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Phorbol myristate acetate suppresses breast cancer cell growth via down-regulation of P-Rex1 expression

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Protein & Cell 2016年第6期7卷 445-449页

作者： Chuu-Yun A.Wong Haihong Jiang peter W.abel Margaret A.Scofield Yan Xie Taotao Wei Yaping Tu Department of Pharmacology Creighton University School of MedicineOmahaNE 68178USA National Laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of SciencesBeijing 100101China

Dear Editor,P-Rex1 is a Rac-selective guanine nucleotide exchange factor （GEF） that is synergistically activated by G-protein coupled receptors and receptor tyrosine kinases （Welch et al., 2002）. We previously reported that aberrantly upreg- ulated P-Rex1 promotes prostate cancer metastasis by activating Racl signals （Qin et al., 2009）.

关键词： Breast Cancer Cell Growth Human Luminal Breast Cancer Breast Cancer Cell Cycle Suppress Breast Cancer Cell Growth Promote Prostate Cancer Metastasis

Breast Cancer Metastasis Depends on Proteasome Degradation of Regulator of G-protein Signaling 4

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Breast Cancer Metastasis Depends on Proteasome Degradation o...

Targeting androgen receptor and trail： a novel treatment paradigm for breast cancer

The First International Symposium on Membrane Biology--The Tenth National Symposium on Membrane Biology

作者： Dennis W.Wolff Joseph K.Kirui peter W.abel Department of Pharmacology Creighton University School of Medicine

＜正＞Aberrant signaling through G-protein coupled receptors promotes metastasis,the major cause of breast cancer *** identified Regulator of G-protein Signaling4（RGS4）as a novel suppressor of breast cancer migration and invasion,important steps of metastatic *** blocking signals initiated through Gi-coupled receptors,such as protease-activated receptor1and CXC chemokine receptor4,

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中国药理学与毒理学杂志 2017年第10期31卷 954-954页

作者： Ya-ping TU Yan XIE peter W abel Tao-tao WEI Xu LUO Department of Pharmacology Creighton University School of Medicine Omaha NE 68178 USA National Laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China University of Nebraska Medical Center Omaha NE 68198

OBJECTIVE TNF-related apoptosis-inducing ligand(TRAIL)is a promising cancer therapeutic agent due to its minimal toxicity to normal tissues and remarkable apoptotic activity in ***,most breast cancer cells are resistant to TRAIL-induced *** objectives are to investigate the underlying molecular mechanisms and to develop strategies to overcome such *** To identify modulators of TRAIL-induced apoptosis,we carried out a genome wide si RNA *** validate the screening result,we either silenced or overexpressed the identified genes in various breast cancer cells and changes in growth and TRAIL-induced cell apoptosis were determined in vitro and in an orthotopic xenograft mouse ***,we investigated whether small molecules targeting the identified genes improve the effectiveness of *** We unexpectedly identified androgen receptor(AR)to be responsible for TRAIL *** AR is classically viewed as the key factor in prostate cancer progression,we found that AR expression levels were markedly elevated in human invasive breast cancer specimens including triple-negative breast cancers(TNBC)that are highly aggressive with poor ***,breast cancer cell lines express different levels of AR that correlated with their TRAIL *** overexpression in MDA-MB-231 and MDA-MB-436 cells suppressed the TRAIL sensitivity whereas knockdown of AR rendered MCF-7 and MDA-MB-453 cells sensitive to TRAIL-induced *** overexpression also induced TRAIL resistance in breast tumors in ***,we observed an upregulation of the TRAIL receptor,death receptor 5(DR5)in breast cancer cells,following the removal or inhibition of AR by its antagonists Casodex and *** with AR antagonists also enhanced TRAIL-induced breast cancer cell *** AR signaling suppresses TRAIL-induced breast cancer cell apoptosis,in part,by suppressing DR5 expression,and a combination of AR antag

关键词： TNF-related apoptosis-inducing ligand apoptosis resistance breast cancer death receptor 5 androgen receptor antagonists

Follistatin, a Novel Biomarker for Malignant Gliomas

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Neuroscience & Medicine 2015年第3期6卷 121-129页

作者： Elvira Lekka Nicolas Tsesmetzis Katherine M. Ashton peter abel Charles Davies Gregory Hall Timothy Dawson Robert W. Lea Department of Neurosurgery Lancashire Teaching Hospitals NHS Trust Royal Preston Hospital Preston UK Faculty of Life Sciences University of Manchester Manchester UK Department of Pathology Lancashire Teaching Hospitals NHS Trust Royal Preston Hospital Preston UK School of Pharmacy and Biomedical Sciences University of Central Lancashire Preston UK

Molecular biomarkers are commonly used for the management of several types of malignant tumours in routine clinical practice. However, this is not the case for malignant gliomas. Cytokines and Angiogenesis factors are potential candidates due to their intrinsic role in tumourigenesis. Pre- and post-operative serum from 36 malignant glioma patients and 36 controls was analysed using the Bio-Plex Pro Angiogenesis and Cytokines Assay (Bio-Rad, USA). Amongst the molecules tested, the serum concentration of follistatin was significantly higher in patients than in controls. Moreover, the serum concentration of follistatin of the patients postoperatively was significantly reduced compared to that preoperatively. Factors such as age and gender did not affect the concentrations of follistatin measured in the serum of patients pre- and post-operatively as well as healthy controls. This is the first report of follistatin as potential biomarker for the detection of malignant gliomas.

关键词： Serum Malignant Gliomas Follistatin Biomarker Cancer

An Interview with peter Deadman—Acupuncture Pioneer and Founder of The Journal of Chinese Medicine

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Chinese Medicine and Culture 2024年第1期7卷 19-28页

作者： Ioannis Solos Charles Buck peter Deadman Saint George Clinic and Research Institute Scottsdale 85251the United States of America Northern College of Acupuncture Micklegate YO16LJthe United Kingdom British Acupuncture Council London W129HQthe United Kingdom The Register of Chinese Herbal Medicine London WC1N 3GSthe United Kingdom

This interview was conducted on August 21st, 2022 by Charles Buck and Ioannis Solos. peter Deadman has worked in the field of health promotion for 50 years. He co-founded Infinity Foods(an organic and natural foods workers co-op) in 1971, followed by the Brighton Natural Health Centre-a charity dedicated to teaching ways to improve personal, community and planetary health and wellbeing. He qualified as an acupuncturist in 1978 and in Chinese herbal medicine in 1990. He founded The Journal of Chinese Medicine(UK) in 1979(Fig. 1), and co-authored A Manual of Acupuncture(published in 1998). He is the author of Live Well Live Long: Teachings from the Chinese Nourishment of Life Tradition. He has taught Chinese medicine and health promotion internationally for decades and is a dedicated practitioner and teacher of Qi Gong(气功).

关键词： Acupuncture Medicine herbal

Experimental investigation on slip conditions during thread rolling with flat dies

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Friction 2024年第1期12卷 136-143页

作者： Stefan VOLZ peter GROCHE Institute for Production Engineering and Forming Machines Technical University DarmstadtOtto-Berndt Straße 2Darmstadt 64287Germany

The process design of flat die rolling operations can be a tedious and costly process due to the challenges posed by small process *** this work,an effort is made to closely investigate and understand the process limits caused by excessive slippage of the *** measurements are carried out to capture the characteristics of excessive slippage and the influence of the stroke rate and the tribological system on this process *** differences in slippage were observed,depending on the tribological *** systems with polymer based lubricants showed excessive slippage at low stroke rates,systems using oil or no lubricant endured higher stroke rates before process limits were *** optical measurements revealed three major forms of slippage:successful rolling without slippage,failure due to excessive slippage at process start,and failure due to excessive slippage at around one workpiece rotation.

关键词： rolling incremental forming thread rolling slippage profile rolling

Skeletal muscle as a molecular and cellular biomarker of disease progression in amyotrophic lateral sclerosis:a narrative review

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Neural Regeneration Research 2024年第4期19卷 747-753页

作者： peter H.King Department of Neurology and Center for Neurodegeneration and Experimental Therapeutics The University of Alabama at BirminghamBirminghamALUSA Birmingham Veterans Affairs Medical Center BirminghamALUSA

Amyotrophic lateral sclerosis is a fatal multisystemic neurodegenerative disease with motor neurons being a primary *** progressive weakness is a hallmark feature of amyotrophic lateral sclerosis,there is considerable heterogeneity,including clinical presentation,progression,and the underlying triggers for disease *** on longitudinal studies with families harboring amyotrophic lateral sclerosis-associated gene mutations,it has become apparent that overt disease is preceded by a prodromal phase,possibly in years,where compensatory mechanisms delay symptom *** 85-90%of amyotrophic lateral sclerosis is sporadic,there is a strong need for identifying biomarkers that can detect this prodromal phase as motor neurons have limited capacity for *** Food and Drug Administration-approved therapies work by slowing the degenerative process and are most effective early in the *** muscle,including the neuromuscular junction,manifests abnormalities at the earliest stages of the disease,before motor neuron loss,making it a promising source for identifying biomarkers of the prodromal *** accessibility of muscle through biopsy provides a lens into the distal motor system at earlier stages and in real *** advent of“omics”technology has led to the identification of numerous dysregulated molecules in amyotrophic lateral sclerosis muscle,ranging from coding and non-coding RNAs to proteins and *** technology has opened the door for identifying biomarkers of disease activity and providing insight into disease mechanisms.A major challenge is correlating the myriad of dysregulated molecules with clinical or histological progression and understanding their relevance to presymptomatic phases of *** are two major goals of this *** first is to summarize some of the biomarkers identified in human amyotrophic lateral sclerosis muscle that have a clinicopathological correlation with disease activi

关键词： amyotrophic lateral sclerosis biomarkers clinicopathological correlation disease progression muscle biomarkers neurogenic atrophy neuromuscular junction non-coding RNAs presymptomatic stages skeletal muscle SOD1G93A mouse model

A product version of the Hilton-Milner-Frankl theorem

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Science China Mathematics 2024年第2期67卷 455-474页

作者： peter Frankl Jian Wang Alfréd Rényi Institute of Mathematics Hungarian Academy of SciencesBudapest H-1053Hungary Department of Mathematics Taiyuan University of TechnologyTaiyuan 030024China

Two families F and G of k-subsets of {1, 2,..., n} are called non-trivial cross t-intersecting if|F ∩ G|≥t for all F ∈ F, G ∈ G and | ∩ {F : F ∈ F}| < t, | ∩ {G : G ∈ G}| < t. In the present paper,we determine the maximum product of the sizes of two non-trivial cross t-intersecting families of k-subsets of{1, 2,..., n} for n≥4(t + 2)2k2, k≥5, which is a product version of the Hilton-Milner-Frankl theorem.

关键词： extremal set theory cross t-intersecting family product version non-trivial

A Population Dynamics Approach to the Distribution of Space Debris in Low Earth Orbit

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Communications on Applied Mathematics and Computation 2024年第1期6卷 340-353页

作者： John Jurkiewicz peter Hinow Department of Mathematical Sciences University of Wisconsin-MilwaukeeMilwaukeeWI53201USA

The presence of the debris in the Earth’s orbit poses a significant risk to human activity in outer *** debris population continues to grow due to ground launches,the loss of external parts from space ships,and uncontrollable collisions between objects.A computationally feasible continuum model for the growth of the debris population and its spatial distribution is therefore *** we propose a diffusion-collision model for the evolution of the debris density in the low-Earth orbit and its dependence on the ground-launch *** parametrize this model and test it against data from publicly available object catalogs to examine timescales for the uncontrolled ***,we consider sensible launch policies and cleanup strategies and how they reduce the future risk of collisions with active satellites or space ships.

关键词： Population dynamics Space debris Kessler syndrome Diffusion Low-Earth orbit