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Timely completion of multiple life-saving interventions for traumatic haemorrhagic shock: a retrospective cohort study

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Burns & Trauma 2019年第1期7卷 204-212页

作者： Biswadev Mitra Jordan Bade-Boon Mark C.Fitzgerald Ben Beck peter A.cameron National Trauma Research Institute The Alfred Hospital89 Commercial RoadMelbourneVIC 3004Australia Emergency&Trauma Centre The Alfred HospitalMelbourneAustralia School of Public Health and Preventive Medicine Monash University MelbourneAustralia Trauma Service The Alfred HospitalMelbourneAustralia Faculty of Medicine Laval University Quebec City QuebecCanada

Background:Early control of haemorrhage and optimisation of physiology are guiding principles of resuscitation after *** outcomes have been previously associated with single,timely *** aim of this study was to assess the association between multiple timely life-saving interventions(LSIs)and outcomes of traumatic haemorrhagic shock ***:A retrospective cohort study was undertaken of injured patients with haemorrhagic shock who presented to Alfered Emergency&Trauma Centre between July 01,2010 and July 31,*** studied included chest decompression,control of external haemorrhage,pelvic binder application,transfusion of red cells and coagulation products and surgical control of bleeding through angio-embolisation or operative *** primary exposure variable was timely initiation of≥50%of the indicated *** association between the primary exposure variable and outcome of death at hospital discharge was adjusted for potential confounders using multivariable logistic regression *** association between total pre-hospital times and pre-hospital care times(time from ambulance at scene to trauma centre),in-hospital mortality and timely initiation of≥50%of the indicated interventions were ***:Of the 168 patients,54(32.1%)patients had≥50%of indicated LSI completed within the specified time *** delivery of LSI was independently associated with improved survival to hospital discharge(adjusted odds ratio(OR)for in-hospital death 0.17;95%confidence interval(CI)0.03–0.83;p=0.028).This association was independent of patient age,pre-hospital care time,injury severity score,initial serum lactate levels and *** patients with pre-hospital time of≥2 h,2(3.6%)received timely ***-hospital care times of≥2 h were associated with delayed LSIs and with in-hospital death(unadjusted OR 4.3;95%CI 1.4–13.0).Conclusions:Timely completion of LSI when indicated was completed in a small

关键词： Wounds Bundle of care Haemorrhage shock Resuscitation Emergency department Blood products Timely life-saving interventions Trauma Injuries

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Venous thromboembolism prophylaxis practice and its association with outcomes in Australia and New Zealand burns patients

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Burns & Trauma 2021年第1期9卷 642-651页

作者： Lincoln M.Tracy peter A.cameron Yvonne Singer Arul Earnest Fiona Wood Heather Cleland Belinda J.Gabbe School of Public Health and Preventive Medicine Monash University553 St Kilda RoadMelbourneVictoria3004Australia Emergency and Trauma Centre The Alfred HospitalCommercial RoadMelbourneVictoria3004Australia Victorian Adult Burns Service Alfred Hospital55 Commercial RoadMelbourneVictoria3004AustraliaAustralia Registry Sciences Unit Department of Epidemiology and Preventive MedicineMonash University553 St Kilda RoadMelbourneVictoria3004Australia Biostatistics Unit Department of Epidemiology and Preventive MedicineMonash University553 St Kilda RoadMelbourneVictoria3004Australia Burn Injury Research Unit University of Western Australia35 Stirling HighwayPerthWestern Australia6009Australia Health Data Research UK Swansea University Medical SchoolSwansea UniversitySingleton ParkSwanseaUK

Background:Patients with burn injuries are considered to have an increased risk of venous thromboembolism(VTE).While untreated VTEs can be fatal,no studies have examined chemoprophylaxis *** study aimed to quantify the variation in prevalence of VTE prophylaxis use in patients in Australian and New Zealand burns units and whether prophylaxis use is associated with in-hospital outcomes following burn ***:Admission data for adult burns patients(aged≥16 years)admitted between 1 July 2016 and 31 December 2018 were extracted from the Burns Registry of Australia and New *** effects logistic regression modelling investigated whether VTE prophylaxis usewas associated with the primary outcome of in-hospital ***:There were 5066 admissions over the study *** these patients,81%(n=3799)with a valid response to the VTE prophylaxis data field received some form of VTE *** of VTE prophylaxis ranged from 48.6%to 94.8%of patients between ***-hospital death was recorded in<1%of patients(n=33).After adjusting for confounders,receiving VTE prophylaxis was associated with a decrease in the adjusted odds of in-hospital mortality(adjusted odds ratio=0.21;95%CI,0.07–0.63;p=0.006).Conclusions:Variation in the use of VTE prophylaxis was observed between the units,and prophylaxis use was associated with a decrease in the odds of *** findings provide an opportunity to engage with units to further explore differences in prophylaxis use and develop future best practice guidelines.

关键词： Burn injury Venous thromboembolism Prophylaxis Australia New Zealand

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通过填充剂改性和优化配方减少滞后损失

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现代橡胶技术 2015年第2期41卷 30-36页

作者：韦匀 Michael Jacobsson peter cameron Joel Neilsen

滞后损失是直接关系到汽车燃料效率的一种性能。通过改变各种配合剂的用量,对配方和材料进行优化,可以改善胎面胶的性能,进而减少滞后损失。本文研究了新型节能炭黑ES200。研究表明,通过采用新型节能炭黑ES200,优选各种促进剂进行硫化组... 详细信息

滞后损失是直接关系到汽车燃料效率的一种性能。通过改变各种配合剂的用量,对配方和材料进行优化,可以改善胎面胶的性能,进而减少滞后损失。本文研究了新型节能炭黑ES200。研究表明,通过采用新型节能炭黑ES200,优选各种促进剂进行硫化组合,可改善硫化胶的各种性能,减少滞后损失。

关键词：填充剂橡胶配方 ES200 滞后损失

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可改善胎体胶性能的炭黑

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现代橡胶技术 2015年第5期41卷 8-13页

作者：朱永康 Michael Jacobsson Feng Wang peter cameron

介绍了胎体用ES600、ES601和ES700节能炭黑。这类炭黑的研发旨在为用户提供更多的手段,满足许多不同应用领域对降低滞后损失越来越苛刻的要求。通过对炭黑表面进行化学改性,可以进一步改善胎体胶的滞后性能。选择化学处理炭黑可优化某... 详细信息

介绍了胎体用ES600、ES601和ES700节能炭黑。这类炭黑的研发旨在为用户提供更多的手段,满足许多不同应用领域对降低滞后损失越来越苛刻的要求。通过对炭黑表面进行化学改性,可以进一步改善胎体胶的滞后性能。选择化学处理炭黑可优化某些胶料性能,且不会对其它橡胶性能造成大的影响。橡胶性能的诸多变化可归因于随着填料的改性处理而导致的交联密度提高。通过试验研究表明,上述三个新开发的胎体用"节能炭黑"品种可以全面降低滞后损失。

关键词：炭黑胎体胶滞后性能

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Expedited Discharge of Patients with Diabetic Ketoacidosis in an Emergency Department Short Stay Unit

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Open Journal of Internal Medicine 2019年第4期9卷 112-120页

作者： Parampil Thulasidharan Shibu Kandalam Salem Abo Salah peter Alistair cameron Jignesh Dhirajlal Trivedi Muhammed Kunhi Kayakool Shahsad Ramachan Parambath Pradeep Radhakrishnan Joe Varghese Mathew Jaseem Sirajudeen Department of General Internal Medicine Hamad General Hospital Doha Qatar Department of Epidemiology & Preventive Medicine Monash University Melbourne Australia

Aim: Review of presentation, management and outcome of patients admitted with Diabetic Ketoacidosis (DKA) to an emergency department short stay unit with expedited discharge. Methods: All admitted patients with a discharge diagnosis of “Diabetic Ketoacidosis”, were identified by the file auditing section in the Emergency Department. Data obtained from the medical records were collected using an explicit chart review from January 2012 to June 2013. Data included clinical monitoring, investigations performed, the type and amount of intravenous fluids given, the insulin regime, potassium supplementation and outcome. Results: Out of a total of 120 patients labelled as DKA or hyperglycaemia on arrival, hundred patients fulfilled the criteria for DKA. In the population studied the mean age was 25 years with a male predominance. Eighty-two patients suffered from Type 1 Diabetes Mellitus (T1DM) whilst eighteen patients had Type 2 Diabetes Mellitus (T2DM). Sixteen patients were newly diagnosed during the present admission. Seventy-six (76%) patients were on insulin. The insulin regimen and potassium supplementation were followed as per protocol in all patients. All the patients except one were given intravenous fluid according to protocol. Parameters were monitored adequately except fluid input and output monitoring. The median length of stay in the short stay unit was 1.5833 days. There was no return visit within one week of discharge. Conclusion: The median length of stay was short and there were no documented complications or deaths during the stay. There was poor compliance with documentation of fluid input and output. In this population, the short stay model of care appeared to be safe and efficient.

关键词： Diabetes Mellitus Diabetic Ketoacidosis DKA Audit Emergency Department Expedited Discharge Length of Stay

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专为电动汽车市场的轮胎和橡胶制品设计的炭黑

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橡塑技术与装备 2024年第10期50卷 82-86页

作者：章羽 Abegayl Thomas-Mc Millan Wesley Wampler Leszek Nikiel Michael Widmor peter cameron 全国橡塑机械信息中心北京100143 Tokai Carbon CB Ltd.

本文探讨了特种炭黑材料EV 800在电动汽车轮胎和橡胶制品中的应用。EV 800具有可持续性、高结构和适宜的表面积,且已通过ISCC Plus认证,它能增强轮胎强度和耐久性,减少滚动阻力,提升电动汽车的能效。本文总结了EV 800对轮胎性能的积极影... 详细信息

本文探讨了特种炭黑材料EV 800在电动汽车轮胎和橡胶制品中的应用。EV 800具有可持续性、高结构和适宜的表面积,且已通过ISCC Plus认证,它能增强轮胎强度和耐久性,减少滚动阻力,提升电动汽车的能效。本文总结了EV 800对轮胎性能的积极影响,并通过实验对比确认了其作为电动汽车轮胎材料的适宜性,强调了其强度、能效提升和可持续性特点。

关键词： EV 800 炭黑材料滚动阻力可持续性

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对WHO严重急性呼吸综合征诊断标准用于门诊患者的评价:前瞻性观察研究

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英国医学杂志中文版 2003年第4期6卷 210-214页

作者： Timothy H Rainer peter A cameron De Villiers Smit Kim L Ong Alex Ng Wing Huang David Chan Po Nin Anil T Ahuja Lowis Chan Yik Si Joseph J Y Sung 张隽 Accident and Emergency Medicine Academic Unit Chinese University of Hong KongShatinNew TerritoriesHong Kong China associate professor Accident and Emergency Medicine Academic Unit Chinese University of Hong KongShatinNew TerritoriesHong Kong China professor and director Accident and Emergency Medicine Academic Unit Chinese University of Hong KongShatinNew TerritoriesHong Kong China assistant professor Accident and Emergency Medicine Academic Unit Cbinese University of Hong KongShatinNew TerritoriesHong Kong China associate professor Accident and Emergency Medicine Academic Unit Chinese University of Hong KongShatinNew Territories.Hong Kong China medical officer Accident and Emergency Medicine Academic Unit Chinese University of Hong KongShatinNew TerritoriesHong Kong China medical officer Accident and Emergency Medicine Academic Unit Chinese University of Hong KongShatinNew Territories.Hong Kong China professor Accident and Emergency Medicine Academic Unit Chinese University of Hong KongShatinNew TerritoriesHong Kong China professor

目的研究严重急性呼吸综合征(SARS)患者的临床和影像学特征并评价世界卫生组织(WHO)关于SARS诊断指南的准确性。试验设计前瞻性观察研究。研究地点香港新界一所教学医院急诊科新建立的SARS鉴别门诊。研究对象有SARS患者接触史的... 详细信息

目的研究严重急性呼吸综合征(SARS)患者的临床和影像学特征并评价世界卫生组织(WHO)关于SARS诊断指南的准确性。试验设计前瞻性观察研究。研究地点香港新界一所教学医院急诊科新建立的SARS鉴别门诊。研究对象有SARS患者接触史的556名医院工作人员、患者及曾访问过该门诊的工作人员和患者的亲属。主要观察指标 SARS患者的确诊人数。结果 556名研究对象中,收入院141人,其中97人被确诊为SARS。97例确诊患者中,发热、寒战、乏力、肌痛、畏寒、纳差、呕吐、腹泻、颈痛等非呼吸道症状的发生率均显著高于其他患者。WHO关于诊断可疑SARS患者指南的准确性为83％,其阴性预计值为86％(95％可信区间为83％～89％),敏感性为26％(17％～36％),特异性为96％(93％～97％)。结论现行WHO关于诊断可疑SARS患者的指南,用于诊断入院前的患者尚不够敏感,而每天随诊、评价非呼吸道和全身的症状以及胸部X线检查可能是更好的鉴别工具。

关键词： WHO 严重急性呼吸综合征诊断世界卫生组织 SARS 病毒

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Diverse plant mixtures sustain a greater arbuscular mycorrhizal fungi spore viability than monocultures after 12 years

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Journal of Plant Ecology 2020年第4期13卷 478-488页

作者： peter Dietrich Christiane Roscher Adam Thomas Clark Nico Eisenhauer Bernhard Schmid cameron Wagg Institute of Ecology and Evolution Friedrich-Schiller-University JenaDornburger Strasse 15907743 JenaGermany Department of Evolutionary Biology and Environmental Studies University of ZurichWinterthurerstrasse 1908057 ZurichSwitzerland Department of Physiological Diversity UFZHelmholtz Centre for Environmental ResearchPermoserstrasse 1504318 LeipzigGermany German Centre of Integrative Biodiversity Research(iDiv)Halle-Jena-Leipzig Deutscher Platz 5e04103 LeipzigGermany Institute of Biology Leipzig UniversityDeutscher Platz 5e04103 LeipzigGermany Department of Geography University of ZurichWinterthurerstrasse 1908057 ZurichSwitzerland Fredericton Research and Development Center Agriculture and Agri-Food Canada850 Lincoln RoadFrederictonNew Brunswick E3B 1P9Canada

Aims Intensive land management practices can compromise soil biodiversity,thus jeopardizing long-term soil *** mycorrhizal fungi(AMF)play a pivotal role in promoting soil productivity through obligate symbiotic associations with ***,it is not clear how properties of plant communities,especially species richness and composition influence the viability of AMF populations in *** Here we test whether monocultures of eight plant species from different plant functional groups,or a diverse mixture of plant species,maintain more viable AMF *** address this question,we extracted AMF spores from 12-year old plant monocultures and mixtures and paired single AMF spores with single plants in a factorial design crossing AMF spore origin with plant species *** Findings AMF spores from diverse plant mixtures were more successful at colonizing multiple plant species and plant individuals than AMF spores from plant ***,we found evidence that AMF spores originating from diverse mixtures more strongly increased biomass than AMF from monocultures in the legume Trifolium repens *** viability and ability to interact with many plant species were greater when AMF spores originated from 12-year old mixtures than *** results show for the first time that diverse plant communities can sustain AMF viability in soils and demonstrate the potential of diverse plant communities to maintain viable AMF propagules that are a key component to soil health and productivity.

关键词： aboveground–belowground interactions biodiversity biomass production mutualism plant–AMF interaction root colonization

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Neurotransmitter systems in mouse airways

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中国药理学与毒理学杂志 2017年第10期31卷 1015-1016页

作者： peter W ABEL cameron M KIEFFER Ya-ping TU Department of Pharmacology Creighton University School of Medicine

OBJECTIVE The objective of this study was to characterize the neurotransmitter systems that cause constriction of murine *** Murine precision cut lung slices(PCLS)and trachea were prepared,placed into perfusion chambers equipped with platinum electrodes and stimulated transmurally(1.0 ms,50 V,0.1-30 Hz).To measure PCLS constriction,changes in airway luminal area in response to electric field stimulation(EFS)were captured as video images quantified using Image J *** trachea,changes in isometric tension were recorded using Grass force *** response curves were generated in the absence and the presence of the inhibitors magnesium,atropine and capsaicin and responses analyzed and compared using a student's t-test(P<0.05).RESULTS EFS caused airway constriction in a frequency-dependent manner that was best fit by a biphasic ***-specific stimulation was verified by Mg^(2+) *** airway constriction to 30 Hz EFS in PCLS was(51.8±3.0)%while tracheal constriction averaged(551±80)***,in PCLS the muscarinic receptor antagonist atropine(10μmol·L^(-1))blocked(99.5±7.2)%of EFS induced constriction at 1 Hz,but only blocked(23.3±3.8)%of EFS induced constriction at 30 Hz and eliminated the first phase but not the second phase of the biphasic EFS *** with capsaicin to deplete sensory neurotransmitters significantly increased EFS constriction supporting the presence of sensory neurotransmitter systems in *** These data are consistent with parasympathetic constriction of airways by acetylcholine at lower EFS frequencies while higher frequencies release sensory dilator *** data provide evidence for multiple nerve types innervating airways which may provide novel targets for treatment of lung disease.

关键词： airways nerve stimulation airway constriction atropine capsaicin

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Bleeding outcomes after non-emergency percutaneous coronary intervention in the very elderly

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Journal of Geriatric Cardiology 2017年第10期14卷 624-631页

作者： Vimalraj Bogana Shanmugam Dennis T Wong Hashrul Rashid James D cameron Yuvaraj Malaiapan peter J Psaltis Monash Cardiovascular Research Centre Clayton Campus of Monash University Victoria Australia South Australian Health and Medical Research Institute Adelaide Australia

Background Octogenarians constitute an increasing proportion of patients presenting for non-emergency percutaneous coronary intervention （PCI）. Methods This study evaluated the in-hospital procedural characteristics and outcomes, including the bleeding events of 293 octogenarians presenting between January 2010 and December 2012 for non-emergency PCI to a single large volume tertiary care Aus- tralian center. Comparisons were made with 293 consecutive patients aged less than or equal to 60 years, whose lesions were matched with the octogenarians. Results Non-ST elevation myocardial infarction was the most frequent indication for non-emergency PCI in octoge- narians. Compared to the younger cohort, they had a higher prevalence of co-morbidities and more complex coronary disease, comprising more type C and calcified lesions. Peri-procedural use of low molecular weight heparin （LMWH; 1.0% vs. 5.8%; P 〈 0.001） and glycopro- tein IIb/IIIa inhibitors （2.1% vs. 9.6%; P 〈 0.001） was lower, while femoral arterial access was used more commonly than in younger patients （80.9% vs. 67.6%; P 〈 0.001）. Overall, there was a non-significant trend towards higher incidence of all bleeding events in the elderly （9.2% vs. 5.8%; P = 0.12）. There was no significant difference in access site or non-access site bleeding and major or minor bleeding between the two cohorts. Sub-analysis did not reveal any significant influence on bleeding rates by the use of LMWH, glycoprotein IIb/IIIa inhibitors or femoral arterial access. In addition, there were no significant differences in the rates of in-hospital mortality, stroke or acute stent thrombosis between the two groups. Conclusions In this single center study, we did not observe significant increases in adverse in-hospital outcomes including the incidence of bleeding in octogenarians undergoing non-emergency PCI.

关键词： Bleeding Coronary artery disease Octogenarians Percutaneous coronary intervention

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