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Injectable“cocktail”hydrogel with dual-stimuli-responsive drug release,photothermal ablation,and drug-antibody synergistic effect

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SmartMat 2024年第2期5卷 43-53页

作者： Li Zhao Jiawen xu Yao Tong pengyu Gong Fucheng Gao Hui Li Yanyan Jiang Key Laboratory for Liquid-Solid Structural Evolution&Processing of Materials(Ministry of Education) School of Materials Science and EngineeringShandong UniversityJinanChina Department of Pathology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinanChina Department of Clinical Laboratory The Second HospitalCheeloo College of MedicineShandong UniversityJinanChina

The combination of the first-line standard chemotherapeutic drug doxorubicin hydrochloride(DOX)and the molecular-targeted drug Herceptin(HCT)has emerged as a promising strategy for human epidermal growth receptor 2(HER-2)overexpressing breast cancer treatment.However,insufficient drug accumulation and severe cardiotoxicity are two major challenges that limit its clinical application.Herein,an in situ forming gold nanorods(AuNRs)-sodium alginate(ALG)hybrid hydrogel encapsulating DOX and HCT was engineered for tumor synergistic therapy involving injectable,dual-stimuli-responsive drug release,photothermal ablation,and drug-antibody synergistic therapy.The photothermal agent AuNRs,anticancer drug DOX,and anticancer antibody HCT were mixed in ALG solution,and after injection,the soluble ALG was quickly transformed into a hydrogel in the presence of Ca^(2+)in the body.Significantly,the hybrid hydrogel exhibits an extremely high photothermal conversion efficiency of 70%under 808 nm laser irradiation.The thermal effect can also provide photothermal stimulation to trigger the drug release from the gel matrix.In addition,the drug release rate and the releasing degree are also sensitive to the pH.In vitro studies demonstrated that the PEI-AuNR/DOX/HCT/ALG hydrogel has facilitated the therapeutic efficiency of each payload and demonstrated a strong synergistic killing effect on SK-BR-3 cells.In vivo imaging results showed that the local drug delivery system can effectively reduce the nonspecific distribution in normal tissues and increase drug concentration at tumor sites.The proposed hydrogel system shows significant clinical implications by easily introducing a sustainable photothermal therapy and a potential universal carrier for the local delivery of multiple drugs to overcome the challenges faced in HER-2 overexpressing cancer therapy.

关键词： dual-stimuli-responsive drug release HER-2 overexpressing breast cancer injectable hydrogel photothermal therapy synergistic effect

Huangqi Guizhi Wuwu Decoction suppresses inflammation and bone destruction in collagen-induced arthritis mice

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Chinese Herbal Medicines 2024年第2期16卷 274-281页

作者： Jiamin Bao Yongjia Song Minghui Hang Hao xu Qiang Li pengyu Wang Tao Chen Mengxiong Xia Qi Shi Yongjun Wang Xiaoyun Wang Qianqian Liang School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghai 201203China Longhua Hospital Shanghai University of Traditional Chinese MedicineShanghai 200032China Spine Institute Shanghai University of Traditional Chinese MedicineShanghai 200032China Key Laboratory of Theory and Therapy of Muscles and Bones Ministry of EducationShanghai University of Traditional Chinese MedicineShanghai 201203China Shanghai Research Institute of Acupuncture and Meridian Shanghai University of Traditional Chinese MedicineShanghai 200032China

Objective: Rheumatoid arthritis(RA) is a chronic inflammatory and destructive arthritis, characterized by inflammatory infiltration and bone destruction. Huangqi Guizhi Wuwu Decoction(HGWD) is traditional Chinese medicine, which has been applied in the treatment of RA in clinical. The aim of this study was to investigate the therapeutic effect of HGWD on collagen-induced arthritis(CIA) mouse model.Methods: DBA/1J female mice were used to establish the collagen-induced arthritis(CIA) model. HGWD was administered intragastrically once a day for four weeks starting on the 22nd day after the first immunization. The body weight, hind paw thickness and clinical score were measured every five days. Gait analysis, histopathological staining, enzyme-linked immunosorbent assay(ELISA), ultrasound imaging and micro-computed tomography imaging were performed to determine the effects of HGWD treatment on inflammation and bone structure in this model. Moreover, Real-time PCR and Western blot analysis were used to detect inflammatory factors m RNA and protein levels after HGWD intervention in RAW264.7 cells.Results: HGWD attenuated symptoms of arthritis, suppressed inflammatory synovium area and the serum levels of inflammatory factors, inhibited joint space enlargement in the knee and ankle joints,reduced numbers of osteoclasts, protected bone destruction, as well as improved motor function.HGWD decreased the expression of m RNA for inflammatory factors and the protein expression levels of p-NF-ΚB and IL-17.Conclusion: These results suggested that HGWD suppresses inflammation, attenuates bone erosion and maintains motor function in collagen-induced arthritis mice.

关键词： bone destruction collagen-induced arthritis Huangqi Guizhi Wuwu Decoction inflammation rheumatoid arthritis

Elastic Modulus,Hardness,and Fracture Toughness of Li_(6.4)La_(3)Zr_(1.4)Ta_(0.6)O_(12) Solid Electrolyte

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Chinese Physics Letters 2021年第9期38卷 108-116页

作者： Shan Hu pengyu xu Luize Scalco de Vasconcelos Lia Stanciu Hongwei Ni Kejie Zhao State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081China School of Mechanical Engineering Purdue UniversityWest LafayetteIndiana 47907USA School of Materials Engineering Purdue UniversityWest LafayetteIndiana 47907USA

Li_(6.4)La_(3)Zr_(1.4)Ta_(0.6)O_(12)(LLZTO) is a promising inorganic solid electrolyte due to its high Li+conductivity and electrochemical stability for all-solid-state batteries.Mechanical characterization of LLZTO is limited by the synthesis of the condensed phase.Here we systematically measure the elastic modules,hardness,and fracture toughness of LLZTO poly crystalline pellets of different densities using the customized environmental nanoindentation.The LLZTO samples are sintered using the hot-pressing method with different amounts of Li2CO3 additives,resulting in the relative density of the pellets varying from 83% to 98% and the largest grain size of 13.21 ± 5.22 μm.The mechanical properties show a monotonic increase as the sintered sample densifies,elastic modulus and hardness reach 158.47± 10.10 GPa and 11.27± 1.38 GPa,respectively,for LLZTO of 98% density.Similarly,fracture toughness increases from 0.44 to 1.51 MPa·m^(1/2),showing a transition from the intergranular to transgranular fracture behavior as the pellet density increases.The ionic conductivity reaches 4.54 × 10^(-4 )S/cm in the condensed LLZTO which enables a stable Li plating/stripping in a symmetric solid-state cell for over 100 cycles.This study puts forward a quantitative study of the mechanical behavior of LLZTO of different microstructures that is relevant to the mechanical stability and electrochemical performance of all-solid-state batteries.

关键词： toughness Elastic Solid

考虑智能网联车辆影响的八车道高速公路施工区可变限速控制方法

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东南大学学报（自然科学版） 2024年第2期54卷 353-359页

作者：过秀成肖哲张一鸣张叶平许鹏宇东南大学交通学院南京211189 江苏省规划设计集团有限公司交通规划与工程设计院南京210019

为提升车联网环境下高速公路施工区交通运行效率及安全水平,提出了一种基于强化学习的可变限速控制方法.选取智能驾驶模型和真车试验模型,分别对传统人工车辆和智能网联车辆的跟驰行为进行建模,构建了以瓶颈下游路段交通流量为效率指标... 详细信息

为提升车联网环境下高速公路施工区交通运行效率及安全水平,提出了一种基于强化学习的可变限速控制方法.选取智能驾驶模型和真车试验模型,分别对传统人工车辆和智能网联车辆的跟驰行为进行建模,构建了以瓶颈下游路段交通流量为效率指标、瓶颈路段速度标准差为安全指标的复合奖励值,利用深度确定性策略梯度算法,分车道动态求解最佳限速值.仿真结果表明,所提可变限速控制方法在不同智能网联车辆渗漏率条件下均能有效提升交通流运行效率和安全水平,且在智能网联车辆渗漏率较低时,提升效果更加显著.当智能网联车辆渗漏率为1.0时,瓶颈下游路段交通流量提升10.1%,瓶颈路段速度标准差均值下降68.9%;当智能网联车辆渗漏率为0时,瓶颈下游路段交通流量提升20.7%,瓶颈路段速度标准差均值下降78.1%.智能网联车辆的引入能够提升至多52.0%的瓶颈下游路段交通流量.

关键词：可变限速控制深度确定性策略梯度算法八车道高速公路施工区智能网联车辆协同自适应巡航控制

Rapid Seedless Synthesis of Gold Nanoplates with Microscaled Edge Length in a High Yield and Their Application in SERS

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Nano-Micro Letters 2016年第4期8卷 328-335页

作者： Sheng Chen pengyu xu Yue Li Junfei xue Song Han Weihui Ou Li Li Weihai Ni Department of Chemistry College of SciencesShanghai University Division of i-Lab & Key Laboratory for Nano-Bio Interface Research Suzhou Institute of Nano-Tech & Nano-BionicsChinese Academy of Sciences

We report a facile and reproducible approach toward rapid seedless synthesis of single crystalline gold nanoplates with edge length on the order of microns.The reaction is carried out by reducing gold ions with ascorbic acid in the presence of cetyltrimethylammonium bromide(CTAB).Reaction temperature and molar ratio of CTAB/Au are critical for the formation of gold nanoplates in a high yield,which are,respectively,optimized to be 85 °C and 6.The highest yield that can be achieved is 60 % at the optimized condition.The synthesis to achieve the microscaled gold nanoplates can be finished in less than 1 h under proper reaction conditions.Therefore,the reported synthesis approach is a time-and costeffective one.The gold nanoplates were further employed as the surface-enhanced Raman scattering substrates and investigated individually.Interestingly,only those adsorbed with gold nanoparticles exhibit pronounced Raman signals of probe molecules,where a maximum enhancement factor of 1.7 9 10~7 was obtained.The obtained Raman enhancement can be ascribed to the plasmon coupling between the gold nanoplate and the nanoparticle adsorbed onto it.

关键词： Gold nanoplates Seedless synthesis SERS CTAB

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艾滋病抑郁症的中医研究现状和思考

中华中医药杂志 2024年第3期39卷 1401-1404页

作者：陈守生李鹏宇徐赫文郭会军河南中医药大学郑州450046 河南中医药大学第一附属医院郑州450000 河南省病毒性疾病中医药防治重点实验室郑州450000

艾滋病抑郁症是艾滋病病程中常见的精神障碍疾病,对HIV/AIDS患者的生活质量、服药依从性、疗效等产生了严重影响,但目前仍无统一的诊疗方案。归纳分析近年来艾滋病抑郁症的中医相关文献,认为其病因病机主要有不良情绪刺激、久病气血耗... 详细信息

艾滋病抑郁症是艾滋病病程中常见的精神障碍疾病,对HIV/AIDS患者的生活质量、服药依从性、疗效等产生了严重影响,但目前仍无统一的诊疗方案。归纳分析近年来艾滋病抑郁症的中医相关文献,认为其病因病机主要有不良情绪刺激、久病气血耗伤、痰瘀阻滞心神等;目前其辨证分型仍不统一,现代医家多使用丹栀逍遥散、柴胡汤加龙骨牡蛎汤、归脾汤等方治疗;其治疗措施除中药外,针灸、情志护理等非药物疗法也不可忽视。文章对艾滋病抑郁症相关中医研究进行分析和总结,并提出自己的思考,以期为中医临床选方治疗提供参考。

关键词：艾滋病抑郁症辨证论治中医药针灸

From active fault segmentation to risks of earthquake hazards and property and life losses—A case study from the Xianshuihe-Xiaojiang fault zone

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Science China Earth Sciences 2023年第6期66卷 1345-1364页

作者： Jia CHENG Chong xu Jian MA Xiwei xu pengyu ZHU National Institute of Natural Hazards Ministry of Emergency Management of ChinaBeijing 100085China Key Laboratory of Compound and Chained Natural Hazards Dynamics Ministry of Emergency Management of ChinaBeijing 100085China Institute of Engineering Mechanics China Earthquake AdministrationHarbin 150080China School of Earth Sciences and Resources China University of Geosciences(Beijing)Beijing 100083China

Strong earthquakes generally rupture along active faults,and associated ground motion can cause earthquake disasters,property losses,and casualties from kilometers to tens of kilometers away.Therefore,one of the most effective ways to find earthquake’s dangerous parts of faults is to study the seismic hazards on fault segments.After that,we can also evaluate the probabilities of landslides hazard,property losses,and casualties.In this study,using fault slip rates and magnitude-frequency relationship as constraints,we calculated the earthquake occurrence rates for the segments along the Xianshuihe-Xiaojiang fault zone.We obtained 11 sites of single-segment or multi-segment rupturing risk.We also provided these potential events conditional probabilities in the next 30 years.For the 11 potential earthquakes,we calculated the property loss of residential buildings in the ground motion field.The most significant property loss is CNY 7.65 billion caused by the single-segment rupturing of the F19 segment on the Anninghe fault.We applied the deep learning neural network method in predicting the number of casualties for the potential earthquakes,showing that the most significant event is the multi-segment rupturing of the F29 and F30 segments on the Anninghe fault with the predicted death number of 279-317.We also evaluated the probabilities of earthquake landslides after the potential earthquakes.The results show that areas with intense compressional tectonic stress are highly unstable and prone to earthquake induced landslides,including the southern section of the Yuke fault,the southern section of the Xianshuihe fault,and the conjugated area between the southern section of the Daliangshan fault and the Lianfeng fault.These areas have a considerable number of earthquake landslides with probabilities>10%.The methodology and results will give us a new effective way of applying active fault data in earthquake hazard and risk analysis and provide a scientific path for earthquake prevention,disaster reduction,and emergency r

关键词： Xianshuihe-Xiaojiang fault Fault segmentation Multi-segment rupture Probabilities of landslide Property losses

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调峰和调频工况下磷酸铁锂电池组的冷却研究

低温与超导 2024年第3期52卷 88-95页

作者：郭鹏宇王铭民许栋栋郭东亮国网江苏省电力有限公司南京210024 国网江苏省电力有限公司电力科学研究院南京211103

本文对储能电池在调峰和调频工况下的风冷和液冷冷却技术进行研究。采用有限元技术建立了实际调峰和调频工况下电池的热模型,并进行仿真分析;通过现场真实测量温度验证了模型的正确性;在搭建的产热模型上进一步仿真,分别进行风冷和液冷... 详细信息

本文对储能电池在调峰和调频工况下的风冷和液冷冷却技术进行研究。采用有限元技术建立了实际调峰和调频工况下电池的热模型,并进行仿真分析;通过现场真实测量温度验证了模型的正确性;在搭建的产热模型上进一步仿真,分别进行风冷和液冷定量模拟。结果表明:调峰调频运行工况下电池温度升高明显,室温下,调频工况下仿真最后温度升高到30.8℃,调峰工况下仿真最后温度升高到36.8℃;采用的风冷液冷两种冷却方案均可在一定程度上改善电池组冷却状态,但冷却效果差异较大,风冷可使最终温度下降2℃左右,而液冷温度控制效果更好,但经济性较差,可在实际工况中结合现场情况灵活使用。

关键词：锂离子电池调峰调频风冷液冷有限元仿真

基于电子鼻和顶空固相微萃取结合气相色谱-嗅闻-质谱联用技术分析不同品种羊肉煮制风味特征

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食品与发酵工业 2024年第10期50卷 298-305页

作者：陈鹏羽张德权李少博王卫徐乐张佳敏张锐陈丽成都大学食品与生物工程学院肉类加工四川省重点实验室四川成都610106 中国农业科学院农产品加工研究所农业农村部农产品质量安全收贮运管控重点实验室北京100193

为探究不同品种羊肉煮制后风味的差异,采用电子鼻和顶空固相微萃取结合气相色谱-嗅闻-质谱联用(headspace solid-phase microextraction gas chromatography-olfactometry-mass spectrometer,HS-SPME-GC-O-MS)技术,对煮制后欧拉羊、巴寒杂交羊和宁夏滩羊背最长肌和霖肉挥发性风味化合物成分进行了比较分析。结果表明,欧拉羊肉煮制后的电子鼻图谱轮廓区别于巴寒杂交羊和宁夏滩羊。运用HS-SPME-GC-O-MS技术对煮制羊肉挥发性风味指纹进行分析,3种羊肉共检出30种挥发性化合物,主要包括醛类、醇类、酯类及其他类,其中20种挥发性化合物可被嗅闻出,19种香气活度值≥1的关键香气化合物,包括1-辛烯-3-醇、己醛、壬醛、辛醛、乙酸乙酯、二甲基三硫和2-戊基呋喃等。结合多元数据统计结果分析,发现巴寒杂交羊肉和宁夏滩羊肉煮制后的挥发性化合物成分相近,与欧拉羊肉差距较大,这与电子鼻结果一致。该项研究为羊肉风味品质评价、产地溯源、真伪鉴别提供可靠的数据参考。

关键词：羊肉煮制气相色谱-嗅闻-质谱联用产地溯源挥发性风味物质