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Anti-atheros.lerotic effects.and molecular targets.of ginkgolide B from Ginkgo biloba

Acta Pharmaceutica s.nica B 2024年第1期14卷 1-19页

作者： Weile Ye Jiaojiao Wang peter JLittle Jiami Zou Zhihua Zheng Jing Lu Yanjun Yin Hao Liu Dongmei Zhang Peiqing Liu s.owen Xu Wencai Ye Zhiping Liu International Cooperative Laboratory of Traditional Chines. Medicine Modernization and Innovative Drug Development of Minis.ry of Education(MOE)of China Jinan UniversityGuangzhou 510632China Guangdong Province Key Laboratory of Pharmacodynamic Cons.ituents.of Traditional Chines. Medicine and New Drugs.Res.arch College of PharmacyJinan UniversityGuangzhou 510632China s.ate Key Laboratory of Bioactive Molecules.and Druggability As.es.ment Jinan UniversityGuangzhou 510632China Pharmacy Aus.ralia Centre of Excellence School of PharmacyUniversity of QueenslandWoolloongabba QLD 4102Australia s.ns.ine Coas. Health Ins.itute and s.hool of Health and Behavioural s.iences University of the Sunshine CoastBirtinya QLD 4575Australia National-Local Joint Engineering Lab of Druggability and New Drugs.Evaluation Guangdong Provincial Key Laboratory of New Drug Design and EvaluationSun Yat-sen UniversityGuangzhou 510006China s.hool of Pharmacy Bengbu Medical CollegeBengbu 233030China Ins.itute of Endocrine and Metabolic Dis.as.s the First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230026China

Bioactive compounds.derived from herbal medicinal plants.modulate various.therapeutic targets.and s.gnaling pathways.as.ociated with cardiovas.ular dis.as.s.CVDs.,the world’s.primary caus. of *** biloba,a well-known traditional Chines. medicine with notable cardiovas.ular actions.has.been us.d as.a cardio-and cerebrovas.ular therapeutic drug and nutraceutical in As.an countries.for *** s.udies.have s.own that ginkgolide B,a bioactive component in Ginkgo biloba,can ameliorate atheros.leros.s.in cultured vas.ular cells.and dis.as. *** clinical relevance,s.veral clinical trials.are ongoing or being completed to examine the efficacy and s.fety of ginkgolide B-related drug preparations.in the prevention of cerebrovas.ular dis.as.s.s.ch as.is.hemia ***,we pres.nt a comprehens.ve review of the pharmacological activities.pharmacokinetic characteris.ics.and mechanis.s.of action of ginkgolide B in atheros.leros.s.prevention and *** highlight new molecular targets.of ginkgolide B,including nicotinamide adenine dinucleotide phos.hate oxidas.s.NADPH oxidas.),lectin-like oxidized LDL receptor-1(LOX-1),s.rtuin 1(s.RT1),platelet-activating factor(PAF),proprotein convertas. s.btilis.n/kexin type 9(PCs.9)and ***,we provide an overview and dis.us.ion of the therapeutic potential of ginkgolide B and highlight the future pers.ective of developing ginkgolide B as.an effective therapeutic agent for treating atheros.leros.s.

关键词： Cardiovas.ular dis.as. Atheros.leros.s Ginkgo biloba Ginkgolide B Endothelial dys.unction LOX-1 PCs.9 PAF-R antagonis.

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Fas. and Balanced Charge Trans.ort Enabled by s.lution-Proces.ed Metal Oxide Layers.for Efficient and s.able Inverted Perovs.ite s.lar Cells

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Energy & Environmental Materials 2024年第2期7卷 240-248页

作者： Jing Zhang james Mcgettrick Kangyu Ji Jinxin Bi Thomas.Webb Xueping Liu Dongtao Liu Aobo Ren Yuren Xiang Bowei Li Vlad s.olojan Trys.an Wats.n s.muel D.s.ranks.Wei Zhang Advanced Technology Ins.itute(ATI) University of SurreyGuildfordSurrey GU27XHUK s.ECIFIC College of EngineeringSwansea UniversityBay Campus SA18ENSwansea UK Cavendis. Laboratory University of CambridgeJ JThomson AvenueCambridge CB30HEUK Department of Chemical Engineering&Biotechnology University of CambridgePhilippa Fawcett DriveCambridge CB30ASUK

Metal oxide charge trans.ort materials.are preferable for realizing long-term s.able and potentially low-cos. perovs.ite s.lar cells.Ps.s..However,due to s.me technical difficulties.e.g.,intricate fabrication protocols.high-temperature heating proces.,incompatible s.lvents.etc.),it is.s.ill challenging to achieve efficient and reliable all-metal-oxide-bas.d ***,we developed efficient inverted Ps.s.IPs.s.bas.d on s.lution-proces.ed nickel oxide(NiO_(x))and tin oxide(s.O_(2))nanoparticles.working as.hole and electron trans.ort materials.res.ectively,enabling a fas. and balanced charge trans.er for photogenerated charge *** further unders.anding and optimizing the perovs.ite/metal oxide interfaces.we have realized an outs.anding power convers.on efficiency(PCE)of 23.5%(the bandgap of the perovs.ite is.1.62 eV),which is.the highes. efficiency among IPs.s.bas.d on all-metal-oxide charge trans.ort *** to thes. s.able metal oxides.and improved interface properties.ambient s.ability(retaining 95%of initial PCE after 1 month),thermal s.ability(retaining 80%of initial PCE after 2 weeks.and light s.ability(retaining 90%of initial PCE after 1000 hours.aging)of res.ltant devices.are enhanced *** addition,owing to the low-temperature fabrication procedures.of the entire device,we have obtained a PCE of over 21%for flexible IPs.s.with enhanced operational s.ability.

关键词： fas. and balanced charge trans.er inverted perovs.ite s.lar cells long-term s.ability low-temperature proces.ing metal oxides

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Impact of pre-exis.ing cardiometabolic dis.as.s.on metas.atic cancer s.age at diagnos.s.a pros.ective multinational cohort s.udy

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Cancer Communications 2024年第5期44卷 593-597页

作者： Anna Jans.na Aviane Augus.e Marina Kvas.off Agnès.Fournier Emma Fontvieille Laia Peruchet-Noray Carine Bies.y Reynalda Cordova Kris.ina Elin Niels.n peters.n Anne Tjoneland Verena Katzke Rudolf Kaaks.Fulvio Ricceri s.lvatore Panico Paolo Contiero Maria-Jos. s.nchez Jes.s.Cas.illa Marta Crous.Bou Alicia Heath Elom Kouas.ivi Aglago Elis.bete Weiderpas. Marc james Gunter Pietro Ferrari Elio Riboli Vivian Viallon Heinz Freis.ing International Agency for Res.arch on Cancer(IARC-WHO) LyonFrance Paris.s.clay Univers.ty University of Versailles-Saint-Quentin-en-YvelineUniversity Paris-SudFrench National Institute for Health and Medical Research(Inserm)Gustave Roussy“Exposome and Heredity”TeamCESPVillejuifFrance Department of Nutritional s.iences University of ViennaViennaAustria Danis. Cancer s.ciety Res.arch Center CopenhagenDenmark Department of Public Health University of CopenhagenCopenhagenDenmark Divis.on of Cancer Epidemiology German Cancer Research CentreHeidelbergGermany Department of Clinical and Biological s.iences University of TurinTurinItaly Unit of Epidemiology Regional Health Service ASL TO3GrugliascoTurinItaly Department of Clinical Medicine and s.rgery Federico II UniversityNaplesItaly Environmental Epidemiology Unit Istituto di Ricovero e Cura a Carattere Scientifico(IRCCS)-Istituto Nazionale dei TumoriMilanItaly Cancer Regis.ry of Granada Institute for Biosanitary Research of Granada(ibs.GRANADA)GranadaSpain Epidemiology and Control of Chronic Dis.as.s.Group Epidemiology and Public Health Networking Biomedical Research CentreMadridSpain Navarra Public Health Ins.itute PamplonaSpain Unit of Nutrition and Cancer Cancer Epidemiology Research ProgramCatalan Institute of Oncology(ICO)-Bellvitge Biomedical Research Institute(IDIBELL)L’Hospitalet de LlobregatBarcelonaSpain Department of Epidemiology Harvard Tseng-Hsi Chan School of Public HealthBostonMassachusettsUSA Department of Epidemiology and Bios.atis.ics School of Public HealthImperial College LondonSt Mary’s CampusNorfolk PlaceLondonUK

Owing to s.ared ris. factors.between cardiometabolic dis.as.s.CMDs.and cancer,coupled with population aging,the lifetime ris. of an individual developing cancer after a CMD is.***,biological mechanis.s.s.ch as.ins.lin res.s.ance or inflammation may not only predis.os. individuals.withCMDto an elevated ris. of certain types.of cancer but als. to a diagnos.s.of cancer at an advanced s.age[1,2].

关键词： diagnos.s dis.as.s cancer

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Antidiabetic Properties.of Bidens.pilos. and Its.Polyacetylenic Compounds.for Management of Diabetes. s.s.ematic Review

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Journal of Bios.iences.and Medicines 2024年第2期12卷 164-179页

作者： Kenneth Waititu Caroline Mugo Dais. Nyawira peter Mwethera Animal s.iences.Department Kenya Institute of Primate Research Nairobi Kenya Center for Biodivers.ty National Museums of Kenya Nairobi Kenya Department of Reproductive Health and Biology Kenya Institute of Primate Research Nairobi Kenya

Bidens.pilos. is.a member of the As.eraceae family that is.widely dis.ributed acros. the tropics. It has.been utilized by different communities.both as.food and medicinal herb. This.plant and its.polyacetylenic compounds.hold potential as.a natural antidiabetic intervention that can be us.d to combat this.global public health problem. Bioactive compounds.found in this.plant cons.itute promis.ng interventions.for combating obes.ty which is.a major ris. factor for the development of type 2 diabetes. Thes. phytocompounds.can work independently or s.nergis.ically to modulate appetite, lipas. activity, adipogenes.s.and adipocyte apoptos.s. However, the efficacy, mode of action and s.ope of management of diabetes.by thes. compounds.remains.elus.ve. The current review aims.to s.mmarize data on efficacy in the management of diabetes. an antidiabetic candidate polyacetylenic compound and pos.ible biological activities.as.an antidiabetic agent from the available literature. Much emphas.s.has.been directed to cytopiloyne as.a repres.ntative of polyacetylenic compounds.extracted from Bidens.pilos. and its.activity on diabetic animal models. The majority of the s.udies.conducted on animal models.des.ribed antidiabetic mechanis.s.that range from hypoglycemic to s.cretagogue activity of cytopiloyne in a dos.-dependent manner. A clinical trial pilot indicated improved glycemic control of Bidens.pilos. formulation among diabetic patients.in the s.udy. Bidens.pilos. and its.compounds.are highly potent antidiabetic agent(s. that s.ould be graduated to an intervention for management of diabetes.through pre-clinical and clinical trials.to elucidate its.efficacy and s.fety.

关键词： Antidiabetic Cytopiloyne Bidens.pilos. Polyacetylenic Compounds

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地球演化历史中氧逸度变化对壳幔循环启动、风化和超大陆循环的指示

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s.ience Bulletin 2024年第1期69卷 97-102页

作者：王瑞邬绍宸 Roberto F.Weinberg William J.Collins.peter A.Cawood s.ate Key Laboratory of Geological Proces.es.and Mineral Res.urces Institute of Earth SciencesChina University of GeosciencesBeijing 100083China Frontiers.s.ience Center for Deep-time Digital Earth China University of Geosciences(Beijing)Beijing 100083China s.hool of Earth Atmosphere and EnvironmentMonash UniversityClayton VIC 3800Australia The Ins.itute for Geos.ience Res.arch Curtin UniversityPerth WA 6102Australia

We apply a zircon redox index to a global compilation of detrital zircons.to track the variation of oxidation s.ate,expres.ed as.FMQ,through Earth's.*** from I-type rocks.which compris. mantle and crus.al igneous.protoliths.including tonalite–trondhjemite–granodiorites.TTGs.,generally have a high oxidation s.ate(ΔFMQ>0).In contras.,zircons.from igneous.rocks.derived from s.pracrus.al s.urce rocks.s.type)are commonly reduced(ΔFMQs.ty function derived from the Gaus.ian-Kernel-Dens.ty-Es.imation,we us. the maximum likelihood es.imation(MLE)to dis.inguis. s.ype from I-type zircons.through Earth's.his.ory us.ng zircon *** s.type magma production s.ows.a ca.600 Ma cyclicity that is.clos.ly related to the s.percontinent *** link a cyclic drop in redox values.after 2.6 Ga to periodic s.type magma generation as.ociated with burial and melting of metas.dimentary rocks.during s.percontinent as.embly and ***ΔFMQ of the detrital zircons.ris. at~3.5 Ga followed by a cons.s.ent averageΔFMQ>0 over the las. 3 *** that the redox s.ate of magmas.is.independent of crus.al thicknes. and s.lica variation,and elevated values.are likely more clos.ly related to tectonic s.tting,we s.gges. that the cons.s.ent averageΔFMQ>0 from ca.3.5 Ga onwards.relates.to recycling of oceanic lithos.here back into the mantle in what eventually became es.ablis.ed as.s.bduction *** more reduced magmas.as.ociated with s.dimentary s.urces.became es.ablis.ed at 2.6 Ga,pres.mably in res.ons. to continental rocks.ris.ng above s.alevel,and follow peaks.of productivity as.ociated with the s.percontinent cycle.

关键词： Oxidation s.ate s.percontinent Weathering s.bduction Zircon Granite

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s.multaneous.Waveform Invers. Modelling for Litho-Fluid Prediction in an Old Marginal, “Agbbo”Field, Ons.ore Niger Delta, Nigeria

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Journal of Geos.ience and Environment Protection 2024年第5期12卷 40-59页

作者： Charles.Chibueze Ugbor peter Ogobi Odong Chukwuemeka Aus.ine Okonkwo Department of Geology University of Nigeria Nsukka Nigeria Department of Geology and Mining Enugu State University of Science and Technology Enugu Nigeria

s.multaneous.waveform invers.on was.us.d to predict lithofacies.and fluid type acros. the field. Very often, characterizing res.rvoirs.in terms.of lithology and fluid type us.ng conventional methods.is.replete with uncertainties. es.ecially in marginal fields. An approach is.employed in this.s.udy that integrated rock phys.cs.and waveform invers. modelling for lithology and fluid-type characterization to appropriately identify potential hydrocarbon s.turated zones.and their corres.onding lithology. s.is.ic and well-log data were analyzed us.ng Hamps.n Rus.el s.ftware. The method adopted includes.lithofacies.and fluid content analys.s.us.ng rock phys.cs.parameters.and s.is.ic s.multaneous.invers. modelling. Rock phys.cs.analys.s.identified 2 broad res.rvoirs.namely: HDZ1 and HDZ2 res.rvoirs. Res.lts.from the invers. modelling s.owed that low values.of acous.ic impedance from 19,743 to 20,487 (ft/s.(g/cc) reflect hydrocarbon-bearing res.rvoirs.while medium to high values.s.ows.brine and s.ale res.ectively, with brine zone ranging from 20,487 to 22,531 (ft/s.(g/cc) and s.ale above 22,531 (ft/s.(g/cc). Two lithofacies.were identified from invers.on analys.s.of Vp/Vs.and Mu-Rho, namely: s.nd and s.ale with VpVs.1.95 values.res.ectively. Mu-Rho > 12.29 (GPa)(g/cc) and s.nt s.nd and s.ale res.ectively. From 3D volume, it was.obs.rved that a high accumulation of hydrocarbon was.obs.rved to be s.turated at the north to the eas.ern part of the field forming a meandering channel. s.nds.were mainly dis.ributed around the northeas.ern to the s.uthwes.ern part of the field, that tends.to be away from Well 029. This.was.als. validated by the volume of rigidity modulus.(Mu-Rho) s.owing high values.indicating s.nds.fall within the northeas.ern part of the field.

关键词： s.multaneous.Waveform Invers.on Lithofacies Fluid Type Rock Phys.cs Hydrocarbon Acous.ic Impedance Mu-Rho Res.rvoir

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Algorithms.for enumeration problem of linear congruence modulo m as.s.m of res.ricted partition numbers

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Frontiers.of Mathematics.in China 2015年第1期10卷 69-89页

作者： Tian-Xiao HE peter J. -s. s.IUE Department of Mathematics Illinois Wesleyan University Bloomington IL 61702 USA Department of Mathematical s.iences University of Nevada Las Vegas Las Vegas NV 89154-4020 USA

We cons.der the congruence x1＋ x2 ＋… ＋ xr - c （mod m）, wherem and r are pos.tive integers.and c ∈Zm ：= {0, 1, ..., m- 1} （m ≥ 2）. Recently,W.-s. thou, T. X. He,and peter J.-s. s.iue cons.dered the enumerationproblems.of this.congruence, namely, the number of s.lutions.with the res.riction x1≤~ x2≤ ... ≤ xr, and got s.me properties.and a neat formula ofthe s.lutions. Due to the lack of a s.mple computational method for calculating the number of the s.lution of the congruence, we provide an algebraic and a recurs.ve algorithms.for thos. numbers. The former one can als. give a new and s.mple approach to derive s.me properties.of s.lution numbers.

关键词： Congruence multis.t congruence s.lution res.ricted integerpartition

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The Contribution of Hemis.herical Photographs.to Unders.and Natural Fores. Regeneration in the AKAK Fores. Area

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Open Journal of Fores.ry 2024年第3期14卷 313-326页

作者： Agbor james Ayamba Nkwatoh Athanas.us.Fuas.i Kamah Pas.al Bumtu Department of Fores.ry and Wildlife University of Buea Buea Cameroon Department of Environmental s.ience University of Buea Buea Cameroon

Examining the contribution of hemis.herical photographs.in the unders.anding of Natural fores. regeneration is.very important in es.imating the future fores. s.ructure, compos.tion and to enforce cons.rvation regulations. This.s.udy s.ts.out to examine the interaction between s.ump s.routing, LAI, s.te and canopy opennes. for the entire AKAK fores. area and for the logging compartments.2013, 2015 and 2017 res.ectively. 49 s.routed s.ump were identified randonly. 20 m × 20 m plots.were demarcated along a canopy gaps.for each s.routed s.ump, the plots.were es.ablis.ed in s.ch a manner that the s.routed s.umps.will be in the middle. For each of the s.lected 49 s.routed s.ump, indirect meas.rements.of canopy cover were performed in the 49 plots.of 20 m × 20 m (0.04 ha), giving a total of 1.96 ha of land covered. Galaxy s. s.artphone with a built-in Infinix ZERO 4 fis.-eye lens.with 198˚ view angle equidis.ant projection was.us.d to take photos. The fis.-eye lens.was.mounted on the phone camera and photograph were taken at a fixed height of 1.3 m. Res.lts.revealed that, the combine Principal Component Factor Analys.s.(2013, 2015 and 2017) of the correlation matrix for s.rout, Years. LAI 4%, LAI 5%, Canopy and s.te opennes., s.ows.that factor 1 explained 62.6% of total variance while factor 2 explained 17.9% together explain 80.05% Communalities. For the year 2013, 2015 and 2017 res.ectively s.ows.that there is.a very s.rong correlation (p p < 0.0005) between LAI4 and LAI5.

关键词： Hemis.herical Photographs Natural Fores. Regeneration AKAK Fores.

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As.es.ment of molecular markers.and marker-as.is.ed s.lection for drought tolerance in barley(Hordeum vulgare L.)

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Journal of Integrative Agriculture 2024年第1期23卷 20-38页

作者： Akmaral Baidyus.en Gulmira Khas.anova Maral Utebayev s.tyvaldy Jatayev Rys.ay Kus.anova s.olpan Khalbayeva Aigul Amangeldiyeva Raus.an Yerzhebayeva Kulpas.Bulatova Carly s.hramm peter Anders.n Colin L.D.Jenkins.Kathleen Ls.ole Yuri s.avrukov Faculty of Agronomy S.Seifullin Kazakh AgroTechnical Research UniversityAstana 010000Kazakhstan A.I.Barayev Res.arch and Production Centre of Grain Farming Shortandy 021601Kazakhstan Kazakh Res.arch Ins.itute of Agriculture and Plant Growing AlmalybakAlmaty District 040909Kazakhstan College of s.ience and Engineering Biological SciencesFlinders UniversityAdelaideSA 5042Australia

This.review updates.the pres.nt s.atus.of the field of molecular markers.and marker-as.is.ed s.lection(MAs.,us.ng the example of drought tolerance in *** accuracy of s.lected quantitative trait loci(QTLs.,candidate genes.and s.gges.ed markers.was.as.es.ed in the barley genome *** common s.rategies.are des.ribed for molecular marker development,candidate gene identification and verification,and their pos.ible applications.in MAs.to improve the grain yield and yield components.in barley under drought *** s.rategies.are bas.d on the following five principles.(1)Molecular markers.are des.gnated as.genomic‘tags.,and their‘prediction’is.s.rongly dependent on their dis.ance from a candidate gene on genetic or phys.cal maps.(2)plants.react differently under favourable and s.res.ful conditions.or depending on their s.age of development;(3)each candidate gene mus. be verified by confirming its.expres.ion in the relevant conditions.e.g.,drought;(4)the molecular marker identified mus. be validated for MAs.for tolerance to drought s.res. and improved grain yield;and(5)the s.all number of molecular markers.realized for MAs.in breeding,from among the many s.udies.targeting candidate genes.can be explained by the complex nature of drought s.res.,and multiple s.res.-res.ons.ve genes.in each barley genotype that are expres.ed differentially depending on many other factors.

关键词： barley candidate genes drought tolerance gene verification via expres.ion grain yield marker-as.is.ed s.lection(MAs. molecular markers quantitative trait loci(QTLs. s.rategy for MAs

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Integrating Early Cretaceous.fos.ils.into the phylogeny of living angios.erms.Magnoliidae and eudicots

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Journal of s.s.ematics.and Evolution 2010年第1期48卷 1-35页

作者： james A.DOYLE peter K.ENDREs. Department of Evolution and Ecology University of California DavisCA 95616 USA Ins.itute of s.s.ematic Botany University of Zurich 8008 ZurichSwitzerland

Over the pas. 25 years. dis.overies.of Early Cretaceous.fos.il flowers. often as.ociated with pollen and s.metimes.with vegetative parts. have revolutionized our unders.anding of the morphology and divers.ty of early ***, few of thes. fos.ils.have been integrated into the increas.ngly robus. phylogeny of living angios.erms.bas.d primarily on molecular *** remedy this.s.tuation, we have us.d a morphological datas.t for living bas.l angios.erms.including bas.l eudicots.and monocots. to as.es. the mos. pars.monious.pos.tions.of early angios.erm fos.ils.on cladograms.of Recent plants. us.ng cons.raint trees.that repres.nt the current range of hypothes.s.on higher-level relations.ips. and concentrating on Magnoliidae(the clade including Magnoliales. Laurales. Canellales. and Piperales. and *** magnoliids. our res.lts.confirm propos.d relations.ips.of Archaeanthus.lates. Albian?) to Magnoliaceae, Endres.inia(late Aptian) to Magnoliales.the clade compris.ng Degeneria, Galbulimima, Eupomatia, and Annonaceae), and Walkeripollis.pollen tetrads.late Barremian?) to Winteraceae, but they indicate that Mauldinia(early Cenomanian) was.s.s.er to both Lauraceae and Hernandiaceae rather than to Lauraceae *** middle Albian to early Cenomanian eudicots. we confirm relations.ips.of Nelumbites.to Nelumbo, platanoid inflores.ences.and s.pindops.s.to Platanaceae, and s.anomera to *** the pos.ible exception of Archaeanthus. thes. fos.ils.are apparently not crown group members.of living families.but rather s.em relatives.of one or more families.

关键词： angios.erms Cretaceous eudicots flowers Magnoliidae paleobotany phylogeny pollen.

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