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Gynecology and Obstetrics Clinical Medicine 2024年第2期4卷 122-125页

作者： peter Petros Retired Pelvic Surgeon SydneyNew South WalesAustralia

INTRODUCTION It is not sufficient to describe an anatomical *** answer is required to the question,‘what is it for'.Salvador Gil-Vernet(1892-1987)was a famous Spanish anatomist and urologist and Nobel Prize *** anatomical structure in question is the role of the pubourethral ligament(PUL)in the cure of stress urinary incontinence(SUI).The 1990 Integral Theory,on which the tension-free vaginal tape(TVT)operation is based,described two separate closure mechanisms for the urethra,both reliant on the PUL,distally and at the bladder neck,with the bladder neck the most important.

关键词： urinary bladder operation

Bound State Description of Particles from a Quantum Field Theory of Fermions and Bosons, Compatible with Relativity

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Journal of High Energy Physics, Gravitation and Cosmology 2024年第2期10卷 562-573页

作者： Hans-peter Morsch HOFF J&uumllich Germany

Both, the dilemma to find a quantum field theory consistent with Einstein’s law of relativity and the problem to describe existing particles as bound states of matter has been solved by calculating bound state matrix elements from a dual fermion-boson Lagrangian. In this formalism, the fermion binding energies are compensated by boson energies, indicating that particles can be generated out of the vacuum. This yields quantitative solutions for various mesons ω (0.78 GeV) - Υ (9.46 GeV) and all leptons e, μ and τ, with uncertainties in the extracted properties of less than 1‰. For transparency, a Web-page with the address htpps://*** has been constructed, where all calculations can be run on line and also the underlying fortran source code can be inspected.

关键词： Quantum Field Theory of Fermion and Boson Fields Hadrons and Leptons Described as Bound States of Relativistic Fermions and Bosons Leading to a Total Energy Equal to Zero

Rbfox1 controls alternative splicing of focal adhesion genes in cardiac muscle cells

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Journal of Molecular Cell Biology 2024年第1期16卷 54-65页

作者： peter Zorn Jaime Calvo Sánchez Tala Alakhras Barbara Schreier Michael Gekle Stefan Hüttelmaier Marcel Köhn Junior Group‘Non-coding RNAs and RBPs in Human Diseases’ Medical FacultyUniversity of Halle–Wittenberg06120 Halle(Saale)Germany Julius Bernstein Institute of Physiology Medical FacultyUniversity of Halle–Wittenberg06112 Halle(Saale)Germany Institute of Molecular Medicine Medical FacultyUniversity of Halle–Wittenberg06120 Halle(Saale)Germany

Alternative splicing is one of the major cellular processes that determine the tissue-specific expression of protein ***,it remains challenging to identify physiologically relevant and tissue-selective proteins that are generated by alternative ***,we investigated the target spectrum of the splicing factor Rbfox1 in the cardiac muscle context in more *** using a combination of in silico target prediction and in-cell validation,we identified several focal adhesion proteins as alternative splicing targets of *** focused on the alternative splicing patterns of vinculin(metavinculin isoform)and paxillin(extended paxillin isoform)and identified both as potential Rbfox1 *** analyses suggested that both isoforms are promoted by Rbfox1 due to binding in the *** adhesions play an important role in the cardiac muscle context,since they mainly influence cell shape,cytoskeletal organization,and cell–matrix *** data confirmed that depletion of Rbfox1 changed cardiomyoblast morphology,cytoskeletal organization,and multinuclearity after differentiation,which might be due to changes in alternative splicing of focal adhesion ***,our results indicate that Rbfox1 promotes alternative splicing of focal adhesion genes in cardiac muscle cells,which might contribute to heart disease progression,where downregulation of Rbfox1 is frequently observed.

关键词： Rbfox1 alternative splicing focal adhesion cardiac muscle cells

Gene complementation analysis indicates that parasitic dodder plants do not depend on the host FT protein for flowering

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Plant Communications 2024年第5期5卷 104-108页

作者： Sina Mackelmann Andrea Kanel Lara M.Kosters peter Lyko Dirk Prufer Gundula A.Noll Susann Wicke Institute of Plant Biology and Biotechnology University of MuensterSchlossplatz 848143 MuensterGermany Institute for Biology Humboldt-University of BerlinHaus 22Philippstr.1310115 BerlinGermany Fraunhofer Institute for Molecular Biology and Applied Ecology IME Schlossplatz 848143 MuensterGermany

Dear Editor,Cuscuta,a genus of parasitic plants,poses a significant threat to global agriculture due to its broad host range that encompasses numerous cultivated *** plants form specialized feeding organs(haustoria)that connect to the host vascular tissue and import water,nutrients,secondary metabolites,small RNAs,mRNAs,and *** such protein is FT,a peptide hormone and florigen that was recently proposed to cause the synchronization of flowering in the parasite–host system(Shen et al.,2020).

关键词： specialized organs analysis

Hepatocellular Ballooning is Due to Highly Pronounced Glycogenosis Potentially Associated with Steatosis and Metabolic Reprogramming

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Journal of Clinical and Translational Hepatology 2024年第1期12卷 52-61页

作者： Silvia Ribback Kristin peters Mohd Yasser Jessica Prey Paula Wilhelmi Qin Su Frank Dombrowski peter Bannasch Institut für Pathologie Universitaetsmedizin GreifswaldGreifswaldGermany Cell Marque Millipore-SigmaRocklinCAUSA German Cancer Research Center(DKFZ) HeidelbergGermany

Background and Aims:Hepatocellular ballooning is a common finding in chronic liver disease,mainly characterized by rarefied cytoplasm that often contains Mallory-Denk bodies(MDB).Ballooning has mostly been attributed to degeneration but its striking resemblance to glycogenotic/steatotic changes characterizing preneoplastic hepatocellular lesions in animal models and chronic human liver diseases prompts the question whether ballooned hepatocytes(BH)are damaged cells on the path to death or rather viable cells,possibly involved in neoplastic ***:Using specimens from 96 cirrhotic human livers,BH characteristics were assessed for their glycogen/lipid stores,enzyme activities,and proto-oncogenic signaling cascades by enzyme-and immunohistochemical approaches with serial paraffin and cryostat ***:BH were present in 43.8%of cirrhotic *** pronounced excess glycogen storage of(glycogenosis)and/or lipids(steatosis)were characteristic,ground glass features and MDB were often *** glucose-6-phosphatase,increased glucose-6-phosphate dehydrogenase activity and altered immunoreactivity of enzymes involved in glycolysis,lipid metabolism,and cholesterol biosynthesis were ***,components of the insulin signaling cascade were upregulated along with insulin dependent glucose transporter glucose transporter 4 and the v-akt murine thymoma viral oncogene homolog/mammalian target of rapamycin signaling pathway associated with de novo ***:BH are hallmarked by particularly pronounced glycogenosis with facultative steatosis,many of their features being reminiscent of metabolic aberrations documented in preneoplastic hepatocellular lesions in experimental animals and chronic human liver ***,BH are not damaged entities facing death but rather viable cells featuring metabolic reprogramming,indicative of a preneoplastic nature.

关键词： Chronic liver disease Carbohydrate metabolism Insulin signaling Preneoplasia Metabolic reprogramming

Global and International Security Under Spatial Grasp Paradigm

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International Relations and Diplomacy 2024年第2期12卷 72-85页

作者： peter Simon Sapaty National Academy of Sciences KyivUkraine

Global and international security cannot be provided from a single point or a set of separate points whatever powerful these might be(even with quantum supercomputers!).It should rather be deeply embedded and integrated with bodies of real systems wherever in physical,virtual,or combined spaces they may *** global security capabilities should not only be distributed,but rather be really spatial,self-organized,and dynamic,also exhibiting overall integrity,awareness,and consciousness *** paper describes applicability of the patented and revealed in 10 books Spatial Grasp Model and Technology(SGT)and its basic Spatial Grasp Language(SGL)which conceptually and functionally match security problems of large distributed and heterogeneous *** investigates very practical security solutions for finding and tracing distribution of forbidden items,world roaming criminals,recovery from natural and human-made disasters,tracing and elimination of moving dangerous objects in terrestrial and celestial spaces,as well as analysis and restoration of damaged transport *** advises how different security infrastructures can be organized and managed,and how to cooperate and integrate within global security systems with higher awareness and consciousness levels over *** provided security-oriented version of SGL can be quickly implemented and integrated with existing distributed management and security systems.

关键词： global security international security critical infrastructures Spatial Grasp Technology Spatial Grasp Language distributed language interpretation self-recovering security scenarios global security awareness and consciousness

Getting Physical before a Medical Physical and How It Leads to Doctor Becoming Patient: A Curious Case of Transient Raised Transaminases

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Open Journal of Gastroenterology 2024年第8期14卷 261-266页

作者： peter Cassar Nicholas Delicata Department of Medicine Department of Nephrology and General Medicine Mater Dei Hospital Msida Malta Department of Medicine Department of Gastroenterology Mater Dei Hospital Msida Malta

This case report sheds light on a curious case of rhabdomyolysis in an otherwise healthy twenty-eight-year-old male and its direct effect on liver function tests. This case report provides a fresh perspective on the doctor-patient dynamic where a medic becomes a doctor. Attention is also drawn to the mental and socioeconomic repercussions of having a health issue whilst applying for a home loan.

关键词： Rhabdomyolysis Transaminase Creatinine Kinase

High-Performance and Large-Area Inverted Perovskite Solar Cells Based on NiO_(x) Films Enabled with A Novel Microstructure-Control Technology

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Energy & Environmental Materials 2024年第1期7卷 153-159页

作者： Guibin Shen Xin Li Yuqin Zou Hongye Dong Dongping Zhu Yanglin Jiang Xin Ren Ng Fen Lin peter Müller-Buschbaum Cheng Mu Key Laboratory of Advanced Light Conversion Materials and Biophotonics Department of ChemistryRenmin University of ChinaBeijing 100872China Solar Energy Research Institute of Singapore(SERIS) National University of SingaporeSingapore 117574Singapore Physik-Department Lehrstuhl für Funktionelle MaterialienTechnische Universität MünchenJames-Franck-Straße 185748Garching Germany Heinz Maier-Leibnitz Zentrum(MLZ) Technische Universität MünchenLichtenbergstr.185748Garching Germany

The improvement in the efficiency of inverted perovskite solar cells(PSCs)is significantly limited by undesirable contact at the NiO_(x)/perovskite *** this study,a novel microstructure-control technology is proposed for fabrication of porous NiO_(x)films using Pluronic P123 as the structure-directing agent and acetylacetone(AcAc)as the coordination *** synthesized porous NiO_(x)films enhanced the hole extraction efficiency and reduced recombination defects at the NiO_(x)/perovskite ***,without any modification,the power conversion efficiency(PCE)of the PSC with MAPbl_(3)as the absorber layer improved from 16.50%to 19.08%.Moreover,the PCE of the device composed of perovskite Cs0.05(MA_(0.15)FA_(0.85))_(0.95)Pb(I_(0.85)Br_(0.15))_(3)improved from 17.49%to 21.42%.Furthermore,the application of the fabricated porous NiO_(x)on fluorine-doped tin oxide(FTO)substrates enabled the fabrication of large-area PSCs(1.2 cm^(2))with a PCE of 19.63%.This study provides a novel strategy for improving the contact at the NiO_(x)/perovskite interface for the fabrication of high-performance large-area perovskite solar cells.

关键词： interfacial contact inverted and large-area perovskite solar cells photovoltaic materials porous NiO_(x)films renewable energy

Script-Based GPU-Ready ELM Development for Continuous Code Integration

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Journal of Computer and Communications 2024年第5期12卷 102-106页

作者： peter Schwartz Dali Wang Fengming Yuan peter Thornton Oak Ridge National Laboratory Environmental Sciences Division Oak Ridge USA

Designing and optimizing complex scientific code for new computing architectures is a challenging task. To address this issue in the E3SM land model (ELM) development, we developed a software tool called SPEL, which facilitates code generation, verification, and performance tuning using compiler directives within a Function Unit Test framework. In this paper, we present a SPEL extension that leverages the version control system (e.g., Git) to autonomous code generation and demonstrate its application to continuous code integration and development of the ELM software system. The study can benefit the scientific software development community.

关键词： E3SM Land Model GPU Code Porting Continuous Code Integration SPEL Scientific Software Refactorization

Impact of cancer diagnosis on life expectancy by area-level socioeconomic groups in New South Wales, Australia: a population-based study

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Cancer Biology & Medicine 2024年第8期21卷 692-702页

作者： Md Mijanur Rahman Michael David David Goldsbury Karen Canfell Kou Kou Paramita Dasgupta peter Baade Xue Qin Yu The Daffodil Centre The University of SydneyA Joint Venture with Cancer Council NSWSydneyNSW 1340Australia School of Medicine and Dentistry Griffith UniversityGold CoastQLD 4222Australia Cancer Council Queensland BrisbaneQLD 4006Australia

Objective: Improvement in cancer survival over recent decades has not been accompanied by a narrowing of socioeconomic disparities. This study aimed to quantify the loss of life expectancy(LOLE) resulting from a cancer diagnosis and examine disparities in LOLE based on area-level socioeconomic status(SES).Methods: Data were collected for all people between 50 and 89 years of age who were diagnosed with cancer, registered in the NSW Cancer Registry between 2001 and 2019, and underwent mortality follow-up evaluations until December 2020. Flexible parametric survival models were fitted to estimate the LOLE by gender and area-level SES for 12 common ***: Of 422,680 people with cancer, 24% and 18% lived in the most and least disadvantaged areas, respectively. Patients from the most disadvantaged areas had a significantly greater average LOLE than patients from the least disadvantaged areas for cancers with high survival rates, including prostate [2.9 years(95% CI: 2.5±3.2 years) vs. 1.6 years(95% CI: 1.3±1.9 years)] and breast cancer [1.6 years(95% CI: 1.4±1.8 years) vs. 1.2 years(95% CI: 1.0±1.4 years)]. The highest average LOLE occurred in males residing in the most disadvantaged areas with pancreatic [16.5 years(95% CI: 16.1±16.8 years) vs. 16.2 years(95% CI: 15.7±16.7 years)] and liver cancer [15.5 years(95% CI: 15.0±16.0 years) vs. 14.7 years(95% CI: 14.0±15.5 years)]. Females residing in the least disadvantaged areas with thyroid cancer [0.9 years(95% CI: 0.4±1.4 years) vs. 0.6 years(95% CI: 0.2±1.0 years)] or melanoma [0.9 years(95% CI: 0.8±1.1 years) vs. 0.7 years(95% CI: 0.5±0.8 years)] had the lowest average ***: Patients from the most disadvantaged areas had the highest LOLE with SES-based differences greatest for patients diagnosed with cancer at an early stage or cancers with higher survival rates, suggesting the need to prioritise early detection and reduce treatment-related barriers and survivorship challenges to improve life expec

关键词： Cancer diagnosis life expectancy loss of life expectancy area-level socioeconomic status flexible parametric model