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Xanthan Sulfuric Acid： An Efficient b.o-supported and Recy- clab.e Solid Acid Catalyst for the Synthesis of 2-Aryl Thiadiazolo b.nzimidazoles

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Chinese Journal of Chemistry 2012年第4期30卷 947-950页

作者： Kuarm,b.Suresh Janardan,b. Crooks,peter A. Rajitha,b. Department of Chemistry National Institute of TechnologyWarangalAPIndia Department of Pharmaceutical Sciences College of PharmacyUniversity of Arkansas for Medical SciencesLittle RockAR 72205U.S.A.

Xanthan sulfuric acid is an efficient solid acid catalyst for the preparation of 2-aryl b.nzimidazoles in excellent yields. This method is applicab.e for the reaction of b.nzo[c][ 1,2,5]thiadiazole-4,5-diamine with aldehydes b. sim- ple physical grinding at room temperature. The salient features of the present methodology is cheaper process, easy synthesis of stab.e catalyst and the catalyst can b. easily recycled without significant loss of activity.

关键词： b.nzimidazoles b.nzo[c]thiadiazole-4,5-diamine b.odegradab.e recyclab.e xanthan sulfuric acid (XSA)

Resistance to receptor tyrosine kinase inhib.tion in cancer： molecular mechanisms and therapeutic strategies

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Frontiers of Medicine 2015年第2期9卷 134-138页

作者： peter b. Alexander Xiao-Fan Wang Department of Pharmacology and Cancer b.ology Duke University Medical Center Durham NC 27710 USA

Drug resistance is a major factor that limits the efficacy of targeted cancer therapies. In this review, we discuss the main known mechanisms of resistance to receptor tyrosine kinase inhib.tors, which are the most prevalent class of targeted therapeutic agent in current clinical use. Here we focus on b.pass track resistance, which involves the activation of alternate signaling molecules b. tumor cells to b.pass inhib.tion and maintain signaling output, and consider the prob.ems of signaling pathway redundancy and how the activation of different receptor tyrosine kinases translates into intracellular signal transduction in different cancer types. This information is presented in the context of research strategies for the discovery of new targets for pharmacological intervention, with the goal of overcoming resistance in order to improve patient outcomes.

关键词： targeted therapy drug resistance receptor tyrosine kinases cancer

Microneedle-b.sed skin patch for b.ood-free rapid diagnostic testing

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Microsystems & Nanoengineering 2020年第1期6卷 255-265页

作者： Xue Jiang peter b.Lillehoj Department of Mechanical Engineering Rice UniversityHoustonTX 77005USA Department of b.oengineering Rice UniversityHoustonTX 77030USA

Rapid diagnostic tests are one of the most commonly used tests to detect and screen for infectious diseases in the developing *** these tests are simple,inexpensive,and readily availab.e,they rely on finger-prick b.ood sampling,which requires trained medical personnel,poses risks of infection,and can complicate cooperation in young children,asymptomatic individuals,and communities with b.ood ***,we report a novel microneedle-b.sed skin patch for the rapid detection of protein b.omarkers in dermal interstitial *** collection is facilitated b. a hydrophilic hollow microneedle array that autonomously extracts and transports interstitial fluid to an antib.dy-b.sed lateral flow test strip via surface tension for colorimetric antigen *** employ a simple gold enhancement treatment to enhance the detection sensitivity of this colloidal gold-b.sed lateral flow assay and elucidate the underlying mechanism of this enhancement mechanism through experimental *** proof-of-concept,this device was used to detect Plasmodium falciparum histidine-rich protein 2,a b.omarker for malaria infection,which could b. detected at concentrations as low as 8ng/*** test can b. completed inb.st of our knowledge,this work is the first demonstration of a microneedle-b.sed lateral flow assay for rapid protein detection in dermal interstitial *** addition to its simplicity,minimally invasive nature,and low cost,this diagnostic device can b. readily adapted to detect other protein b.omarkers in interstitial fluid,making it a promising tool for point-of-care testing.

关键词： needle patch readily

Genetic outcomes from the translocations of the critically endangered woylie

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Current Zoology 2013年第3期59卷 294-310页

作者： Carlo PACIONI Adrian F. WAYNE peter b. S. SPENCER School of Veterinary and Life Sciences Murdoch University Murdoch 6150 Western Australia Department of Environment and Conservation Science Division Manjimup 6258 Western Australia

Translocations are an important conservation strategy for many species. However simply ob.erving demographic growth of a translocated population is not sufficient to infer species recovery. Adequate genetic representation of the source population（s） and their long-term viab.lity should also b. considered. The woylie b.ttongia penicillata ogilb.i has b.en sub.ect to more formal translocations for conservation than any other marsupial that, up until recently, has resulted in one of the most suc- cessful species recoveries in Australia. We used mitochondrial and nuclear DNA markers to assess the genetic outcomes of trans- located woylie populations. These populations have lost genetic variab.lity, differentiated fxom their source population and the supplementation program on two island populations appears to have failed. We discuss the conservation implications that our re- suits have for managing threatened species, outline some general recommendations for the management of present and future translocations and discuss the appropriate sampling design for the estab.ishment of new populations or captive b.eeding programs that may mitigate the genetic ＇erosion＇ seen in our study species. This research provides some practical outcomes and a pragmatic understanding of translocation b.ology. The findings are directly applicab.e to other translocation programs .

关键词： b.ttongia penicillata Macropod translocation Supplementation Microsatellites mtDNA

Radial b.sis Function Networks Applied in b.cterial Classification b.sed on MALDI-TOF-MS

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Chemical Research in Chinese Universities 2002年第4期18卷 453-457页

作者： HARRINGTON peter de b. VOORHEES Kent J. REES Jon Ohio University Center for Intelligent Chemical Instrumentation Department of Chemistry and Biochemistry Ohio UniversityDepartment of Chemistry and Geochemistry Colorado School of MinesDepartment of Chemistry and Geochemistry Colorado School of Mines Athens Ohio 45701-2979 USA Golden CO 80401 USAGolden CO 80401 USA

The radial b.sis function networks were applied to b.cterial classification b.sed on the matrix-assisted laser desorption/ionization time-of-flight mass spectrometric (MALDI-TOF-MS) data. The classification of b.cteria cultured at different time was discussed and the effect of the network parameters on the classification was investigated. The cross-validation method was used to test the trained networks. The correctness of the classification of different b.cteria investigated changes in a wide range from 61.5% to 92.8%. Owing to the complexity of b.ological effects in b.cterial growth, the more rigid control of b.cterial culture conditions seems to b. a critical factor for improving the rate of correctness for b.cterial classification.

关键词： Radial b.sis function network Matrix-assisted laser desorption/ionization Time-of-flight mass spectrometry b.cterium Classification

Influence of towing speed on effectiveness of rolling dynamic compaction

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Journal of Rock Mechanics and Geotechnical Engineering 2020年第1期12卷 126-134页

作者： b.endan T.Scott Mark b.Jaksa peter W.Mitchell School of Civil Environmental and Mining EngineeringThe University of AdelaideSouth Australia5005Australia Aurecon AdelaideSouth Australia5000Australia

The influence of towing speed on the effectiveness of the 4-sided impact roller using earth pressure cells(EPCs)is *** field trials were undertaken;the first trial used three EPCs placed at varying depths b.tween 0.5 m and 1.5 m with towing speeds of 9-12 km/*** second used three EPCs placed at a uniform depth of 0.8 m,with towing speeds of 5-15 km/*** findings from the two trials confirmed that towing speed influences the pressure imparted to the ground and hence compactive *** paper proposes that the energy imparted to the ground is b.st describ.d in terms of work done,which is the sum of the change in b.th potential and kinetic *** practice of using either kinetic energy or gravitational potential energy should b. avoided as neither can accurately quantify rolling dynamic compaction(RDC)when towing speed is varied.

关键词： Rolling dynamic compaction(RDC) Optimum towing speed Ground improvement

Stair evacuation simulation b.sed on cellular automata considering evacuees' walk preferences

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Chinese Physics b 2015年第6期24卷 687-693页

作者：丁宁张辉陈涛 peter b.Luh Department of Automation Tsinghua University Institute of Pub.ic Safety Research Tsinghua University Department of Electrical and Computer Engineering University of Connecticut

As a physical model, the cellular automata （CA） model is widely used in many areas, such as stair evacuation. However, existing CA models do not consider evacuees＇ walk preferences nor psychological status, and the structure of the b.sic model is unapplicab.e for the stair structure. This paper is to improve the stair evacuation simulation b. addressing these issues, and a new cellular automata model is estab.ished. Several evacuees＇ walk preference and how evacuee＇s psychology influences their b.haviors are introduced into this model. Evacuees＇ speeds will b. influenced b. these features. To validate this simulation, two fire drills held in two high-rise b.ildings are video-recorded. It is found that the simulation results are similar to the fire drill results. The structure of this model is simple, and it is easy to further develop and utilize in different b.ildings with various kinds of occupants.

关键词： b.ilding evacuation stair simulation cellular automata walk preferences

Chlorophyll, anthocyanin, and gas exchange changes assessed b. spectroradiometry in Fragaria chiloensis under salt stress

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Journal of Integrative Plant b.ology 2014年第5期56卷 505-515页

作者： Miguel Garriga Jorge b. Retamales Seb.stián Romero-b.avo peter D.S. Caligari Gustavo A. Lob.s Faculty of Agricultural Sciences Plant Breeding and Phenomic Center Universidad de Talca Instituto de b.ología Vegetaly b.otecnología Universidad de Talca

Chlorophyll and anthocyanin contents provide a valuab.e indicator of the status of a plant’s physiology, b.t to b. more widely utilized it needs to b. assessed easily and non‐destructively. This is particularly evident in terms of assessing and exploiting germplasm for plant‐b.eeding programs. We report, for the first time, experiments with Fragaria chiloensis（L.）Duch. and the estimation of the effects of response to salinity stress（0, 30, and 60 mmol NaCl/L） in terms of these pigments content and gas exchange. It is shown that b.th pigments（which interestingly, themselves show a high correlation） give a good indication of stress response. b.th pigments can b. accurately predicted using spectral reflectance indices（SRI）;however, the accuracy of the predictions was slightly improved using multilinear regression analysis models and genetic algorithm analysis. Specifically for chlorophyll content, unlike other species, the use of pub.ished SRI gave b.tter indications ofstress response than Normalized Difference Vegetation *** effect of salt on gas exchange is only evident at the highest concentration and some SRI gave b.tter prediction performance than the known Photochemical Reflectance Index. This information will therefore b. useful for identifying tolerant genotypes to salt stress for incorporation in b.eeding programs.

关键词： Gas exchange high‐throughput phenotyping pigment phenomic photosynthesis reflectance spectral reflectance indices

Trib.logical Properties of DLC Film Prepared b. C^+ Ion b.am-assisted Deposition (Ib.D)

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Journal of Wuhan University of Technology(Materials Science) 2006年第1期21卷 49-52页

作者：白秀琴 peter b.hm Reliab.lity Engineering Institute Wuhan University of Technology Wuhan 430063ChinaWuhan Research Institute of Materials Protection Wuhan 430030 China IAVF Antrieb.technik AG 76187 KarlsruheGermany

C ^＋ ion b.am-assisted deposition was utilized to prepare deposit diamond-like carb.n （ DLC ） film. With the help of a series of experiments such as Raman spectroscopy, FT-IR spectroscopy, AFM and nanoindentation , the DLC film has b.en recognized as hydrogenated DLC film and its trib.logicul properties have b.en evaluated. The b.ll-on-disc testing results show that the hardness and the trib.logicul properties of the DLC film produced b. C^ ＋ ion b.am- assisted deposition are improved significantly. DLC film produced b. C ^＋ ion b.am- assisted deposition is positive to have a prosperous trib.logicul application in the near future.

关键词： DLC film C ^+ ion b.am- assisted deposition (Ib.D) trib.logical properties