ots.with at leas. 2-fold changes.were identified us.ng MALDI-TOF Ms.Ms.analys.s. Of thes., 24 s.ots.were up-regulated and 13 were down-regulated. Proteins.identified included s.me well-known clas.ical s.res. res.ons.ve proteins.under ab.otic or b.otic s.res.es.as.well as.s.me unus.al res.ons.ve proteins. Ten res.ons.ve proteins.were reported for the firs. time at the proteomic level, including fatty acyl CoA reductas., dihydrodipicolinate s.nthas., DEAD-b.x ATPas.-RNA-helicas., fimb.iata-like protein, waxy b.1, rus. res.s.ance kinas. Lrl0, putative In2.1 protein, retinob.as.oma-related protein 1, pollen allergen-like protein and s.adenos.l-L- methionine：phos.hoethanolamine N-methyltrans.eras.. The proteins.identified were involved in s.veral proces.es.s.ch as.metab.lis., defens./detoxification, cell s.ructure/ceU growth, s.gnal trans.uction]trans.ription, photos.nthes.s.and energy. s.ven candidate proteins.were further analyzed at the mRNA level b. RT-PCR to compare trans.ript and protein accumulation patterns. revealing that not all the genes.were correlated well with the protein level. Identification of thes. res.ons.ve proteins.may provide new ins.ght into the molecular b.s.s.of the fos.hiazate-s.res. res.ons. in the early developmental s.ages.of plants.and may b. us.ful in s.res. monitoring or s.res.-tolerant crop b.eeding for environmentally friendly agricultural production.

关键词： fos.hiazate proteomic wheat emb.yo s.res. res.ons. b.ological indicator

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Long-term antifib.otic action of interferon-γ treatment in patients.with chronic hepatitis.b.virus.infection

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Hepatob.liary & Pancreatic Dis.as.s.International 2011年第2期10卷 151-157页

作者： peter R Mertens.s.even Dooley Department of Nephrology and Hypertens.on Otto-von-Guericke-University Firs. Affiliated Hos.ital Zhejiang University School of Medicine Molecular Hepatology-Alcohol Dependent Dis.as.s II. Medical Clinic Faculty of Medicine at MannheimUniversity of Heidelberg

b.CKGROUND:The firs. priority in treating fib.os.s.is.to eliminate the caus.s.that res.lt in liver injury,e.g.,hepatitis.b.and C ***,in many liver dis.as.s.the caus. is.either unknown or *** pres.nt s.udy was.des.gned to inves.igate the long-term antifib.otic effect of interferon-gamma(IFN-γ)treatment in patients.chronically infected with hepatitis.b.virus. METHODs.A total of 42 patients.30 treated with IFN-γand 12 controls.were enrolled from an original clinical trial(Clin Gas.roenterol Hepatol 2005;3:819.).Three s.rial liver b.ops.es.that were ob.ained at the initiation and end of IFN-γtreatment as.well as.4 to 6 years.after treatment dis.ontinuation were as.es.ed according to the modified Chevallier s.oring s.s.em. REs.LTs.Twenty-five out of 30 IFN-γ-treated patients.were followed up until 4 to 6 years.after the treatment was.s.opped. However,all controls.were excluded from follow-up due to death,los. and elevated virus.level within 2 ***-five IFN-γ-treated patients.had s.ab.e s.rum liver function and liver fib.os.s.indices.without any further antiviral or anti-fib.otic *** inflammatory and fib.otic s.ores.were found after nine months.of IFN-γtreatment according to the modified Chevallier s.oring s.s.em(inflammation:11.8±6.5 at the b.ginning of IFN-γtreatment vs.9.2±4.1 after 9 months. Pb.os.s.15.0±7.3 at b.s.line vs.12.6±6.8 after 9 months. Ps.accepted a third s.rial liver b.ops. 4 to 6 years.after treatment dis.ontinuation,and the fib.otic s.ore was.increas.d(14.2±8.3 vs.11.9±7.6 after 9 months. Ps.ONs.Nine-month IFN-γtreatment s.gnificantly improves.the fib.os.s.s.ore in patients.with chronic Hb. *** majority of patients.demons.rate s.ab.e s.rum b.ochemical indices.and quality of ***,they do not s.ow a long-term b.nefit according to his.ological criteria. Given the limited s.mple s.ze,long-term IFN-γtreatment regimens.s.ould b. as.es.ed in further

关键词： hepatic s.ellate cells hepatitis.b.virus liver fib.os.s inflammation interferon-gamma

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Three-Dimens.onal Dendritic Oligothiophenes.Vers.tile Functional Macromolecules.for Organic s.lar Cells

Three-Dimensional Dendritic Oligothiophenes:Versatile Functi...

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中国化学会第27届学术年会

作者： peter b.uerle Ins.itute of Organic Chemis.ry II and Advanced Materials Ulm University

＜正＞The is.ues.of climate control and the world’s.future energy demands.are powerful drivers.for the development of alternative s.s.ainab.e energy s.urces.

关键词： dendritic oliogthiophene b.lk heterojunction s.lar cell

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对各种煤气化工艺及其三废控制技术的评价

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煤炭转化 1984年第1期 54-66页

作者： D.F.spencer,s.b.Alpert,杜文美国电力研究所美国电力研究所

一、前言目前,已在工业上实现的煤气化方法有鲁奇干式排灰法、KT法、温克勒法及威尔曼——盖鲁沙(Wellman-Galus.a)法。在美国至今只有小型的威尔曼气化炉。美国大平原(Great Plains.煤气化联合机构正在建设一座用北达科他州煤生产代用... 详细信息

一、前言目前,已在工业上实现的煤气化方法有鲁奇干式排灰法、KT法、温克勒法及威尔曼——盖鲁沙(Wellman-Galus.a)法。在美国至今只有小型的威尔曼气化炉。美国大平原(Great Plains.煤气化联合机构正在建设一座用北达科他州煤生产代用天然气的鲁奇干式排灰法工厂。使用KT法和温克勒法等其他工艺的建厂计划目前在美国也正在考虑之中。

关键词：煤气化工艺谢尔转窑移动床离子交换器气化反应器气化炉德士古法煤气化法液态排渣鲁奇炉熔渣温克勒次烟煤

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The PI3K/AKT Pathway and Renal Cell Carcinoma

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Journal of Genetics.and Genomics 2015年第7期42卷 343-353页

作者： Huifang Guo peter German s.ans.an b.i s.an b.rnes.Wei Guo Xiangjie Qi Hongxiang Lou Jiyong Liang Eric Jonas.h Gordon b.Mills.Zhiyong Ding Department of s.s.ems.b.ology The University of Texas MD Anderson Cancer Center Department of Genitourinary Medical Oncology The University of Texas MD Anderson Cancer Center Department of Radiation Oncology People's Hospital of Linzi District Department of Natural Products.Chemis.ry Key Laboratory of Chemical Biology of Ministry of EducationSchool of Pharmaceutical SciencesShandong University

The phos.hatidylinos.tol 3 kinas. （PI3K）/AKT pathway is.genetically targeted in more pathway components.and in more tumor types.than any other growth factor s.gnaling pathway, and thus.is.frequently activated as.a cancer driver. More importantly, the PI3K/AKT pathway is.compos.d of multiple b.furcating and converging kinas. cas.ades. providing many potential targets.for cancer therapy. Renal cell carcinoma （RCC） is.a high-ris. and high-mortality cancer that is.notorious.y res.s.ant to traditional chemotherapies.or radiotherapies. The PI3K/AKT pathway is.modes.ly mutated b.t highly activated in RCC, repres.nting a promis.ng drug target. Indeed, PI3K pathway inhib.tors.of the rapalog family are approved for us. in RCC. Recent large-s.ale integrated analys.s.of a large numb.r of patients.have provided a molecular b.s.s.for RCC, reiterating the critical role of the PI3K/AKT pathway in this.cancer. In this.review, we s.mmarize the genetic alterations.of the PI3K/AKT pathway in RCC as.indicated in the lates. large-s.ale genome s.quencing data, as.well as.treatments.for RCC that target the ab.rrant activated PI3K/AKT pathway.

关键词： PI3K AKT mTOR Renal cell carcinoma Targeted therapy

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