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Tuning gelatin-based hydrogel towards bioadhesive ocular tissue engineering applications

Bioactive Materials 2021年第11期6卷 3947-3961页

作者： Sina Sharifi Mohammad Mirazul Islam hannah Sharifi Rakibul Islam Darrell Koza Felisa Reyes-Ortega David Alba-Molina per h.nilsson Claes h.Dohlman Tom Eirik Mollnes James Chodosh Miguel Gonzalez-Andrades Massachusetts Eye and Ear and Schepens Eye Research Institute Department of OphthalmologyHarvard Medical SchoolBostonMAUSA Department of Immunology Oslo University HospitalRikshospitaletUniversity of OsloOsloNorway Department of Physical Sciences Eastern Connecticut State UniversityWillimanticCTUSA Linnaeus Center for Biomaterials Chemistry Linnaeus UniversityKalmarSweden Research Laboratory Nordland HospitalBodøNorway Centre of Molecular Inflammation Research Norwegian University of Science and TechnologyTrondheimNorway Maimonides Biomedical Research Institute of Cordoba(IMIBIC) Department of OphthalmologyReina Sofia University Hospital and University of CordobaCordobaSpain Faculty of health Sciences K.G.Jebsen TRECUniversity of TromsøNorway

Gelatin based adhesives have been used in the last decades in different biomedical applications due to the excellent biocompatibility,easy processability,transparency,non-toxicity,and reasonable mechanical properties to mimic the extracellular matrix(ECM).Gelatin adhesives can be easily tuned to gain different viscoelastic and mechanical properties that facilitate its ocular *** herein grafted glycidyl methacrylate on the gelatin backbone with a simple chemical modification of the precursor,utilizing epoxide ring-opening reactions and visible *** chemical modification allows the obtaining of an elastic protein-based hydrogel(GELGYM)with excellent biomimetic properties,approaching those of the native *** can be modulated to be stretched up to 4 times its initial length and withstand high tensile stresses up to 1.95 MPa with compressive strains as high as 80%compared to Gelatin-methacryloyl(GeIMA),the most studied derivative of gelatin used as a *** is also highly biocompatible and supports cellular adhesion,proliferation,and migration in both 2 and 3-dimensional *** characteristics along with its super adhesion to biological tissues such as cornea,aorta,heart,muscle,kidney,liver,and spleen suggest widespread applications of this hydrogel in many biomedical areas such as transplantation,tissue adhesive,wound dressing,bioprinting,and drug and cell delivery.

关键词： Natural-based hydrogel Gelatin Biocompatible Biomimetic Bioadhesive Cornea

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Why People Live in Flood-Prone Areas in Akuressa, Sri Lanka

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International Journal of Disaster Risk Science 2018年第2期9卷 143-156页

作者： Johan Askman Olof nilsson per Becker Division of Risk Management and Societal Safety Lund University

To investigate why people live in areas at high risk of floods, a qualitative case study was carried out in the areas around Akuressa, in southwest Sri Lanka. Data collection consisted mainly of semistructured interviews with local residents and government officials. The purpose was to study why people live in areas at high risk of floods, by looking beyond the purely physical aspects of living with hazards and exploring the underlying social factors. Four main factors were identified: an overall good living situation; a sense of place; difficulties relocating; and being well-adapted to the situation. The analysis also examined whether government officials shared the views of local residents. The findings highlighted both areas of consensus and discrepancies related to risk awareness, and the efficiency of risk reduction measures that had been implemented by the government. The case study identified and explored underlying social factors, such as risk normalization, risk trade-offs, and push-and-pull processes, which seem to influence the decision to live in a high-risk area.

关键词： Flood risk Risk awareness Risk perception Sri Lanka

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Characterizing gastrointestinal stromal tumors and evaluating neoadjuvant imatinib by sequencing of endoscopic ultrasound-biopsies

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World Journal of Gastroenterology 2017年第32期23卷 5925-5935页

作者： per hedenstrom Bengt nilsson Akif Demir Carola Andersson Fredrik Enlund Ola nilsson Riadh Sadik Division of Medical Gastro-enterology Department of Internal MedicineSahlgrenska University Hospital Department of Surgery Sahlgrenska University Hospital Department of Clinical Pathology and Genetics Sahlgrenska University Hospital

AIM To evaluate endoscopic ultrasound(EUS)-guided biopsies for the pretreatment characterization of gastrointestinal stromal tumors(GIST) to personalize the management of *** All patients with lesions suspected to be GIST who were referred for EUS-sampling at a tertiary Swedish center were eligible for inclusion 2006-2015. During the observational study phase(2006-2011), routine fine-needle-aspiration(EUS-FNA) was *** 2012-2015, we converted to an interventional, randomized protocol with dual sampling EUS-FNA and fine-needle-biopsy-sampling(EUS-FNB) for all lesions. c-KIT-and DOG-1-immunostaining was attempted in all samples and a manual count of the Ki-67-index was performed. FNB-sampled tissue and the resected specimens were subjected to Sanger sequencing of the KIT and platelet-derived growth factor alpha(PDGFRA) genes. RESULTS In all, 64 unique patients with GIST were included, and of these, 38 were subjected to pretreatment dual sampling. EUS-FNB had a higher diagnostic sensitivity when compared head-to-head with EUS-FNA(98% vs 58%, P he mutation profiles(KIT-mutation 73%, PDGFRA-mutation 18%, wild-type 7%) were fully congruent with those detected in the corresponding resected specimens. In imatinib-na?ve patients, the Ki-67_(EUS) was comparable with the Ki-67-index in the corresponding surgical specimens(Ki-67_(SURG))(2.7% vs 2.9%, P = 0.68). In patients treated with neoadjuvant imatinib who also carried mutations indicating sensitivity, the Ki-67 EUS was higher than the Ki-67_(SURG)(2.5% vs 0.2%, P = 0.005), with a significant reduction in the Ki-67-index of-91.5%(95%CI:-82.4 to-96.0, P = 0.005). CONCLUSION EUS-guided biopsy sampling is accurate for the pretreatment diagnosis and characterization of GISTs and allows the prediction and evaluation of tumor response to neoadjuvant imatini

关键词： Endosonography Fine-needle biopsy Gastrointestinal stromal tumor KIT Platelet-derived growth factor alpha Tumor proliferation rate Ki-67 index Neoadjuvant treatment Imatinib

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Catquest-9SF functioning over a decade–a study from the Swedish National Cataract Register

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Eye and Vision 2020年第1期7卷 553-562页

作者： Mats Lundström Maria Kugelberg per Montan Ingela nilsson Madeleine Zetterberg Konrad Pesudovs Anders Behndig Department of Clinical Sciences/Ophthalmology Faculty of MedicineLund UniversityTrossögatan 437137 KarlskronaLundSweden Department of Clinical Neuroscience Division of Ophthalmology and VisionKarolinska InstitutetStockholmSweden St Erik Eye hospital StockholmSweden Capio Medocular LundSweden Department of Clinical Neuroscience Institute of Neuroscience and PhysiologySahlgrenska Academy at the University of GothenburgGothenburgSweden University of New South Wales AdelaideSAAustralia Department of Clinical Sciences/Ophthalmology UmeåUniversityUmeåSweden

Background:The Swedish National Cataract Register(NCR)collects data on cataract surgery outcomes during March,including patient-reported outcomes using the Catquest-9SF questionnaire for over 11 *** studies from NCR have shown that the preoperative visual acuity has improved over *** main purpose of this study was to evaluate the Catquest-9SF Rasch scoring performance in this changing environment.A second purpose was to describe clinical data over the same period for those who completed the ***:The performance of the Catquest-9SF was analysed by a separate Rasch analysis for each year,resulting in a preoperative and postoperative score for each participating patient in the annual *** clinical data and questionnaire scoring were analysed for each year in the period 2008-2018 ***:Data were available for 42,023 eyes for 11 annual cohorts(2008-2018).The psychometric properties of the questionnaire were stable during the study *** separation(precision)for the whole period was 2.58 and varied between 2.45 and *** person reliability was 0.87 and varied between 0.86 and *** targeting of question difficulty to person ability became less accurate over time meaning that the item activities became easier to carry out without *** average targeting for the whole period was−2.06 and changed from−1.92 in 2008 to−2.31 in *** person score improved both before surgery and after surgery,indicating that patients are undergoing surgery at a more able level and getting better *** average improvement by surgery decreased from 3.41 logits in 2008 to 3.21 logits in 2018(p=0.003).Over time,patient age decreased from 75 to 74 years(phe proportion of women decreased from 63.9 to 57.9%(phe mean preoperative visual acuity in both the operated eye and the better eye improved over time(0.47 to 0.40 logMAR,phe mean post

关键词： Cataract extraction Outcomes Questionnaire Patient-reported outcomes Rasch analysis

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Direct generation of linearly polarized photon emission with designated orientations from site-controlled InGaN quantum dots

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Light(Science & Applications) 2014年第1期3卷 323-329页

作者： Anders Lundskog Chih-Wei hsu K Fredrik Karlsson Supaluck Amloy Daniel nilsson Urban Forsberg per Olof holtz Erik Janzen Department of Physics Chemistry and Biology(IFM) Linkoping UniversitySE-58183 LinkopingSweden Department of Physics Faculty of ScienceThaksin UniversityPhattalung 93110Thailand

Semiconductor quantum dots(QDs)have been demonstrated viable for efficient light emission applications,in particular for the emission of single photons on ***,the preparation of QDs emitting photons with predefined and deterministic polarization vectors has proven *** to linearly polarized photons is essential for various *** this report,a novel concept to directly generate linearly-polarized photons is *** concept is based on InGaN QDs grown on top of elongated GaN hexagonal pyramids,by which the predefined elongation determines the polarization vectors of the emitted photons from the *** growth scheme should allow fabrication of ultracompact arrays of photon emitters,with a controlled polarization direction for each individual emitter.

关键词： GaN InGaN photoluminescence polarized emission quantum dot

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Oxidized organic molecules in the tropical free troposphere over Amazonia

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National Science Review 2024年第1期11卷 174-184页

作者： Qiaozhi Zha Diego Aliaga Radovan Krejci Victoria A.Sinclair Cheng Wu Giancarlo Ciarelli Wiebke Scholz Liine heikkinen Eva Partoll Yvette Gramlich Wei huang Markus Leiminger Joonas Enroth Otso per?kyl? Runlong Cai Xuemeng Chen Alkuin Maximilian Koenig Fernando Velarde Isabel Moreno Tuukka Pet?j? Paulo Artaxo Paolo Laj Armin hansel Samara Carbone Markku Kulmala Marcos Andrade Douglas Worsnop Claudia Mohr Federico Bianchi Institute for Atmospheric and Earth System Research/Physics University of Helsinki Joint International Research Laboratory of Atmospheric and Earth System Sciences Nanjing University Department of Environmental Science & Bolin Centre for Climate Research Stockholm University Department of Chemistry and Molecular Biology University of Gothenburg Institute for Ion and Applied Physics University of Innsbruck Ionicon Analytik Gmbh Laboratory for Atmospheric Physics Institute for Physics Research Universidad Mayor de San Andrés Institute of Physics University of Sao Paulo Institute for Geosciences and Environmental Research (IGE) University of Grenoble Alpes Agrarian Sciences Institute Federal University of Uberl?ndia Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical Technology Department of Atmospheric and Oceanic Sciences University of Maryland Aerodyne Research Inc. Department of Environmental System Science ETH Zürich Switzerland and Laboratory of Atmospheric Chemistry Paul Scherrer Institute

New particle formation(NPF) in the tropical free troposphere(FT) is a globally important source of cloud condensation nuclei, affecting cloud properties and climate. Oxidized organic molecules(OOMs)produced from biogenic volatile organic compounds are believed to contribute to aerosol formation in the tropical FT, but without direct chemical observations. We performed in situ molecular-level OOMs measurements at the Bolivian station Chacaltaya at 5240 m above sea level, on the western edge of Amazonia. For the first time, we demonstrate the presence of OOMs, mainly with 4–5 carbon atoms, in both gas-phase and particle-phase(in terms of mass contribution) measurements in tropical FT air from Amazonia. These observations, combined with air mass history analyses, indicate that the observed OOMs are linked to isoprene emitted from the rainforests hundreds of kilometers away. Based on particle-phase measurements, we find that these compounds can contribute to NPF, at least the growth of newly formed nanoparticles, in the tropical FT on a continental scale. Thus, our study is a fundamental and significant step in understanding the aerosol formation process in the tropical FT.

关键词： oxidized organic molecules tropical aerosol formation Amazon free troposphere

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Spinal and supraspinal control of motor function during maximal eccentric muscle contraction:Effects of resistance training

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Journal of Sport and health Science 2018年第3期7卷 282-293页

作者： per Aagaard Department of Sports Science and Clinical Biomechanics University of Southern Denmark

Neuromuscular activity is suppressed during maximal eccentric(ECC)muscle contraction in untrained subjects owing to attenuated levels of central activation and reduced spinal motor neuron(MN)excitability indicated by reduced electromyography signal amplitude,diminished evoked h-reflex responses,increased autogenic MN inhibition,and decreased excitability in descending corticospinal motor *** ECC muscle force recorded during maximal voluntary contraction can be increased by superimposed electrical muscle stimulation only in untrained individuals and not in trained strength athletes,indicating that the suppression in MN activation is modifiable by resistance *** support of this notion,maximum ECC muscle strength can be increased by use of heavy-load resistance training owing to a removed or diminished suppression in neuromuscular ***(weeks to months)of heavy-load resistance training results in increased h-reflex and V-wave responses during maximal ECC muscle actions along with marked gains in maximal ECC muscle strength,indicating increased excitability of spinal MNs,decreased presynaptic and/or postsynaptic MN inhibition,and elevated descending motor ***,the use of supramaximal ECC resistance training can lead to selectively elevated V-wave responses during maximal ECC contraction,demonstrating that adaptive changes in spinal circuitry function and/or gains in descending motor drive can be achieved during maximal ECC contraction in response to heavy-load resistance training.

关键词： Corticospinal excitability Eccentric muscle contraction h-reflex Neuromuscular plasticity Resistance training V-wave

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high-performance Flow Classification of Big Data Using hybrid CPU-GPU Clusters of Cloud Environments

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Tsinghua Science and Technology 2024年第4期29卷 1118-1137页

作者： Azam Fazel-Najafabadi Mahdi Abbasi hani h.Attar Ayman Amer Amir Taherkordi Azad Shokrollahi Mohammad R.Khosravi Ahmed A.Solyman Department of Computer Engineering Faculty of EngineeringBu-Ali Sina UniversityHamedan ***Iran Department of Energy Engineering Zarqa UniversityZarqa 13132Jordan Department of Informatics University of OsloOslo 0316Norway Department of Computer Science MalmöUniversityMalmö20506Sweden Shandong Provincial University Laboratory for Protected horticulture Weifang University of Science and TechnologyWeifang 261100China Department of Electrical and Electronics Engineering NişantaşıUniversityIstanbul 34481742Türkiye

The network switches in the data plane of Software Defined Networking (SDN) are empowered by an elementary process, in which enormous number of packets which resemble big volumes of data are classified into specific flows by matching them against a set of dynamic rules. This basic process accelerates the processing of data, so that instead of processing singular packets repeatedly, corresponding actions are performed on corresponding flows of packets. In this paper, first, we address limitations on a typical packet classification algorithm like Tuple Space Search (TSS). Then, we present a set of different scenarios to parallelize it on different parallel processing platforms, including Graphics Processing Units (GPUs), clusters of Central Processing Units (CPUs), and hybrid clusters. Experimental results show that the hybrid cluster provides the best platform for parallelizing packet classification algorithms, which promises the average throughput rate of 4.2 Million packets per second (Mpps). That is, the hybrid cluster produced by the integration of Compute Unified Device Architecture (CUDA), Message Passing Interface (MPI), and OpenMP programming model could classify 0.24 million packets per second more than the GPU cluster scheme. Such a packet classifier satisfies the required processing speed in the programmable network systems that would be used to communicate big medical data.

关键词： OpenMP Compute Unified Device Architecture(CUDA) Message Passing Interface(MPI) packet classification medical data tuple space algorithm Graphics Processing Unit(GPU)cluster

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Two decades of fire activity over the PEEX domain:a look from space,with contribution from models and ground-based measurements

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Big Earth Data 2024年第2期8卷 350-396页

作者： Larisa Sogacheva Timo h.Virtanen Anu-Maija Sundström Pekka Kolmonen Mikhail Sofiev hanna K.Lappalainen Antti Arola Finnish Meteorological Institute Climate Research ProgrammeHelsinkiFinland Finnish Meteorological Institute Space and Earth Observation CentreHelsinkiFinland Institute for Atmospheric and Earth System Research/Physics Faculty of ScienceUniversity of HelsinkiHelsinkiFinland

It has been suggested that forest fires will become more frequent/intense with changing climate,which would increase aerosol/gas emissions into the atmosphere.A better under-standing of the relations between meteorological conditions,fires,and fire emissions will help estimate the climate response via forest *** this study,we use ERA5 meteor-ological products,including temperature,precipitation,and soil moisture,to explain the frequency of forest fires and the amount of radiant energy released per time unit by burning vegetation(fire radiative power,FRP).We explore the relation-ships between satellite-retrieved fire products and aerosol properties(aerosol optical depth,AOD),carbon monoxide(CO),formaldehyde(hChO),and nitrogen dioxide(NO_(2))con-centrations over the PEEX domain,which covers different vegetation zones(***/grasslands,forest,arctic tun-dra)of Pan-Eurasia and *** analyse the concentrations of black carbon and absorbing organic carbon using groundbased AErosol RObotic *** analysis covers the months of May to August from 2002 to *** show posi-tive temperature trends in the Northern zone(>65°N)in June and August(1.56°C and 0.64°C,respectively);all statistically significant trends for precipitation and soil moisture are *** can explain increased fire activity in Siberia over the recent years(2019-2022).Over the whole PEEX domain,FC and FRP trends remain insignificant or negative;a decrease in AOD may address those negative *** show that intrasummer variations exist for cropland/grassland fires,which occur most often in May and August,while Siberian forest fires occur more often in July and *** show that CO concentration has been gradually decreasing in the last two decades in May and *** trends are negative in May,June,and over summer for all regions,in July in Europe,China,the Southern zone(he PEEX *** trends are not significant in all ***_(2)trends are positive in May and

关键词： PEEX wild fires satellite trend enhancement ratios

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Morphometric Attributes of Two Native Forage Species According to Water Source Distance in Semiarid Central Grasslands of Argentina

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Phyton-International Journal of Experimental Botany 2024年第8期93卷 2063-2074页

作者： Carla Etel Suárez María Sol Rossini Ernesto Francisco Atilio Morici héctor Daniel Esterlich Laboratorio de Ecología en Ambientes Semiáridos Ecología VegetalFacultad de AgronomíaUNLPamSanta Rosa6300Argentina Facultad de Ciencias Veterinarias UNLPamGeneral Pico6360Argentina Becaria Doctoral CONICET APNFacultad de AgronomíaUNLPamSanta Rosa6300Argentina

The semiarid grasslands of Argentina’s central region have been modified by domestic livestock grazing,both in their composition and *** increase in the proportion of woody and non-forage species and the decrease in forage species are some of the most evident results of this *** is limited available information about the effect of differential grazing pressures on morphometric attributes of native species,and it also depends on the life histories of the species in this *** objective of this work was to evaluate some morphometric aspects in the grasses Poa ligularis Nees ex Steud and Piptochaetium napostaense(Speg.).hack according to distance from the water source in communities in the central semiarid region of *** study area included areas of low grassland,golden forests,and secondary forests in grasslands(6 fields with 9 paddocks).Grazing pressure was established based on the distance to the water source,so sampling areas were designated near the water source(grazing pressure is greater)and far from the water source(grazing pressure light)in each of the *** both species,specimens were selected at random,and the following attributes were measured:crown diameter at ground level(cm),burial depth(cm),average tiller weight per plant(***^(−1)),and the density of tillers per unit of crown surface(***^(−2)crown).The morphometric attributes evaluated showed differences according to the distance to the watering hole and in the different *** species presented similar behaviors for the *** were significant differences in the depth of burial and the average weight of tillers per plant,being greater in the areas close to the water *** the distance to the watering hole,there were no significant differences in crown diameter and tiller density,but the highest values were recorded for the former near the watering hole and for the second far from the watering *** pastures with low

关键词： Grazing pressure tiller density tiller weight crown burial depth Poa ligularis Piptochaetium napostaense

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