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世界核心医学期刊文摘（皮肤病学分册） 2006年第4期2卷 28-29页

作者： Thual N. penven k. Chevallier J.-M. D. Leroy 李晓莉 Service de Dermatologie Centre Hospitalier Universitaire Avenue Georges Clé menceau 14033 Caen Cedex

Back.round. Dermatomyositis is a rare inflammatory dermatosis for which an iatrogenic origin has been described in very few cases. We report a case of dermatomyositis occurring after fluvastatin intak.. Case report. A 76-year-old male patient sought medical attention for a photodistributed rash and considerable muscular weak.ess present for one month. Two months earlier, fluvastatin had been introduced following the discovery of dyslipidemia. Serum creatine phosphok.nase levels were elevated. Histological examination of a muscle biopsy was consistent with a diagnosis of dermatomyositis. Investigation for neoplasia and associated autoimmune disease proved negative. All clinical and laboratory abnormalities diminished spontaneously without recourse to corticosteroids with in one month of the final intak. of fluvastatin. After a follow-up period of three years, no recurrence was observed and no signs of neoplasia or connectivitis were found. Discussion. Iatrogenic dermatomyositis has only been reported in rare cases. Certain drugs have been incriminated, notably D-penicillamine. Six cases of drug-induced dermatomyositis have been described with statins: simvastatin, atorvastatin, pravastatin and lovastatin. Of these cases, only one resolved spontaneously after withdrawal of the drug alone without use of corticosteroids. Our case concerns intak. of fluvastatin, an HMG-CoA reductase inhibitor with rare though well-k.own muscular side effects: elevated serum CPk. myalgia and rhabdomyolysis. Six cases of polymyositis have also been reported. Ours is the first case of dermatomyositis described with this category of statins. It is also the second reported case showing improvement after withdrawal of the lipid-lowering agent and without corticosteroids. Thus in cases of dermatomyositis, this iatrogenic picture should be sought routinely.

关键词：皮肌炎氟伐他汀药物诱发多发性肌炎横纹肌溶解他汀药物结缔组织病自身免疫疾病降脂药肌痛

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健康人中性粒细胞性小汗腺炎1例(法国)

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世界核心医学期刊文摘（皮肤病学分册） 2005年第12期1卷 34-34页

作者： Morice A. penven k. Comoz F. D. Leroy 罗素菊 Service de Dermatologie CHU Avenue Georges Clé menceau 14033 Caen Cedex France

Back.round. Neutrophilic eccrine hidradenitis occurs mostly in patients receiving chemotherapy for acute myeloblastic leuk.mia, rarely in healthy patients. Histopathologic pattern is characteristic and includes selective necrosis of the eccrine glands with a local neutrophilic infiltrate. Case report. We report the case of a 41 year- old woman with no medical past history who developed during 2 years successive papulous sk.n eruptions. The latter always resolved spontaneously. Sk.n biopsy led to the diagnosis showing typical features of neutrophilic eccrine hidradenitis. Discussion. Our case is original because the neutrophilic eccrine hidradenitis had occured in a healthy woman. Neither malignant hematologic disease nor visceral cancer was disclosed in this patient in the following 31 months.

关键词：粒细胞性小乳头小汗腺恶性血液病皮肤活检疾病病史组织病理学内脏肿瘤

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