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Influence of degree of interlock on confined strength of j.inted hard rock masses

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j.urnal of Rock Mechanics and Geotechnical Engineering 2020年第6期12卷 1152-1170页

作者： Navid Bahrani peter k.kaiser a Department of Civil and Resource Engineering Dalhousie UniversityHalifaxNova ScotiaCanada b Bharti School of Engineering Laurentian UniversitySudburyOntarioCanada

The strength of j.inted rock mass is strongly controlled by the degree of interlock between its constituent rock *** degree of interlock constrains the kinematic freedom of individual rock blocks to rotate and slide along the block forming *** HoekeBrown(HB)failure criterion and the geological strength index(GSI)were developed based on experiences from mine slopes and tunneling proj.cts in moderately to poorly interlocked j.inted rock *** has since then been demonstrated that the approach to estimate the HB strength parameters based on the GSI strength scaling equations(called the‘GSI strength equations’)tends to underestimate the confined peak strength of highly interlocked j.inted rock masses(***>65),where the rock mass is often non-persistently j.inted,and the intact rock blocks are strong and *** estimation of the confined strength of such rock masses is relevant when designing mine pillars and abutments at great depths,where the confining pressure is high enough to prevent block rotation and free sliding on block *** this article,a grain-based distinct element modeling approach is used to simulate j.inted rock masses of various degrees of interlock and to investigate the influences of block shape,j.int persistence and j.int surface condition on the confined peak *** focus is on non-persistently j.inted and blocky(persistently j.inted)rock masses,consisting of hard and homogeneous rock blocks devoid of any strength degrading defects such as *** results from this investigation confirm that the GSI strength equations underestimate the confined strength of highly interlocked and non-persistently j.inted rock ***,the GSI strength equations are found to be valid to estimate the confined strength of persistently j.inted rock masses with smooth and non-dilatant j.int surfaces.

关键词： Rock mass strength Degree of interlock Non-persistently j.inted rock mass Blocky rock mass Geological strength index(GSI) GSI strength equations

Contribution of precursor compounds to the release of per-and polyfluoroalkyl substances(PFASs) from waste water treatment plants(WWTPs)

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j.urnal of Environmental Sciences 2017年第11期29卷 80-90页

作者： Ulrika Eriksson peter Haglund Anna k?rrman Man-Technology-Environment (MTM) Research Centre School of Science and Technology ?rebro University Department of Chemistry Umea University

Per-and polyfluoroalkyl substances（PFASs） are ubiquitous in sludge and water from waste water treatment plants, as a result of their incorporation in everyday products and industrial processes. In this study, we measured several classes of persistent PFASs,precursors, transformation intermediates, and newly identified PFASs in influent and effluent sewage water and sludge from three municipal waste water treatment plants in Sweden, sampled in 2015. For sludge, samples from 2012 and 2014 were analyzed as *** of precursors in sludge exceeded those of perfluoroalkyl acids and sulfonic acids（PFCAs and PFSAs）, in 2015 the sum of polyfluoroalkyl phosphoric acid esters（PAPs） were 15–20 ng/g dry weight, the sum of fluorotelomer sulfonic acids（FTSAs） was 0.8–1.3 ng/g,and the sum of perfluorooctane sulfonamides and ethanols ranged from non-detected to 3.2 ng/g. Persistent PFSAs and PFCAs were detected at 1.9–3.9 ng/g and 2.4–7.3 ng/g dry weight, respectively. The influence of precursor compounds was further demonstrated by an observed substantial increase for a maj.rity of the persistent PFCAs and PFSAs in water after waste water treatment. Perfluorohexanoic acid（PFHxA）, perfluorooctanoic acid（PFOA）, perfluorohexane sulfonic acid（PFHxS）, and perfluorooctane sulfonic acid（PFOS）had a net mass increase in all WWTPs, with mean values of 83%, 28%, 37% and 58%,respectively. The load of precursors and intermediates in influent water and sludge combined with net mass increase support the hypothesis that degradation of precursor compounds is a significant contributor to PFAS contamination in the environment.

关键词： diPAPs FTSAs Waste water Daily discharge PFCA precursor

Ultrastrong and ductile BCC high-entropy alloys with low-density via dislocation regulation and nanoprecipitates

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j.urnal of Materials Science & Technology 2022年第15期110卷 109-116页

作者： Xuehui Yan peter k.Liaw Yong Zhang Beij.ng Advanced Innovation Center of Materials Genome Engineering State Key Laboratory for Advanced Metals and MaterialsUniversity of Science and Technology BeijingBeijing 100083China Department of Materials Science and Engineering The University of TennesseeKnoxvilleTN 37996United States of America

The high strength is a typical advantage of body-centered-cubic high-entropy alloys(BCC–HEAs).However,brittleness and weak strain-hardening ability are still their Achilles'***,extraordinary strength together with good tensile ductility are achieved in(Zr_(0.5)Ti_(0.35)Nb_(0.15))_(100-x)Al_(x) alloys(at.%,x=10 and 20)at room *** low densities of less than 6 g/cm^(3)are exhibited in these *** nanoprecipitates and diversifying dislocation motions are the keys to achieving such salient *** is worth noting that the tensile strength of 1.8 GPa in(Zr_(0.5)Ti_(0.35)Nb_(0.15))_(80)Al_(20)alloy is a record-high value known in reported BCC–HEAs,as well as a tensile strain over 8%.Furthermore,the maximum strain of~25%in(Zr_(0.5)Ti_(0.35)Nb_(0.15))_(90)Al_(10)alloy can challenge existing limit value,and is accompanied with a tensile strength of 1.2 *** current work does not only provide novel ultra-strong and tough structural materials with low density,but also sheds new light on designing BCC–HEAs with attractive performances and strain-hardening ability.

关键词： High-entropy alloys Mechanical properties Dislocation Nanoprecipitates Strain hardening

Radial Basis Function Networks Applied in Bacterial Classification Based on MALDI-TOF-MS

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Chemical Research in Chinese Universities 2002年第4期18卷 453-457页

作者： HARRINGTON peter de B. VOORHEES kent j. REES j.n Ohio University Center for Intelligent Chemical Instrumentation Department of Chemistry and Biochemistry Ohio UniversityDepartment of Chemistry and Geochemistry Colorado School of MinesDepartment of Chemistry and Geochemistry Colorado School of Mines Athens Ohio 45701-2979 USA Golden CO 80401 USAGolden CO 80401 USA

The radial basis function networks were applied to bacterial classification based on the matrix-assisted laser desorption/ionization time-of-flight mass spectrometric (MALDI-TOF-MS) data. The classification of bacteria cultured at different time was discussed and the effect of the network parameters on the classification was investigated. The cross-validation method was used to test the trained networks. The correctness of the classification of different bacteria investigated changes in a wide range from 61.5% to 92.8%. Owing to the complexity of biological effects in bacterial growth, the more rigid control of bacterial culture conditions seems to be a critical factor for improving the rate of correctness for bacterial classification.

关键词： Radial basis function network Matrix-assisted laser desorption/ionization Time-of-flight mass spectrometry Bacterium Classification

The tumor suppressor RASSF1A is a novel effector of small G protein Rap1A

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Protein & Cell 2011年第3期2卷 237-249页

作者： Sunil k.Verma Trivadi S.Ganesan Uday kishore peter j.Parker Department of Medical Oncology Medical Sciences DivisionThe University of OxfordOxford OX39DUUK Ovarian Cancer Group CRUK Molecular Oncology LaboratoriesWeatherall Institute of Molecular MedicineJohn Radcliffe HospitalHeadingtonOxford OX39DSUK Protein Phosphorylation Laboratory London Research InstituteCRUK Lincoln's Inn Fields Laboratories44 Lincoln's Inn FieldsLondon WC2A 3PXUK kings College London The Division of Cancer StudiesSection of Cancer Cell Biology and Imaging2nd FloorNew Hunt's HouseGuy's HospitalSt Thomas StreetLondon SE11ULUK Current address:Center for Cellular and Molecular Biology Uppal RoadHyderabad 500007India Current address:Cancer Institute&Institute of Molecular Medicine Amrita Institute of Medical SciencesElamakkara P.O.KochiKerala 682026India Center for Infection Immunity and Disease MechanismsBiosciencesSchool of Health Sciences and Social CareBrunel UniversityUxbridge UB83PHWest LondonUK

Rap1A is a small G protein implicated in a spectrum of biological processes such as cell proliferation,adhesion,differentiation,and *** downstream effectors through which Rap1A mediates its diverse effects are largely *** we show that Rap1A,but not the related small G proteins Rap2 or Ras,binds the tumor suppressor Ras association domain family 1A(RASSF1A)in a manner that is regulated by phosphorylation of *** with Rap1A is shown to influence the effect of RASSF1A on microtubule behavior.

关键词： RASSF1A Rap1A microtubule vimentin protein-protein interaction

Predicting responses to platin chemotherapy agents with biochemically-inspired machine learning

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Signal Transduction and Targeted Therapy 2019年第1期4卷 636-647页

作者： Eliseos j.Mucaki j.nathan Z.L.Zhao Daniel j.Lizotte peter k.Rogan Department of Biochemistry Schulich School of Medicine and DentistryWestern UniversityLondonON N6A 2C1Canada Department of Computer Science Faculty of ScienceWestern UniversityLondonON N6A 2C1Canada Department of Epidemiology&Biostatistics Schulich School of Medicine and DentistryWestern UniversityLondonON N6A 2C1Canada Cytognomix Inc.LondonON N5X 3X5Canada Department of Oncology Schulich School of Medicine and DentistryWestern UniversityLondonON N6A 2C1Canada

The selection of effective genes that accurately predict chemotherapy responses might improve cancer *** compare optimized gene signatures for cisplatin,carboplatin,and oxaliplatin responses in the same cell lines and validate each signature using data from patients with *** support vector machine learning is used to derive gene sets whose expression is related to the cell line GI 50 values by backwards feature selection with *** genes and functional pathways distinguishing sensitive from resistant cell lines are identified by contrasting signatures obtained at extreme and median GI 50 *** of gene signatures at different thresholds are combined to reduce the dependence on specific GI 50 values for predicting drug *** most accurate gene signatures for each platin are:cisplatin:BARD1,BCL2,BCL2L1,CDkN2C,FAAP24,FEN1,MAP3k1,MAPk13,MAPk3,NFkB1,NFkB2,SLC22A5,SLC31A2,TLR4,and TWIST1;carboplatin:AkT1,EIF3k,ERCC1,GNGT1,GSR,MTHFR,NEDD4L,NLRP1,NRAS,RAF1,SGk1,TIGD1,TP53,VEGFB,and VEGFC;and oxaliplatin:BRAF,FCGR2A,IGF1,MSH2,NAGk,NFE2L2,NQO1,PANk3,SLC47A1,SLCO1B1,and *** from The Cancer Genome Atlas(TCGA)patients with bladder,ovarian,and colorectal cancer were used to test the cisplatin,carboplatin,and oxaliplatin signatures,resulting in 71.0%,60.2%,and 54.5%accuracies in predicting disease recurrence and 59%,61%,and 72%accuracies in predicting remission,*** cisplatin signature predicted 100%of recurrence in non-smoking patients with bladder cancer(57%disease-free;N=19),and 79%recurrence in smokers(62%disease-free;N=35).This approach should be adaptable to other studies of chemotherapy responses,regardless of the drug or cancer types.

关键词： bladder chemotherapy signature

Mass Transport in Nanowire Synthesis:An Overview of Scalable Nanomanufacturing

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j.urnal of Materials Science & Technology 2015年第6期31卷 523-532页

作者： Matthew j.Crane peter j.Pauzauskie Department of Chemical Engineering University of WashingtonSeattleWA 98195-1750.USA Department of Materials Science & Engineering Seattle.WA 98195-2120USA Fundamental Computational Science Directorate Pacific Northwest National LaboratoryRichland.WAUSA

The ability to rationally engineer the growth and nanomanufacturing of one-dimensional nanowires in high volumes has the potential to enable applications of nanoscale materials in a diverse range of fields including energy conversion and storage,catalysis,sensing,medicine,and information *** review provides a roadmap for the development of large-scale nanowire *** myriad techniques exist for bench-scale nanowire synthesis,these growth strategies typically fall within two maj.r categories:1) anisotropically-catalyzed growth and 2) confined,template-based ***,comparisons between growth methods with different mass transport pathways have led to confusion in interpreting observations,in particular Gibbs-Thomson *** review mass transport in nanowire synthesis techniques to unify growth models and to allow for direct comparison of observations across different *** addition,we discuss the applicability of nanoscale,Gibbs-Thomson effects on mass transport and provide guidelines for the development of new growth *** explore the scalability of these complex processes with dimensionless numbers and consider the effects of pressure,temperature,and precursor material on nanowire growth.

关键词： Nanowire Mass transport Modeling Scalable growth

CCS Research Development and Deployment in a Clean Energy Future： Lessons from Australia over the Past Two Decades

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Engineering 2017年第4期3卷 477-484页

作者： peter j. Cook CO2CRC Ltd.& peter Cook Centre for Carbon Capture and Storage Research The University of Melbourne Melbourne VIC 2010 Australia

There is widespread, though by no means universal, recognition of the importance of carbon capture and storage （CCS） as a carbon mitigation technology. However, the rate of deployment does not match what is required for global temperatures to stay well below 2℃. Although some consider the hurdles to achieving the widespread application of CCS to he almost insurmountable, a more optimistic view is that a great deal is now known about CCS through research, demonstration, and deployment. We know how to do it; we are confident it can be done safely and effectively; we know what it costs; and we know that costs are decreasing and will continue to do so. We also know that the world will need CCS as long as countries, companies, and communities continue to use fossil fuels for energy and industrial processes. What is lacking are the necessary policy drivers, along with a technology-neutral approach to decrease carbon emissions in a cost-effective and timely manner while retaining the undoubted benefits of ready access to reliable and secure electricity and energy-intensive industrial products. In this paper, Australia is used as an example of what has been undertaken in CCS over the past 20 years, particularly in research and demonstration, hut also in international collaboration. Progress in the large-scale deployment of CCS in Australia has been too slow. However, the world＇s largest storage proj.ct will soon be operational in Australia as part of the Gorgon liquefied natural gas （LNG） proj.ct, and investigations are underway into several large-scale CCS Flagship program opportunities. The organization and progress of the Cooperative Research Centre for Greenhouse Gas Technologies （CO2CRC） Otway Proj.ct, which is currently Australia＇s only operational storage proj.ct, is discussed in some detail because of its relevance to the commercial deployment of CCS. The point is made that there is scope for building on this Otway activity to investigate more broadly （through the p

关键词： Carbon dioxide Carbon capture and storage Otway Australia

Quantitative image analysis of celiac disease

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World j.urnal of Gastroenterology 2015年第9期21卷 2577-2581页

作者： Edward j.Ciaccio Govind Bhagat Suzanne k Lewis peter H Green Department of Medicine Celiac Disease CenterColumbia UniversityNew YorkNY 10032United States

We outline the use of quantitative techniques that are currently used for analysis of celiac *** processing techniques can be useful to statistically analyze the pixular data of endoscopic images that is acquired with standard or videocapsule *** is shown how current techniques have evolved to become more useful for gastroenterologists who seek to understand celiac disease and to screen for it in suspected *** directions for focus in the development of methodology for diagnosis and treatment of this disease are *** is evident that there are yet broad areas where there is potential to expand the use of quantitative techniques for improved analysis in suspected or known celiac disease patients.

关键词： Celiac disease Frequency analysis Motility Videoca