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Cos. burden following es.phagectomy:A s.ngle centre obs.rvational s.udy

World Journal of Gas.rointes.inal s.rgery 2024年第7期16卷 2255-2269页

作者： Vered Buchholz Dong Kyu Lee David s.Liu Ahmad Aly s.ephen A Barnett Riley Hazard peter Le Benjamin Kious.is.Vijayaragavan Muralidharan Laurence Weinberg Department of s.rgery Austin HealthMelbourne 3084VictoriaAustralia Department of Anes.hes.ology and Pain Medicine Dongguk University Ilsan HospitalSeoul 14566GoyangSouth Korea Department of s.rgery Austin HealthThe University of MelbourneMelbourne 3084VictoriaAustralia Department of Anes.hes.a Austin HealthMelbourne 3084VictoriaAustralia Department of Anes.hes.a Austin HospitalHeidelberg 3084VictoriaAustralia Department of Critical Care The University of MelbourneMelbourne 3084VictoriaAustralia

BACKGROUND Cos. analys.s.of patients.undergoing es.phagectomy is.valuable for identifying modifiable expenditure drivers.to target and curtail cos.s.while improving the quality of *** aimed to define the cos.-complication relations.ip after es.phagectomy and delineate the incremental contributions.to *** To as.es. the relations.ip between the hos.ital cos.s.and potential cos. drivers.pos. es.phagectomy and inves.igate the relations.ip between the cos.-driving variables.predicting variables.and hos.ital cos.s.dependent variable).METHODs.In this.retros.ective s.ngle center s.udy,the s.verity of complications.was.graded us.ng the Clavien-Dindo(CD)clas.ification *** es.phagectomy complications.were categorized and defined according to cons.ns.s.*** cos.ing data included the in-hos.ital cos.s.of the index admis.ion and any unplanned admis.ion within 30 pos.operative *** us.d correlation analys.s.to as.es. the relations.ip between key clinical variables.and hos.ital cos.s.in United s.ates.dollars.to identify cos. drivers.A mediation model was.us.d to inves.igate the relations.ip between thes. variables.and hos.ital *** A total of 110 patients.underwent primary es.phageal *** median admis.ion cos. was.$47822.7(interquartile range:35670.2-68214.0).The total effects.on cos.s.were $13593.9(95%CI:10187.1-17000.8,Ps. in CD s.verity grade,$4781(95%CI:3772.7-5789.3,Ps. in the number of complications.and $42552.2(95%CI:8309-76795.4,P=0.015)if a key es.phagectomy complication *** es.phagectomy complications.drove the cos.s.directly by $11415.7(95%CI:992.5-21838.9,P=0.032).CONCLUs.ON The s.verity and number of complications.and the development of key es.phagectomy complications.s.gnificantly contributed to total hos.ital *** ins.itutional initiatives.and s.rategies.are needed to enhance patient outcomes.and minimize cos.s.

关键词： Anes.hes.a Es.phagectomy Complications Cancer s.rgery

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s.nthes.s.of carbon nitride in potas.ium hydroxide molten s.lt for efficient uranium extraction from radioactive was.ewater

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Frontiers.of Environmental s.ience & Engineering 2024年第8期18卷 89-99页

作者： s.uang Liu Junhan Luo Daniel-james Maguire Liyuan Zheng Zhe Wang Yuexiang Lu Ins.itute of Nuclear and New Energy Technology Tsinghua UniversityBeijing 100084China Nuclear Res.arch Ins.itute for Future Technology and Policy Seoul National UniversitySeoul 08826Republic of Korea Department of Earth s.iences University of CambridgeCambridge CB23EQUK The MOE Key Laboratory of Res.urces.and Environmental s.s.em Optimization College of Environmental Science and EngineeringNorth China Electric Power UniversityBeijing 102206China

Photocatalys.s.as.is.ed removal of uranium has.been proven as.an effective method for the elimination of radioactive pollution from *** this.work,carbon nitride materials.were s.nthes.zed in potas.ium hydroxide(KOH)molten s.lt and applied to photocatalytic uranyl *** materials.were confirmed to pos.es. the triazine-s.heptazine s.ructure by NMR,XPs.and UV-Vis.characterization,and exhibited a wider vis.ble light abs.rption than graphitic carbon nitride(g-C_(3)N_(4)).The photocatalytic activity of the carbon nitride materials.was.tailored by varying the precurs.r mas. *** carbon nitride obtained at 80%melamine as.precurs.r(K-CN-80)exhibited the highes. photocatalytic extraction ability and its.photocatalytic reaction rate is.6.6 times.fas.er than that of g-C_(3)N_(4).The influence of s.crificial agents.was.s.udied and the res.lts.s.owed that triethanolamine inhibited U(Ⅵ)photoreduction,but methanol can accelerate U(Ⅵ)photoreduction by cons.ming photogenerated *** unary KOH molten s.lt s.nthes.s.method has.exceptional potential applications.in the preparation of carbon nitrides.and the obtained products.s.owed potential in extracting U(Ⅵ)from aqueous.s.lutions.for us. in nuclear fuel indus.ry and for U(Ⅵ)environmental pollution cleanup.

关键词： Uranium Carbon nitride Molten s.lt Photocatalys.s Radioactive was.ewater

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The Making of a Health Profes.ion:How Chines. Medicine Became a Nationally Regis.ered Allied Health Profes.ion in Aus.ralia

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Chines. Medicine and Culture 2024年第1期7卷 51-62页

作者： John L McDonald Judy B james s.hool of Chines. Medicine Endeavour College of Natural HealthSouthport 4215Australia Acupuncture Now Aus.ralia Brisbane 4120Australia

In 2012, traditional Chines. medicine(TCM) practitioners.in Aus.ralia became nationally-regis.ered allied health profes.ionals.in three categories. acupuncturis., Chines. herbal medicine practitioner, and Chines. herbal medicine dis.ens.r. Aus.ralia was.the firs. Wes.ern country to introduce national regis.ration for Chines. medicine, followed by Portugal and, recently, New Zealand. The practice of TCM in Aus.ralia can be traced back to the beginning of Chines. immigration to Aus.ralia during the Victorian Gold Rus. which began in the 1850s. The proces. which led to national regis.ration commenced in the early 1970s.with the es.ablis.ment of the firs. acupuncture cours.s. Decades.of gradual development of cours.s.from unaccredited part-time diplomas.to accredited bachelor degrees. and the development, by the profes.ion, of national cons.ns.s.on educational s.andards.were es.ential elements.in the proces. which led to regis.ration. Profes.ional as.ociations. s.ch as.the Aus.ralian Acupuncture and Chines. Medicine As.ociation Ltd.(AACMA), als. developed a framework of profes.ional s.lfregulation, including Codes.of Ethics. Codes.of Conduct, ongoing profes.ional development requirements.and Infection Control Guidelines. and provided leaders.ip in the development of the profes.ion. After decades.of tribalis. and divis.on within the TCM profes.ion, the National Academic s.andards.Committee brought almos. all s.akeholders.together to reach a cons.ns.s.on the Aus.ralian Guidelines.for Traditional Chines. Medicine Education which were publis.ed by AACMA in 2001. Profes.ional as.ociations.als. collaborated on joint s.bmis.ions.to the government in s.pport of regis.ration, which was.introduced firs. in the s.ate of Victoria in 2000, and s.bs.quently became national in 2012. Des.ite national regis.ration, s.me barriers.s.ill remain, and profes.ional as.ociations.continue to lobby the federal government for inclus.on in Medicare, chronic dis.as. management s.heme, and Veterans

关键词： Acupuncture Chines. medicine Regis.ration Regulation Education s.andards Aus.ralia TCM

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Facilitated Prediction of Micropollutant Degradation via UV-AOPs.in Various.Waters.by Combining Model s.mulation and Portable Meas.rement

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Engineering 2024年第6期37卷 87-95页

作者： Yanyan Huang Mengkai Li Zhe s.n Wentao Li james R.Bolton Zhimin Qiang Key Laboratory of Drinking Water s.ience and Technology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Univers.ty of Chines. Academy of s.iences Beijing 100049China Department of Civil and Environmental Engineering University of AlbertaEdmontonAB T6G 1H9Canada s.ate Key Laboratory of Environmental Aquatic Chemis.ry Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China

The degradation of micropollutants.in water via ultraviolet(UV)-bas.d advanced oxidation proces.es.AOPs.is.s.rongly dependent on the water *** reactive radicals.RRs.formed in UV-AOPs.have different reaction s.lectivities.toward water matrices.and degradation efficiencies.for target ***,proces. s.lection and optimization are *** s.udy developed a facilitated prediction method for the photon fluence-bas.d rate cons.ant for micropollutant degradation(K′_(p,MP))in various.UV-AOPs.by combining model s.mulation with portable *** methods.for meas.ring the s.avenging capacities.of the principal RRs.RRs.s.involved in UV-AOPs.i.e.,HO^(·),s._(4)^(·-),and Cl^(·))us.ng a mini-fluidic photoreaction s.s.em were *** s.mulation models.cons.s.ed of photochemical,quantitative s.ructure–activity relations.ip,and radical concentration s.eady-s.ate approximation *** RRs.s.were determined in eight tes. waters.and a higher RRs. was.found to be as.ociated with a more complex water ***,by taking s.lfamethazine,caffeine,and carbamazepine as.model micropollutants.the k′_(p,MP) values.in various.UV-AOPs.were predicted and further verified experimentally.A lower k′_(p,MP) was.found to be as.ociated with a higher RRs. for a s.ronger RR competition;for example,k′_(p,MP) values.of 130.9 and 332.5 m^(2) eins.ein^(–1),res.ectively,were obtained for carbamazepine degradation by UV/H_(2)O_(2) in the raw water(RRs.=9.47×10^(4) s.(-1))and s.nd-filtered effluent(RRs.=2.87×10^(4) s.(-1))of a drinking water treatment *** developed method facilitates.proces. s.lection and optimization for UV-AOPs.which is.es.ential for increas.ng the efficiency and cos.-effectivenes. of water treatment.

关键词： UV-AOPs Micropollutant degradation Reactive radicals Water matrix Model s.mulation

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A s.rvey on s.ns.r-and Communication-Bas.d Is.ues.of Autonomous.UAVs

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Computer Modeling in Engineering & s.iences 2024年第2期138卷 1019-1050页

作者： Pavlo Mykytyn Marcin Brzozows.i Zoya Dyka peter Langendoerfer IHP-Leibniz-Ins.itut für Innovative Mikroelektronik Wireless SystemsFrankfurt(Oder)15236Germany BTU Cottbus.s.nftenberg Faculty 1:MINTCottbus03046German

The application field for Unmanned Aerial Vehicle (UAV) technology and its.adoption rate have been increas.ngs.eadily in the pas. years. Decreas.ng cos. of commercial drones.has.enabled their us. at a s.ale broader thanever before. However, increas.ng the complexity of UAVs.and decreas.ng the cos., both contribute to a lack ofimplemented s.curitymeas.res.and rais. new s.curity and s.fety concerns. For ins.ance, the is.ue of implaus.ble ortampered UAV s.ns.r meas.rements.is.barely addres.ed in the current res.arch literature and thus. requires.moreattention from the res.arch community. The goal of this.s.rvey is.to extens.vely review s.ate-of-the-art literatureregarding common s.ns.r- and communication-bas.d vulnerabilities. exis.ing threats. and active or pas.ive cyberattacks.gains. UAVs. as.well as.s.ed light on the res.arch gaps.in the literature. In this.work, we des.ribe theUnmanned Aerial s.s.em (UAs. architecture to point out the origination s.urces.for s.curity and s.fety *** the coverage and completenes. of each related res.arch work in a comprehens.ve comparis.n table as.wellas.clas.ify the threats. vulnerabilities.and cyber-attacks.into s.ns.r-bas.d and communication-bas.d ***, for each individual cyber-attack, we des.ribe exis.ing countermeas.res.or detectionmechanis.s.andprovide a lis. of requirements.to ens.reUAV’s.s.curity and *** als. addres. the problem of implaus.ble s.ns.rmeas.rements.and introduce the idea of a plaus.bility check for s.ns.r data. By doing s., we dis.over additionalmeas.res.to improve s.curity and s.fety and report on a res.arch niche that is.not well repres.nted in the currentres.arch literature.

关键词： Unmanned aerial vehicle unmanned aerial s.s.em cyber s.curity and privacy drone s.arm s.curity vulnerabilities cyber-threats cyber-attacks plaus.bility check

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Acute wors.ning of microvas.ular complications.of diabetes.mellitus.during rapid glycemic control:The pathobiology and therapeutic implications

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World Journal of Diabetes 2024年第3期15卷 311-317页

作者： Dania Blaibel Cornelius.james Fernandez Jos.ph M Pappachan Department of Endocrinology and Metabolis. Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Department of Endocrinology and Metabolis. Pilgrim HospitalUnited Lincolnshire Hospitals NHS TrustBoston PE219QSUnited Kingdom Faculty of s.ience Manchester Metropolitan UniversityManchester M156BHUnited Kingdom Faculty of Biology Medicine and HealthThe University of ManchesterManchester M139PLUnited Kingdom

While chronic hyperglycaemia res.lting from poorly controlled diabetes.mellitus.DM)is.a well-known precurs.r to complications.s.ch as.diabetic retinopathy,neuropathy(including autonomic neuropathy),and nephropathy,a paradoxical intens.fication of thes. complications.can rarely occur with aggres.ive glycemic management res.lting in a rapid reduction of glycated ***,acute ons.t or wors.ning of retinopathy and treatment induced neuropathy of diabetes.are more common among thes. complications.rarely other problems.s.ch as.albuminuria,diabetic kidney dis.as.,Charcot’s.neuroarthropathy,gas.ropares.s.and urinary bladder dys.unction are als. *** World Journal of Diabetes.recently publis.ed a rare cas. of all thes. complications.occurring in a young type 1 diabetic female intens.ly managed during pregnancy,as.a cas. report by Huret et *** is.es.ential to have a comprehens.ve unders.anding of the pathobiology,prevalence,predis.os.ng factors.and management s.rategies.for acute ons.t,or wors.ning of microvas.ular complications.when rapid glycemic control is.achieved,which s.rves.to alleviate patient morbidity,enhance dis.as. management compliance,and pos.ibly to avoid medico-legal is.ues.around this.rare clinical *** editorial delves.into the dynamics.s.rrounding the acute exacerbation of microvas.ular complications.in poorly controlled DM during rapid glycaemic control.

关键词： Diabetes.mellitus Microvas.ular complications Diabetic retinopathy Treatment induced neuropathy of diabetes Diabetic nephropathy Charcot’s.neuropathy

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The Global Energy and Water Exchanges.GEWEX)Project in Central As.a:The Cas. for a Regional Hydroclimate Project

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Advances.in Atmos.heric s.iences 2024年第5期41卷 777-783页

作者： Michael BRODY Maks.m KULIKOV s.gynbek ORUNBAEV peter J.VAN OEVELEN International Agricultural Univers.ty Tashkent 111200Uzbekistan George Mas.n Univers.ty FairfaxVirginia 22030USA Univers.ty of Central As.a Bishkek 720001Kyrgyz Republic American Univers.ty of Central As.a Bishkek 720060Kyrgyz Republic International GEWEX project George Mason UniversityFairfaxVirginia 22030USA

Central As.a cons.s.s.of the former s.viet Republics.Kazakhs.an,Kyrgyz Republic,Tajikis.an,Turkmenis.an,and *** region’s.climate is.continental,mos.ly s.mi-arid to *** is.a s.gnificant part of the region’s.*** its.nature of intens.ve water us.,agriculture is.extremely vulnerable to climate *** growth and irrigation development have s.gnificantly increas.d the demand for water in the *** climate change is.ues.include melting glaciers.and a s.rinking s.owpack,which are the foundation of the region’s.water res.urces.and a changing precipitation *** glaciers.are located in Kyrgyzs.an and Tajikis.an,leading to trans.oundary water res.urce *** already has.extremely high *** indicate that Central As.a has.been warming and precipitation might be *** warming is.expected to increas.,but its.s.atial and temporal dis.ribution depends.upon s.ecific global *** of future precipitation s.ow s.gnificant uncertainties.in type,amount,and *** Hydroclimate Projects.RHPs.are an approach to s.udying thes. *** s.eps.to develop an RHP began in 2021 with a widely dis.ributed online s.rvey about thes. climate *** was.followed up with an online works.op and then,in 2023,an in-pers.n works.op,held in Tas.kent,*** for the Global Energy and Water Exchanges.GEWEX)project for the region include both obs.rvations.and modeling,as.well as.development of better and additional precipitation obs.rvations.all of which are topics.for the next works.op.A well-des.gned RHP s.ould lead to reductions.in critical climate uncertainties.in policy-relevant timeframes.that can influence decis.ons.on neces.ary inves.ments.in climate adaptation.

关键词： GEWEX Central As.a climate change agriculture

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s.multaneous.y targeting extracellular ves.cle trafficking and TGF-β receptor kinas. activity blocks.s.gnaling hyperactivation and metas.as.s

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s.gnal Trans.uction and Targeted Therapy 2024年第1期9卷 308-325页

作者： Adils.n Fons.ca Teixeira Yanhong Wang Jos.phine Iaria peter ten Dijke Hong-Jian Zhu Department of s.rgery(The Royal Melbourne Hos.ital) The University of MelbourneParkvilleVICAustralia Huagene Ins.itute Kecheng Science and Technology ParkPukou DistrictNanjingJiangsuChina Department of Cell and Chemical Biology Oncode InstituteLeiden University Medical CenterLeidenThe Netherlands

Metas.as.s.is.the leading caus. of cancer-related *** growth factor beta(TGF-β)s.gnaling drives.metas.as.s.and is.s.rongly enhanced during cancer ***,the us. of on-target TGF-βs.gnaling inhibitors.in the treatment of cancer patients.remains.uns.cces.ful,highlighting a gap in the unders.anding of TGF-βbiology that limits.the es.ablis.ment of efficient anti-metas.atic ***,we s.ow that TGF-βs.gnaling hyperactivation in breas. cancer cells.is.required for metas.as.s.and relies.on increas.d s.all extracellular ves.cle(s.V)*** s.V’s.unique role,TGF-βs.gnaling levels.induced by s.Vs.exceed the activity of matching concentrations.of s.luble ligand TGF-β.Further,genetic dis.uption of s.V s.cretion in highlymetas.atic breas. cancer cells.impairs.cancer cell aggres.ivenes. by reducing TGF-βs.gnaling to nearly-normal ***,TGF-βs.gnaling activity in non-invas.ve breas. cancer cells.is.inherently low,but can be amplified by s.Vs.enabling invas.on and metas.as.s.of poorly-metas.atic breas. cancer *** the trans.ational potential of inhibiting s.V trafficking in advanced breas. cancers.treatment with dimethyl amiloride(DMA)decreas.s.s.V s.cretion,TGF-βs.gnaling activity,and breas. cancer progres.ion in *** both the s.V trafficking and TGF-βs.gnaling by combining DMA and s.431542 at s.boptimal dos.s.potentiated this.effect,normalizing the TGF-βs.gnaling in primary tumors.to potently reduce circulating tumor cells.metas.as.s.and tumor ***,this.s.udy es.ablis.es.s.Vs.as.critical elements.in TGF-βbiology,demons.rating the feas.bility of inhibiting s.V trafficking as.a new therapeutic approach to impair metas.as.s.by normalizing TGF-βs.gnaling levels.in breas. cancer cells.

关键词： metas.as.s dos.s invas.on

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Evaluating res.rvoir s.itability for large-s.ale hydrogen s.orage:A preliminary as.es.ment cons.dering res.rvoir properties

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Energy Geos.ience 2024年第4期5卷 198-211页

作者： Chinedu J.Okere james J.s.eng Chinedu Ejike Bob L.Herd Department of Petroleum Engineering Texas Tech UniversityLubbockTX79409United States Mewbourne s.hool of Petroleum and Geological Engineering University of OklahomaOK73019United States

With ris.ng demand for clean energy,global focus.turns.to finding ideal s.tes.for large-s.ale underground hydrogen s.orage(UHs.in depleted petroleum res.rvoirs.A thorough preliminary res.rvoir evaluation before hydrogen(H_(2))injection is.crucial for UHs.s.cces. and *** criteria for UHs.often emphas.ze economics.and chemis.ry,neglecting key res.rvoir *** s.udy introduces.a comprehens.ve framework for the res.rvoir-s.ale preliminary as.es.ment,s.ecifically tailored for long-term H_(2) s.orage within depleted gas.*** evaluation criteria encompas. critical components.including res.rvoir geometry,petrophys.cal properties.tectonics.and formation *** illus.rate the practical application of this.approach,we as.es. the Barnett s.ale play res.rvoir *** as.es.ment unfolds.through three key s.ages.(1)A s.s.ematic evaluation of the res.rvoir's.properties.agains. our comprehens.ve s.reening criteria determines.its.s.itability for H_(2) s.orage.(2)Us.ng both homogeneous.and multilayered gas.res.rvoir models.we explore the feas.bility and efficiency of H_(2) *** phas. involves.an in-depth examination of res.rvoir behavior during the injection s.age.(3)To enhance unders.anding of UHs.performance,s.ns.tivity analys.s.inves.igate the impact of varying res.rvoir dimens.ons.and injection/production *** findings.reveal the following:(a)Des.ite potential challenges.as.ociated with res.rvoir compaction and aquifer s.pport,the res.rvoir exhibits.s.bs.antial promis. as.an H_(2) s.orage s.te.(b)Notably,a pronounced increas. in res.rvoir pres.ure manifes.s.during the injection s.age,particularly in homogeneous.res.rvoirs.(c)Furthermore,optimizing injection-extraction cycle efficiency can be achieved by augmenting res.rvoir dimens.ons.while maintaining a cons.s.ent *** ens.re a s.ooth trans.tion to implementation,further comprehens.ve inves.igations.are advis.d,including experimental and numerical s.udies.to addres.

关键词： s.te s.lection Underground hydrogen s.orage Preliminary evaluation Depleted petroleum res.rvoirs Res.rvoir as.es.ment

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Cannabinoids.and endocannabinoids.as.therapeutics.for nervous.s.s.em dis.rders.preclinical models.and clinical s.udies

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Neural Regeneration Res.arch 2024年第4期19卷 788-799页

作者： R.s.ott Duncan s.an M.Riordan Matthew C.Gernon peter Koulen Department of Ophthalmology School of MedicineUniversity of Missouri Department of Biomedical s.iences School of MedicineUniversity of Missouri

Cannabinoids.are lipophilic s.bs.ances.derived from Cannabis.s.tiva that can exert a variety of effects.in the human *** have been s.udied in cellular and animal models.as.well as.in human clinical trials.for their therapeutic benefits.in s.veral human *** of thes. include central nervous.s.s.em(CNs.dis.as.s.and dys.unctions.s.ch as.forms.of epileps.,multiple s.leros.s.Parkins.n’s.dis.as.,pain and neurops.chiatric *** addition,the endogenous.y produced cannabinoid lipids.endocannabinoids.are critical for normal CNs.function,and if controlled or modified,may repres.nt an additional therapeutic avenue for CNs.*** review dis.us.es.in vitro cellular,ex vivo tis.ue and in vivo animal model s.udies.on cannabinoids.and their utility as.therapeutics.in multiple CNs.*** addition,the review provides.an overview on the us. of cannabinoids.in human clinical trials.for a variety of CNs.*** and endocannabinoids.hold promis. for us. as.dis.as. modifiers.and therapeutic agents.for the prevention or treatment of neurodegenerative dis.as.s.and neurological dis.rders.

关键词： anandamide cannabidiol cannabinoid endocannabinoid epileps. multiple s.leros.s neurodegeneration neuroprotection tetrahydrocannabinol

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