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Analysis of Spatiotemporal Differences and Influencing Factors of Land Use Carbon Emissions in Ningxia

Huanjing Kexue/Environmental Science 2024年第9期45卷 5049-5059页

作者： Wang, Ya-Juan Zhai, chen-Xi Liu, Cai-Yu chen, Ze-Yu School of Economics and Management Ningxia University Yinchuan 750021 China

Analyzing the spatiotemporal differences in land use carbon emissions systematically and exploring their influencing factors for the rational allocation of land resources is of great importance and promoting collaborative emission reduction in this region. Based on the calculation of land use carbon emissions in Ningxia and its prefecture-level cities from 2000 to 2021，the regional differences in carbon emissions，economic efficiency，and carbon sink capacity were reflected through the difference index，carbon emission intensity，economic contribution rate，and carbon sink ecological carrying capacity. The results were as follows：① From 2000 to 2021，the land use carbon emissions in Ningxia showed a significant increase by 110 919 400 t. Construction land was the main carbon source land，accounting for 99.57% of the total carbon emissions in 2021，and forest land was the main type of carbon absorption，accounting for 79.22% of the total carbon absorption in 2021. ② During the research period，the carbon emission difference among prefecture-level cities showed a trend of first rising and then slightly falling，with the gap reaching the maximum in 2016. ③ Although the overall difference in carbon emission intensity among prefecture-level cities showed a trend of narrowing and convergence，the economic contribution coefficient and carbon sink ecological carrying coefficient had significant differences，and the economic contribution rate and carbon emission contribution rate were both in a relatively unbalanced state，with obvious regional differences. ④ Land use carbon emission intensity，land use structure，economic development level，and population all played a promoting role in land use carbon emission，with contribution rates of 56.48%，41.27%，85.20%，and 9.29%，respectively. The contribution value of land use carbon intensity per unit GDP was negative，which inhibited the increase of land use carbon emission. © 2024 Science Press. All rights reserved.

关键词： Carbon sequestration

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Pyrimethamine upregulates BNIP3 to interfere SNARE-mediated autophagosome-lysosomal fusion in hepatocellular carcinoma

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Journal of Pharmaceutical Analysis 2024年第2期14卷 211-224页

作者： Jingjing Wang Qi Su Kun chen Qing Wu Jiayan Ren Wenjuan Tang Yu Hu Zeren Zhu cheng cheng Kaihui Tu Huaizhen He Yanmin Zhang School of Pharmacy Health Science CenterXi'an Jiaotong UniversityXi'an710061China

Hepatocellular carcinoma (HCC) is one of the most common tumor types and remains a major clinical challenge. Increasing evidence has revealed that mitophagy inhibitors can enhance the effect of chemotherapy on HCC. However, few mitophagy inhibitors have been approved for clinical use in humans. Pyrimethamine (Pyr) is used to treat infections caused by protozoan parasites. Recent studies have reported that Pyr may be beneficial in the treatment of various tumors. However, its mechanism of action is still not clearly defined. Here, we found that blocking mitophagy sensitized cells to Pyr-induced apoptosis. Mechanistically, Pyr potently induced the accumulation of autophagosomes by inhibiting autophagosome-lysosome fusion in human HCC cells. In vitro and in vivo studies revealed that Pyr blocked autophagosome-lysosome fusion by upregulating BNIP3 to inhibit synaptosomal-associated protein 29 (SNAP29)-vesicle-associated membrane protein 8 (VAMP8) interaction. Moreover, Pyr acted synergistically with sorafenib (Sora) to induce apoptosis and inhibit HCC proliferation in vitro and in vivo. Pyr enhances the sensitivity of HCC cells to Sora, a common chemotherapeutic, by inhibiting mitophagy. Thus, these results provide new insights into the mechanism of action of Pyr and imply that Pyr could potentially be further developed as a novel mitophagy inhibitor. Notably, Pyr and Sora combination therapy could be a promising treatment for malignant HCC.

关键词： Pyrimethamine BNIP3 SNARE Autophagosome-lysosome fusion Hepatocellular carcinoma Sorafenib

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PSRDP:A Parallel Processing Method for Pulsar Baseband Data

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Research in Astronomy and Astrophysics 2024年第1期24卷 300-310页

作者： Ya-Zhou Zhang Hai-Long Zhang Jie Wang Xin-chen Ye Shuang-Qiang Wang Xu Du Han Wu Ting Zhang Shao-Cong Guo Meng Zhang Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Radio Astronomy Chinese Academy of SciencesNanjing 210008China National Astronomical Data Center Beijing 100101China Southeast University Nanjing 211189China School of Cyber Science and Engineering Qufu Normal UniversityQufu 273165China

To address the problem of real-time processing of ultra-wide bandwidth pulsar baseband data,we designed and implemented a pulsar baseband data processing algorithm(PSRDP)based on GPU parallel computing *** can perform operations such as baseband data unpacking,channel separation,coherent dedispersion,Stokes detection,phase and folding period prediction,and folding integration in GPU *** tested the algorithm using the J0437-4715 pulsar baseband data generated by the CASPSR and Medusa backends of the Parkes,and the J0332+5434 pulsar baseband data generated by the self-developed backend of the Nan Shan Radio *** obtained the pulse profiles of each baseband *** experimental analysis,we have found that the pulse profiles generated by the PSRDP algorithm in this paper are essentially consistent with the processing results of Digital Signal Processing Software for Pulsar Astronomy(DSPSR),which verified the effectiveness of the PSRDP ***,using the same baseband data,we compared the processing speed of PSRDP with DSPSR,and the results showed that PSRDP was not slower than DSPSR in terms of *** theoretical and technical experience gained from the PSRDP algorithm research in this article lays a technical foundation for the real-time processing of QTT(Qi Tai radio Telescope)ultra-wide bandwidth pulsar baseband data.

关键词： (stars:)pulsars:general methods:data analysis techniques:miscellaneous

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Interaction mechanism between BaZrO_(3)/Y_(2)O_(3) refractory and Ti_(2)Ni alloy melts

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Journal of Iron and Steel Research(International) 2024年第6期31卷 1376-1388页

作者： Xiao Hou Guang-yao chen Jian Liu Ming-rui Lv Fei-hai Yu Qi-sheng Feng Rong-bin Li Xiong-gang Lu Chong-he Li State Key Laboratory of Advanced Special Steel and Shanghai Key Laboratory of Advanced Ferromeallurgy and School of Materials Science and Engineering Shanghai UniversityShanghai 200072China Shanghai Special Casting Engineering Technology Research Center Shanghai 201605China Zhejiang Institute of Advanced Materials Shanghai UniversityJiashan 314100ZhejiangChina School of Materials Science and Engineering Shanghai DianJi UniversityShanghai 201306China

The titanium alloys with highly chemical activity require stable crucible refractories that can withstand the erosion of alloy *** phase composition and microstructure are crucial factors that affect the stability of the refractory *** effect of Y_(2)O_(3) on the composition and microstructure of BaZrO_(3) crucible was systematically investigated,and the improved mechanism of the stability of BaZrO_(3)/Y_(2)O_(3) crucible was clarified in comparison with the BaZrO_(3) *** results showed that the erosion layer thickness of the BaZrO_(3)/Y_(2)O_(3) crucible was only 63μm,which was far less than that in the BaZrO_(3) crucible(485μm),and the erosion layer in the BaZrO_(3)/Y_(2)O_(3) crucible also exhibited a higher density than that in the BaZrO_(3) *** the sintering,Y_(2)O_(3) could improve the densification of the BaZrO_(3) crucible due to the solid solution effect between Y_(2)O_(3) and ZrO_(2),which also caused the evaporation of BaO,resulting in the generation of a Y_(2)O_(3)(ZrO_(2))film on the surface of the ***,the Y_(2)O_(3)(ZrO_(2))had higher thermodynamic stability than Y_(2)O_(3),confirming that the BaZrO_(3)/Y_(2)O_(3) crucible with high density exhibited a superior erosion resistance to titanium *** dual-phase structure provides a strategy to design a long-life and stable refractory for melting titanium alloys.

关键词： Barium zirconate Yttrium oxide Dual-phase refractory Titanium alloy Interaction

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Structural insights on anti-biofilm mechanism of heated slightly acidic electrolyzed water technology against multi-resistant Staphylococcus aureus biofilm on food contact surface

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Food Science and Human Wellness 2024年第3期13卷 1556-1566页

作者： Pianpian Yan Ramachandran Chelliah Kyoung Hee Jo Xiuqin chen Akanksha Tyagi Hyeon Yeong Jo Fazle Elahi Nam Chan Woo Min Seung Wook Deog Hwan Oh Department of Food Science and Biotechnology College of Agriculture and Life SciencesKangwon National UniversityChuncheon 24341South Korea Kangwon Institute ofInclusive Technology(KIIT) Kangwon National UniversityChuncheon 24341South Korea Saveetha School of Engineering (SIMATS)UniversitySriperumbudur 600124India Seoulin Bioscience Company Seongnam-si 13488South Korea

Slightly acidic electrolyzed water(SAEW)has proven to be an efficient and novel sanitizer in food and agriculture *** study assessed the efficacy of SAEW(30 mg/L)at 40℃on the inactivation of foodbome pathogens and detachment of multi-resistant Staphylococcus aureus(MRSA)*** underlying mechanism of MRS A biofilm under heated SAEW at 40℃treatment on metabolic profiles was *** results showed that the heated SAEW at 40℃significantly effectively against foodbome pathogens of 1.96-7.56(lg(CFU/g))reduction in pork,chicken,spinach,and *** heated SAEW at 40℃treatment significantly reduced MRS A biofilm cells by 2.41(lg(CFU/cm^(2))).The synergistic effect of SAEW treatment showed intense anti-biofilm activity in decreasing cell density and impairing biofilm cell *** metabolic response of MRSA biofilms,treated by SAEW at 40℃,revealed the alterations of intracellular metabolites,including amino acids,organic acid,fatty acid,and ***,signaling pathways involved in amino acid metabolism,energy metabolism,nucleotide synthesis,carbohydrate metabolites,and lipid biosynthesis were functionally disrupted by the SAEW at 40℃*** per our knowledge,this is the first research to uncover the potential mechanism of heated SAEW treatment against MRSA biofilm on food contact surface.

关键词： Multi-resistant Staphylococcus aureus Metabolic profile SAEW Biofilm Hurdle technology Electrode material

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Betulinic acid protects against ovarian impairment by decreasing F-2 toxin-induced oxidative stress and inflammation associated with the downregulation of p38 expression in mice

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Food Science and Human Wellness 2024年第3期13卷 1292-1302页

作者： Li Kong Xinyu Gao Lijuan Zhu Xing Lin You Huang Chunlin Huang Wenjiang Yang Yazhi chen Haoqiang Zhao Jing Wu Zhihang Yuan Jin’e Yi Hunan Engineering Research Center of Livestock and Poultry Health Care College of Veterinary MedicineHunan Agricultural UniversityChangsha 410128China

F-2 toxin is an estrogenic mycotoxin that causes reproductive disorders in *** acid(BA)is a natural pentacyclic lupane-structure triterpenoid that has diverse pharmacological *** this study,the antioxidative and anti-inflammatory effects of BA and its underlying mechanism are explored in F-2 toxin-triggered mouse ovarian *** found that BA alleviated the F-2 toxin-induced ovarian impairment by stimulating follicle growth,reducing inflammatory cell infiltration,repairing damaged mitochondria and endoplasmic ***,BA not only reversed F-2 toxin-induced reduction of follicle stimulating hormone(FSH)and luteinizing hormone(LH)levels in the serum,but also restrained the protein expression of the estrogen receptors a(ERa)and ERβ.Moreover,BA restored the balance of F-2 toxin-induced ovarian redox system ***,we found that 0.25 mg/kg BA played an anti-inflammatory role in the F-2 toxin-induced ovarian impairment by decreasing interleukin-1β(IL-1β).IL-6,and tumor necrosis factor-α(TNF-α)mRNA expression,as well as inhibiting p38 protein *** data demonstrated that BA exerts its protective effect on F-2 toxin-induced ovarian oxidative impairment and inflammation by inhibiting p38 expression,which implies a natural product-based medicine to ameliorate F-2 toxin-caused female reproductive toxicity and provides a detoxifying method for food contaminated by mycotoxin.

关键词： Betulinic acid F-2 toxin Ovarian damage p38 MAPK signaling pathway

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“两委”组织法集成化的路径与方法

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学术研究 2024年第5期 71-79+177+2页

作者：江国华陈嘉林武汉大学法学院武汉大学中华民族共同体法治研究院武汉大学“四部委”铸牢中华民族共同体意识研究基地武汉大学国家2011计划司法文明协同创新中心武汉大学湖北省人大常委会地方立法研究与人才培养基地

“两委”组织法的集成化应贯彻人民当家作主、全过程人民民主以及底线公平的原则，充分践行以人民为中心的法律修改精神。从修改的策略来看，应在“两委”组织法的基础之上进行大修，并通过集成化的方式进行合修，从务虚走向务实，夯实... 详细信息

“两委”组织法的集成化应贯彻人民当家作主、全过程人民民主以及底线公平的原则，充分践行以人民为中心的法律修改精神。从修改的策略来看，应在“两委”组织法的基础之上进行大修，并通过集成化的方式进行合修，从务虚走向务实，夯实基层组织的经济基础。在修改的基本方法中，“两委”组织法的修改应紧扣“自治范围”这个主要矛盾，把握“法治与自治”这一对核心范畴，抓住“共建共治共享”这个治理模式，推动基层治理体系和治理能力的现代化发展。

关键词： “两委”组织法集成化原则与方法

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Establishment of an Iron Deficiency Model by Iron Depletion in Pregnant Rats

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Biomedical and Environmental Sciences 2024年第2期37卷 210-215页

作者： chen Xi HAN Chao ZHAO Jin Peng SHEN Shi WANG Li Yuan REN Shou WANG Tong Lei MA Yan XU Ze Chao HUO Jun Sheng Key Laboratory of Trace Element Nutrition National Health Commission of the People’s Republic of ChinaNational Institute for Nutrition and HealthChinese Center for Disease Control and PreventionBeijing 100050China

Anemia,a global public health problem,has significant adverse consequences on the cognitive development of children and the work capacity of adults;affecting social and economic ***,roughly 43%of children under five years of age,38%of pregnant women,and 29%of nonpregnant women had *** during pregnancy significantly increases the risk of low birth weight and preterm birth.A 10 g/L increase in hemoglobin has been estimated to decrease the risk of maternal and perinatal mortality by 29%and 28%.

关键词： mortality pregnancy anemia

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MGMT activated by Wnt pathway promotes cisplatin tolerance through inducing slow-cycling cells and nonhomologous end joining in colorectal cancer

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Journal of Pharmaceutical Analysis 2024年第6期14卷 863-877页

作者： Haowei Zhang Qixin Li Xiaolong Guo Hong Wu chenhao Hu Gaixia Liu Tianyu Yu Xiake Hu Quanpeng Qiu Gang Guo Junjun She Yinnan chen Department of General Surgery The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an710061China Center for Gut Microbiome Research Med-X InstituteThe First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an710061China Department of High Talent The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an710061China

Chemotherapy resistance plays a pivotal role in the prognosis and therapeutic failure of patients with colorectal cancer(CRC).Cisplatin(DDP)-resistant cells exhibit an inherent ability to evade the toxic chemotherapeutic drug effects which are characterized by the activation of slow-cycle programs and DNA *** the elements that lead to DDP resistance,O^(6)-methylguanine(O^(6)-MG)-DNA-methyltransferase(MGMT),a DNA-repair enzyme,performs a quintessential *** this study,we clarify the significant involvement of MGMT in conferring DDP resistance in CRC,elucidating the underlying mechanism of the regulatory actions of MGMT.A notable upregulation of MGMT in DDP-resistant cancer cells was found in our study,and MGMT repression amplifies the sensitivity of these cells to DDP treatment in vitro and in ***,in cancer cells,MGMT overexpression abolishes their sensitivity to DDP ***,the interaction between MGMT and cyclin dependent kinase 1(CDK1)inducing slow-cycling cells is attainted via the promotion of ubiquitination degradation of ***,to achieve nonhomologous end joining,MGMT interacts with XRCC6 to resist chemotherapy *** transcriptome data from samples of 88 patients with CRC suggest that MGMT expression is co-related with the Wnt signaling pathway activation,and several Wnt inhibitors can repress drug-resistant *** summary,our results point out that MGMT is a potential therapeutic target and predictive marker of chemoresistance in CRC.

关键词： Colorectal cancer MGMT Chemotherapy resistance Slow-cycling cells Nonhomologous end joining Wnt pathway

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Nanopore design of sulfur doped hollow carbon nanospheres for superior potassium-ion battery anodes

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Rare Metals 2024年第5期43卷 2103-2114页

作者： Zhen-Dong Liu Hui-Yan Feng Yu-chen Wang Fei Wang Yue Liu Jian-Xiao Yang Yue Gu Jun Tan Chong Ye cheng-Zhi Zhang Ji Hua Laboratory Foshan 528000China School of Chemical Engineering and Light Industry Guangdong University of TechnologyGuangzhou 510006China Hunan Province Key Laboratory for Advanced Carbon Materials and Applied Technology College of Materials Science and EngineeringHunan UniversityChangsha 410082China

Sulfur doped carbonaceous materials are promising anodes for potassium-ion batteries because of their ability to bridge active sites and induce C/S electron coupling,resulting in increased ion storage capacitance However,the large potassium ions could cause significant volume expansion and structure collapse during operation in sulfur doped carbonaceous anodes,which lead to rapidly capacity sacrifice during long-term *** design for anchoring sulfur atom in carbon skeleton is a novel way to alleviate the structure collapse and maintain the cycling ***,this study developed a controlled nanopore and sulfur doped carbon sphere structure(S-NPHCSs).In potassium-ion batteries S-NPHCSs anode demonstrated exceptional performance with a high reversible capacity of 247 mAh·g^(–1)after 50 cycles at 0.2 A·g^(–1)and delivered a long cycle stability of 600 cycles at a high current density of 1.0 A·g^(–1).Interconnected nanopores and doped sulfur structure not only expand the accumulation space and offer ample active sites for diffusion and adsorption of potassium ions,but also build stable channels through nanopore structure to ensure the cyclic *** finding provides a fundamental theory for designing nanopore structures and introducing sulfur doped carbonaceous materials to enhance capacitive potassium storage and long cycle stability.

关键词： Nanopore Carbon materials Sulfur doping Anode Potassium-ionbatteries

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