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Solution-phase synthesis of ordered mesoporous carbon as resonant-gravimetric sensing material for room-temperature H2S detection

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Chinese Chemical Letters 2020年第6期31卷 1680-1685页

作者： Jiawei Ni Tao Zhao lei Tang pengpeng Qiu Wan Jiang Lianjun Wang Pengcheng Xu Wei Luo State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringInstitute of Functional MaterialsDonghua UniversityShanghai 201620China State Key Laboratory of Transducer Technology Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China College of Life and Environmental Sciences Shanghai Normal UniversityShanghai 200234China University of Chinese Academy of Sciences Beijing 100049China

H2S can cause multiple diseases and poses a great threat to human ***,the precise detection of extremely toxic H2S at room temperature is still a great ***,a facile solvent evaporation induced aggregating assembly(EIAA)method has been applied for the production of ordered mesoporous carbon(OMCs)in an acidic THF/H2 O solution with high-molecular-weight poly(ethylene oxide)-b-polystyrene(PEO-b-PS)copolymers as the structure-directing agent,formaldehyde and resorcinol as carbon *** with the continuous evaporation of THF from the mixed solution,cylindrical micelles are formed in the solution and further assemble into highly ordered *** obtained OMCs possesses a two-dimensional(2 D)hexagonal mesostructure with uniform and large pore diameter(~19.2 nm),high surface area(599 m2/g),and large pore volume(0.92 cm3/g).When being used as the resonant cantilever gas sensor for room-temperature H2S detection,the OMCs has delivered not only a superior gas sensing performance with ultrafast re s ponse(14 s)and recovery(21 s)even at low concentration(2 ppm)but also an excellent selectivity toward H2S among various common interfering ***,the limit of detection is better than 0.2 ppm,indicating its potential application in environmental monitoring and health protection.

关键词： Mesoporous materials Carbon Self-assembly Resonant cantilever gas sensor H2S

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新时代大学生雷锋精神培育的价值意蕴、现实挑战与实践路径

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辽宁农业职业技术学院学报 2024年第3期26卷 55-59页

作者：李鹏鹏宋蒙新余学院江西新余338004

新时代培育大学生雷锋精神具有促进大学生全面发展、引领社会文明风尚、推进中国式现代化的价值意蕴。当前在实践中还存在认知雷锋精神内涵的深度不够、培育雷锋精神的主动性不够、培育雷锋精神形式单一的现实挑战,应从学校优化内容供... 详细信息

新时代培育大学生雷锋精神具有促进大学生全面发展、引领社会文明风尚、推进中国式现代化的价值意蕴。当前在实践中还存在认知雷锋精神内涵的深度不够、培育雷锋精神的主动性不够、培育雷锋精神形式单一的现实挑战,应从学校优化内容供给、学生发挥主观能动、创新传播教育载体、营造浓厚环境氛围的实践路径培育大学生雷锋精神。

关键词：雷锋精神价值意蕴现实挑战实践路径

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Rapid response of brain metastasis to crizotinib in a patient with KLC1-ALK fusion and MET gene amplification positive non-small cell lung cancer:a case report

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Cancer Biology & Medicine 2017年第2期14卷 183-186页

作者： Peng Wang Pei Xiao Yingnan Ye pengpeng Liu lei Han Li Dong Chunhua She Jinpu Yu Department of Neuro-Oncology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin's Clinical Research Center for Cancer Cancer Molecular Diagnostic Center Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin's Clinical Research Center for Cancer

Non-small cell lung cancer(NSCLC) ranks as the leading cause of cancer-related death in the world. Brain metastasis(BM) is a common complication of NSCLC, with 25%–40% of patients developing BM during the course of the disease. A significant strategy of local disease control in the central nervous system is radiation therapy. With the development of precision medicine,the concept of treating lung cancer BM has gradually changed. In this case, we performed a surgical procedure to obtain enough tumor tissue for the detection of the target gene and other related experiments after the patient was informed. Finally, we found that the patient had both hepatocyte growth factor receptor(MET) gene amplification and kinesin light chain 1-anaplastic lymphoma kinase fusion(KLC1-ALK) through next-generation sequencing and showed sensitivity to the targeted therapy of crizotinib. The patient exhibited good response. Our case was successful and underwent targeted therapy with the guidance of precise diagnosis.

关键词： NSCLC precision medicine KLC1-ALK fusion MET amplification next-generation sequencing

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Benefit of everolimus as a monotherapy for a refractory breast cancer patient bearing multiple genetic mutations in the PI3K/AKT/mTOR signaling pathway

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Cancer Biology & Medicine 2018年第3期15卷 314-321页

作者： Yehui Shi Wenwen Zhang Yingnan Ye Yanan Cheng lei Han pengpeng Liu Weipeng Zhao Zhongsheng Tong Jinpu Yu Medical Oncology Department of Breast Cancer Tianjin Medical University Cancer Institute&HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin's Clinical Research Center for CancerKey Laboratory of Cancer Immunology and BiotherapyTianjin 300060China Cancer Molecular Diagnostics Core Tianjin Medical University Cancer Institute&HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin's Clinical Research Center for CancerKey Laboratory of Cancer Immunology and BiotherapyTianjin 300060China Department of Immunology Tianjin Medical University Cancer Institute&HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin's Clinical Research Center for CancerKey Laboratory of Cancer Immunology and BiotherapyTianjin 300060China

A postmenopausal patient with a diagnosis of estrogen receptor(ER)(+), progesterone receptor(PR)(+), and human epidermal growth factor receptor-2(HER2)(-) breast cancer was reported. The patient refused surgery and was resistant to conventional chemotherapy regimens. Computed tomography and the circulating tumor cell test indicated that the patient's tumor burden increased rapidly even after several chemotherapy sessions. Multiple genetic aberrances in the phosphatidylinositol3-kinases(PI3 K) signaling pathway were detected via next-generation sequencing(NGS)-based liquid biopsy, including a p. G1007 R missense mutation in exon 21 of PIK3 CA(33.61%), a p.L70 fs frameshift mutation in exon 3 of phosphatase and tension homolog deleted on chromosome ten(PTEN)(49.14%), and a p. D1542 Y missense mutation in exon 32 of mammalian target of rapamycin(m TOR)(1.66%). Therefore, only the m TOR inhibitor everolimus was administered to the patient. Partial remission(PR) was observed after 2 months, and sustained stable disease(SD) was observed after a year and a half. Subsequent sequencing showed that the mutation ratio of PIK3 CA decreased to 4.17%, and that the PTEN and m TOR mutations disappeared, which revealed the significant curative effect of everolimus. We report the first case of successful monotherapy treatment using everolimus in a patient with advanced breast cancer bearing mutations in genes involved in the PI3 K/ARK/m TOR signaling pathway. The success of this case highlights the invaluable clinical contribution of NGS-based liquid biopsy, as it successfully provided an optimal therapeutic target for the patient with advanced breast cancer.

关键词： Breast cancer everolimus next-generation sequencing liquid biopsy PI3K/AKT/mTOR

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基于***+Django的大坝安全监测信息管理系统开发

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软件 2024年第1期45卷 47-49,82页

作者：尹光景李晨玉曾子彬赵芃芃雷鹏常留红中国水利水电第八工程局有限公司湖南长沙410004 长沙理工大学水利与环境工程学院湖南长沙410114

随着大坝安全监测向自动化、智能化和高精度化发展,统一管理监测数据,提升系统的跨平台性、兼容性和易维性已成为提高大坝安全监测信息化管理水平的关键。归纳分析大坝安全监测常用的电阻式、差阻式、振弦式等传感器参数及监测变量信息... 详细信息

随着大坝安全监测向自动化、智能化和高精度化发展,统一管理监测数据,提升系统的跨平台性、兼容性和易维性已成为提高大坝安全监测信息化管理水平的关键。归纳分析大坝安全监测常用的电阻式、差阻式、振弦式等传感器参数及监测变量信息,设计数据标准化导入模板。基于前后端分离开发模式,采用***+Django框架,运用RESTful API统一功能接口。开发集多类型数据源的导入、预处理、查询及报表快速生成等功能的信息管理系统,实现监测数据的集中规范化管理。研究成果已应用于某水电站,显著提高了大坝安全监测信息管理的效率,可在类似工程中推广应用。

关键词：大坝安全监测信息管理系统前后端分离 Vue.js Django

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山东省长山列岛北部海域浅表层海洋灾害地质特征及成因机制分析

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山东国土资源 2024年第4期40卷 25-32页

作者：张燕挥张一勇晓宇雷雁翔张朋朋孟屹明山东省物化探勘查院山东济南250013 山东省地质勘查工程技术研究中心山东济南250013

海洋灾害地质作为影响海洋资源开发、海洋工程建设活动的重要因素,越来越受到人们的重视。通过对长山列岛北部海域多波束测量、浅地层剖面测量工作成果资料的解译研究,分析了影响海底浅表层潜在海洋灾害地质的因素,查明了主要灾害类型... 详细信息

海洋灾害地质作为影响海洋资源开发、海洋工程建设活动的重要因素,越来越受到人们的重视。通过对长山列岛北部海域多波束测量、浅地层剖面测量工作成果资料的解译研究,分析了影响海底浅表层潜在海洋灾害地质的因素,查明了主要灾害类型、埋藏特征和分布范围,编制了灾害地质分布图,分析了灾害地质的形成机制及危害性,研究区灾害类型主要有海底冲刷槽、浅层气、埋藏古河道、断层等。为研究区海洋资源的开发利用,尤其海洋牧场建设等工作提供科学依据。

关键词：灾害地质浅表层特征分析长山列岛山东省

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Measurement and analysis of the extreme ultraviolet emission band of laser-produced antimony plasmas

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Plasma Science and Technology 2019年第4期21卷 61-65页

作者： Shiquan CAO Maogen SU Qi MIN Duixiong SUN lei WU Siqi HE Kaiping WANG pengpeng MA Chenzhong DONG Key Laboratory of Atomic and Molecular Physics&Functional Material of Gansu Province.College of Physics and Electronic Engineering Northwest Normal UniversityLanzhou 730070People's Republic of China

The temporal evolution of extreme ultraviolet(EUV)emission spectra of laser-produced antimony(Sb)plasmas has been measured in the 7-16 nm wavelength region using spatio?temporally resolved lase-produced plasma spectroscopy *** spectral profiles involve an intense quasi-continuous band with superimposed intense characteristic radiation and are different with the increase of delay *** spectral structures were also analyzed according to Hartree-Fock calculations with configuration interaction effects and contributed from 4d^4/;4d-4p,and 4d-5f unresolved transition arrays of Sb7*-Sb131.A steady-state collisionalradiative model was used to estimate the electron temperature and density range of Sb *** work would enrich the spectral data of highly-charged ions and provided a possible selection for developing EUV light sources.

关键词： laser-produced plasmas highly-charged ions EUV emission antimony

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Hepatitis B virus-associated follicular lymphoma presents T-cell inflamed phenotype and response to lenalidomide

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Cancer Communications 2022年第2期42卷 170-174页

作者： Nan Wang Wei Qin Zhong Zheng Ming Zhao Jie Xiong Hai Fang Rui Sun Yichao Wang Chen Li lei DongXiaojian Sun Li Wang pengpeng Xu Shu Cheng Haimin Xu Fan Zhang Weili Zhao State Key Laboratory of Medical Genomics National Research Center for Translational Medicine at ShanghaiShanghai Institute of HematologyRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025P.R.China Network&Information Center Shanghai Jiao Tong UniversityShanghai 200025P.R.China Department of Pathology Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025P.R.China Laboratory of Molecular Pathology Pôle de Recherches Sino-Français en Science du Vivant et GénomiqueShanghai 200025P.R.China

Dear Editor,Follicular lymphoma(FL)represents the most common subtype of indolent non-Hodgkin's lymphoma(NHL)with distinct pathological,cytogenetic,and molecular features,accounting for 9.7%of NHLs in China[1].FL maintains a differentiation stage similar to germinal center(GC)B cells and is divided into grades 1,2,3A,and 3B[2].Up to 90%of FLs harbor the t(14;18)(q32;q21)/BCL2 apoptosis regula-tor(BCL2)-immunoglobulin heavy locus(IGH)transloca-tion and epigenetic modifier mutations,particularly lysine methyltransferase 2D(KMT2D)and CREB-binding pro-tein(CREBBP)[2].

关键词： lymphoma BCL2 NHL

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基于人工智能的全自动化一站式CT血流储备分数在冠心病患者中的诊断与预后价值

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Science Bulletin 2024年第10期69卷 1472-1485页

作者：郭邦俊姜孟春郭翔唐春香钟健陆梦洁刘春雨张晓蕾乔红艳周帆许棚棚薛艺郑敏文侯阳王怡宁张佳胤张波张代民徐磊胡秀华周长圣李建华杨志文毛新生卢光明张龙江 Department of Radiology Jinling HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing 210002China Department of Radiology Affiliated Hospital of Jining Medical UniversityJining 272007China Department of Radiology Xijing HospitalFourth Military Medical UniversityXi’an 733399China Department of Radiology Shengjing Hospital of China Medical UniversityShenyang 110022China Department of Radiology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100005China Institute of Diagnostic and Interventional Radiology and Department of CardiologyShanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai 200235China Department of Radiology Jiangsu Taizhou People’s HospitalTaizhou 225399China Department of Cardiology Nanjing First HospitalNanjing Medical UniversityNanjing 210012China Department of Radiology Beijing Anzhen HospitalCapital Medical UniversityBeijing 100029China Department of Radiology Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310020China Department of Cardiology Jinling HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing 210002China Shukun(Beijing)Network Technology Co. Ltd.Beijing 102200China

Currently,clinically available coronary CT angiography(CCTA)derived fractional flow reserve(CT-FFR)is time-consuming and *** propose a novel artificial intelligence-based fully-automated,on-site CT-FFR technology,which combines the automated coronary plaque segmentation and luminal extraction model with reduced order 3 dimentional(3D)computational fluid dynamics.A total of 463 consecutive patients with 600 vessels from the updated China CT-FFR study in Cohort 1 undergoing both CCTA and invasive fractional flow reserve(FFR)within 90 d were collected for diagnostic performance *** Cohort 2,a total of 901 chronic coronary syndromes patients with index CT-FFR and clinical outcomes at 3-year follow-up were retrospectively *** Cohort 3,the association between index CT-FFR from triple-rule-out CTA and major adverse cardiac events in patients with acute chest pain from the emergency department was further *** diagnostic accuracy of this CT-FFR in Cohort 1 was 0.82 with an area under the curve of 0.82 on a per-patient *** with the manually dependent CT-FFR techniques,the operation time of this technique was substantially shortened by 3 times and the number of clicks from about 60 to *** CT-FFR technique has a highly successful(>99%)calculation rate and also provides superior prediction value for major adverse cardiac events than CCTA alone both in patients with chronic coronary syndromes and acute chest ***,the novel artificial intelligencebased fully automated,on-site CT-FFR technique can function as an objective and convenient tool for coronary stenosis functional evaluation in the real-world clinical setting.

关键词： Artificial intelligence Coronary CTA CT-derived fractional flow reserve Fully-automated Outcomes

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分体组合式矩形顶管机关键技术探究——结合中铁装备地下停车场项目

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隧道建设（中英文） 2019年第3期39卷 504-510页

作者：范磊蒋鹏鹏薛广记中铁工程装备集团有限公司河南郑州450016

为解决分体组合式矩形顶管机高精高效掘进难题,以中铁装备厂区地下停车场项目为依托,对矩形顶管机分体组合式结构适应性、位姿(位置与姿态)控制、组合式小刀盘开挖系统设计等关键技术展开研究:1)提出新型组合连接形式,解决因设备组合带... 详细信息

为解决分体组合式矩形顶管机高精高效掘进难题,以中铁装备厂区地下停车场项目为依托,对矩形顶管机分体组合式结构适应性、位姿(位置与姿态)控制、组合式小刀盘开挖系统设计等关键技术展开研究:1)提出新型组合连接形式,解决因设备组合带来的密封、管线联通等结构适应性问题; 2)创新盾体铰接结构,提出分体组合式顶管机复合位姿控制方法,即以纠偏油缸为主,双螺旋输送机互馈出渣为辅的协同纠偏策略,多刀盘转向转速控制与主机周向多点加压控制相结合的纠滚策略,实现浅覆土、零间距隧洞的高精度施工; 3)基于回归分析方法,探讨小刀盘扭矩系数随刀盘直径、刀盘布置位置的变化规律,建立直径3 m以下小刀盘扭矩系数的计算模型,为多刀盘系统驱动配置提供理论依据。

关键词：地下停车场矩形顶管机分体组合式复合位姿控制扭矩系数数学模型

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