检索结果-南通市图书馆

Vibrotactile coordinated reset stimulation for the treatment of Parkinson's disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2022年第7期17卷 1495-1497页

作者： peter A.Tass Department of Neurosurgery Stanford University School of MedicineStanfordCAUSA

Introduction of the treatment concept:Regular deep brain stimulation(rDBS)is the standard therapy for the treatment of medically refractory Parkinson’s disease(PD)(Benabid et al.,2009).Notwithstanding its significant therapeutic effects,rDBS may cause side effects,characterized as rDBSinduced movement disorders(BaizabalCarvallo and Jankovic,2016).

关键词： stimulation al. treatment

Untangling the history of oroclines and mountain belts

在线全文

学校读者我要写书评

暂无评论

National Science Review 2022年第5期9卷 179-180页

作者： peter A.Cawood School of Earth Atmosphere and Environment Monash University

Oro clines are map-view bends of the Earth’s lithosphere formed by rotation of originally quasilinear linear rock units about a sub-vertical axis [1].They can have amplitudes and wavelengths on the order of hundreds of kilometres and are a significant feature of many active and ancient mountain belts(Fig.1,*** orocline,Bolivian orocline,Betic-Rif Belt,

关键词：

Characteristics of hepatocellular carcinoma in cirrhotic and non-cirrhotic non-alcoholic fatty liver disease

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

world Journal of Gastroenterology 2015年第4期21卷 1189-1196页

作者： Christopher Leung Sern wei Yeoh Desmond Patrick Shara Ket Kaye Marion Paul Gow peter w Angus Liver Transplant Unit Austin HospitalHeidelbergVictoria 3084Australia Department of Medicine The University of MelbourneAustin CampusHeidelbergVictoria 3084Australia Statistics and Operations Research Group School of Mathematical and Geospatial Sciences College of ScienceEngineering and HealthRMIT UniversityMelbourneVictoria 3000Australia

AIM: To determine characteristics and prognosticpredictors of patients with hepatocellular carcinoma(HCC) in association with non-alcoholic fatty liver disease(NAFLD).METHODS: we reviewed the records of all patients with NAFLD associated HCC between 2000 and 2012. Data collected included demographics; histology; presence or absence of cirrhosis, size and number of HCC, alpha-fetoprotein, body mass index(BMI), and the presence of diabetes, hypertension, or ***: Fifty-four patients with NAFLD associated HCC were identified. Mean age was 64 years with 87% male. Fifteen percent(8/54) were not cirrhotic. 11%, 24% and 50% had a BMI of were diabetic, 44% hypertensive and 26% hyperlipidaemic. Thirty-four percent of the patients had ≤ 1 of these risk factors. Non-cirrhotics had a significantly larger mean tumour diameter at diagnosis than cirrhotics(P = 0.041). Multivariate analysis did not identify any other patient characteristics that predicted the size or number of ***: HCC can develop in NAFLD without cirrhosis. At diagnosis such tumours are larger than those in cirrhotics, conferring a poorer prognosis.

关键词： Hepatocellular carcinoma Non-alcoholic fatty liver

Climate change and its consequences for water and wastewater management

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Environmental Science & Engineering 2009年第1期3卷 2-11页

作者： peter A.wILDERER Institute of Advanced Studies on Sustainability Amalienstr7580799 MunichGermany

Life,in combination with solar radiation and abiotic processes,is most probably the reason why liquid water has existed on Earth for over billions of years,and the global mean temperature has remained in a lifeenabling *** to limit or even reverse global warming must be derived from the knowledge of the Earth’s complex life-support *** this context,the balance between liquid and gaseous water plays a crucial role,and water management becomes an important field of innovation and action,globally,on the scale of watersheds but also on the very local *** use,reuse,and temporary storage of water in urban settings must be considered to limit over-extraction of water from natural resources,and to maintain the life supporting function of *** the same time,public health requirements,cost efficiency,and reliability demands are to be met.

关键词： ecosystem management tools self-regulation urbanization water-climate relationship water reuse

The evolution and refinement of vasoepididymostomy techniques

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2013年第1期15卷 49-55页

作者： peter T Chan Department of Urology Royal Victoria Hospital McGill University Health Center Montreal Quebec H3A 1A1 Canada

Obstructive azoospermia secondary to epididymal obstruction can be corrected by microsurgical reconstruction with vasoepididymostomy （VE）. Although alternative management such as epididymal or testicular sperm aspiration in conjunction with intracytoplasmic sperm injection is feasible, various studies have established the superior cost-effectiveness of VE as a treatment of choice. Microsurgical VE is considered one of the most technically challenging microsurgeries. Its success rate is highly dependent on the skills and experience of the surgeons. Various techniques have been described in the literature for VE. we have pioneered a technique known as longitudinal intussusception VE （LIVE） in which the epididymal tubule is opened longitudinally to obtain a larger opening to allow its tubular content to pass through the anastomosis. Our preliminary data demonstrated a patency rate of over 90%. This technique has been widely referenced in the recent literature including robotic-assisted microsurgery. The history of the development of different VE approaches, the oreoDerative evaluation along with the techniaues of various VE will be described in this article.

关键词： longitudinal intussusception vasoepididymostomy (LIVE) intracytoplasmic sperm injection (ICSI) male infertility microsurgery obstructive azoospermia vasoepididymostomy (VE)

Accelerating materials discovery using artificial intelligence, high performance computing and robotics

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

npj Computational Materials 2022年第1期8卷 767-775页

作者： Edward O.Pyzer-Knapp Jed w.Pitera peter w.J.Staar Seiji Takeda Teodoro Laino Daniel P.Sanders James Sexton John R.Smith Alessandro Curioni IBM Research Europe-Daresbury DaresburyUK IBM Almaden Research Centre San JoseCAUSA IBM Research Europe Zurich RüschlikonSwitzerland IBM Research Tokyo TokyoJapan IBM Thomas J.watson Research Centre Yorktown HeightsNYUSA

New tools enable new ways of working,and materials science is no *** materials discovery,traditional manual,serial,and human-intensive work is being augmented by automated,parallel,and iterative processes driven by Artificial Intelligence (AI),simulation and experimental *** this perspective,we describe how these new capabilities enable the acceleration and enrichment of each stage of the discovery *** show,using the example of the development of a novel chemically amplified photoresist,how these technologies’ impacts are amplified when they are used in concert with each other as powerful,heterogeneous workflows.

关键词： artificial computing enable

Nitric oxide and oxygen radicals induced apoptosis via bcl-2 and p53 pathway in hypoxia-reoxygenated cardiomyocytes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2003年第1期46卷 28-39页

作者：沈剑刚丘幸生姜泊张德良忻文娟 peter C.w.Fung 赵保路 Laboratory of Visual Information Processing Center for Brain and Cognitive Sciences Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China Institute of Chinese Medicine First Military Medical University Guangzhou 510515 China

Neonatal rat cardiomyocytes were subjected to 24 h of hypoxia 95%N2/5%CO2 and 24 h of hypoxia plus 4 h of reoxygenation 95%O2/5%CO2. 24 h of hypoxia increased the levels of NO, --23NO/NO, TBARS and LDH. 24 h of hypoxia plus 4 h of reoxygenation decreased the levels of NO, --23NO/NO, but further increased TBARS and LDH. The hypoxia up-regulated the expression of bcl-2, p53 and p21/waf1/cip1 but the reoxygenation down-regulated the expression of bcl-2, and further up-regulated p53 and p21/waf1/cip1. The hypoxia increased cell apoptosis and reoxygena-tion further increased both apoptotic and necrotic cell death. NO, -23NO/NO, TBARS, DNA frag-mentation and cell apoptosis were enhanced by SNP and inhibited by L-NAME respectively. In addition, SOD/catalase down-regulated the expression of p53, p21/wafl/cipl and TBARS but up-regulated bcl-2 and increased indirectly the level of NO, --23NO/NO, and inhibited DNA frag-mentation. The results suggest that hypoxia-induced cell death is associated with the activation of NO, bcl-2 and p53 pathway, while hypoxia-reoxygenation induced cell death via the generation of reactive oxygen species and activation of p53 pathway. The present study clarified that NO may be an initiative signal to apoptotic cell death and the activation of bcl-2, p53 and p21/waf1/cip1 path-way in hypoxic and hypoxia-reoxygenated cardiomyocytes.

关键词： apoptosis, hypoxia-reoxygenation, nitric oxide, oxygen radical, bcl-2, p53, p21/waf1/cip1.

Maintaining biodiversity will define our long-term success

在线全文

学校读者我要写书评

暂无评论

Plant Diversity 2020年第4期42卷 211-220页

作者： peter Raven Mathis wackernagel Missouri Botanical Garden 4344 Shaw BlvdSt.LouisMO63110USA Global Footprint Network 1528 Webster StreetSuite 11OaklandCA94612USA

Human beings are not only a part of our planet's ecosystems,but also,they are massively overusing *** makes ecosystem protection,including biodiversity preservation,vital for humanity's *** speed and scale of the threat are unprecedented in human *** long arch of evolution has been confronted with such a high level of human impact,that we are now facing the sixth mass extinction event,66 million years after the last *** threat heightens the imperative for bold human *** paper identifies three strategies for such an ***,and possibly most challenging,human demand needs to be curbed so it fits within the bounds of what Earth's ecosystems can *** meeting this quantitative goal,biodiversity preservation efforts will not be able to get ***,in the transition time,we must focus on those locations and areas where most biodiversity is *** a focus on‘hotspots’will help safeguard the largest portion of biodiversity with least ***,to direct biodiversity preservation strategies,we need to much better document the existence and distribution of biodiversity around the *** information technologies could help with this critical *** conclusion,biodiversity preservation is no longer just a concern for specialized biologist but is becoming a societal necessity if humanity wants to have a stable future.

关键词： Biodiversity Hotspots Biocapacity Conservation strategy

Emerging and Innovative Materials for Hydropower Engineering Applications:Turbines,Bearings,Sealing,Dams and waterways,and Ocean Power

在线全文

学校读者我要写书评

暂无评论

Engineering 2022年第1期8卷 148-158页

作者： Emanuele Quaranta peter Davies European Commission Joint Research Centre Ispra 21027Italy Marine Structures Laboratory IFREMER Centre BretagnePlouzané29280France

The hydropower sector is currently experiencing several technological *** technologies and practices are emerging to make hydropower more flexible and more *** materials have also been recently developed to increase performance,durability,and reliability;however,no systematic discussions can be found in the ***,in this paper,novel materials for hydropower applications are presented,and their performance,advantages,and limitations are *** example,composites can reduce the weight of steel equipment by 50%to 80%,polymers and superhydrophobic materials can reduce head losses by 4%to 20%,and novel bearing materials can reduce bearing wear by 6%.These improvements determine higher efficiencies,longer life span,waste reduction,and maintenance needs,although the initial cost of some materials is not yet competitive with respect to the costs of traditional *** novel materials are described here based on the following categories:novel materials for turbines,dams and waterways,bearings,seals,and ocean hydropower.

关键词： Bearing Composite Dam Hydropower Material Ocean Seal Turbine