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Open Journal of Gastroenterology 2024年第8期14卷 261-266页

作者： peter Cassar nicholas Delicata Department of Medicine Department of Nephrology and General Medicine Mater Dei Hospital Msida Malta Department of Medicine Department of Gastroenterology Mater Dei Hospital Msida Malta

This case report sheds light on a curious case of rhabdomyolysis in an otherwise healthy twenty-eight-year-old male and its direct effect on liver function tests. This case report provides a fresh perspective on the doctor-patient dynamic where a medic becomes a doctor. Attention is also drawn to the mental and socioeconomic repercussions of having a health issue whilst applying for a home loan.

关键词： Rhabdomyolysis Transaminase Creatinine Kinase

A flexible,thin-film microchannel electrode array device for selective subdiaphragmatic vagus nerve recording

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Microsystems & Nanoengineering 2024年第1期10卷 115-128页

作者： Jongcheon Lim peter A.Zoss Terry L.Powley Hyowon lee Matthew P.Ward Weldon School of Biomedical Engineering Purdue UniversityWest LafayetteINUSA Birck Nanotechnology Center Purdue UniversityWest LafayetteINUSA Center for Implantable Devices Purdue UniversityWest LafayetteINUSA Department of Psychological Sciences Purdue UniversityWest LafayetteINUSA Purdue Institute of Integrative Neuroscience Purdue UniversityWest LafayetteINUSA Indiana University School of Medicine IndianapolisINUSA

The vagus nerve(VN)plays an important role in regulating physiological conditions in the gastrointestinal(GI)tract by communicating via the parasympathetic pathway to the enteric nervous system(ENS).However,the lack of knowledge in the neurophysiology of the VN and GI tract limits the development of advanced treatments for autonomic dysfunctions related to the *** better understand the complicated underlying mechanisms of the VN-GI tract neurophysiology,it is necessary to use an advanced device enabled by microfabrication *** several candidates including intraneural probe array and extraneural cuff electrodes,microchannel electrode array devices can be used to interface with smaller numbers of nerve fibers by securing them in the separate channel *** microchannel electrode array devices to interface teased nerve structures are relatively bulky with thickness around 200µ*** thick design can potentially harm the delicate tissue structures,including the nerve *** this paper,we present a flexible thin film based microchannel electrode array device(thickness:11.5µm)that can interface with one of the subdiaphragmatic nerve branches of the VN in a *** demonstrated recording evoked compound action potentials(ECAP)from a transected nerve ending that has multiple nerve ***,our analysis confirmed that the signals are from C-fibers that are critical in regulating autonomic neurophysiology in the GI tract.

关键词： electrode recording film

Review with meta-analysis relating North American,European and Japanese snus or smokeless tobacco use to major smoking-related diseases

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World Journal of Meta-Analysis 2022年第3期10卷 130-142页

作者： peter nicholas lee Katharine Jane Coombs Janette Susan Hamling Department of Medical Statistics and Epidemiology P.N.Lee Statistics and Computing LtdSutton SM25DASurreyUnited Kingdom Department of Medical Statistics and Epidemiology RoeLee Statistics LtdSutton SM25DASurreyUnited Kingdom

BACKGROUND While extensive information exists relating cigarette smoking to the risk of lung cancer,chronic obstructive pulmonary disease(COPD),ischaemic heart disease(IHD)or acute myocardial infarction(AMI),and stroke,far less information is available on risks from moist snuff(“snus”)or smokeless tobacco(ST)in United States/Canada,Europe or *** To summarize data from the selected countries on risks of the four diseases associated with current ST or snus *** Publications in English in 1990-2020 were considered that,based on epidemiological studies in North America,Europe or Japan,estimated risks of lung cancer,COPD,IHD/AMI,or stroke according to use of ST or *** studies should involve at least 100 cases of the disease considered,and not be restricted to those with specific other *** literature searches were conducted,selecting papers initially from examination of titles and abstracts,and then from full *** papers were sought from reference lists in selected papers,reviews and *** each disease,relative risk estimates adjusted at least for age were extracted relating ST or snus use to risk,and combined using random-effects *** estimates were mainly for current *** or non-current use,but results for ever vs never use were also *** Seven publications reported results for ST use from six United States *** most useful results came from four studies which provided results for current *** ***-effects meta-analyses of these results showed an increased risk for each disease,clearest for lung cancer(relative risk 1.59,95%confidence interval 1.06-2.39,based on 4 estimates)and COPD(1.57,1.09-2.26,n=3),but also significant(at P<0.05)for IHD(1.26,1.10-1.45,n=4)and stroke(1.27,1.03-1.57,n=4).Also including results for ever *** use from two other studies increased the lung cancer estimate to 1.80(1.23-2.64,n=6),but had little effect on the other *** snus,16 pu

关键词： Smokeless tobacco Moist snuff Lung disease Cardiovascular disease Meta-analysis Review

Evidence relating cigarette,cigar and pipe smoking to lung cancer and chronic obstructive pulmonary disease:Meta-analysis of recent data from three regions

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World Journal of Meta-Analysis 2023年第5期11卷 228-252页

作者： peter nicholas lee Katharine J Coombs Jan S Hamling Medical Statistics and Epidemiology P.N.Lee Statistics and Computing Ltd.Sutton SM25DASurreyUnited Kingdom Statistics P.N.Lee Statistics and Computing LtdSutton SM25DASurreyUnited Kingdom Statistics RoeLee Statistics LtdSutton SM25DAUnited Kingdom

BACKGROUND There is a need to have up-to-date information for various diseases on the risk related to the use of different smoked products and the use of other nicotinecontaining ***,we contribute to the information pool by presenting up-to-date quantitative evidence for North America,Europe and Japan and for both lung cancer and chronic obstructive pulmonary disease(COPD)on the relative risk(RR)relating to current vs never product use for each of the three smoked tobacco products,cigarettes,cigars and *** To estimate lung cancer and COPD current smoking RRs for the three products using recent data for the three *** Publications in English from 2010 to 2020 were considered that,based on epidemiological studies in the three regions,estimated the current smoking RR of lung cancer and/or COPD for one or more of the three *** studies should involve at least 100 cases of the disease considered,not be restricted to specific lung cancer types or populations with specific medical conditions,and should be of cohort or nested case-control study design or randomized controlled *** searches were conducted on MEDLINE separately for lung cancer and for COPD,examining titles and abstracts initially,and then full *** papers were sought from reference lists of selected papers,reviews and *** each study identified,the most recent available data on each product were entered on current smoking,as well as on characteristics of the study and the RR *** RR estimates were derived using random-effects *** cigarette smoking,where far more data were available,heterogeneity was studied by a wide range of *** cigar and pipe smoking,a more limited heterogeneity analysis was carried *** were compared with those from previous meta-analyses published since *** Current cigarette smoking:For lung cancer,44 studies(26 North American,14 European,three Japanese,and one in mu

关键词： Cigarettes Cigars Pipes Lung cancer Meta-analysis Review

Systematic review with meta-analysis of the epidemiological evidence in Europe,Israel,America and Australasia on smoking and COVID-19

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World Journal of Meta-Analysis 2021年第4期9卷 353-376页

作者： peter nicholas lee Janette S Hamling Katharine Jane Coombs Department of Statistics P.N.Lee Statistics and Computing Ltd.Sutton SM25DAUnited Kingdom Department of Statistics RoeLee Statistics Ltd.Sutton SM25DASurreyUnited Kingdom

BACKGROUND Previous meta-analyses related smoking to death or severe infection from coronavirus disease 2019(COVID-19)in hospitalized patients,but considered only a few studies,did not adjust for demographics and comorbidities,and inadequately defined *** To review and meta-analyse epidemiological evidence on smoking and COVID-19,considering a range of endpoints,populations and smoking definitions and the effect of *** Studies were identified from publications in English up to 30 September,2020 involving at least 100 individuals,carried out in Europe,Israel,America or Australasia,not restricted to those with specific other diseases,and providing information relating smoking to various COVID-related ***-analyses were carried out for combinations of population and endpoint,with variation studied by smoking definition,adjustment level and other *** From 96 publications,74 studies were identified,37 in the United States,10 in the United Kingdom,with up to four in the other *** involved over a million individuals,and 37 involved less than a *** results for smoking were available in 42 studies,with adjustment not considered in 20 *** were considered by *** significant effect of smoking on COVID-19 positivity was seen in the general population,but there was a reduced risk in those ***-adjusted estimates for current(vs never)smoking were 0.87(95%confidence interval:0.52-1.47)in the general population and 0.52(0.43-0.64)in those *** those hospitalized due to COVID-19,unadjusted rates were significantly increased in current smokers(1.20,1.01-1.42)and ever smokers(1.64,1.41-1.91),but those adjusted for comorbidities showed no increase for current(0.82,0.52-1.30)or ever smokers(1.00,0.76-1.32).There was little evidence to suggest that smoking was associated with intensive care *** those hospitalized with COVID-19,best-adjusted estimates were 0.88(0.72-1.08)for cu

关键词： Smoking COVID-19 Meta-analyses Review Europe America

Evidence relating cigarettes,cigars and pipes to cardiovascular disease and stroke:Meta-analysis of recent data from three regions

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World Journal of Meta-Analysis 2023年第6期11卷 290-312页

作者： peter nicholas lee Katharine J Coombs Jan S Hamling Medical Statistics and Epidemiology P.N.Lee Statistics and Computing Ltd.Sutton SM25DASurreyUnited Kingdom

BACKGROUND More recent data are required relating to disease risk for use of various smoked products and of other products containing *** we published metaanalyses of recent results for chronic obstructive pulmonary disease and lung cancer on the relative risk(RR)of current compared to never product use for cigarettes,cigars and pipes based on evidence from North America,Europe and *** now report corresponding up-to-date evidence for acute myocardial infarction(AMI),ischaemic heart disease(IHD)and *** To estimate,using recent data,AMI,IHD and stroke RRs by region for current smoking of cigarettes,cigars and *** Publications in English from 2015 to 2020 were considered that,based on epidemiological studies in the three regions,estimated the current smoking RR of AMI,IHD or stroke for one or more of the three *** studies should involve at least 100 cases of stroke or cardiovascular disease(CVD),not be restricted to populations with specific medical conditions,and should be of cohort or nested case-control study design or randomized controlled trials.A literature search was conducted on MEDLINE,examining titles and abstracts initially,and then full *** papers were sought from reference lists of selected papers,reviews and *** each study identified,we entered the most recent available data on current smoking of each product,as well as the characteristics of the study and the RR *** RR estimates were derived using random-effects meta-analysis for stroke and,in the case of CVD,separately for IHD and *** cigarette smoking,where far more data were available,heterogeneity was studied by a wide range of *** cigar and pipe smoking,a more limited heterogeneity analysis was carried out.A more limited assessment of variation in risk by daily number of cigarettes smoked was also *** Current cigarette smoking:Ten studies gave a random-effects RR for AMI of 2.72[95%confide

关键词： Cigarettes Cigars Pipes Cardiovascular disease Stroke Meta-analysis Review

Cost burden following esophagectomy:A single centre observational study

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2255-2269页

作者： Vered Buchholz Dong Kyu lee David S Liu Ahmad Aly Stephen A Barnett Riley Hazard peter Le Benjamin Kioussis Vijayaragavan Muralidharan Laurence Weinberg Department of Surgery Austin HealthMelbourne 3084VictoriaAustralia Department of Anesthesiology and Pain Medicine Dongguk University Ilsan HospitalSeoul 14566GoyangSouth Korea Department of Surgery Austin HealthThe University of MelbourneMelbourne 3084VictoriaAustralia Department of Anesthesia Austin HealthMelbourne 3084VictoriaAustralia Department of Anesthesia Austin HospitalHeidelberg 3084VictoriaAustralia Department of Critical Care The University of MelbourneMelbourne 3084VictoriaAustralia

BACKGROUND Cost analyses of patients undergoing esophagectomy is valuable for identifying modifiable expenditure drivers to target and curtail costs while improving the quality of *** aimed to define the cost-complication relationship after esophagectomy and delineate the incremental contributions to *** To assess the relationship between the hospital costs and potential cost drivers post esophagectomy and investigate the relationship between the cost-driving variables(predicting variables)and hospital costs(dependent variable).METHODS In this retrospective single center study,the severity of complications was graded using the Clavien-Dindo(CD)classification *** esophagectomy complications were categorized and defined according to consensus *** costing data included the in-hospital costs of the index admission and any unplanned admission within 30 postoperative *** used correlation analysis to assess the relationship between key clinical variables and hospital costs(in United States dollars)to identify cost drivers.A mediation model was used to investigate the relationship between these variables and hospital *** A total of 110 patients underwent primary esophageal *** median admission cost was $47822.7(interquartile range:35670.2-68214.0).The total effects on costs were $13593.9(95%CI:10187.1-17000.8,P<0.001)for each increase in CD severity grade,$4781(95%CI:3772.7-5789.3,P<0.001)for each increase in the number of complications,and $42552.2(95%CI:8309-76795.4,P=0.015)if a key esophagectomy complication *** esophagectomy complications drove the costs directly by $11415.7(95%CI:992.5-21838.9,P=0.032).CONCLUSION The severity and number of complications,and the development of key esophagectomy complications significantly contributed to total hospital *** institutional initiatives and strategies are needed to enhance patient outcomes and minimize costs.

关键词： Anesthesia Esophagectomy Complications Cancer Surgery

Topic Modeling Based Warning Prioritization from Change Sets of Software Repository

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Journal of Computer Science & Technology 2020年第6期35卷 1461-1479页

作者： Jung-Been lee Taek lee Hoh peter In College of Informatics Korea UniversitySeoul 02841Korea College of Knowledge-Based Services Engineering Sungshin UniversitySeoul 02844Korea

Many existing warning prioritization techniques seek to reorder the static analysis warnings such that true positives are provided first. However, excessive amount of time is required therein to investigate and fix prioritized warnings because some are not actually true positives or are irrelevant to the code context and topic. In this paper, we propose a warning prioritization technique that reflects various latent topics from bug-related code blocks. Our main aim is to build a prioritization model that comprises separate warning priorities depending on the topic of the change sets to identify the number of true positive warnings. For the performance evaluation of the proposed model, we employ a performance metric called warning detection rate, widely used in many warning prioritization studies, and compare the proposed model with other competitive techniques. Additionally, the effectiveness of our model is verified via the application of our technique to eight industrial projects of a real global company.

关键词： automated static analysis topic modeling warning prioritization

Electronic and optical properties of CdS/CdZnS nanocrystals

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Chinese Physics B 2012年第8期21卷 441-448页

作者： A.John peter Chang Woo lee epartment of Chemical Engineering and Green Energy Center College of EngineeringKyung Hee University1 SeochunGihungYonginGyeonggi 446-701S.Korea Department of Physics Govt.Arts CollegeMelurMadurai-62510India Department of Chemical Engineering and Green Energy Center College of EngineeringKyung Hee University1 SeochunGihungYonginGyeonggi 446-701S.Korea

Cd1-xZnxS nanocrystals are prepared by a co-precipitation method with different atomic fractions of Zn. The texture, structural transformation and optical properties with increasing x value in Cd1-xZnxS are studied with scanning electron microscopy, electron diffraction patterning, and absorption spectra respectively. Quantum confinement in a strained CdS/Cd1-xZnxS related nanodot with various Zn content values is investigated theoretically. Binding energies on exciton bound CdS/CdxZn1-xS quantum dot are computed, with consideration of the internal electric field induced by the spontaneous and piezoelectric polarizations, and thereby the interband emission energy is calculated as a function of the dot radius. The optical band gap from the UV absorption spectrum is compared with the interband emission energy computed theoretically. Our results show that the average diameter of composite nanoparticles ranges from 3 nm to 6 nm. The X-ray diffraction pattern shows that all the peaks shift towards the higher diffracting angles with an increase in Zn content. The lattice constant gradually decreases as the Zn content increases. The strong absorption edge shifts towards the lower wavelength region and hence the band gap of the films increases as the Zn content increases. The values of the absorption edge are found to shift towards the shorter wave length region and hence the direct band gap energy varies from 2.5 eV for the CdS film and 3.5 eV for the ZnS film. Our numerical results are in good agreement with the experimental results.

关键词： quantum dots quasicrystals semiconductor

Radiative life time of an exciton confined in a strained GaN/Ga_(1-x)Al_xN cylindrical dot:built-in electric field effects

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Chinese Physics B 2011年第7期20卷 367-372页

作者： Chang Woo lee A.John peter Department of Chemical Engineering and Green Energy Center College of EngineeringKyung Hee University1 SeochunGihungYonginGyeonggi 446-701Republic of Korea Department of Physics Government Arts and Science CollegeMelur-625106India

The binding energy of an exciton in a wurtzite GaN/GaAlN strained cylindrical quantum dot is investigated theoretically. The strong built-in electric field due to the spontaneous and piezoelectric polarizations of a GaN/GaAlN quantum dot is included. Numerical calculations are performed using a variational procedure within the single band effective mass approximation. Valence-band anisotropy is included in our theoretical model by using different hole masses in different spatial directions. The exciton oscillator strength and the exciton lifetime for radiative recombination each as a function of dot radius have been computed. The result elucidates that the strong built-in electric field influences the oscillator strength and the recombination life time of the exciton. It is observed that the ground state exciton binding energy and the interband emission energy increase when the cylindrical quantum dot height or radius is decreased, and that the exciton binding energy, the oscillator strength and the radiative lifetime each as a function of structural parameters （height and radius） sensitively depend on the strong built-in electric field. The obtained results are useful for the design of some opto-photoelectronic devices.

关键词： quantum dot donor bound excitons oscillator strength