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Fucoxanthin suppresses OxLDL-induced inflammation via activation of Nrf2 and inhibition of NF-κB signaling

Asian Pacific Journal of Tropical Biomedicine 2022年第5期12卷 207-215页

作者： peramaiyan rajendran Abdullah M AlZahrani Department of Biological Sciences College of ScienceKing Faisal UniversityAl Ahsa 31982Saudi Arabia

Objective:To explore the impact of fucoxanthin on oxidized low-density lipoprotein(OxLDL)-induced stress and inflammation in human endothelial cells and its underlying ***:HUVECs were treated with OxLDL and/or fucoxanthin for a range of time points and *** evaluated the effects of fucoxanthin on OxLDL-induced HUVECs using the MTT assay,reactive oxygen species accumulation assay,ELISA,RT-PCR,immunofluorescence,and Western ***:Fucoxanthin enhanced the cell viability in a dose dependent manner after OxLDL ***,fucoxanthin pretreatment significantly decreased OxLDL-induced reactive oxygen species production and prevented the activation of the nuclear factor kappa-B pathway,which led to substantial suppression of pro-inflammatory gene ***-induced upregulation of interleukin-6,intercellular adhesion molecule-1,vascular cell adhesion molecule-1,interleukin-1β,monocyte chemotactic protein-1,cyclooxygenase-1,and tumor necrosis factor-αwas significantly reduced by ***:Fucoxanthin can inhibit OxLDL-induced vascular inflammation and oxidative stress in HUVECs by targeting Nrf2 signaling pathways.

关键词： Oxidized low-density lipoprotein Fucoxanthin Atherosclerosis Inflammation Oxidative stress Cell viability HUVEC Nrf2 signaling pathway NF-κB

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Exposure to polycyclic aromatic hydrocarbons with special focus on cancer

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Asian Pacific Journal of Tropical Biomedicine 2015年第3期5卷 182-189页

作者： Thamaraiselvan Rengarajan peramaiyan rajendran Natarajan Nandakumar Boopathy Lokeshkumar Palaniswami rajendran Ikuo Nishigaki Department of Chemical Pathology School of medical SciencesUniversiti Sains Malaysia.Health Campus NPO-International Laboratory of Biochemistry Department of Microbiology Immunology and Genetics.Ben Gurion University of the Negev Department of Pharmacology and Environmental Toxicology.Dr.ALM PG IBMS University of Madras Department of Applied Zoology and Biotechnology Vivekananda CollegeAffiliated to Madurai Kamaraj University

Polycyclie aromatic hydrocarbons(PAHs) are a group of compounds consisting of two or more fused aromatic *** of them are formed during incomplete combustion of organic materials such as wood and fossil fuels,petroleum products,and *** composition of PAH mixtures varies with the source and is also affected by selective weathering effects in the *** are ubiquitous pollutants frequently found in a variety of environments such as fresh water and marine sediments,the atmosphere,and *** to their widespread distribution,the environmental pollution due to PAHs has aroused global *** PAHs and their epoxides are highly toxic,mutagenic and/or carcinogenic to microorganisms as well as to higher forms of life including *** main aim of this review is to provide contemporary information on PAH sources,route of exposure,worldwide emission rate,and adverse effects on humans,especially with reference to cancer.

关键词： PAH Environmental pollution DMBA Benzo(a)pyrene Cancer

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Garcinol suppresses the growth of human hepatocellular carcinoma by inducing abrogation of STAT3 phosphorylation,acetylation and dimerization

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中国药理学与毒理学杂志 2015年第S1期29卷 82-83页

作者： Muthu K SHANMUGAM Snehajyoti CHATTERJEE peramaiyan rajendran Feng LI Parijat SENAPATI Kwong Fai WONG Alan Prem KUMAR John MLUK Kam Man HUI Gautam SETHI Tapas K KUNDU Department of Pharmacology Yong Loo Lin School of Medicine National University of Singapore Singapore 117957 Jawaharlal Nehru Centre for Advanced Scientific Research Molecular Biology and Genetics Unit Transcription and Disease Laboratory Jakkur P.O. Bangalore 560064 India Cancer Science Institute of Singapore National University of Singapore Singapore 117456 School of Biomedical Sciences Faculty of Health Sciences Curtin University Western Australia Division of Cellular and Molecular Research Humphrey Oei Institute of Cancer Research National Cancer Centre Singapore 169610 Institute of Molecular and Cell Biology Singapore 138673

OBJECTIVE Hepatocellular carcinoma(HCC)is the fifth most common malignancy worldwide and the third cause of global cancer *** of signal transducer and activator of transcription 3(STAT3)is commonly observed in tumor cells and is a critical mediator of on cogenic signaling in HCC and controls the expression of several genes involved in proliferation,survival,metastasis and *** drug-targeted therapies,besides being expensive,are associated with serious side effects and ***,novel agents that can suppress STAT3 activation have potential for both prevention and treatment of *** the present report,we investigated whether the potent HAT/KAT inhibitor,garcinol,(apolyisoprenylatedbenzophenone),could suppress STAT3 activation in HCC cells and in nude mice *** The effect of garcinol on HCC cell lines wasdetermined by MTT assay,immunoblotting,DNA binding assays,immuno-fluorescenceand immune-histochemical *** effect of garcinolon the inhibition of tumor growth in vivo was also investigated using HCCxenograft tumor modelin athymic nu/nu *** We found that garcinol could inhibit constitutive STAT3 activation in a dose-and time-dependent manner both by inhibiting STAT3 phosphorylation and acetylation in HCC *** investigated for molecular mechanism(s),we found that garcinol interferes with the dimer formation of STAT3 thereby inhibits its nuclear *** modeling showed that garcinol could bind to the SH2 domain of STAT3 and suppresses its dimerization in *** understand the cellular mechanism(s)of inhibition of STAT3 function by garcinol,we observed that upon inhibition of STAT3 dimerization bygarcinol,STAT3 DNA binding ability gets *** inhibition of STAT3 activation by garcinol led to the suppression of various gene products involved in proliferation,survival,and ***,when administered i.p.,garcinol inhibited the growth of human HCC xenograft tumors in

关键词： STAT3 HCC garcinol acetylation dimerization nude m

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