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Corrected QT interval in cirrhosis:A systematic review and metaanalysis

World Journal of Hepatology 2023年第9期15卷 1060-1083页

作者： Vasileios periklis papadopoulos Konstantinos Mimidis Dialysis AKESIOS Dialysis CenterXanthi 67150Greece First Department of Internal Medicine Democritus University of ThraceAlexandroupolis 68100Greece

BACKGROUND Corrected QT(QTc)interval is prolonged in patients with liver cirrhosis and has been proposed to correlate with the severity of the ***,the effects of sex,age,severity,and etiology of cirrhosis on QTc have not been *** the same time,the role of treatment,acute illness,and liver transplantation(Tx)remains largely *** To determine the mean QTc in patients with cirrhosis,assess whether QTc is prolonged in patients with cirrhosis,and investigate whether QTc is affected by factors such as sex,age,severity,etiology,treatment,acute illness,and liver *** In the present systematic review and meta-analysis,the searching protocol“{[QTc]OR[QT interval]OR[QT-interval]OR[Q-T syndrome]}AND{[cirrhosis]OR[Child-Pugh]OR[MELD]}”was applied in PubMed,EMBASE,and Google Scholar databases to identify studies that reported QTc in patients with cirrhosis and published after ***-three studies were considered *** concerning first author,year of publication,type of study,method used,sample size,mean age,female ratio,alcoholic etiology of cirrhosis ratio,Child-Pugh A/B/C ratio,mean model for end-stage liver disease(MELD)score,treatment withβ-blockers,episode of acute gastrointestinal bleeding,formula for QT correction,mean pulse rate,QTc in patients with cirrhosis and controls,and QTc according to etiology of cirrhosis,sex,Child-Pugh stage,MELD score,and liver Tx status(pre-Tx/post-Tx)were *** Newcastle-Ottawa quality assessment scale appraised the quality of the eligible *** estimates,expressed as proportions or standardized mean differences,were combined using the randomeffects,generic inverse variance method of DerSimonian and ***,sensitivity analysis,and meta-regressions were applied to assess *** QTc combined mean in patients with cirrhosis was 444.8 ms[95%confidence interval(CI):440.4-449.2;P<0.001 when compared with the upper normal limit of 440 ms],presenting high heterog

关键词： Liver cirrhosis Corrected QT interval Child-Pugh stage Model for end-stage liver disease score Liver transplantation Meta-analysis

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Salvinia-like slippery surface with stable and mobile water/air contact line

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National Science Review 2021年第5期8卷 119-129页

作者： Xiaomei Li Jinlong Yang Kaixuan Lv periklis papadopoulos Jing Sun Dehui Wang Yanhua Zhao Longquan Chen Dapeng Wang Zuankai Wang Xu Deng Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of China State Key Laboratory of Polymer Physics and Chemistry Institute of Applied ChemistryChinese Academy of Sciences Physics Department University of Ioannina University Research Center of Ioannina (URCI) Institute of Materials Science and Computing Department of Mechanical Engineering City University of Hong Kong School of Physics University of Electronic Science and Technology of China

Superhydrophobic surfaces are widely used in many industrial settings, and mainly consist of rough solid protrusions that entrap air to minimize the liquid/solid area. The stability of the superhydrophobic state favors relatively small spacing between protrusions. However, this in turn increases the lateral adhesion force that retards the mobility of drops. Here we propose a novel approach that optimizes both properties simultaneously. Inspired by the hydrophobic leaves of Salvinia molesta and the slippery Nepenthes pitcher plants, we designed a Salvinia-like slippery surface(SSS) consisting of protrusions with slippery heads. We demonstrate that compared to a control surface, the SSS exhibits increased stability against pressure and impact, and enhanced lateral mobility of water drops as well as reduced hydrodynamic drag. We also systematically investigate the wetting dynamics on the SSS. With its easy fabrication and enhanced performance, we envision that SSS will be useful in a variety of fields in industry.

关键词： slippery Cassie state Salvinia molesta stability low adhesion drag reduction

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Structural Analysis of a RC Shear Wall by Use of a Truss Model

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Open Journal of Civil Engineering 2022年第3期12卷 320-352页

作者： Panagis G. papadopoulos periklis E. Lamprou Division of Structural Engineering Department of Civil Engineering Aristotle University of Thessaloniki Thessaloniki Greece

Purpose of present work is to develop a reliable and simple method for structural analysis of RC Shear Walls. The shear wall is simulated by a truss model as the bar of a truss is the simplest finite element. An iterative method is used. Initially, there are only concrete bars. Repeated structural analyses are performed. After each structural analysis, every concrete bar exceeding tensile strength is replaced by a steel bar. For every concrete bar exceeding compressive strength, first its section area is increased. If this is not enough, a steel bar is placed at the side of it. For every steel bar exceeding tensile or compressive strength, its section area is increased. After the end of every structural analysis, if all concrete and steel bars fall within tensile and compressive strengths, the output data are written and the analysis is terminated. Otherwise, the structural analysis is repeated. As all the necessary conditions (static, elastic, linearized geometric) are satisfied and the stresses of ALL concrete and steel bars fall within the tensile and compressive strengths, the results are acceptable. Usually, the proposed method exhibits a fast convergence in 4 - 5 repeats of structural analysis of the RC Shear Wall.

关键词： Reinforced Concrete Shear Wall Structural Analysis Truss Model Iterative Method Computer Program Boundary Columns and Beam Grid of Horizontal and Diagonal Reinforcing Steel Bars

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Digital Communications and Networks

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Digital Communications and Networks 2022年第3期8卷 235-236页

作者： Ruidong Li Shiwen Mao periklis Chatzimisios Constandinos X.Mavromoustakis Intelligent computation and network laboratory(ICNL)at Kanazawa University Japan the Wireless Engineering Research and Education Center(WEREC) Department of Information and Electronic Engineering at the International Hellenic University(Greece) Constandinos X.Mavromoustakis is currently a Professor at the Department of Computer Science at the University of Nicosia Cyprus

Guest editorial The emerging applications,suchas Augmented and Virtual Realities(AR/VR),InternetofThings(IoT),4K/8Kstreaming,raisestrongrequirementsto movecomputationfrom thecloudtotheedgestobecloser *** are tremendous possibilities for the network edge,which may includeavariety ofentities,such as small datacenters,end devices,and resource-abundant network *** together provide the network computation and intelligence to users.

关键词： network IoT Communications

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Transcatheter aortic valve replacement and stroke： a comprehensive review

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Journal of Geriatric Cardiology 2018年第1期15卷 95-104页

作者： periklis A Davlouros Virginia C Mplani Ioanna Koniari Grigorios Tsigkas George Hahalis Department of Cardiology Patras University Hospital Rion Patras Greece

Transcatheter aortic valve implantation （TAVR） has emerged as an alternative, rapidly evolving treatment option for patients with se- vere aortic stenosis and high surgical risk. Stroke is a devastating complication being confined mainly in the periprocedural and 30-day pe- riod following TAVR, with a lower and relatively constant frequency thereafter. Early stroke is mainly due to debris embolization during the procedure, whereas later events are associated with patient specific factors. Despite the fact that the rate of clinical stroke has been constantly decreasing compared to initial TAVR experience, modern neuro-imaging with MRI suggests that new ischemic lesions post-TAVR are almost universal. The impact of the latter is largely unknown. However, they seem to correlate with a reduction in neurocognitive function. Because TAVR is set to expand its indication to lower surgical-risk patients, stroke prophylaxis during and after TAVR becomes of paramount importance. Based on clinical and pathophysiological evidence, three lines of research are actively employed towards this direction： improvement in valve and delivery system technology with an aim to reduce manipulations and contact with the calcified aortic arch and native valve, antithrombotic therapy, and embolic protection devices. Careful patient selection, design of the procedure, and tailored antithrombotic strategies respecting the bleeding risks of this fragile population constitute the main defense against stroke following TAVR.

关键词： Aortic stenosis Stroke Transcatheter aortic valve replacement

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Liver replacement therapy with extracorporeal blood purification techniques current knowledge and future directions

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World Journal of Clinical Cases 2023年第17期11卷 3932-3948页

作者： Panagiotis Papamichalis Katerina G Oikonomou Asimina Valsamaki Maria Xanthoudaki periklis Katsiafylloudis Evangelia Papapostolou Apostolia-Lemonia Skoura Michail Papamichalis Marios Karvouniaris Antonios Koutras Eleni Vaitsi Smaragdi Sarchosi Antonios Papadogoulas Dimitrios papadopoulos Intensive Care Unit General Hospital of LarissaLarissa 41221ThessalyGreece Department of Transfusion Medicine University Hospital of LarissaLarissa 41110ThessalyGreece Department of Cardiology University Hospital of LarissaLarissa 41110ThessalyGreece Intensive Care Unit AHEPA University HospitalThessaloniki 54636Greece 1^(st) Department of Obstetrics and Gynecology General Hospital of Athens“ALEXANDRA”National and Kapodistrian University of AthensAthens 11528Greece Department of Anesthesiology University Hospital of LarissaLarissa 41110ThessalyGreece

Clinically,it is highly challenging to promote recovery in patients with acute liver failure(ALF)and acute-on-chronic liver failure(ACLF).Despite recent advances in understanding the underlying mechanisms of ALF and ACLF,standard medical therapy remains the primary therapeutic *** transplantation(LT)is considered the last option,and in several cases,it is the only intervention that can be ***,this intervention is limited by organ donation shortage or exclusion criteria such that not all patients in need can receive a *** option is to restore impaired liver function with artificial extracorporeal blood purification *** first such systems were developed at the end of the 20th century,providing solutions as bridging therapy,either for liver recovery or *** enhance the elimination of metabolites and substances that accumulate due to compromised liver *** addition,they aid in clearance of molecules released during acute liver decompensation,which can initiate an excessive inflammatory response in these patients causing hepatic encephalopathy,multiple-organ failure,and other complications of liver *** compared to renal replacement therapies,we have been unsuccessful in using artificial extracorporeal blood purification systems to completely replace liver function despite the outstanding technological evolution of these *** middle to high-molecular-weight and hydrophobic/protein-bound molecules remains extremely *** majority of the currently available systems include a combination of methods that cleanse different ranges and types of molecules and ***,conventional methods such as plasma exchange are being re-evaluated,and novel adsorption filters are increasingly being used for liver *** strategies are very promising for the treatment of liver ***,the best method,system,or device has not been developed yet,and its probability of

关键词： Liver failure Transplantation Blood purification Liver replacement therapy Artificial extracorporeal systems Transplant-free survival

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Capsule endoscopy retention as a helpful tool in the management of a young patient with suspected small-bowel disease

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World Journal of Gastroenterology 2007年第8期13卷 1289-1291页

作者： Chryssostomos Kalantzis periklis Apostolopoulos Panagiota Mavrogiannis Dimitrios Theodorou Xenophon Papaharalampous Ioannis Bramis Nikolaos Kalantzis Gastroenterology Department NIMTS Hospital 10-12 Monis Petraki str. Athens Greece 1st Propedeutic Surgical Clinic University of Athens Medical School Hippocration Hospital Athens Greece Radiology Department University of Athens Medical School Areteion Hospital Athens Greece

Capsule endoscopy is an easy and painless procedure permitting visualization of the entire small-bowel during its normal peristalsis. However, important problems exist concerning capsule retention in patients at risk of small bowel obstruction. The present report describes a young patient who had recurrent episodes of overt gastrointestinal bleeding of obscure origin, 18 years after small bowel resection in infancy for ileal atresia. Capsule endoscopy was performed, resulting in capsule retention in the distal small bowel. However, this event contributed to patient management by clearly identifying the site of obstruction and can be used to guide surgical intervention, where an anastomotic ulcer is identified.

关键词： Capsule endoscopy Retention Small bowel obstruction Obscure gastrointestinal bleeding Surgery

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Editorial: Special issue on “mobile edge computing”

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Digital Communications and Networks 2020年第2期6卷 187-188页

作者： Chatzimisios, periklis Granelli, Fabrizio Abid, Riduan M. Alexander TEl Thessaloniki ATEITHE Comp Syst Secur & Networks CSSN Res Lab Thessaloniki Greece Alexander TEl Thessaloniki ATEITHE Dept Informat Thessaloniki Greece Univ Trento Dept Informat Engn & Comp Sci DISI Trento Italy European Inst Innovat & Technol ICT Labs Consortium Framework Budapest Hungary DISI Dept Educ Trento Italy Univ Estadual Campinas Campinas SP Brazil Univ Tokyo Tokyo Japan Al Akhawayn Univ Comp Sci Ifrane Morocco Auburn Univ Auburn AL 36849 USA

Mobile Edge Computing(MEC)has seen its fast growth in the past ***,taking advantage of the computation capabilities in edge devices,elegantly offloads the computation burden from cloud computing,but provides a much improved end-to-end *** has a wide range of applications,such as 5G wireless networking,Internet of Things(IoT),and collaborative autonomous *** big need driving the future MEC is new network communications,architectures,and protocols that enable the data to move and compute in the mobile edge devices and networks.

关键词： mobile IoT network

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Transcatheter versus surgical aortic valve replacement in severe, symptomatic aortic stenosis

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Journal of Geriatric Cardiology 2018年第1期15卷 76-85页

作者： Tsigkas Grigorios Despotopoulos Stefanos Makris Athanasios Koniari Ioanna Armylagos Stylianos Davlouros periklis Hahalis George Department of Cardiology Medical School University of Patras Patras Greece

Aortic stenosis （AS） is the most common type of valvular heart disease in the elderly. Surgical aortic valve replacement （SAVR） has been the standard practice for treating severe, symptomatic AS, but recently new treatment options have emerged, Transcatheter aortic valve replacement （TAVR） is now an established treatment option in patients at high surgical risk. In this review, we focus on recent developments and compare the two treatment methods in specific populations in terms of efficacy and safety （e.g., in patients with history of prior thoracic surgery, type of anesthesia employed, access site used or need for permanent pacing）. The impact of comorbidities （pulmonary hypertension, arterial hypertension and obesity paradox）, the cost-effectiveness of TAVR vs. SAVR and advances in transcatheter valve technology as well as issues that merit further investigation are further discussed. Moreover, outcomes and complications of TAVR in patients of different risk category （extremely high, high, intermediate and low risk） are analyzed. We strongly believe that during the following years, TAVR may evolve as the treatment of choice in a broader group of patients with symptomatic AS and beyond those with intermediate and high-risk features.

关键词： Aortic stenosis Aortic valve replacement Stent valve Transcatheter aortic valve replacement

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Incidence, pathophysiology, predictive factors and prognostic implications of new onset atrial fibrillation following transcatheter aortic valve implantation

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Journal of Geriatric Cardiology 2018年第1期15卷 50-54页

作者： Ioanna Konlari Grigorios Tsigkas Nikolaos Kounisx Dimitrios Velissaris Emmanouil Chourdakis periklis Davlouros George Hahalis Department of Cardiology University Hospital of Patras Rion Patras Greece Department of Internal Medicine University Hospital of Patras Rion Patras Greece Krankenhaus der Barmherzigen Bruder Trier Germany

1 Introduction Atrial fibrillation （AF） constitutes the most frequent cardiac arrhythmia with an increasing prevalence and incidence in the general population, demonstrating a significant impact on cardiovascular morbidity and mortality. AF has been correlated with an increased risk of stroke, systemic embolism and long term morbidity compared to individuals with sinus rhythm. The highest prevalence of AF is reported in elderly as well as in patients with severe aortic stenosis, ranging between 16% and 40% in the latter. In the general population, AF scales the death risk up to 1.5 and 1.9 fold in men and women, respectively,

关键词： Atrial fibrillation Mortality Prognosis Transcatheter aoric valve implantation

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