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Tumor organoids for cancer research and personalized medicine

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Cancer Biology & Medicine 2022年第3期19卷 319-332页

作者： Hui Yang Yinuo wang Peng wang Ning Zhang pengyuan wang Translational Cancer Research Center Peking University First HospitalBeijing 100034China Division of General Surgery Peking University First HospitalBeijing 100034China

Organoids are three-dimensional culture systems generated from embryonic stem cells,induced pluripotent stem cells,and adult stem *** are capable of cell proliferation,differentiation,and *** stimulation by signal factors and/or growth factors,organoids self-assemble to replicate the morphological and structural characteristics of the corresponding *** provide an extraordinary platform for investigating organ development and mimicking pathological *** biobanks derived from a wide range of carcinomas have been established to represent different lesions or stages of clinical ***,genomic and transcriptomic analyses have confirmed maintenance of intra-and interpatient heterogeneities in ***,this technology has the potential to revolutionize drug screening and personalized *** this review,we summarized the characteristics and applications of organoids in cancer research by the establishment of organoid biobanks directly from tumor organoids or from genetically modified non-cancerous *** also analyzed the current state of organoid applications in drug screening and personalized medicine.

关键词： Organoids cancer research heterogeneity personalized medicine clinical cancer therapy

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慢性胰腺炎抗炎和抗纤维化治疗的研究进展

中华消化病与影像杂志（电子版） 2024年第4期14卷 289-296页

作者：谭欣王鹏源胡良皞海军军医大学第一附属医院消化内科上海200433 联勤保障部队第九八一医院消化内科河北承德067000

慢性胰腺炎(CP)以胰腺慢性炎症及纤维化为特征,胰腺腺泡细胞损伤、星状细胞活化及炎症细胞浸润共同影响疾病进程。长期以来,CP治疗以控制症状和防治并发症为主,临床上暂无干预疾病发展的有效药物。因此,寻找可干预的分子靶点和药物是CP... 详细信息

慢性胰腺炎(CP)以胰腺慢性炎症及纤维化为特征,胰腺腺泡细胞损伤、星状细胞活化及炎症细胞浸润共同影响疾病进程。长期以来,CP治疗以控制症状和防治并发症为主,临床上暂无干预疾病发展的有效药物。因此,寻找可干预的分子靶点和药物是CP研究的重要方向。本文综述了CP的发病机制及抗炎抗纤维化治疗研究进展,以期为CP的治疗提供更多选择。

关键词：慢性胰腺炎炎症纤维化胰腺星状细胞药物干预

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基于工作量点数法绩效分配模式研究

中国医院 2024年第3期28卷 1-5页

作者：张舜瑞田雨韩晓宁罗一松王鹏远北京大学第一医院北京市100034

实施以增加知识价值为导向的分配政策,是深化公立医院薪酬制度改革的方向。笔者介绍了样本医院在新形势新要求下绩效分配改革探索实践,综合运用RBRVS与KPI管理工具,建立可量化的关键绩效指标体系,并根据全口径贡献值评价制定了工作量、... 详细信息

实施以增加知识价值为导向的分配政策,是深化公立医院薪酬制度改革的方向。笔者介绍了样本医院在新形势新要求下绩效分配改革探索实践,综合运用RBRVS与KPI管理工具,建立可量化的关键绩效指标体系,并根据全口径贡献值评价制定了工作量、运营、质量、科教、工资五大模块的分配体系,以期从分配理念和方法、分配策略等角度,构建充分体现公立医院公益性原则和知识价值导向的分配模型,实现工作量与工作质量的平衡,促进价值医疗的实现,推动医疗事业不断发展。

关键词：工作量绩效分配关键绩效指标价值医疗

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Monitoring gas-and particulate-phase short-chain polychlorinated paraffins in the urban air of Dalian by a self-developed passive sampler

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Journal of Environmental Sciences 2019年第6期31卷 287-295页

作者： Yifan wang Xiuhua Zhu Yuan Gao Hao Bai pengyuan wang Jiping Chen Heping Yuan Longxing wang Xiaoxiao Li Wei wang School of Environmental and Chemical Engineering Dalian Jiaotong University Dalian Institute of Chemical Physics Chinese Academy of Sciences College of Chemistry Jilin University Dalian Meteorological Observatory

The concentration of short-chain polychlorinated paraffins(SCCPs) in the urban air of Dalian,China was monitored from September 2016 to August 2017 with a self-developed passive sampler(PAS1) and an active high-volume sampler, simultaneously. PAS1 successfully collected the entire target SCCPs in the ambient air. Air SCCPs sampled by PAS1 were found be in the linear uptake stage during 181 days of sampling. Passive and active samples showed comparable congener profiles, and the dominant contributors of SCCPs in the two kinds of samples were similar. A significant linear correlation was observed between the total concentration of SCCPs sampled by PAS1 and active sampler in the four seasons. The passive sampling rates of the PAS1 for the gas and particulate phases of SCCPs were measured. The quantitative structure–property relationship of the sampling rate of PAS1(Rair) for gas-phase SCCPs was studied. From the molecular point of view, Rairwas mainly affected by the molecular weight and sub-cooled liquid vapor pressure of SCCPs. In general, SCCPs in the urban air of Dalian mainly existed in gas phase,lower molecular weight SCCPs primarily occurred in the gas phase, whereas higher molecular weight SCCPs were predominately adsorbed or absorbed on airborne particles. The air concentration of SCCPs in the four seasons were different, the correlation of the concentration of SCCPs in the air with the meteorology parameters was conducted. The exposure risk by intake air SCCPs of the residents around the sampling sites was evaluated according to the European risk assessment standards.

关键词： Ambient air Short-chain polychlorinated paraf fins Passive sampler Active sampling Passive sampling

中医特色护理联合耳穴压豆应用于缺血性脑卒中后失眠患者的效果分析

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现代医药卫生 2024年第7期40卷 1126-1129页

作者：曾琳瑶刘彩云王鹏远杨士杰平顶山市中医医院脑病科河南平顶山467000

目的探讨中医特色护理联合耳穴压豆应用于缺血性脑卒中后失眠患者的效果。方法选择2022年1月至2023年1月平顶山市中医医院收治的缺血性脑卒中后失眠患者82例作为研究对象,其中男49例(59.76%),女33例(40.24%),按照随机数字表法将其分为... 详细信息

目的探讨中医特色护理联合耳穴压豆应用于缺血性脑卒中后失眠患者的效果。方法选择2022年1月至2023年1月平顶山市中医医院收治的缺血性脑卒中后失眠患者82例作为研究对象,其中男49例(59.76%),女33例(40.24%),按照随机数字表法将其分为对照组和观察组,各41例。对照组给予耳穴压豆干预,观察组在对照组护理基础上给予中医特色护理,对比分析两组患者临床疗效、睡眠质量及不良情绪。结果观察组患者临床治疗总有效率高于对照组(95.12%vs.78.05%),差异有统计学意义(P<0.05);两组患者匹兹堡睡眠指数量表(PSQI)评分均较干预前降低,且观察组PSQI评分低于对照组[(3.21±1.03)分vs.(7.41±1.65)分],差异均有统计学意义(P<0.05);两组患者抑郁-焦虑-压力量表中文简版(DASS-21)各维度分数均较干预前降低,且观察组分数低于对照组,差异均有统计学意义(P<0.05)。结论中医特色护理联合耳穴压豆干预应用于缺血性脑卒中后失眠患者可以有效提高临床疗效,改善其睡眠质量,减少不良情绪的发生。

关键词：中医特色护理耳穴压豆缺血性脑卒中失眠睡眠质量

中医推拿联合中药封包对中风后痉挛性偏瘫患者肢体功能和日常生活能力的影响研究

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现代医药卫生 2024年第11期40卷 1888-1891,1895页

作者：刘彩云王鹏远曾琳瑶杨士杰平顶山市中医医院脑病科河南平顶山467000

目的探讨中医推拿联合中药封包治疗对中风后痉挛性偏瘫患者肢体功能和日常生活能力的影响。方法选取2020年9月至2023年9月该院收治的中风后痉挛性偏瘫患者112例,采用随机数字表法将其均分为常规组(常规西医治疗)和联合组(常规西医治疗+... 详细信息

目的探讨中医推拿联合中药封包治疗对中风后痉挛性偏瘫患者肢体功能和日常生活能力的影响。方法选取2020年9月至2023年9月该院收治的中风后痉挛性偏瘫患者112例,采用随机数字表法将其均分为常规组(常规西医治疗)和联合组(常规西医治疗+中医推拿+中药封包),比较2组患者临床疗效、肌肉张力(改良Ashworth分级标准)、运动功能(Fugl-Meyer运动功能评定量表)、平衡能力(Berg平衡评定量表)、日常生活能力(Barthel指数)变化情况。结果联合组患者临床疗效(91.07%)高于常规组(73.21%),差异有统计学意义(P<0.05);联合组患者治疗后改良Ashworth分级情况优于常规组,治疗后Fugl-Meyer运动功能、Berg平衡评定量表评分及Barthel指数评分均高于常规组,差异均有统计学意义(P<0.05)。结论中风后痉挛性偏瘫患者应用中医推拿联合中药封包治疗可显著提高疗效,恢复肢体运动功能及平衡能力,缓解肌肉张力,改善日常生活能力。

关键词：中风痉挛性偏瘫并发症中医推拿中药封包肢体功能日常生活能力

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中药抗胰腺纤维化治疗慢性胰腺炎的研究进展

中国医刊 2024年第2期59卷 117-122页

作者：黄邦伟王鹏源胡良皞李兆申海军军医大学第一附属医院消化内科上海市胰腺病研究所上海200433

慢性胰腺炎(chronic pancreatic,CP)是一种进行性的胰腺纤维炎症综合征,最终导致胰腺内外分泌功能受损,严重影响患者的生活质量。胰腺纤维化(pancreatic fibrosis,PF)是慢性胰腺炎的主要病理特征,而胰腺星状细胞(pancreatic stellate ce... 详细信息

慢性胰腺炎(chronic pancreatic,CP)是一种进行性的胰腺纤维炎症综合征,最终导致胰腺内外分泌功能受损,严重影响患者的生活质量。胰腺纤维化(pancreatic fibrosis,PF)是慢性胰腺炎的主要病理特征,而胰腺星状细胞(pancreatic stellate cells,PSCs)活化是PF发生发展的关键环节。

关键词：慢性胰腺炎胰腺纤维化中药胰腺星状细胞药物评价

Molecular typing and resistance mechanisms of carbapenem resistantPseudomonas aeruginosa isolated from a Chinese surgical intensivecare unit

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Chinese Medical Journal 2014年第6期127卷 1071-1076页

作者： Yi Meiying wang pengyuan Liu Yucun China 100029 China 100034

Background Carbapenems are an important class of drugs for the treatment of Pseudomonas aeruginosa(P. aeruginosa) infections. However, carbapenem resistance has been commonly observed in nonfermenter species of bacteria. The purpose of this study was to investigate the molecular epidemiology and carbapenem resistant mechanisms of P. aeruginosa isolated from a surgical intensive care unit(SICU) in China. Methods The molecular typing was analyzed by REP-PCR. Enzyme activity was measured with a 260 nm wavelength spectrophotometer. The levels of outer membrane proteins OprD and OprN were measured by Western blotting. The levels of mexA gene transcriptional expression were measured by quantitative real-time PCR. The metallo-beta-lactamase genes IMP, VIM, SPM, GES, and GIM were amplified by PCR. DNA fragments were sequenced by an automated ABI PRISM *** Forty-two strains resistant to carbapenems isolated from a SICU were analyzed. REP-PCR revealed 34 belonging to type A, a predominant strain in this SICU. But we did not find metallo-beta-lactamases IMP, VIM, SPM, GES, or GIM genes by PCR. With a three-dimensional extract test, we found 34 strains producing high levels of AmpC enzymes. We also observed the activity of beta-lactamases enzymes in the imipenem resistant group, which was statistically different from the sensitive group. Western blotting revealed that 23 strains showed loss of OprD, 18 strains had decreased OprD expression, and 14 strains expressed OprN. We discovered 27 strains that overexpressed mexA by quantitative real-time PCR, and the resistance rate to meropenem was statistically different between the overexpressing group and the lowexpressing group. Nucleotide sequences and deduced amino acid sequence analysis revealed that eight strains carried mutations in the mexR gene operon down regulating MexAB-OprM. The nucleotide sequences of mexR genes from PA36, PA41 and PA48 were submitted to the Genebank with accession numbers of AY899299, AY899300,

关键词： Pseudomonas aeruginosa fl-lactamase AmpC porin protein OprD elflux pump carbapenem resistance

Design of an aircraft autonomous traction taxiing system based on hydraulic secondary control

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Chinese Journal of Aeronautics 2024年第6期37卷 348-359页

作者： Xiaochao LIU Zhongyi QIU Hao ZHANG pengyuan QI Zhenyu wang Yaoxing SHANG Zongxia JIAO Research Institute for Frontier Science Beihang UniversityBeijing 100083China School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100083China Ningbo Institute of Technology Beihang UniversityNingbo 315800China Tianmushan Laboratory Xixi Octagon CityYuhang DistrictHangzhou 310023China Science and Technology on Aircraft Control Laboratory Beihang UniversityBeijing 100083China Beijing Tianma Intelligent Control Technology Co. Ltd.Beijing 101399China China Coal Research Institute Beijing 100013China

At present,aircraft taxiing at ground airports needs to be provided with a thrust by the main *** taxiing process is inefficient,has high fuel consumption and serious pollution,and is prone to safety *** this paper,a new configuration of aircraft autonomous traction taxiing system is proposed based on the principle of hydraulic secondary control,in which a hydraulic motor drive device is installed at the front wheels of the aircraft to drive the wheels to rotate forward or *** on this,autonomous taxiing can be realized without relying on the main engines,thus greatly improving airport operation ***,this paper analyzes the influencing factors of the autonomous traction taxiing process,and investigates the parameter matching design of the new configuration ***,this paper develops the ground principle prototype,designs the aircraft longitudinal bonding force observer and the aircraft wheel disturbance moment observer,and proposes the speed control method of the aircraft front wheel autonomous traction taxiing by considering the ground bonding force saturation ***,the ground taxiing test is conducted,and the results show that the new configuration proposed in this paper presents a new solution for aircraft autonomous traction taxiing.

关键词： Autonomous traction taxi-ing Hydraulic secondary control Hydraulic motors Saturation characteristics Disturbance observation Speed control