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Pyrroloquinoline quinone:a potential neuroprotective compound for neurodegenerative diseases targeting metabolism

Neural Regeneration Research 2025年第1期20卷 41-53页

作者： Alessio Canovai pete a.williams Department of Biology University of PisaPisaItaly Department of Clinical Neuroscience Division of Eye and VisionSt.Erik Eye HospitalKarolinska InstitutetStockholmSweden

Pyrroloquinoline quinone is a quinone described as a cofactor for many bacterial dehydrogenases and is reported to exert an effect on metabolism in mammalian cells/*** quinone is present in the diet being available in foodstuffs,conferring the potential of this compound to be supplemented by dietary *** quinone’s nutritional role in mammalian health is supported by the extensive deficits in reproduction,growth,and immunity resulting from the dietary absence of pyrroloquinoline quinone,and as such,pyrroloquinoline quinone has been considered as a“new vitamin.”Although the classification of pyrroloquinoline quinone as a vitamin needs to be properly established,the wide range of benefits for health provided has been reported in many *** this respect,pyrroloquinoline quinone seems to be particularly involved in regulating cell signaling pathways that promote metabolic and mitochondrial processes in many experimental contexts,thus dictating the rationale to consider pyrroloquinoline quinone as a vital compound for mammalian *** the regulation of different metabolic mechanisms,pyrroloquinoline quinone may improve clinical deficits where dysfunctional metabolism and mitochondrial activity contribute to induce cell damage and *** quinone has been demonstrated to have neuroprotective properties in different experimental models of neurodegeneration,although the link between pyrroloquinoline quinone-promoted metabolism and improved neuronal viability in some of such contexts is still to be fully ***,we review the general properties of pyrroloquinoline quinone and its capacity to modulate metabolic and mitochondrial mechanisms in physiological *** addition,we analyze the neuroprotective properties of pyrroloquinoline quinone in different neurodegenerative conditions and consider future perspectives for pyrroloquinoline quinone’s potential in health and disease.

关键词： metabolism mitochondria neurodegenerative disease neuroprotection pyrroloquinoline quinone retinal diseases

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Glycolysis and glucose metabolism as a target for bioenergetic and neuronal protection in glaucoma

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Neural Regeneration Research 2024年第8期19卷 1637-1638页

作者： pete a.williams Robert J.Casson Department of Clinical Neuroscience Division of Eye and VisionSt.Erik Eye HospitalKarolinska InstitutetStockholmSweden Ophthalmic Research Laboratories Discipline of Ophthalmology and Visual SciencesUniversity of AdelaideAdelaideAustralia

Vision is arguably our most valued sense,yet approximately 340 million people globally suffer blindness or moderate visual impairment,highlighting the need to further develop and advance treatments for ophthalmic *** refers to a group of ocular disorders united by a clinically characteristic optic neuropathy with associated retinal ganglion cell loss.

关键词： metabolism glaucoma globally

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智慧的较量——美联局密码破译专家纪实

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疯狂英语（初中天地） 2007年第12期 46-47页

作者： pete williams 宁波

破译隐藏在词句、符号和短语中的真正意义。不,我们不是在说《达·芬奇密码》,而是美国联邦调查局在现实生活中与犯罪活动的交锋。皮特·威廉姆斯将为我们更详尽地报道。约瑟夫·史密斯涉嫌绑架及谋杀11岁的卡里·布鲁西亚,在等待庭讯... 详细信息

破译隐藏在词句、符号和短语中的真正意义。不,我们不是在说《达·芬奇密码》,而是美国联邦调查局在现实生活中与犯罪活动的交锋。皮特·威廉姆斯将为我们更详尽地报道。约瑟夫·史密斯涉嫌绑架及谋杀11岁的卡里·布鲁西亚,在等待庭讯的日子里,他从监狱里寄出了一封信,信里写了些什么?

关键词：密码破译奥尔森 FBI

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核心区训练

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2015年

作者： (美)Mark Verstegen，(美)pete williams

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PROGRESS ON IMPROVING AGRICULTURAL NITROGEN USE EFFICIENCY: UK−CHINA VIRTUAL JOINT CENTERS ON NITROGEN AGRONOMY

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Frontiers of Agricultural Science and Engineering 2022年第3期9卷 475-489页

作者： Tom MISSELBROOK Zhaohai BAI Zejiang CAI Weidong CAO Alison CARSWELL Nicholas COWAN Zhenling CUI David RCHADWICK Bridget EMMETT Keith GOULDING Rui JIANG Davey LJONES Xiaotang JU Hongbin LIU Yuelai LU Lin MA David POWLSON Robert MREES Ute SKIBA pete SMITH Roger SYLVESTER-BRADLEY John williams Lianhai WU Minggang XU Wen XU Fusuo ZHANG Junling ZHANG Jianbin ZHOU Xuejun LIU Rothamsted Research North WykeOkehamptonDevon EX202SBUK Center for Agricultural Resources Research Chinese Academy of SciencesShijiazhuang 050021China Qiyang Agro-ecosystem of National Field Experimental Station Yongzhou 426182China College of Resources and Environmental Sciences Nanjing Agricultural UniversityNanjing 210095China UK Centre for Ecology and Hydrology Bush EstatePenicuikMidlothian EH260QBUK College of Resources and Environmental Sciences China Agricultural UniversityBeijing 100193China School of Natural Sciences Bangor UniversityBangor LL572UWUK UK Centre for Ecology and Hydrology Bangor LL572UWUK Rothamsted Research HarpendenHertfordshire AL52JQUK College of Resources and Environment Northwest A&F UniversityYangling 712100China Institute of Agricultural Resources and Regional Planning Chinese Academy of Agricultural SciencesBeijing 100081China School of International Development University of East AngliaNorwichNorfolk NR47TJUK Scotland’s Rural College(SRUC) West Mains RoadEdinburghEH93JGUK Institute of Biological and Environmental Sciences University of AberdeenAberdeen AB243FXUK ADAS Boxworth Battlegate RoadBoxworthCambridge CB234NNUK.

Two virtual joint centers for nitrogen agronomy were established between the UK and China to facilitate collaborative research aimed at improving nitrogen use efficiency(NUE)in agricultural production systems and reducing losses of reactive N to the *** focus areas were improving fertilizer NUE,use of livestock manures,soil health,and policy development and knowledge *** to fertilizer NUE included attention to application rate in the context of yield potential and economic considerations and the potential of improved practices including enhanced efficiency fertilizers,plastic film mulching and cropping *** utilization of livestock manures requires knowledge of the available nutrient content,appropriate manure processing technologies and integrated nutrient management *** carbon,acidification and biodiversity were considered as important aspects of soil *** centers identified a range of potential actions that could be taken to improve N management,and the research conducted has highlighted the importance of developing a systemslevel approach to assessing improvement in the overall efficiency of N management and avoiding unintended secondary effects from individual *** this context,the management of fertilizer emissions and livestock manure at the farm and regional scales appear to be particularly important targets for mitigation.

关键词： CINAg N-CIRCLE nitrogen use efficiency reactive nitrogen sustainable production

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GREENHOUSE GAS AND AMMONIA EMISSION MITIGATION PRIORITIES FOR UK POLICY TARGETS

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Frontiers of Agricultural Science and Engineering 2023年第2期10卷 268-280页

作者： Sarah BUCKINGHAM Cairistiona F.E.TOPP pete SMITH Vera EORY David R.CHADWICK Christina K.BAXTER Joanna M.CLOY Shaun CONNOLLY Emily C.COOLEDGE Nicholas J.COWAN Julia DREWER Colm DUFFY Naomi JFOX Asma JEBARI Becky JENKINS Dominika J.KROL Karina A.MARSDEN Graham A.MCAULIFFE Steven J.MORRISON Vincent O'FLAHERTY Rachael RAMSEY Karl G.RICHARDS Rainer ROEHE Jo SMITH Kate SMITH Taro TAKAHASHI Rachel E.THORMAN John williams Jeremy WILTSHIRE Robert M.REES Scotland’s Rural College EdinburghEH93JGUK Institute of Biological&Environmental Sciences AberdeenAB243UUUK School of Natural Sciences Bangor UniversityBangorGwyneddLL572DGUK Agricultural Development and Advisory Service(ADAS) BoxworthCambridgeCB234NNUK School of Biological and Chemical Sciences University of GalwayH91 TK33Ireland Centre for Ecology and Hydrology Bush EstateMidlothianEH260QBUK The James Hutton Institute DundeeDD25DAUK Rothamsted Research North WykeOkehamptonDevonEX202SBUK Ricardo Energy&Environment HarwellOxonOX110QRUK Environment Soils and Land Use DepartmentTeagascCounty WexfordY35 TC97Ireland Agri-food and Biosciences Institute HillsboroughCounty DownBT266DRUK Bristol Veterinary School University of BristolSomersetBS405DUUK

Agriculture is essential for providing food and maintaining food security while concurrently delivering multiple other ecosystem services. However,agricultural systems are generally a net source of greenhouse gases and ammonia. They, therefore, need to substantively contribute to climate change mitigation and net zero ambitions. It is widely acknowledged that there is a need to further reduce and mitigate emissions across sectors, including agriculture to address the climate emergency and emissions gap. This discussion paper outlines a collation of opinions from a range of experts within agricultural research and advisory roles following a greenhouse gas and ammonia emission mitigation workshop held in the UK in March 2022. The meeting identified the top mitigation priorities within the UK's agricultural sector to achieve reductions in greenhouse gases and ammonia that are compatible with policy targets. In addition, experts provided an overview of what they believe are the key knowledge gaps, future opportunities and cobenefits to mitigation practices as well as indicating the potential barriers to uptake for mitigation scenarios discussed.

关键词： agriculture ammonia greenhouse gas mitigation net zero

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