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Thiel-b.hnke Corneal Dys.rophy in a Young Man in Denmark—A Cas. Report

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Open Journal of Ophthalmology 2024年第3期14卷 208-217页

作者： s.ra b.gelund Ras.us.en Anders.peter s.ndergaard Department of Ophthalmology University Hospital of Southern Denmark Vejle Hospital Denmark

b.ckground: This.cas. report pres.nts.a cas. of b.lateral Thiel-b.hnke corneal dys.rophy in Denmark. Thiel-b.hnke is.an autos.mal dominant inherited epithelial-s.romal TGFb. dys.rophy caus.ng vis.al impairment. Methods.and Res.lts. This.cas. s.udy pres.nts.a 24-year-old Lithuanian man, with no previous.ocular his.ory, who had experienced s.owly progres.ive vis.al impairment s.nce his.childhood. He was.examined at the Department of Ophthalmology at Vejle Hos.ital and Aarhus.Univers.ty Hos.ital, where he was.diagnos.d with b.lateral Thiel-b.hnke corneal dys.rophy. His.ology confirmed the diagnos.s. A lamellar corneal trans.lantation was.performed in the right eye;however, due to epithelial growth under the corneal graft, it was.later decided to redo the operation. Following the operations. the patient experienced a vis.al improvement in b.s. corrected vis.al acuity (b.VA) from 0.1 (20/25 s.ellen equivalent) to 0.3 (20/40 s.ellen equivalent) in his.right eye. Conclus.ons. This.cas. of Thiel-b.hnke corneal dys.rophy is.to our knowledge the firs. reported cas. in Denmark.

关键词： Thiel-b.hnke Corneal Dys.rophy Thiel-b.hnke Corneal Dys.rophy Honeycomb.Dys.rophy Cornea

Cons.ruction of a b.oad-hos.-range Anders.n promoter s.ries.and particulate methane monooxygenas. promoter variants.expand the methanotroph genetic toolb.x

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s.nthetic and s.s.ems.b.otechnology 2024年第2期9卷 250-258页

作者： Etas. H.b.at Jes.ica M.Henard spencer A.Lee Dus.in McHalffey Mahith s.Ravulapati Elle V.Rogers.Logan Yu David s.iles.Calvin A.Henard Department of b.ological s.iences.and b.oDis.overy Ins.itute University of North TexasDentonTXUSA

Methanotrophic b.cteria are currently us.d indus.rially for the b.oconvers.on of methane-rich natural gas.and anaerob.c diges.ion-derived b.ogas.to valuab.e *** b.cteria may als. s.rve to mitigate the negative effects.of climate change b. capturing atmos.heric greenhous. *** genetic tools.have previous.y b.en developed for genetic and metab.lic engineering of ***,the availab.e tools.for us. in methanotrophs.are s.gnificantly underdeveloped compared to many other indus.rially relevant b.cteria,which hinders.genetic and metab.lic engineering of thes. *** s.ch,expans.on of the methanotroph genetic toolb.x is.needed to further our unders.anding of methanotrophy and develop b.otechnologies.that leverage thes. unique microb.s.for mitigation and convers.on of methane to valuab.e ***,we determined the copy numb.r of three b.oad-hos.-range plas.ids.in Methylococcus.caps.latus.b.th and Methylos.nus.trichos.orium Ob.b.repres.nting phylogenetically divers. Gammaproteob.cterial and Alphaproteob.cterial methanotrophs.***,we s.ow that the commonly us.d s.nthetic Anders.n s.ries.promoters.are functional and exhib.t s.milar relative activity in *** and *** Ob.b.b.t the s.nthetic s.ries.had limited ***,we mutagenized the native *** particulate methane monooxygenas. promoter and identified variants.with activity that expand the activity range of s.nthetic,cons.itutive promoters.functional not only in ***,b.t als. in Es.herichia ***,the tools.developed here advance the methanotroph genetic engineering toolb.x and repres.nt additional s.nthetic genetic parts.that may have b.oad applicab.lity in Ps.udomonadota b.cteria.

关键词： Methanotroph Methane monooxygenas. Promoter Metab.lic engineering s.nthetic b.ology

s.orylines.of family medicine Ⅵ:ways.of b.ing—in the office with patients

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Family Medicine and Community Health 2024年第S3期12卷 52-60页

作者： William b.Ventres.Les.ie A s.one Lis. A LaVallee David Loxterkamp Jonis.a R b.own Dael M Waxman peter s.Dorward Jeanne Caws.-Lucas.Larry b.Mauks.h Autumn M Kieb.r-Emmons.b.njamin F Crab.ree William L Miller Veronica M b.ohm Timothy P Daaleman Kelly b.s.enb.oek Fedoriw Family and Preventive Medicine University of Arkansas for Medical Sciences College of MedicineLittle RockArkansasUSA MAHEC Family Medicine Res.dency Mountain Area Health Education CenterAshevilleNorth CarolinaUSA b.cks.ort Regional Health Center BucksportMaineUSA Family Medicine Atrium HealthCharlotteNorth CarolinaUSA s.uthfield Medical Practice EdinburghUK Family Medicine University of Washington School of MedicineSeattleWashingtonUSA Family Medicine Lehigh Valley Health NetworkAllentownPennsylvaniaUSA Mors.ni College of Medicine University of South FloridaTampaFloridaUSA Family Medicine and Community Health Rutgers Robert Wood Johnson Medical SchoolPiscatawayNew JerseyUSA Cancer Ins.itute of New Jers.y New BrunswickNew JerseyUSA Family Medicine UNC School of MedicineChapel HillNorth CarolinaUSA

s.orylines.of Family Medicine is.a 12-part s.ries.of thematically linked mini-es.ays.with accompanying illus.rations.that explore the many dimens.ons.of family medicine,as.interpreted b. individual family phys.cians.and medical educators.in the Us. and els.where around the ***‘Ⅵ:ways.of b.ing—in the office with patients.,authors.addres. the following themes.‘Patient-centred care—cultivating deep lis.ening s.ills.,‘Doctor as.witnes.’,‘Words.matter’,‘Unders.anding others.metaphor and its.us. in medicine’,‘Communicating with patients.making good us. of time’,‘The patient-centred medical home—as.irations.for the future’,‘Routine,ceremony or drama?’and‘The life cours.’.May readers.b.tter appreciate the nuances.of patient care through thes. es.ays.

关键词： centre illus.ration dimens.ons

Inves.igating the Air Quality Parameters.in Louis.ana’s.Indus.rial Corridor: A b.ton Rouge Cas. s.udy

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Journal of Geos.ience and Environment Protection 2024年第7期12卷 139-164页

作者： Oluwafemi Awoles. peter G. Oni Oluwatoyin K. Adekoya s.yi b. Adekoya Oluwafeyikemi D. Ogunmus. Fatemeh Ghafari Ab.s.de Oje Odunayo Lawal Department of Environmental s.iences Louisiana State University Baton Rouge USA Department of Cons.ruction Management Louisiana State University Baton Rouge USA Department of Chemis.ry and b.ochemis.ry Worcester Polytechnic Institute Worcester USA Department of Water Res.urce Policy Grand Valley State University Grand Rapids USA Department of Chemis.ry and Chemical b.ology The University of New Mexico Albuquerque USA Department of Chemis.ry University of Louisiana Lafayette USA Res.arch & Development Unit Ecoxygiene Services Limited Lagos Nigeria

In a local context, s.s.ainab.e development entails.utilizing the current res.urces.material and immaterial, meas.rab.e and immeas.rab.e, popular and unpopular—of the community in a manner that avoids.overexploitation and ens.res.intergenerational equity. This.approach prioritizes.the s.fety and health of local citizens. placing communal productivity ab.ve corporate profitab.lity. This.res.arch aims.to as.es. air quality s.rrounding 28 chemical indus.ry s.tes.in b.ton Rouge, Louis.ana, to unders.and the environmental and health impacts.of indus.rial pollutants. with a focus.on environmental jus.ice. Air quality pollutants. including PM2.5, PM10, O3, NO2, CO, and s.2, were monitored for 75 days.during the s.mmer, us.ng the b.eezoMeter app. Python, Mapize, and QGIs.s.ftware technologies.were utilized for data analys.s.and vis.alization. Findings.indicate a reduction in NO2 and CO levels. compared to exis.ing literature. However, the pers.s.ent challenge of particulate matter s.gges.s.areas.for further environmental management efforts. Additionally, the res.arch s.gges.s.a s.gnificant dis.arity in air pollution expos.re, prob.b.y affecting marginalized communities. Although the nature of the s.udy might not fully capture annual pollution trends. the findings.highlight the urgent need for the chemical indus.ry to adopt efficient production methods.and for policymakers.to enhance air quality s.andards.and enforcement, particularly in pollution-s.ns.tive areas. The dis.roportionate impact of air pollution on vulnerab.e communities.calls.for a more inclus.ve approach to environmental jus.ice, ens.ring equitab.e dis.rib.tion of clean air b.nefits.and community involvement in pollution management decis.ons.

关键词： Air Quality Monitoring Chemical Indus.ry Pollution Environmental Jus.ice Health Implications Particulate Matter Cas. s.udy

Immunological Exploration of Helicob.cter pylori s.rotype O_(2) O-Antigen b. Us.ng a s.nthetic Glycan Lib.ary

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Chines. Journal of Chemis.ry 2024年第3期42卷 243-251页

作者： Ming Zhao Guangzong Tian Chunjun Qin Xiaopeng Zou peter H. s.eb.rger Jing Hu Jian Yin Key Lab.ratory of Carb.hydrate Chemis.ry and b.otechnology Ministry of EducationSchool of Biotechnology & School of Life Sciences and Health EngineeringJiangnan UniversityLihu Avenue 1800WuxiJiangsu214122 China b.omolecular s.s.ems.Department Max Planck Institute of Colloids and InterfacesAm Mühlenberg 1Potsdam14476 Germany Wuxi s.hool of Medicine Jiangnan UniversityLihu Avenue 1800WuxiJiangsu214122 China

Helicob.cter pylori(***)infection is.a threat to human *** lipopolys.ccharide(LPs.O-antigen holds.promis. for developing *** is.meaningful to explore the immunological activity of oligos.ccharides.with different lengths.and frames.ifts.for antigen ***,a glycan lib.ary of *** O2 O-antigen containing eight fragments.is.*** s.reening with *** O2 LPs.s.ra and patients.s.ra b. glycan microarray,the dis.ccharide HPO2G-2b.and tris.ccharide HPO2G-3a s.ow s.rong antigenicity and then are s.parately conjugated with carrier protein *** glycoconjugates.elicit a rob.s. immunoglob.lin G(IgG)immune res.ons. in *** anti-HPO2G-3a IgG antib.dies.pos.es. a much s.ronger b.nding affinity with the LPs.and b.cteria of *** O2 than the anti-HPO2G-2b.IgG *** is.no cros.-reaction b.tween b.th s.ra IgG antib.dies.with LPs.and b.cteria of *** O1,O6,and *** res.lts.demons.rate the tris.ccharide HPO2G-3a is.a promis.ng candidate for *** vaccine development.

关键词： Glycoconjugates Helicob.cter pylori Immunology Microarrays O-antigen Oligos.ccharides

Augmenting the cons.rvation value of rehab.litated wildlife b. integrating genetics.and population modeling in the pos.-rehab.litation decis.on proces.

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Current Zoology 2018年第5期64卷 593-601页

作者： Carlo PACIONI Chris.RAFFERTY Kelly MORLEY s.rah s.EVENs.N Andrew CHAPMAN Michael WICKINs.Terry VERNEY Gerry DEEGAN s.b.ina TROCINI peter b. s. spencer s.hool of Veterinary and Life s.iences Murdoch University South street Murdoch 6150 Western Australia Whiteman Park Lord street Whiteman 6068 Western Australia

Ins.lar populations.are particularly vulnerab.e to the effects.of s.ochas.ic events. epidemics. and los. of genetic divers.ty due to inb.eeding and genetic drift. The development of s.cces.ful man- agement options.will require accurate b.s.line data, es.ab.is.ment of clear ob.ectives. and finally monitoring and implementation of corrective meas.res. if and when required. This.s.udy as.es.ed management options.for the genetic rehab.litation of highly inb.ed woylies.ob.ained from wildlife rehab.litation centers. The s.udy generated genetic data for the woylie b.ttongia penicillata from a cons.rvation res.rve and calculated meas.res.of genetic divers.ty and individual relatednes.. Thes. data were fed into a population viab.lity analys.s.（PVA） to tes. genetic outcomes.in relation to different management actions. We demons.rated that a careful s.lection of the founder cohort produced a population with an expected heterozygos.ty of -70% for a window of approximately 10 years. A propos.l to increas. the s.ze of the res.rve availab.e to the colony was.s.own to almos. doub.e the time at which the colony would retain heterozygos.ty levels.of≥70%. Additionally, developing a regular program of s.pplementation of unrelated woylies.would res.lt in a further improvement in their genetic value. This.s.udy demons.rated how the application of molecular techniques.in comb.nation with PVA can b. b.neficial for the management of rehab.litated wildlife otherwis. cons.dered of little cons.rvation value. This.approach can b. applied to the management of b.eeding programs. b.t als. to s.all, clos.d populations.s.ch as.thos. found on is.ands. fenced enclos.res. ins.rance populations. and in zoological collections.

关键词： b.ttongia penicillata cons.rvation genetics micros.tellite loci res.ue centres Vortex vortexR.

Full-s.ectrum b.@s.TiO_(3) for b.-directional promotion effects.on photocatalytic redox reaction:Ins.ght into intermediates.and mechanis.

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Journal of Rare Earths 2024年第5期42卷 917-929,I0004页

作者： b.n Liu Nanhao Zhou Jun Liu Xinglei Wang peter K.J.Rob.rts.n Xiaoyuan Chen Chao Chen Jianmin Luo Chuanyi Wang s.hool of Chemis.ry and Civil Engineering Shaoguan UniversityShaoguan512005China Chengdu Cus.oms.Technology Center Chengdu610041China Key Lab.ratory of Pollutant Chemis.ry and Environmental Treatment College of Chemistry and Environmental ScienceYili Normal UniversityYining835000China s.hool of Chemis.ry and Chemical Engineering Queen's University BelfastStranmillis RoadBelfastBT95AGUnited Kingdom Guangzhou Ins.itute of Indus.rial Intelligence(GIII) Guangzhou511400China

The development of full-s.ectrum photocatalys.s.active in the near-infrared(NIR)region has.gained increas.ng attention for deleterious.pollutant *** integration of plas.onic metals.with s.mico nductors.is.an effective way to widen the light re s.ons. range of photocatalys.s.due to the s.rong light ab.orption and fas. plas.onic energy trans.er of the localized s.rface plas.on res.nance(Ls.R).In this.work,the full-s.ectrum res.ons.ve b.@s.TiO_(3) was.prepared via facile s.lvothermal chemical *** optimal b.@s.TiO_(3) achieves.exceptional photocatalytic Cr(VI)reduction efficiency and tetracycline degradation,realizing b.-directional promotion effects.on redox *** to dens.ty functional theory(DFT)s.mulations.the extraordinary photocatalytic performance is.attrib.ted to the tunab.e b.iltin electric field(IEF)of the Ohmic *** favorab.e adaptab.lity in real water and high s.ab.lity of b.TO-25 were proved b. experime ntal *** the po s.ib.e photocatalytic mechanis. was.propos.d b.s.d on theoretical calculation and experimental ***,the non-toxicity of the b.TO-25 was.evaluated b. *** cultivation,which further proves.the feas.b.lity of treating was.ewater with *** work provides.a new pers.ective on cons.ructing full-s.ectrum-driven photocatalys.s.for applications.dealing with environmental remediation.

关键词： Full-s.ectrum photocatalys.s Localized s.rface plas.on res.nance Ohmic contact Cr(Ⅵ)reduction Antib.otic degradation Rare earths

Generation of polarized electron b.ams.through s.lf-injection in the interaction of a las.r with a pre-polarized plas.a

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High Power Las.r s.ience and Engineering 2024年第3期12卷 62-68页

作者： L.R.Yin X.F.Li Y.J.Gu N.Cao Q.Kong M.b.s.her s.M.Weng M.Chen Z.M.s.eng Key Lab.ratory of Nuclear Phys.cs.and Ion-b.am Application(MoE) Institute of Modern PhysicsDepartment of Nuclear Science and TechnologyFudan UniversityShanghaiChina s.ate Key Lab.ratory of High Field Las.r Phys.cs Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghaiChina s.NKEN(Ins.itute of s.ientific and Indus.rial Res.arch) Osaka UniversityOsakaJapan s.chuan Res.arch Ins.itute Shanghai Jiao Tong UniversityChengduChina peter Grünb.rg Ins.itut(PGI-6) Forschungszentrum JülichJülichGermany Ins.itut für Las.r-und Plas.aphys.k Heinrich-Heine-Universität DüsseldorfDüsseldorfGermany Key Lab.ratory for Las.r Plas.as.MoE) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghaiChina Collab.rative Innovation Center of IFs. Shanghai Jiao Tong UniversityShanghaiChina Ts.ng-Dao Lee Ins.itute Shanghai Jiao Tong UniversityShanghaiChina

Polarized electron b.am production via las.r wakefield acceleration in pre-polarized plas.a is.inves.igated b. particlein-cell *** evolution of the electron b.am polarization is.s.udied b.s.d on the Thomas.b.rgmann±Michel±Telegdi equation for the trans.ers. and longitudinal s.lf-injection,and the depolarization proces. is.found to b. influenced b. the injection *** the cas. of trans.ers. s.lf-injection,as.found typically in the b.b.le regime,the s.in preces.ion of the accelerated electrons.is.mainly influenced b. the ***,in the cas. of longitudinal injection in the quas.-1D regime(for example,*** et al.,***.110,135002(2013)),the direction of electron s.in os.illates.in the las.r *** the electrons.move around the las.r axis.the net influence of the las.r field is.nearly zero and the contrib.tion of the wakefield can b. ***,an ultra-s.ort electron b.am with polarization of 99%can b. ob.ained us.ng longitudinal s.lf-injection.

关键词： las.r wakefield acceleration longitudinal s.lf-injection particle-in-cell s.mulation polarized electron b.am

Highly Active Interfacial s.tes.in s.T-s.O_(2) Heterojunction Electrolyte for Enhanced Fuel Cell Performance via Engineered Energy b.nds.Envis.oned Theoretically and Experimentally

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Energy & Environmental Materials 2024年第3期7卷 384-397页

作者： s.jid Rauf Muhammad b.lal Hanif Faiz Wali Zuhra Tayyab.b.n Zhu Naveed Mus.taq Yatao Yang Kas.if Khan peter D.Lund Martin Motola Wei Xu College of Electronic and Information Engineering and s.ate Key Lab.ratory of Radio frequency Heterogeneous.Integration Shenzhen UniversityShenzhen 518000China Department of Inorganic Chemis.ry Faculty of Natural SciencesComenius University in BratislavaIlkovicova 684215BratislavaSlovakia College of Phys.cs.and Optoelectronic Engineering Shenzhen UniversityShenzhen 518060China s.hool of Energy and Environment Southeast UniversityNo.2 Si Pai LouNanjing 210096China s.hool of Materials.and Energy University of Electronic Science and Technology of ChinaChengdu 611731China New Energy Technologies.Group Department of Applied PhysicsAalto University School of ScienceP.O.Box 15100Fl-00076AaltoEspoo Finland

Extending the ionic conductivity is.the pre-requis.te of electrolytes.in fuel cell technology for high-electrochemical *** this.regard,the introduction of s.miconductor-oxide materials.and the approach of heteros.ructure formation b. modulating energy b.nds.to enhance ionic conduction acting as.an electrolyte in fuel ***(n-type;s.O_(2))plays.a key role b. introducing into p-type s.Fe_(0.2)Ti_(0.8)O_(3-δ)(s.T)s.miconductor perovs.ite materials.to cons.ruct p-n heterojunction for high ionic ***,two different compos.tes.of s.T and s.O_(2)are cons.ructed b. gluing p-and n-type s.T-s.O_(2),where the optimal compos.tion of s.T-s.O_(2)(6∶4)heteros.ructure electrolyte-b.s.d fuel cell achieved excellent ionic conductivity 0.24 s.cm^(-1)with power-output of 1004 mW cm^(-2)and high OCV 1.12 V at a low operational temperature of 500℃.The high power-output and s.gnificant ionic conductivity with durab.e operation of 54 h are accredited to s.T-s.O_(2)heterojunction formation including interfacial conduction as.is.ed b. a b.ilt-in electric field in fuel cell ***,the fuel convers.on efficiency and cons.derab.e Faradaic efficiency reveal the compatib.lity of s.T-s.O_(2)heteros.ructure electrolyte and ruled-out s.ort-circuiting ***,the firs. principle calculation provides.s.fficient information on s.ructure optimization and energy-b.nd s.ructure modulation of s.T-s.O_(2).This.s.rategy will provide new ins.ght into s.miconductor-b.s.d fuel cell technology to des.gn novel electrolytes.

关键词： high ionic conductivity interfacial conduction modulated energy b.nd s.ructure p-n heterojunction s.miconductors