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Value of glucose transport protein 1 expression in detecting lymph node metastasis in patients with colorectal cancer

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World Journal of Clinical Cases 2024年第5期12卷 931-941页

作者： Hongsik Kim Song-Yi choi Tae-Young Heo Kyeong-Rok Kim Jisun Lee Min Young Yoo Taek-Gu Lee Joung-Ho Han Department of Internal Medicine Chungbuk National University HospitalCheongju 28644South Korea Department of Pathology Chungnam National University College of MedicineDaejeon 35015South Korea Information and Statistics Chungbuk National UniversityCheongju 28644South Korea Department of Radiology College of MedicineChungbuk National UniversityChungbuk National University HospitalCheongju-si 28644South Korea Department of Nuclear Medicine School of MedicineInha UniversityIncheon 22332South Korea Department of Surgery Chungbuk National UniversityCollege of MedicineCheongju-si 28644South Korea Department of Internal Medicen Chungbuk National UniversityCollege of medicineCheongju-si 28644South Korea

BACKGROUND There are limited data on the use of glucose transport protein 1(GLUT-1)expre-ssion as a biomarker for predicting lymph node metastasis in patients with colorectal ***-1 and GLUT-3,hexokinase(hk)-II,and hypoxia-induced factor(HIF)-1 expressions may be useful biomarkers for detecting primary tumors and lymph node metastasis when combined with fluorodeoxyglucose(FDG)uptake on positron emission tomography/computed tomography(PET/CT).AIM To evaluate GLUT-1,GLUT-3,hk-II,and HIF-1 expressions as biomarkers for detecting primary tumors and lymph node metastasis with 18F-FDG-PET/*** This retrospective study included 169 patients with colorectal cancer who underwent colectomy and preoperative 18F-FDG-PET/CT at Chungbuk National University Hospital between January 2009 and May *** tissue cores from the central and peripheral areas of the tumors were obtained and were examined by a dedicated pathologist,and the expressions of GLUT-1,GLUT-3,hk-II,and HIF-1 were determined using immunohisto-chemical *** analyzed the correlations among their expressions,various clinicopathological factors,and the maximum standardized uptake value(SUVmax)of PET/*** GLUT-1 was found at the center or periphery of the tumors in 109(64.5%)of the 169 ***-1 positivity was significantly correlated with the SUVmax of the primary tumor and lymph nodes,regardless of the biopsy site(tumor center,Phk-II,and HIF-1 expressions were not significantly correlated with the SUVmax of the primary tumor and lymph *** GLUT-1 expression was significantly correlated with the SUVmax of 18F-FDG-PET/CT for primary tumors and lymph *** should consider GLUT-1 expression in preoperative endoscop

关键词： 18F-FDG-PET-CT Biomarker Colorectal neoplasms Glucose transporter type 1 Lymph node

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High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

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Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki Kim Bum Jun Kim Seungyon Koh Hyo Jin Cho Xuelian Jin Byung Gon Kim Jun Young choi Department of Brain Science Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Ajou University Graduate School of MedicineSuwonSouth Korea Department of Neurology Ajou University School of MedicineSuwonSouth Korea Department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration

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The HIF-1α/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair

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Bone Research 2024年第2期12卷 289-301页

作者： Heeseog Kang Amy L.Strong Yuxiao Sun Lei Guo Conan Juan Alec C.Bancroft Ji Hae choi Chase A.Pagani Aysel A.Fernandes Michael Woodard Juhoon Lee Sowmya Ramesh Aaron W.James David Hudson Kevin N.Dalby Lin Xu Robert J.Tower Benjamin Levi Center for Organogenesis Regeneration and TraumaDepartment of SurgeryUniversity of Texas SouthwesternDallasTX 75390USA Section of Plastic Surgery Department of SurgeryUniversity of MichiganAnn ArborMI 48109USA Quantitative Biomedical Research Center Peter O’Donnell Jr.School of Public HealthUniversity of Texas SouthwesternDallasTX 75390USA Department of Orthopedics and Sports Medicine University of WashingtonSeattleWA 98195USA Division of Chemical Biology and Medicinal Chemistry College of PharmacyUniversity of Texas at AustinAustinTX 78712USA Department of Pathology Johns Hopkins UniversityBaltimoreMD 21218USA

While hypoxic signaling has been shown to play a role in many cellular processes,its role in metabolism-linked extracellular matrix(ECM)organization and downstream processes of cell fate after musculoskeletal injury remains to be ***(HO)is a debilitating condition where abnormal bone formation occurs within extra-skeletal *** andhypoxia-inducible factor 1α(HIF-1α)activation have been shown to promote ***,the underlying molecular mechanisms bywhich the HIF-1αpathway in mesenchymal progenitor cells(MPCs)contributes to pathologic bone formation remain to ***,we used a proven mouse injury-induced HO model to investigate the role of HIF-1αon aberrant cell ***-cell RNA sequencing(scRNA-seq)and spatial transcriptomics analyses of the HO site,we found that collagen ECM organizationis the most highly up-regulated biological process in *** mesenchymal cell-specific deletion of Hif1α(Hoxa11-CreER^(T2);Hif1a^(fl/fl))significantly mitigated HO in ***-seq analysis of these Hoxa11-CreER^(T2);Hif1a^(fl/fl)mice identified the PLOD2/LOXpathway for collagen cross-linking as downstream of the HIF-1αregulation of ***,our scRNA-seq data and mechanisticstudies further uncovered that glucose metabolism in MPCs is most highly impacted by HIF-1α*** a translational aspect,a pan-LOX inhibitor significantly decreased HO.A newly screened compound revealed that the inhibition of PLOD2 activity in MPCssignificantly decreased osteogenic differentiation and glycolytic *** suggests that the HIF-1α/PLOD2/LOX axis linked tometabolism regulates HO-forming MPC *** results suggest that the HIF-1α/PLOD2/LOX pathway represents a promisingstrategy to mitigate HO formation.

关键词： metabolism skeletal aberrant

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Risk factors and natural history of breast cancer in younger Chinese women

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World Journal of Clinical Oncology 2014年第5期5卷 1097-1106页

作者： Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung peter hk choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee Department of Clinical Oncology Chinese University of Hong Kong Prince of Wales Hospital Hong Kong Breast Cancer Foundation Jockey Club School of Public Health and Primary Care Chinese University of Hong Kong Department of Surgery Kwong Wah Hospital Diagnostix Pathology Laboratories Ltd Canossa Hospital Kowloon East Cluster Breast Centre Department of Surgery United Christian Hospital Department of Clinical Oncology Pamela Youde Nethersole Eastern Hospital Private Clinical Oncologist Radiotherapy and Oncology Centre Hong Kong Baptist Hospital Comprehensive Oncology Centre Hong Kong Sanatorium and Hospital Hong Kong Adventist Oncology Center Hong Kong Adventist Hospital Department of Clinical Oncology University of Hong Kong Department of Clinical Oncology Tuen Mun Hospital Private Surgeon Department of Clinical Oncology Princess Margaret Hospital

AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent ***: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older ***

关键词： Hong Kong Breast Cancer Registry Breast cancer Younger Chinese women Sociodemographic characteristics Risk factors Clinicopathological characteristics Breast cancer treatment

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Characterization of the plasma mirror system at the J-KAREN-P facility

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High Power Laser Science and Engineering 2022年第4期10卷 26-35页

作者： Akira Kon Mamiko Nishiuchi Yuji Fukuda Kotaro Kondo Koichi Ogura Akito Sagisaka Yasuhiro Miyasaka Nicholas P.Dover Masaki Kando Alexander S.Pirozhkov Izuru Daito Liu Chang Il Woo choi Chang Hee Nam Tim Ziegler Hans-peter Schlenvoigt Karl Zeil Ulrich Schramm Hiromitsu Kiriyama Kansai Photon Science Institute National Institutes for Quantum Science and TechnologyKyoto 619-0215Japan Center for Relativistic Laser Science Institute for Basic ScienceGwangju 61005Republic of Korea Advanced Photonics Research Institute Gwangju Institute of Science and TechnologyGwangju 61005Republic of Korea Department of Physics and Photon Science Gwangju Institute of Science and TechnologyGwangju 61005Republic of Korea Helmholtz-ZentrumDresden-Rossendorf 01328 DresdenGermany Technische Universitat Dresden 01062 DresdenGermany

We report on the design and characterization of the plasma mirror system installed on the J-KAREN-P laser at the Kansai Photon Science Institute,National Institutes for Quantum Science and *** reflectivity of the single plasma mirror system exceeded 80%.In addition,the temporal contrast was improved by two orders of magnitude at 1 ps before the main ***,the laser near-field spatial distribution after the plasma mirror was kept constant at plasma mirror fluence of less than 100 kJ/cm^(2).We also present the results of investigating the difference and the fluctuation in energy,pulse width and pointing stability with and without the plasma mirror system.

关键词： high-powerlasers laser plasma plasma mirror

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Association between smoking,pancreatic insulin secretion and insulin resistance in Chinese subjects with or without glucose intolerance

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Chinese Medical Journal 2007年第24期120卷 2233-2237页

作者： KO Gary Tin-choi TONG peter Chun-Yip SO Wing-Yee COCKRAM Clive S. CHAN Juliana Chung-Ngor Hong Kong Institute of Diabetes and Obesity Hong Kong China Department of Medicine and Therapeutics Chinese University of Hong Kong Prince of Wales Hospital Shatin N.T. Hong KongChina

Background There are studies suggesting smoking may increase the risk of type 2 diabetes. Effects of smoking on insulin secretion and insulin resistance （IR） are, however, controversial. Methods This is a cross-sectional study. Since there were very few smokers among Hong Kong Chinese women, only men （n=-1068） were analyzed in this report. Fasting and 2-hour plasma glucose and insulin were measured. Insulinogenic index as well as beta-cell function and IR based on homeostatic model assessment （HOMA） by computer model （HOMA Calculator v2.2） were calculated. Results Of the 1068 men, 147 had newly diagnosed diabetes, 131 newly diagnosed impaired glucose tolerance （IGT） and 790 were non-diabetic normal controls. Smokers had similar fasting and 2-hour insulin levels, insulinogenic index and HOMA derived beta-cell function as compared to non-smokers in the groups with diabetes, IGT or normal oral glucose tolerance test （OGTT）. IR was also similar between smokers, ex-smokers and non-smokers in those with normal OGTT. In men with IGT or diabetes, after adjustment for age and body mass index, smokers were more insulin resistant as compared to non-smokers （IR, IGT： 1.59±1.07 vs 1.03±0.54, P〈0.05; diabetes： 1.96±1.36 vs 1.06±0.45, P〈0.01）. With Logistic regression analysis, comparing smokers and non-smokers, IR was independently associated with smoking （odds ratio （95% C/）, IGT： 2.23 （1.05, 4.71）; diabetes： 3.92 （1.22, 12.58））. None of the other insulin parameters enter into the model among those with normal OGTT or comparing ex-smokers and non-smoker or smokers and ex-smokers. Conclusions In Chinese men, smoking did not show any direct association with insulin levels and pancreatic insulin secretion. Smoking men with IGT or diabetes appeared more insulin resistant than their non-smoking counterparts.

关键词： smoking diabetes mellitus insulin Chinese

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3D Nanoprinting with Charged Aerosol Particles-An Overview

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Accounts of Materials Research 2021年第11期2卷 1117-1128页

作者： Wooik Jung peter V.Pikhitsa Yoon-Ho Jung Jooyeon Shin Minsung Han Mansoo choi Global Frontier Center for Multiscale Energy Systems Seoul National UniversitySeoul 08826Korea Department of Mechanical Engineering Seoul National UniversitySeoul 08826Korea

CONSPECTUS:Three-dimensional(3D)printing is a revolutionary technology allowing rapid,cost-effectively,and flexible design of desired 3D *** this regard,various techniques for downscaling 3D printing have been developed based on several methodologies in the past decades to exploit the advantages of 3D printing at the micro/*** development of 3D nanoprinting techniques has provided a method to design unique and sophisticated nanoscale 3D objects enabling functional applications that are thus far constrained with conventional planar nanomanufacturing processes such as photolithography and electron beam ***,the versatile and practical realization of 3D nanoprinting in a broad science and engineering field remains challenging due to limitations such as feature size resolution,suitable materials,and design ***,innovative 3D nanoprinting techniques are required to overcome current *** this Account,we describe our achievements in developing 3D nanoprinting with charged aerosols relying on the physics behind counteracting electric *** introduce the generation of charged aerosols,the most feasible in the broad range of fundamental building blocks(mainly all types of metals and alloys,their oxides,polymers,and organics)for 3D ***,charged aerosols can be processed at ambient conditions *** aerosols could be precisely controlled and delivered for the assembly,using electric fields of complicated configurations despite the Brownian diffusion and other chaotic *** converging electric fields are formed around openings by the interactions of two electric *** of the electric fields comes from a negatively biased *** contrast,the counteracting electric field comes from the positive ions distributed on a prepatterned dielectric layer over the *** a result,the positively charged aerosols are focused through these fields to grow with nanoscale resolution only

关键词： printing aerosol lifting

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System Integration in Radiation Oncology Through Networking

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临床医学工程 1998年第3期 107-110页

作者： K.Y.Cheung Ricky Chau peter choi Departmen of Clinical Oncology Hong Kong Prince of Wales Hospital

This paper presents the basic system design and our initial experience on the operation and performance of a fully integrated radiotherapy treatment planning, treatment delivery and patient management network system at the Prince of Wales Hostpital, Hong Kong, The aim of the project is to establish a suitable tool for easy and reliable implementation of routine conformal radiotherapy and to improve the effciency and quality of radiotherapy service through system integration

关键词： In System Integration in Radiation Oncology Through Networking 加心比切

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Tetomerase Examination as a Molecular Tools for a Detection of Colorectal Cancer

Tetomerase Examination as a Molecular Tools for a Detection ...

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第六次全国大肠癌会议暨中日韩大肠癌会议

作者： Bong H. Lee MK Lim JJ Kim hk Kang LS Kim DK KIm CS choi Sung Kim Depts of General Surgery Hallym University Hangang Sacred Heart Hospital Seoul 150-020 Korea Depts of General Surgery Hallym University Hangang Sacred Heart Hospital Seoul 150-020 Korea Depts of General Surgery Hallym University Hangang Sacred Heart Hospital Seoul 150-020 Korea Depts of General Surgery Hallym University Hangang Sacred Heart Hospital Seoul 150-020 Korea Depts of General Surgery Hallym University Hangang Sacred Heart Hospital Seoul 150-020 Korea Depts of General Surgery Hallym University Hangang Sacred Heart Hospital Seoul 150-020 Korea Depts of General Surgery Hallym University Hangang Sacred Heart Hospital Seoul 150-020 Korea Depts of General Surgery Hallym University Hangang Sacred Heart Hospital Seoul 150-020 Korea

＜正＞（Background） The enzyme telomerase maintains a constant telomere length in immortalized cells, allowing unlimited cell proliferation. The most colonic neoplastic cells express the telomerase activity. However ...

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Integrated Design of a Compact and Lightweight S-Band Traveling-Wave Tube Amplifier for a New Class of Microwave Power Module

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Journal of Electromagnetic Analysis and Applications 2013年第3期5卷 96-102页

作者： Heather Song Leslie Tekamp Frank Francisco Ming-Chieh Lin peter H. Stoltz David Smith Gil Wong choi Jin Joo choi Department of Electrical and Computer Engineering University of Colorado Colorado Springs USA Department of Electrical and Computer Engineering University of Colorado Colorado Springs USA Department of Electronics Convergence Engineering Kwangwoon University Seoul South Korea. Samsung Thales Co. Yongin-Si South Korea Tech-X Co. Boulder USA Triton Services Inc. Breinigsville USA

A new class of compact and lightweight S-band 1 kW traveling-wave tube (TWT) is being developed for a microwave power module (MPM) that will be used for phased antenna array radar applications. The proposed S-band MPM provides a tenfold peak power increase compared to state-of-the-art S-band MPMs. In this paper, the design of the vacuum power booster TWT part of the MPM is presented. The compact and lightweight S-band TWT is driven by a 6 kV, 0.9 A electron beam. The amplifier is predicted by large-signal simulations to generate over 1 kW at S-band with 25 dB saturated gain and over 40% efficiency. The stability from unwanted oscillations has been investigated. To suppress the oscillations, the helix circuit has been coated with carbon composite material. The coaxial input and output antennas have been fabricated. For efficiency enhancement, a multi-stage depressed collector (MDC) has been designed using a 3D particle-in-cell (PIC) simulator, VORPAL. The collector design makes use of a current loop based on a feedback mechanism for effective design process. The integrated designs of a helix circuit, an electron gun, a periodic permanent magnet (PPM), antennas, and a collector are presented.

关键词： TWT MPM Compact Lightweight Feedback Current Loop Multi-Stage Collector

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