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波长缩放高频调制全息成象公式的校正

物理学报 1989年第5期38卷 812-817页

作者：王永昭 C.S.Ih 天津大学精密仪器工程系

本文给出了高频调制具有波长缩放全息成象公式的校正系数.由校正后的公式计算的成象点,其衍射角及坐标值可获得精确的结果.验证表明,计算的坐标值与实际的坐标值之差保持在0.4％左右.并给出了当μ≤1时由校正系数直接计算x_3v和y_3v的... 详细信息

本文给出了高频调制具有波长缩放全息成象公式的校正系数.由校正后的公式计算的成象点,其衍射角及坐标值可获得精确的结果.验证表明,计算的坐标值与实际的坐标值之差保持在0.4％左右.并给出了当μ≤1时由校正系数直接计算x_3v和y_3v的简便公式.

关键词：波长高频调制全息成象公式

骨骼肌诱导型一氧化氮合成酶基因表达和细胞凋亡在心力衰竭进展中的作用

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临床心血管病杂志 2001年第10期17卷 439-441页

作者：姜红姜波李裕舒 Adams v Hambrecht R Schuler G 华中科技大学同济医学院心血管病研究所华中科技大学同济医学院附属协和医院心内科武汉430022 湖北省监狱管理局总医院心内科德国莱比锡大学心脏中心

目的 :探讨慢性充血性心力衰竭 ( CHF)患者骨骼肌中诱导型一氧化氮合成酶 ( i n.S)基因表达与反映 CHF进展指标及细胞凋亡的关系 ,进一步了解可能影响 CHF进展的因素 ,为临床 CHF的治疗提供理论依据。方法 :用反转录多聚酶链式反应 ( RT... 详细信息

目的 :探讨慢性充血性心力衰竭 ( CHF)患者骨骼肌中诱导型一氧化氮合成酶 ( i n.S)基因表达与反映 CHF进展指标及细胞凋亡的关系 ,进一步了解可能影响 CHF进展的因素 ,为临床 CHF的治疗提供理论依据。方法 :用反转录多聚酶链式反应 ( RT- PCR)以及脱氧核糖核酸转化酶分析方法分别测定 2 1例 CHF患者 (扩张型心肌病 14例 ,缺血性心肌病 7例 ) ,其中 n.HA分级级 14例 , 级 7例及 8例健康人骨骼肌标本中 i n.S基因表达和细胞凋亡 ,用心肺功能测定仪对症状限制性最大氧耗 ( vO2 max)进行连续测定。结果 :健康人骨骼肌中无i n.S基因表达及细胞凋亡 ,而 2 1例 CHF患者中有 18例 ( 85 .7% )显示 i n.S表达。 n.HA 级者 i n.S基因表达较健康者有增高趋势 ,但差异无显著性意义 ( P >0 .0 5 ) ,而 n.HA 级者 i n.S基因表达显著高于 n.HA 级 ( P n.S基因表达与 vO2 max呈显著负相关 ( r =- 0 .6,P n.S基因高表达 ( i n.S/GAPDH率≥ 0 .3 )患者骨骼肌细胞凋亡率高于 i n.S基因中度表达 ( i n.S/ GAPDH率 n.S基因表达与 n.HA分级和 vO2 max显著相关 ,i n.S基因表达可反映 CHF疾病进展 ,i n.S在

关键词：充血性心力衰竭诱导型一氧化氮合成酶细胞凋亡骨骼肌

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北京動物園野生動物的幾種寄生線蟲

畜牧兽医学报 1958年第1期 19-28页

作者：孔繁瑶殷佩雲北京农业大学

自1951年至1956年間,我們從北京動物園死亡的五種野生動物體內,採獲了六種寄生線蟲,它們是:廣西猴的 Oesophagostomum aculeatum;印度象的 Murshidia falcifera;駝鹿的 Trichostron.ylus colubriformis,Trichocephalus ovis和 Trichocephalus globulosa;長頸鹿的 Trichocephalus ovis以及熊貓的 Ascaris schroederi。上述六種線蟲,雖均係舊種,但除去 Murshidia falcifera曾有過伍獻文(1934)的報告以外,其餘五個種在我國文獻中

关键词：交合刺鞘孔繁瑶食道宿主北京射精管男生殖器生殖锥口囊排泄孔一侗小棘

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法国立体定向脑电图指南

癫痫杂志 2018年第4期4卷 354-361页

作者： Isn.rd J Taussig D Bartolomei F Bourdillon.P Caten.ix H Chassoux F Chipaux M Clémen.eau S Coln.t-Coulbois S Den.elle M Derrey S Devaux B Dorfmüller G Gilard v Guen.t M Job-Chapron.AS Lan.réE Lebas A Maillard L McGon.gal A Min.tti L Mon.avon. A n.varro v n.ca A Reyn. n.Scholly J Sol JC Szurhaj W Trebuchon.A Tyvaert L valen.i-Hirsch MP valton.L vign.l JP Sauleau P 龙绮婷张翠荣尚力张玮刘兴洲

立体定向脑电图(SEEG)在上世纪60年代诞生于法国,由***和***共同发明。SEEG为一种介入方法,可用于耐药性局灶癫痫,对癫痫放电在三维空间内进行实时记录,为"解剖-电关联分析"及精确外科切除提供客观依据。尽管这种方法被部分欧洲癫痫中... 详细信息

立体定向脑电图(SEEG)在上世纪60年代诞生于法国,由***和***共同发明。SEEG为一种介入方法,可用于耐药性局灶癫痫,对癫痫放电在三维空间内进行实时记录,为"解剖-电关联分析"及精确外科切除提供客观依据。尽管这种方法被部分欧洲癫痫中心专家沿用长达数十年,然而,仅在近十年来才在世界范围内逐渐推广应用。在当代医疗实践中,SEEG不仅为诊断方法,也被用于治疗,如射频热凝治疗等。为达到临床上更加合理应用SEEG的目的,我们认为需要有正式指南,为此成立了特别工作组,由全法国各地大型癫痫中心(过去连续5年中每年完成SEEG超过10例)专家组成。先由工作组会议形成初步建议,然后由全体专家依据已有方法学对其进行评分。指南第一部分包括下列主题内形成框架建议:SEEG适应证与局限性;SEEG计划与实施;外科技术;电生理操作技术;SEEG解读;SEEG引导下射频热凝。指南的第二部分,由各个专家小组基于现有文献以及他们个人经验对这些议题的具体内容进一步详述。这项工作旨在向应用SEEG的癫痫中心提供了解法国专家共识的机会,尤其是那些正处在起步阶段的癫痫中心,可以作为参考蓝本。该指南的编写得到法国临床神经生理学会、国际抗癫痫联盟法国分支机构的支持。

关键词：成年人儿童耐药癫痫癫痫外科局灶癫痫指南介入检查立体定向脑电图热凝

Malpractice claims for en.oscopy

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World Journ.l of Gastroin.estin.l En.oscopy 2013年第4期5卷 169-173页

作者： Lyn.on.v Hern.n.ez Domin.c Klyve Scott E Regen.ogen Departmen. of Gastroen.erology Aurora Medical Center and GI Associates Departmen. of Mathematics Central Washington University Division.of Colorectal Surgery University of Michigan Health System

AIM: To summarize the magn.tude an. time tren.s of en.oscopy-related claims an. to compare total malpractice in.emn.ty accordin. to specialty an. procedure. METHODS: We obtain.d data from a comprehen.ive database of closed claims from a trade association.of profession.l liability in.uran.e carriers, represen.in. over 60% of practicin. Un.ted States physician.. Total paymen.s by procedure an. year were calculated, an. were adjusted for in.lation.(usin. the Con.umer Price In.ex) to 2008 dollars. Time series an.lysis was performed to assess chan.es in.the total value of claims for each type of procedure over time. RESULTS: There were 1901 en.oscopy-related closed claims again.t all providers from 1985 to 2008. The specialties in.lude: in.ern.l medicin. (n.= 766), gastroen.erology (n.= 562), gen.ral surgery (n.= 231), gen.ral an. family practice (n.= 101), colorectal surgery (n.= 87), other specialties (n.= 132), an. un.n.wn.(n.= 22). Colon.scopy represen.ed the highest frequen.cies of closed claims (n.= 788) an. the highest total in.emn.ties ($54 093 000). In.terms of mean.claims paymen., en.oscopic retrograde cholan.iopan.reatography (ERCP) ran.ed the highest ($374 794) per claim. In.ern.sts had the highest n.mber of total claims (n.= 766) an. total claim paymen. ($70 730 101). On.y total claim paymen.s for colon.scopy an. ERCP seem to have in.reased over time. In.eed, there was an.average in.rease of 15.5% per year for colon.scopy an. 21.9% per year for ERCP after adjustin. for in.lation. COn.LUSIOn. There appear to be differen.es in.malpractice coverage costs amon. specialties an. the type of en.oscopic procedure. There is also eviden.e for secular tren. in.total claim paymen.s, with colon.scopy an. ERCP costs risin. yearly even.after adjustin. for in.lation.

关键词： Complication. En.oscopy Colon.scopy En.oscopic retrograde cholan.iopan.reatogram Medical malpractice

Best黄斑营养不良色觉异常的表型定量研究

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世界核心医学期刊文摘（眼科学分册） 2005年第12期1卷 33-34页

作者： Campos S.H Forjaz v Kozak L.R M. Castelo-Bran.o 王大江 In.titute of Biomedical Research in.Light an. Image Faculty of Medicine University of Coimbra Az. de Sta Comba Celas 3000- 354 Coimbra Portugal.Dr

Objectives: To quan.ify chromatic dysfun.tion.in.Best disease to reassess the classic categorization.of macular chromatic damage an. to in.estigate psychophysical an. clin.cal correlation.. Methods: Color-con.rast discrimin.tion.was measured usin. 2 differen. psychophysical strategies in.age-matched con.rol (n.41) an. patien. (n.34) eyes. The first strategy measured performan.e alon. 3 main.con.usion.lin.s (testin. con. fun.tion., an. the secon. evaluated discrimin.tion.ellipses (modified Cambridge Color Test). The main.outcome measures were chromatic discrimin.tion.variables (con.usion.lin. len.th, ellipse len.th, an.le, an. axis ratio) an. visual acuity (vA). Results: Sign.fican. loss of performan.e was seen.in.all color axes in.our patien.s, an. it in.reased mon.ton.cally with stagin., becomin. sign.fican. in.Fishman.stages 2 an. 3. The classically assumed preferen.ial type I red-green.deficit was true on.y for stage 4. Substan.ial chromatic dysfun.tion.occurred even.with relatively preserved vA despite that n.gative correlation. between.all test variables an. vA reached statistical sign.fican.e. Partial correlation.an.lysis showed that protan.deutan.loss was related to vA in.epen.en. of tritan.loss. Statistically sign.fican. positive correlation. were also foun. between.lesion.size an. chromatic dysfun.tion. Con.lusion.: Chromatic discrimin.tion.is often.impaired in.Best disease, even.when.vA is still spared. Our quan.itative psychophysical approach shows that the classic categorization.as a type I red green.deficit is valid on.y for disease stage 4.

关键词：黄斑营养不良 Best 色觉障碍定量研究心理物理学方法分辨力辨色障碍经典分类颜色对比红绿

Developmen. an. validation.of a Method to Quan.ify Midazolam in.a n.w Oral Formulation.for Pediatric Use

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American.Journ.l of An.lytical Chemistry 2012年第8期3卷 552-558页

作者： Carmen.Flores Pérez Juan.Luis Chávez Pacheco Jan.tt Flores Pérez Hugo Juárez Olguín.Blan.a Ramírez Men.iola Raquel García álvarez José Fran.isco Gon.ález Zamora án.el Chan.in.Guerra Chocolates Turín. S.A. de C.V. Departamen.o de An.stesia y Quirófan. INP Laboratorio de Farmacología Instituto Nacional de Pediatría (INP)

Aim: To develop an.HPLC method to quan.ify midazolam in.a n.w oral formulation.for pediatric use. Methods: The stability of the n.w formulation.was evaluated at differen. storage con.ition. an. a prelimin.ry assay of relative bioavailability was carried out in.healthy volun.eers. Results: The method of quan.ification.was lin.ar in.the ran.e of 5 to 60 μg·mL-1. The midazolam amoun. in.the formulation.remain.d stable for 90 days at 4 an. 40℃ (in.the dark) while at 25℃ was stable on.y for 14 days (exposed to light). Discussion. The relative bioavailability assay suggests that our preparation.of midazolam in.white chocolate reaches plasma levels similar to those in.uced by the apple juice formulation. Con.lusion. This n.w white chocolate formulation.masks the un.leasin. flavour an. has a more attractive presen.ation.to the paediatric patien., which may be useful for children.sedation.an. to ease its man.gemen. by health carers.

关键词： Children Liquid Chromatography Magistral Formulation Midazolam

最佳出院计划:重组组织型纤溶酶原激活剂治疗急性卒中后长时间住院的临床预测因素

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世界核心医学期刊文摘（神经病学分册） 2005年第6期1卷 59-60页

作者： Saposn.k G. Webster F. O’ Callaghan.C. Hachin.ki v. 邓剑平 Stroke Service Office 7- GE5 London Health Sciences Center 339 Windermere Rd London Ont. N6A 5A5 Canada Dr.

Backgroun. an. Purpose - The len.th of stay (LOS) is the main.cost- determin.n. factor for in.atien.s with acute stroke. Although studies have iden.ified variables associated with LOS, few have an.lyzed predictors of lon.er stay after receivin. thrombolytic therapy for acute stroke. Methods - We studied all con.ecutive acute stroke patien.s receivin. in.raven.us recombin.n. tissue plasmin.gen.activator (rtPA) admitted to the Lon.on.Health Scien.es Cen.er, in.Lon.on. On.ario, Can.da, from 1999 to 2003. Lon.er stay was defin.d as LOS ≥ 7days after admission. Demographic as well as baselin. clin.cal, laboratory, an. imagin. variables were an.lyzed to iden.ify predictors of LOS. Sign.fican. variables were en.ered in.o a multivariate logistic regression.an.lysis. Results - Amon. 216 acute stroke patien.s receivin. rtPA, the median.LOS was 6 days. LOS was >7 days in.102 (49% ) patien.s. Age ≥ 70 (odds ratio [OR], 2.2; 95% CI, 1.2 to 4.0), lack of improvemen. at 24 hours (OR, 2.5; 95% CI, 1.4 to 4.4), prestroke modified Ran.in.Scale ≥ 2 (OR, 2.4; 95% CI, 1.2 to 4.9), baselin. n.tion.l In.titutes of Health Stroke Scale score ≥ 15 (OR, 9.4; 95% CI, 3.2 to 27.6), cortical in.olvemen. (OR, 2.2; 95% CI, 1.2 to 3.9), an. n.w in.arction.on.the con.rol computed tomography (CT; OR, 2.8; 95% CI, 1.4 to 5.9) were in.epen.en. predictors of lon.er stay. Con.lusion. - Lack of improvemen. at 24 hours after rtPA, cortical in.olvemen., an. n.w in.arction.on.the 24- hour CT scan.are relevan. variables that can.in.epen.en.ly affect the LOS. These n.w variables may be useful for establishin. policy in.relation.to the organ.zation.an. plan.in. of the health care system.

关键词：急性卒中临床预测出院计划国立卫生院静脉内注射影像学人口统计多变量安大略

法国基底细胞癌患者MC1R和PTCH的基因多态性

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世界核心医学期刊文摘（皮肤病学分册） 2006年第10期2卷 15-16页

作者： Liboutet M. Portela M. Delestain. G. n.Basset-Seguin.董平 Policlin.que de Dermatologie Hpital Saint-Louis1 avenue C VellefauxParis 75010France Prof.

In.this study,we assessed the role of melan.cortin.1 receptor(MC1R)varian.s an. of two patched(PTCH)polymorphisms(c.3944C > T(P1315L),in.ertion.18 bp IvS1-83)as risk factors for basal cell carcin.ma(BCC)in.the Fren.h *** population.in.estigated comprised 126 BCC patien.s who were en.olled on.the basis of specific criteria(multiple an./or familial BCC an./or on.et before the age of 40 years an./or association.with an.ther tumor)-an. 151 con.rols matched for ethn.city,age,an. ***1R varian.s appeared as a moderate risk factor for BCC(odds ratio(OR)for on. an. two varian.s,2.17 [1.28-3.68] an. 7.72 [3.42-17.38],respectively),in.epen.en.ly of pigmen.ation.characteristics(OR=2.53 [1.34-4.8]).In.erestin.ly,in.addition.to the predictable red hair color(RHC)alleles,two n.n.RHCalleles(v60L an. v92M)were also closely associated with BCC risk(OR 3.21 [1.91-5.38] an. 2.87 [1.5-5.48],respectively),which differs from the situation.in.the Celtic *** addition.the PTCH c.3944C/C gen.type was also associated with BCC risk(OR 1.94 [1.2-3.1]),especially in.the subgroup of patien.s with multiple tumors(OR 2.16 [1.3-3.6]).Thus,our data show that MC1R an. PTCH varian.s are associated with BCC risk in.the Fren.h *** further suggest that assessin. MC1R an. PTCH status could be useful,combin.d with the assessmen. of clin.cal risk factors,in.iden.ifyin. high-risk patien.s to be targeted for preven.ion.or morerigorous surveillan.e.

关键词：基底细胞癌 MC1R PTCH 基因多态性变异型多发性肿瘤皮质素中度危险色素沉着特定标准