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Advances in spinal cord injury:insights from non-human primates

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Neural Regeneration Research 2024年第11期19卷 2354-2364页

作者： Gaetan Poulen Florence E.perrin University of Montpellier INSERMEPHEMontpellierFrance Department of Neurosurgery Gui de Chauliac HospitalMontpellier University Medical CenterMontpellierFrance Institut Universitaire de France(IUF) ParisFrance

Spinal cord injury results in significant sensorimotor deficits,currently,there is no curative treatment for the symptoms induced by spinal cord *** and pre-clinical research on spinal cord injury relies on the development and characterization of appropriate animal *** models should replicate the symptoms observed in human,allowing for the exploration of functional deficits and investigation into various aspects of physiopathology of spinal cord ***-human primates,due to their close phylogenetic association with humans,share more neuroanatomical,genetic,and physiological similarities with humans than ***,the responses to spinal cord injury in nonhuman primates most likely resemble the responses to traumatism in *** this review,we will discuss nonhuman primate models of spinal cord injury,focusing on in vivo assessments,including behavioral tests,magnetic resonance imaging,and electrical activity recordings,as well as ex vivo histological ***,we will present therapeutic strategies developed in non-human primates and discuss the unique specificities of non-human primate models of spinal cord injury.

关键词： behavior cellular analysis non-human primates spinal cord injury tissue analysis

In vivo astrocyte reprogramming following spinal cord injury

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Neural Regeneration Research 2024年第3期19卷 487-488页

作者： Yannick N.Gerber Florence E.perrin MMDN University of MontpellierEPHEINSERMMontpellierFrance Institut Universitaire de France(IUF) ParisFrance

Harmful and helpful roles of astrocytes in spinal cord injury(SCI):SCI induce gradable sensory,motor and autonomic impairments that correlate with the lesion severity and the rostro-caudal location of the injury *** absence of spontaneous axonal regeneration after injury results from neuron-intrinsic and neuron-extrinsic ***,not only adult neurons display limited capability to regrow axons but also the injury environment contains inhibitors to axonal regeneration and a lack of growth-promoting *** other cell populations that respond to the lesion,reactive astrocytes were first considered as only detrimental to spontaneous axonal ***,astrocytes.

关键词： injury impairment programming

The Effect of a Novel Complex, Composed of Ceramide, Energizing Peptide and Camu Camu Extract, on Epidermal Barrier Function and Dermal Antiaging Properties in Ex Vivo Human Skin Small Live Cohort

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Journal of Cosmetics, Dermatological Sciences and Applications 2024年第1期14卷 1-11页

作者： Landau Marina Landau-Blum Shir Samuel Kassirer Audrey Le Mestr Armelle perrin Julien Verdon Laurine Bergeron Corinne Morel Isabelle Imbert Arena Dermatology Herzliya Israel American Medical Program Tel Aviv University Tel Aviv-Yafo Israel Ashland Ashland Specialty Ingredients Sophia Antipolis France

The skin’s primary function is to protect the body against a spectrum of environmental stressors, including mechanical insults, microorganisms, chemicals, and allergens. Located in the outermost layers, the primary structures and components responsible for the skin’s barrier function are susceptible to environmental variables, dermatological conditions, and the aging process. The ensuing alterations to structure, composition, and organizational attributes of the epidermal barrier can impact its integrity and functionality. The aim of this study was to assess the effect of a novel complex composed of a ceramide, energizing peptide, and Camu Camu extract (SUPCERATTM complex) on specific markers of epidermal barrier integrity, as well as epidermal and dermal function. All the experiments were conducted on fresh human abdominal skin explants. Intradermal production of hyaluronic acid, epidermal claudin-1, and ceramide synthase 3 expressions, as well as epidermal lipids content were assessed using specific fluorescent stainings on ex vivo skin after the application of the complex or placebo. Additionally, dermal elastase and collagenase activities were assessed using in tubo enzymatic assays. Lastly, the effect of a cosmetic cream containing SUPCERATTM complex was assessed using subjective Global Aesthetic Improvement Scale (GAIS) in a small cohort of patients after 60 days of use. The application of the SUPCERATTM complex on ex vivo skin led to significant increase in dermal hyaluronic acid content and epidermal activity of claudin-1, ceramide synthase 3 and epidermal ceramide content. Furthermore, in tubo enzymatic assays demonstrated inhibition of both dermal elastase and collagenase activities. In addition, the patient-reported results indicated significant improvements in skin quality and appearance. .

关键词： SUPCERATTM Complex Epidermal Skin Barrier Moisturization Antiaging Ceramide Camu Camu Extract

Decision-Making and Management of Self-Care in Persons with Traumatic Spinal Cord Injuries: A Preliminary Study

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Journal of Behavioral and Brain Science 2024年第2期14卷 47-63页

作者： Paul E. Plonski Jasmin Vassileva Ryan Shahidi Paul B. perrin William Carter Lance L. Goetz Amber Brochetti James M. Bjork Institute for Drug and Alcohol Studies Virginia Commonwealth University Richmond VA USA Richmond Veterans Affairs Medical Center Richmond VA USA Department of Psychiatry Virginia Commonwealth University Richmond VA USA Department of Psychology Virginia Commonwealth University Richmond VA USA Department of Physical Medicine and Rehabilitation Virginia Commonwealth University Richmond VA USA Department of Spinal Cord Injury Cleveland Veterans Affairs Medical Center Cleveland OH USA Department of Pharmacology and Toxicology Virginia Commonwealth University Richmond VA USA

Patients and physicians understand the importance of self-care following spinal cord injury (SCI), yet many individuals with SCI do not adhere to recommended self-care activities despite logistical supports. Neurobehavioral determinants of SCI self-care behavior, such as impulsivity, are not widely studied, yet understanding them could inform efforts to improve SCI self-care. We explored associations between impulsivity and self-care in an observational study of 35 US adults age 18 - 50 who had traumatic SCI with paraplegia at least six months before assessment. The primary outcome measure was self-reported self-care. In LASSO regression models that included all neurobehavioral measures and demographics as predictors of self-care, dispositional measures of greater impulsivity (negative urgency, lack of premeditation, lack of perseverance), and reduced mindfulness were associated with reduced self-care. Outcome (magnitude) sensitivity, a latent decision-making parameter derived from computationally modeling successive choices in a gambling task, was also associated with self-care behavior. These results are preliminary;more research is needed to demonstrate the utility of these findings in clinical settings. Information about associations between impulsivity and poor self-care in people with SCI could guide the development of interventions to improve SCI self-care and help patients with elevated risks related to self-care and secondary health conditions.

关键词： Spinal Cord Injury Self-Care Decision-Making Paraplegia Impulsive Behavior Health Care

Sanya Lectures: Geometry of Spherical Varieties

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Acta Mathematica Sinica,English Series 2018年第3期34卷 371-416页

作者： Nicolas perrin Laboratoire de Mathématiques de Versailles UVSQ CNRS Université Paris-Saclay

These are expanded notes from lectures on the geometry of spherical varieties given in Sanya. We review some aspects of the geometry of spherical varieties. We first describe the structure of B-orbits. Using the local structure theorems, we describe the Picard group and the group of Weyl divisors and give some necessary conditions for smoothness. We later on consider B-stable curves and describe in details the structure of the Chow group of curves as well as the pairing between curves and divisors. Building on these results we give an explicit B-stable canonical divisor on any spherical variety.

关键词： Spherical varieties orbits local structure divisors curves

Combined powder metallurgy routes to improve thermal and mechanical response of Al−Sn composite phase change materials

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Transactions of Nonferrous Metals Society of China 2020年第12期30卷 3226-3239页

作者： Chiara CONFALONIERI Maxime perrin Elisabetta GARIBOLDI Department of Mechanical Engineering Politecnico di MilanoVia La Masa 120156 MilanItaly

Powder metallurgy processes are suitable to produce form-stable solid−liquid phase change materials from miscibility gap *** allow to obtain a composite metallic material with good dispersion of low-melting active phase particles in a high-melting passive matrix,preventing leakage of the particles during phase transition and,therefore,increasing the stability of thermal ***,the matrix provides structural *** aim of this work is to combine conventional powder mixing techniques(simple mixing and ball milling)to improve active phase isolation and mechanical properties of an Al−Sn *** matter of fact,ball milling of Sn powder allows to reduce hardness difference with Al powder;moreover,ball milling of the two powders together results in fine microstructure with improved mechanical *** addition,different routes applied showed that thermal response depends on the microstructure and,in particular,on the particle size of the active *** more detail,coarse active phase particles provide a fast heat release with small undercooling,while small particles solidify more slowly in a wide range of *** the other hand,melting and,consequently,heat storage are independent of the particle size of the active *** potentially allows to“tailor”the thermal response by producing alloys with suitable microstructure.

关键词： metallic phase change materials powder metallurgy thermal stability mechanical properties miscibility gap alloys

Use of longitudinal magnetic resonance imaging in preclinical models of spinal cord injury

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Neural Regeneration Research 2019年第5期14卷 771-772页

作者： Harun Najib Noristani Florence Evelyne perrin INSERM U1198 University of Montpellier

Spinal cord injury(SCI)is a distressing event with grave socio/economic consequences to our *** response following SCI involves blood-spinal cord barrier breakdown,neuroinflammation and formation of a glial scar that altogether govern the feasibility of spontaneous axonal re-growth and limited functional *** advances in understanding SCI pathophysiology have been achieved using numerous transgenic mouse lines developed in different ***,there are inherent strain differences that affect inflammation,gliosis,axon regeneration and ultimately functional recovery after SCI.

关键词： Spinal cord injury(SCI) spinal cord injury

Attempted altruistic infanticide in a context of psychotic decompensation induced by stress linked to the COVID-19 pandemic:a case report

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Forensic Sciences Research 2021年第2期6卷 148-151页

作者： Camille Jantzi Alexandre perrin University centre of Legal Medicine(cUrML) University of GenevaGenevaswitzerland

the mediatization of the CoVID-19 pandemic has created a lot of stress leading sometimes to mental health *** present a case of a thirty-year-old woman with no history of psychotic disease but some vulnerabilities and no criminal record,who attempted to kill her seven-year-old son during a brief delusional episode in the context of fear of the *** was successfully treated by pharmacotherapy and *** was examined by forensic psychiatrists leading to the conclusion that her responsibility was highly diminished,and her reoffending risk was *** add to the literature that the CoVID-19 pandemic has been such a stressor for mentally vulnerable people that it could lead to severe psychiatric decompensation and even criminal acts.

关键词： Forensic sciences forensic psychiatry CoVID-19 infanticide psychosis criminal responsibility forensic evaluation

Microcebus murinus： a novel promising non-human primate model of spinal cord injury

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Neural Regeneration Research 2018年第3期13卷 421-422页

作者： Gaetan Poulen Florence Evelyne perrin University of Montpellier Institut National de la Santé et de la Recherche Médicale Unit 1198 Montpellier France department of neurosurgery gui de chauliac hospital montpellier university medical centerMontpellier France

The number of people affected by spinal cord injuries （SCI） ranges from 2.5 to 4 million worldwide. Traumatic SCI induces a primary injury due to initial mechanical impact that causes focal cellular and blood-spinal cord barrier damages. Subsequently, secondary injuries resulting from infiltration of peripheral monocytes, ischemia, edema,inflammation, glial scar and cystic cavities formation as well as excitotoxicity trigger cellular demise and prevent spontaneous axonal regrowth. Secondary damages, including aggregation of extracellular matrix protein at the lesion epicenter, thus greatly amplify impairments induced by the initial mechanical damage.

关键词： MACACA-FASCICULARIS COMMON MARMOSET RESPONSES