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Cyclic patterns of incidence rate for skin malignant melanoma:association with heliogeophysical activity

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第6期9卷 489-495页

作者： Borislav D.DIMITROV Mariana I.RACHKOVA penka a.atanassova BORDANI Alzano Lombardo(BG)24022ItalyDepartment of Social Medicine and Health ManagementMedical UniversityPlovdiv 4000Bulgaria ASSON-93 Research Co. Mount ProspectILL 60056USA Department of Neurology Medical UniversityPlovdiv 4000Bulgaria

Background:Our previous studies revealed cyclicity in the incidence rate of skin malignant melanoma(SMM;ICD9,Dx:172)in the Czech Republic(period T=7.50～7.63 years),UK(T=11.00 years)and Bulgaria(T=12.20 years).Incidences com- pared with the sunspot index Rz(lag-period dT=+2,+4,+6,+10 or+12 years)have indicated that maximal rates are most likely to appear on descending slopes of the 11-year solar cycle,i.e.,out of *** summarized and explored more deeply these cyclic variations and discussed their possible associations with heliogeophysical activity(HGA)components exhibiting similar cyclicity. Methods:Annual incidences of SMM from 5 countries(Czech Republic,UK,Bulgaria,USA and Canada)over various time spans during the years 1964～1992 were analyzed and their correlations with cyclic Rz(sunspot number)and aa(planetary geomagnetic activity)indices were *** regression analysis with trigonometric approximation and phase-correlation analysis were ***:Previous findings on SMM for the Czech Republic,UK and Bulgaria have been validated,and cyclic patterns have been revealed for USA(T=8.63 years,P<0.05)and Canada(Ontario,T=9.91 years,P<0.10).Also,various 'hypercycles'were established(T=45.5,42.0,48.25,34.5 and 26.5 years,respectively)describing long-term cyclic incidence *** association of SMM for USA and Canada with Rz(dT=+6 and+7 years,respectively)and aa(dT=?10 and+9 years,respectively)was *** interactions of cyclic non-photic influences(UV irradiation,Schumann resonance signal,low-frequency geomagnetic fluctuations)with brain waves absorbance,neuronal calcium dynamics,neuro-endocrine axis modulation,melatonin/serotonin disbalance and skin neuro-immunity impairment as likely causal pathways in melanoma ap- pearance,were also ***:The above findings on cyclicity and temporal association of SMM with cyclic envi- ronmental factors could not only allow for better forecasting models but also lead to a bett

关键词：黑色素瘤皮肤活性手术治疗

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Science Letters:Brain metastases of melanoma-mechanisms of attack on their defence system by engineered stem cells in the microenvironment

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2007年第9期8卷 609-611页

作者： DIMITROV Borislav D. atanassova penka A. RACHKOVA Mariana I. BORDANI Alzano Lombardo Bergamo 24022 Italy Department of Neurology Medical University Plovdiv 4000 Bulgaria ASSON-93 Research Co. Chicago IL 60056 USA

This report gives a better emphasis on the role of targeted effectors (e.g. a combination of 5-FC with CD-NSPCs as compared to the application of NSPCs alone) and how such delivery of pro-drug activating enzymes and other tumor-killing substances may overcome melanocytic defence system, interact with and promote the host defence and immune response modulations not only in melanoma but, potentially, in other highly-metastatic cancers.

关键词：黑色素瘤脑转移神经系统干细胞胞核嘧啶脱氨基酶

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